CA2926793C - Spray-dry formulations for treating pulmonary arterial hypertension - Google Patents

Spray-dry formulations for treating pulmonary arterial hypertension Download PDF

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Publication number
CA2926793C
CA2926793C CA2926793A CA2926793A CA2926793C CA 2926793 C CA2926793 C CA 2926793C CA 2926793 A CA2926793 A CA 2926793A CA 2926793 A CA2926793 A CA 2926793A CA 2926793 C CA2926793 C CA 2926793C
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Canada
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groups
substituted
unsubstituted
alkyl
aryl
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CA2926793A
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English (en)
French (fr)
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CA2926793A1 (en
Inventor
Lawrence S. ZISMAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PULMOKINE Inc
Gilead Sciences Inc
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Individual
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Publication of CA2926793A1 publication Critical patent/CA2926793A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA2926793A 2013-10-11 2014-10-10 Spray-dry formulations for treating pulmonary arterial hypertension Active CA2926793C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361889887P 2013-10-11 2013-10-11
US61/889,887 2013-10-11
PCT/US2014/060039 WO2015054574A1 (en) 2013-10-11 2014-10-10 Spray dry formulations

Publications (2)

Publication Number Publication Date
CA2926793A1 CA2926793A1 (en) 2015-04-16
CA2926793C true CA2926793C (en) 2022-11-22

Family

ID=52813663

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2926793A Active CA2926793C (en) 2013-10-11 2014-10-10 Spray-dry formulations for treating pulmonary arterial hypertension

Country Status (8)

Country Link
US (2) US9925184B2 (https=)
EP (1) EP3054937B1 (https=)
JP (3) JP6483714B2 (https=)
CN (2) CN111743901B (https=)
AU (3) AU2014331796B2 (https=)
CA (1) CA2926793C (https=)
ES (1) ES2959419T3 (https=)
WO (1) WO2015054574A1 (https=)

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Also Published As

Publication number Publication date
EP3054937A1 (en) 2016-08-17
JP2021063119A (ja) 2021-04-22
AU2014331796A1 (en) 2016-04-28
EP3054937A4 (en) 2017-05-03
CA2926793A1 (en) 2015-04-16
EP3054937B1 (en) 2023-07-26
CN106132403A (zh) 2016-11-16
US20160235742A1 (en) 2016-08-18
JP2019089830A (ja) 2019-06-13
AU2022203611A1 (en) 2022-06-16
AU2014331796B2 (en) 2020-05-07
JP2016534153A (ja) 2016-11-04
WO2015054574A1 (en) 2015-04-16
CN106132403B (zh) 2020-04-28
US20180193336A1 (en) 2018-07-12
JP6483714B2 (ja) 2019-03-13
AU2020202556A1 (en) 2020-05-07
CN111743901B (zh) 2023-09-12
US9925184B2 (en) 2018-03-27
JP6823095B2 (ja) 2021-01-27
CN111743901A (zh) 2020-10-09
ES2959419T3 (es) 2024-02-26

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