CA2925332C - Methods of removing alpha-galactose - Google Patents

Methods of removing alpha-galactose Download PDF

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Publication number
CA2925332C
CA2925332C CA2925332A CA2925332A CA2925332C CA 2925332 C CA2925332 C CA 2925332C CA 2925332 A CA2925332 A CA 2925332A CA 2925332 A CA2925332 A CA 2925332A CA 2925332 C CA2925332 C CA 2925332C
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Canada
Prior art keywords
tissue
alpha
galactose
collagen
matrix
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Application number
CA2925332A
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English (en)
French (fr)
Other versions
CA2925332A1 (en
Inventor
Hui Xu
Li Ting Huang
Hua Wan
Rick Owens
Nathaniel Bachrach
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LifeCell Corp
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LifeCell Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/362—Skin, e.g. dermal papillae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3695—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the function or physical properties of the final product, where no specific conditions are defined to achieve this
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2925332A 2013-11-04 2014-11-04 Methods of removing alpha-galactose Active CA2925332C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361899647P 2013-11-04 2013-11-04
US61/899,647 2013-11-04
PCT/US2014/063796 WO2015066668A1 (en) 2013-11-04 2014-11-04 Methods of removing alpha-galactose

Publications (2)

Publication Number Publication Date
CA2925332A1 CA2925332A1 (en) 2015-05-07
CA2925332C true CA2925332C (en) 2022-07-12

Family

ID=51982769

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2925332A Active CA2925332C (en) 2013-11-04 2014-11-04 Methods of removing alpha-galactose

Country Status (10)

Country Link
US (2) US10307510B2 (https=)
EP (2) EP3065790B1 (https=)
JP (1) JP6524597B2 (https=)
CN (1) CN105682697B (https=)
AU (2) AU2014341866B2 (https=)
BR (1) BR112016009178B1 (https=)
CA (1) CA2925332C (https=)
DK (1) DK3065790T3 (https=)
ES (1) ES2846758T3 (https=)
WO (1) WO2015066668A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3509541T3 (da) 2016-09-12 2021-10-11 Gebauer Klopotek Patent Verwaltungs Ug Haftungsbeschraenkt Lentikel til intrastromal hornhindeimplantation
CN106860861B (zh) * 2017-03-03 2020-11-03 北京博辉瑞进生物科技有限公司 一种免疫增强组合物、制备方法及其应用
EP3592397A4 (en) 2017-03-06 2020-12-30 Tei Biosciences, Inc. PERFORATED FABRIC GRAFT
US12350144B2 (en) 2018-07-02 2025-07-08 Gebauer-Klopotek Patent Verw Altungs-Ug Stabilization of collagen scaffolds
JP2021530259A (ja) * 2018-07-02 2021-11-11 ゲバウアー—クロポテック パテント フェアヴァルトゥングス—ウーゲーＧｅｂａｕｅｒ−Ｋｌｏｐｏｔｅｋ Ｐａｔｅｎｔ Ｖｅｒｗａｌｔｕｎｇｓ−Ｕｇ コラーゲン足場の安定処理
WO2021034928A1 (en) * 2019-08-20 2021-02-25 Lifecell Corporation Method of manufacturing particulate tissue products
CN111632196A (zh) * 2020-06-01 2020-09-08 内蒙古自治区中医药研究所 一种去α-半乳糖基抗原脱细胞基质的制备方法
CN115591020A (zh) * 2021-06-28 2023-01-13 金佩奇生物科技（南京）有限公司（Cn） 疝修复真皮补片材料的制备及应用
CN115591019A (zh) * 2021-06-28 2023-01-13 金佩奇生物科技（南京）有限公司（Cn） 脱细胞材料制备方法及其应用
CN114276974A (zh) * 2021-12-24 2022-04-05 上海理工大学 封装细胞的间质材料及其制备方法和应用
CN114377206B (zh) 2021-12-24 2022-09-30 杭州华迈医疗科技有限公司 一种脱细胞基质生物材料的制备方法

Family Cites Families (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5230097A (en) 1975-09-02 1977-03-07 Kaneyasu Miyata Method of mounting different substitute blood vessel
US4801299A (en) 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US5116615A (en) 1989-01-27 1992-05-26 Immunolytics, Inc. Method for treating benign prostatic hypertrophy
SG72614A1 (en) 1989-10-12 2000-05-23 Imutran Ltd Modified biological material
US6482404B1 (en) 1989-10-12 2002-11-19 David James White Transplantation of tissue comprising a DNA sequence encoding a homologous complement restriction factor
US5846715A (en) 1990-05-11 1998-12-08 The Austin Research Institute CD46 variants
US8067149B2 (en) 1990-09-12 2011-11-29 Lifecell Corporation Acellular dermal matrix and method of use thereof for grafting
US5336616A (en) 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
CA2051092C (en) 1990-09-12 2002-07-23 Stephen A. Livesey Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions
US5374539A (en) 1991-06-17 1994-12-20 Nimni; Marcel E. Process for purifying collagen and generating bioprosthesis
JP4038236B2 (ja) 1993-03-16 2008-01-23 オースチン・リサーチ・インスティテュート 異種移植治療におけるブタＧａ１α（１，３）ガラクトシルトランスフェラーゼの使用
US6331658B1 (en) 1993-04-20 2001-12-18 Integris Baptist Medical Center, Inc. Genetically engineered mammals for use as organ donors
US5460962A (en) 1994-01-04 1995-10-24 Organogenesis Inc. Peracetic acid sterilization of collagen or collagenous tissue
US5849991A (en) 1994-01-27 1998-12-15 Bresatch Limited Mice homozygous for an inactivated α 1,3-galactosyl transferase gene
JPH09508277A (ja) 1994-01-27 1997-08-26 ブレサゲン リミテッド ヒト異種移植における超急性拒絶の管理のための物質及び方法
DE69535752D1 (de) 1994-04-13 2008-06-26 Biotransplant Inc Alpha(1,3)galactosyltransferase-negatives schwein
WO1995034202A1 (en) 1994-06-15 1995-12-21 Alexion Pharmaceuticals, Inc. Methods for reducing hyperacute rejection of xenografts
US5547681A (en) 1994-07-14 1996-08-20 Union Carbide Chemicals & Plastics Technology Corporation Dermal patch
AUPM772494A0 (en) 1994-08-30 1994-09-22 Austin Research Institute, The Improvements in production of proteins in host cells
WO1996032905A1 (en) 1995-04-19 1996-10-24 St. Jude Medical, Inc. Matrix substrate for a viable body tissue-derived prosthesis and method for making the same
US5782915A (en) 1995-09-15 1998-07-21 Stone; Kevin R. Articular cartilage heterografts
US6166288A (en) 1995-09-27 2000-12-26 Nextran Inc. Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor
JPH11512933A (ja) 1996-08-02 1999-11-09 ザ オースティン リサーチ インスティテュート キメラグリコシルトランスフェラーゼをコード化する改良された核酸
US6455037B1 (en) 1996-11-01 2002-09-24 Mount Sinai School Of Medicine Of The City University Of New York Cells expressing an αgala nucleic acid and methods of xenotransplantation
US6096347A (en) 1996-11-05 2000-08-01 Purdue Research Foundation Myocardial graft constructs
WO1998025636A1 (en) 1996-12-10 1998-06-18 Purdue Research Foundation Stomach submucosa derived tissue graft
AU732726B2 (en) 1996-12-10 2001-04-26 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue
DE69833545T2 (de) 1997-03-26 2006-12-14 Imperial College Innovations Ltd. In der zellmembran verankertes antikoagulant-fusionsprotein
ES2231980T3 (es) 1997-04-11 2005-05-16 Cryolife, Inc. Descelurizacion de un tejido.
ES2175753T3 (es) 1997-06-27 2002-11-16 Augustinus Bader Injerto biosintetico y metodo para su produccion.
US6482584B1 (en) 1998-11-13 2002-11-19 Regeneration Technologies, Inc. Cyclic implant perfusion cleaning and passivation process
US6652818B1 (en) 1998-11-13 2003-11-25 Regeneration Technologies, Inc. Implant sterilization apparatus
US6613278B1 (en) 1998-11-13 2003-09-02 Regeneration Technologies, Inc. Tissue pooling process
US6371992B1 (en) 1997-12-19 2002-04-16 The Regents Of The University Of California Acellular matrix grafts: preparation and use
WO1999044533A1 (en) 1998-03-06 1999-09-10 Crosscart, Inc. Soft tissue xenografts
US6383732B1 (en) 1999-02-11 2002-05-07 Crosscart, Inc. Method of preparing xenograft heart valves
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
WO1999049029A1 (en) 1998-03-20 1999-09-30 Benitec Australia Ltd Control of gene expression
GB9809280D0 (en) 1998-04-30 1998-07-01 Rpms Technology Ltd Immunosupression
US6432710B1 (en) 1998-05-22 2002-08-13 Isolagen Technologies, Inc. Compositions for regenerating tissue that has deteriorated, and methods for using such compositions
JP2002516254A (ja) 1998-05-26 2002-06-04 ライフセル コーポレイション ヒト赤血球の低温保存
US6933326B1 (en) 1998-06-19 2005-08-23 Lifecell Coporation Particulate acellular tissue matrix
CA2335686C (en) 1998-06-19 2008-11-18 Lifecell Corporation Particulate acellular tissue matrix
US6743574B1 (en) 2000-09-12 2004-06-01 Lifenet Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced
US8563232B2 (en) 2000-09-12 2013-10-22 Lifenet Health Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced
US6734018B2 (en) 1999-06-07 2004-05-11 Lifenet Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced
GB2345638A (en) 1998-09-11 2000-07-19 Tissue Science Lab Limited Injectable collagen compositions
US20020110609A1 (en) 1998-12-28 2002-08-15 David Hung Increasing retrievable fluid from a breast duct
JP2002534118A (ja) 1999-01-13 2002-10-15 ピーピーエル セラピューティクス （スコットランド） リミテッド 二重核移植法及びその結果物
US6267786B1 (en) * 1999-02-11 2001-07-31 Crosscart, Inc. Proteoglycan-reduced soft tissue xenografts
US20030068815A1 (en) 1999-02-11 2003-04-10 Stone Kevin R. Sterilized xenograft tissue
US20020012660A1 (en) 1999-03-04 2002-01-31 Alan Colman Method of preparing a somatic cells for nuclear transfer
CN1266716A (zh) 1999-03-12 2000-09-20 中国人民解放军第四军医大学第一附属医院 交联型猪脱细胞真皮片
US6381026B1 (en) 1999-03-15 2002-04-30 Lifecell Corp. Method of measuring the contour of a biological surface
US8232320B2 (en) 1999-04-28 2012-07-31 The Regents Of The University Of Michigan Antimicrobial nanoemulsion compositions and methods
WO2001030992A2 (en) 1999-10-22 2001-05-03 University Of Pittsburgh Of The Commonwealth System Of Higher Education α1-3 GALACTOSYLTRANSFERASE GENE AND PROMOTER
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US6866686B2 (en) 2000-01-28 2005-03-15 Cryolife, Inc. Tissue graft
WO2001078798A1 (en) 2000-02-10 2001-10-25 Regeneration Technologies, Inc. Assembled implant
US20070009586A1 (en) 2000-02-29 2007-01-11 Cohen Kelman I Wound dressings containing complexes of transition metals and alginate for elastase sequestering
WO2001088096A2 (en) 2000-05-15 2001-11-22 Geron Corporation Ovine tissue for xenotransplantation
EP1315796B1 (en) 2000-08-16 2006-07-12 Duke University Decellularized tissue engineered constructs and tissues
US6743435B2 (en) 2000-08-28 2004-06-01 Collagen Matrix Technologies, Inc. Processing animal tissues by decellularizing, increasing surface area and acylating
US20020077697A1 (en) 2000-12-15 2002-06-20 Ranieri John Paul Processed ratite carotid arteries as xenogeneic small bore vascular grafts
US7126039B2 (en) 2001-03-21 2006-10-24 Geron Corporation Animal tissue with carbohydrate antigens compatible for human transplantation
US6933103B1 (en) 2001-03-21 2005-08-23 Brennen Medical, Inc. Biocompatible tissue for therapeutic use and method of making same
EP1373498A2 (en) 2001-03-21 2004-01-02 Geron Corporation Animal tissue with carbohydrate antigens compatible for human transplantation
CA2445945A1 (en) 2001-04-30 2002-11-07 Rbc Biotechnology, Inc. Modified organs and cells for xenotransplantation
EP1392202A4 (en) 2001-05-07 2009-10-21 Crosscart Inc SUBMUCOSAL XENOTRANSPLANTS
US20030092174A1 (en) 2001-05-14 2003-05-15 Monika Liljedahl Tissues or organs for use in xenotransplantation
GB2375771A (en) 2001-05-24 2002-11-27 Univ Leeds Decellularisation of tissue implant material
WO2003002165A1 (en) 2001-06-28 2003-01-09 Cook Biotech Incorporated Graft prosthesis devices containing renal capsule collagen
TWI284665B (en) 2001-08-17 2007-08-01 Univ Nat Cheng Kung Fabrication method of the porous collagen matrix
EP1436401A4 (en) 2001-09-27 2006-06-14 Timothy Albert Holton STEM-LOOP VECTOR SYSTEM
JP4451658B2 (ja) 2001-10-18 2010-04-14 ライフセル コーポレーション 組織および器官のリモデリング
US7547816B2 (en) 2001-12-21 2009-06-16 The Curators Of The University Of Missouri α(1,3)-galactosyltransferase knockout swine, tissues and organs
CN1582332A (zh) 2001-12-29 2005-02-16 Seoul大学校产学协力财团 转染gfp的克隆猪、敲除gt的克隆猪及其生产方法
ATE421328T1 (de) 2002-02-22 2009-02-15 Intracel Recources Llc Sterile immunogene nicht-tumorigene tumorzell- zusammensetzungen und verfahren
CN1653227A (zh) 2002-04-05 2005-08-10 诺维信北美公司 改善耐久性压烫整理的纤维素材料的强度和抗磨损性的方法
DE60333277D1 (de) 2002-05-02 2010-08-19 Purdue Research Foundation Transplantatkonstrukte mit verbesserter vaskularisierung
AUPS242702A0 (en) 2002-05-21 2002-06-13 Colltech Australia Limited Improved method for the extraction and purification of collagen
US6835385B2 (en) 2002-06-14 2004-12-28 Carol J. Buck Compositions and methods for softening, thinning and removing hyperkeratotic tissue
AU2003238162A1 (en) 2002-06-28 2004-01-19 Cardio Inc Decellularized tissue
AU2003265415A1 (en) 2002-08-14 2004-03-03 Immerge Biotherapeutics, Inc. Alpha(1,3)-GALACTOSYLTRANSFERASE NULL CELLS, METHODS OF SELECTING AND Alpha(1,3)-GALACTOSYLTRANSFERASE NULL SWINE PRODUCED THEREFROM
DK1534819T3 (da) 2002-08-21 2010-04-19 Revivicor Inc Griselignende dyr, som mangler enhver ekspression af funktionel alfa-1,3-galactosyltransferase
US20040037735A1 (en) 2002-08-23 2004-02-26 Depaula Carl Alexander Allograft tissue purification process for cleaning bone
AU2003211379A1 (en) 2002-08-28 2004-03-19 Kinki University Process for producing collagen treated with cysteine protease and collagen treated with cysteine protease
JP3658385B2 (ja) 2002-09-20 2005-06-08 佳宏 高見 皮膚の無細胞化方法、該方法による無細胞化真皮マトリックス及びその製造方法並びに該マトリックスを用いた複合培養皮膚
US7402319B2 (en) 2002-09-27 2008-07-22 Board Of Regents, The University Of Texas System Cell-free tissue replacement for tissue engineering
US7064187B2 (en) 2002-11-26 2006-06-20 Crosscart, Inc. Substantially non-immunogenic injectable collagen
US20040187877A1 (en) * 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of liver tissue
US20040191226A1 (en) 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of body wall
ATE494367T1 (de) 2002-12-18 2011-01-15 Hoffmann La Roche Rekombinante desoxyribonuclease i aus rinder- pankreas mit hoher spezifischer aktivität
US20040175366A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
US20040176855A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
US7067298B2 (en) 2003-03-31 2006-06-27 Ambion, Inc. Compositions and methods of using a synthetic Dnase I
CA2528500A1 (en) 2003-06-06 2004-12-16 University Of Pittsburgh Porcine cmp-n-acetylneuraminic acid hydroxylase gene
US20050013870A1 (en) 2003-07-17 2005-01-20 Toby Freyman Decellularized extracellular matrix of conditioned body tissues and uses thereof
WO2005009134A1 (en) 2003-07-21 2005-02-03 Lifecell Corporation ACELLULAR TISSUE MATRICES MADE FROM GALACTOSE α-1,3-GALACTOSE-DEFICIENT TISSUE
EP1685148A2 (en) 2003-11-05 2006-08-02 University Of Pittsburgh Of The Commonwealth System Of Higher Education PORCINE ISOGLOBOSIDE 3 SYNTHASE PROTEIN, cDNA, GENOMIC ORGANIZATION, AND REGULATORY REGION
US10793873B2 (en) 2003-11-21 2020-10-06 Revivicor, Inc. Use of interfering RNA in the production of transgenic animals
US20050186286A1 (en) 2004-02-25 2005-08-25 Yoshihiro Takami Skin decellularization method, acellular dermal matrix and production method therefore employing said decellularization method, and composite cultured skin employing said matrix
CN104721883A (zh) 2004-03-17 2015-06-24 雷维维科公司 来源于缺乏任何功能性α1,3半乳糖基转移酶表达的动物的组织产品
EP1745128A2 (en) 2004-05-07 2007-01-24 University of Pittsburgh of the Commonwealth System of Higher Education PORCINE FORSSMAN SYNTHETASE PROTEIN, cDNA, GENOMIC ORGANIZATION, AND REGULATORY REGION
US20050266390A1 (en) 2004-06-01 2005-12-01 Yuichiro Ueda Processes for removing cells and cell debris from tissue and tissue constructs used in transplantation and tissue reconstruction
US20060073592A1 (en) 2004-10-06 2006-04-06 Wendell Sun Methods of storing tissue matrices
US20070010897A1 (en) 2005-01-06 2007-01-11 Stone Kevin R Immunochemically modified and sterilized xenografts and allografts
US9216236B2 (en) * 2005-03-07 2015-12-22 Technion Research & Development Foundation Limited Natural tissue-derived decellularized matrix and methods of generating and using same
US7723108B2 (en) 2005-03-16 2010-05-25 Musculoskeletal Transplant Foundation Soft tissue processing
US20100112543A1 (en) 2005-03-16 2010-05-06 Manh-Dan Ngo Processing soft tissue, methods and compositions related thereto
PL1928519T3 (pl) 2005-08-26 2012-08-31 Univ Minnesota Decelularyzacja i recelularyzacja narządów i tkanek
JP5002805B2 (ja) 2005-10-14 2012-08-15 財団法人ヒューマンサイエンス振興財団 生物由来スキャフォールドの作製方法
GB0606231D0 (en) 2006-03-29 2006-05-10 Univ Leeds Improvements relating to decellurisation of tissue matrices for bladder implantation
US20070248575A1 (en) 2006-04-19 2007-10-25 Jerome Connor Bone graft composition
JP5050197B2 (ja) 2006-07-31 2012-10-17 財団法人ヒューマンサイエンス振興財団 生物由来スキャフォールドの作製方法
CN101622007A (zh) 2006-10-06 2010-01-06 人类起源公司 天然(端肽)胎盘胶原组合物
ES2372116T3 (es) 2006-11-16 2012-01-16 The University Of Leeds Preparación de tejido para implantación meniscal.
CA2684011A1 (en) 2007-04-16 2008-10-23 Tissue Science Laboratories Plc Decellularised collagen-containing matrix for guided tissue regeneration
CA2684012A1 (en) 2007-04-16 2008-10-23 Tissue Science Laboratories Plc Vascular implant
US20100119577A1 (en) 2007-05-06 2010-05-13 Byoung-Hyun Min Therapeutic composite for cartilage disorder using extracellular matrix (ecm) scaffold
US20080306610A1 (en) 2007-06-07 2008-12-11 Zimmer Orthobiologics, Inc. Tissue processing for nonimmunogenic implants
WO2008154623A2 (en) 2007-06-12 2008-12-18 Musculoskeletal Transplant Foundation Process for sterilizing acellular soft tissue with irradiation
US20100296969A1 (en) 2007-06-12 2010-11-25 Musculoskeletal Transplant Foundation Process for sterilizing acellular soft tissue under vacuum
JP5538217B2 (ja) 2007-07-10 2014-07-02 ライフセル コーポレーション 組織修復用無細胞組織基質構成体
CZ301086B6 (cs) 2007-10-17 2009-11-04 Bio-Skin, A. S. Sterilní autologní, allogenní nebo xenogenní implantát a zpusob jeho výroby
TWI353845B (en) 2008-03-19 2011-12-11 Food Industry Res & Dev Inst Process for preparing peptide products for promoti
GB0807868D0 (en) 2008-04-30 2008-06-04 Knight David P Cartilage repair material and a method for the preparation thereof
CA2726350C (en) 2008-06-06 2016-07-19 Lifecell Corporation Elastase treatment of tissue matrices
BRPI1008628A2 (pt) 2009-02-18 2016-03-01 Cormatrix Cardiovascular Inc método de tratamento ou prevenção de arritmia cardíaca em um indivíduo
US9155323B2 (en) 2009-05-15 2015-10-13 Siebte Pmi Verwaltungs Gmbh Aqueous process for preparing protein isolate and hydrolyzed protein from an oilseed
US8198408B2 (en) 2009-07-27 2012-06-12 National Cheng Kung University Method for preparing porous collagen matrices
EP2464221A4 (en) 2009-08-11 2012-08-01 Tissue Banks Internat CELLULAR DERMALE ALLOTRANSPLANTATE AND MANUFACTURING METHOD THEREFOR
ES2719816T3 (es) 2010-02-26 2019-07-16 Decell Tech Inc Métodos para la descelularización de tejidos
GB2482166A (en) 2010-07-22 2012-01-25 Tissue Science Lablratories Ltd Manufacture of collagenous material from use in therapy from collagen particles
US9238793B2 (en) 2011-04-28 2016-01-19 Lifecell Corporation Method for enzymatic treatment of tissue products
RU2639477C2 (ru) 2011-04-28 2017-12-21 Лайфселл Корпорейшн Способ ферментативной обработки тканевых продуктов
US10207025B2 (en) 2011-04-28 2019-02-19 Lifecell Corporation Method for enzymatic treatment of tissue products
US20130122583A1 (en) 2011-11-10 2013-05-16 Celxcel Pty Ltd Sterilization process
ES2716993T3 (es) * 2012-03-08 2019-06-18 Lifecell Corp Matrices de colágeno y tejido activadas por enzimas

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