CA2903258C - Heterodimeric bispecific antibodies - Google Patents
Heterodimeric bispecific antibodies Download PDFInfo
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- CA2903258C CA2903258C CA2903258A CA2903258A CA2903258C CA 2903258 C CA2903258 C CA 2903258C CA 2903258 A CA2903258 A CA 2903258A CA 2903258 A CA2903258 A CA 2903258A CA 2903258 C CA2903258 C CA 2903258C
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- amino acid
- bispecific antibody
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- A61P37/00—Drugs for immunological or allergic disorders
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/00—Immunoglobulins specific features
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- C07K2317/00—Immunoglobulins specific features
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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Landscapes
- Health & Medical Sciences (AREA)
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- Immunology (AREA)
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- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791357P | 2013-03-15 | 2013-03-15 | |
| US61/791,357 | 2013-03-15 | ||
| US201461944841P | 2014-02-26 | 2014-02-26 | |
| US61/944,841 | 2014-02-26 | ||
| PCT/US2014/026658 WO2014151910A1 (en) | 2013-03-15 | 2014-03-13 | Heterodimeric bispecific antibodies |
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| CA2903258A1 CA2903258A1 (en) | 2014-09-25 |
| CA2903258C true CA2903258C (en) | 2019-11-26 |
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| CA2903258A Active CA2903258C (en) | 2013-03-15 | 2014-03-13 | Heterodimeric bispecific antibodies |
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| MX (2) | MX357011B (cg-RX-API-DMAC7.html) |
| TW (1) | TW201439117A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014151910A1 (cg-RX-API-DMAC7.html) |
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| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| CN104302665B (zh) * | 2011-12-21 | 2019-04-23 | 安姆根有限公司 | 与新生儿Fc受体的结合增强的变体Fc多肽 |
| HRP20191865T1 (hr) | 2013-01-14 | 2020-01-10 | Xencor, Inc. | Novi heterodimerni proteini |
| JO3519B1 (ar) | 2013-01-25 | 2020-07-05 | Amgen Inc | تركيبات أجسام مضادة لأجل cdh19 و cd3 |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| US9212225B1 (en) | 2014-07-01 | 2015-12-15 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
| UY36245A (es) * | 2014-07-31 | 2016-01-29 | Amgen Res Munich Gmbh | Constructos de anticuerpos para cdh19 y cd3 |
| JP6749312B2 (ja) | 2014-07-31 | 2020-09-02 | アムゲン リサーチ （ミュンヘン） ゲーエムベーハーＡＭＧＥＮ Ｒｅｓｅａｒｃｈ（Ｍｕｎｉｃｈ）ＧｍｂＨ | 最適化された種間特異的二重特異性単鎖抗体コンストラクト |
| WO2016019969A1 (en) | 2014-08-08 | 2016-02-11 | Ludwig-Maximilians-Universität München | Subcutaneously administered bispecific antibodies for use in the treatment of cancer |
| JP2017536341A (ja) * | 2014-10-09 | 2017-12-07 | エンクマフ アーゲー | 卵巣がんの処置における使用のためのＣＤ３εおよびＲＯＲ１に対する二特異性抗体 |
| MX2017006571A (es) * | 2014-11-20 | 2017-09-29 | Hoffmann La Roche | Moleculas de union a antigeno biespecificas activadoras de celulas t. |
| HRP20201928T1 (hr) | 2014-11-20 | 2021-02-05 | F. Hoffmann - La Roche Ag | Kombinirana terapija bispecifičnom antigen vezujućom molekulom koja aktivira t-stanice, za cd3 i folatni receptor 1 (folr1), i antagonistom vezivanja osi pd-1 |
| LT3221357T (lt) * | 2014-11-20 | 2020-08-25 | F. Hoffmann-La Roche Ag | Bendros lengvosios grandinės ir naudojimo būdai |
| RS62332B1 (sr) | 2014-11-26 | 2021-10-29 | Xencor Inc | Heterodimerna antitela koja vezuju cd3 i cd20 |
| CN107406512A (zh) | 2014-11-26 | 2017-11-28 | Xencor公司 | 结合cd3和cd38的异二聚体抗体 |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| RS59203B1 (sr) * | 2014-12-05 | 2019-10-31 | Hoffmann La Roche | Anti-cd79b antitela i postupci primene |
| WO2016094881A2 (en) * | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
| US20160175458A1 (en) | 2014-12-19 | 2016-06-23 | Alkermes, Inc. | Single chain fc fusion proteins |
| CN120988137A (zh) | 2015-01-23 | 2025-11-21 | 赛诺菲 | 抗cd3抗体、抗cd123抗体和与cd3和/或cd123特异性结合的双特异性抗体 |
| JP6640232B2 (ja) | 2015-02-06 | 2020-02-05 | ユニバーシティ オブ メリーランド，ボルチモア | クロストリジウム・ディフィシル感染症の治療のための、クロストリジウム・ディフィシルのトキシンａ及びトキシンｂに対する四重特異性の八量体型結合剤及び抗体 |
| SI3283524T1 (sl) | 2015-04-17 | 2023-06-30 | Amgen Research (Munich) Gmbh | Bispecifični konstrukti protiteles za CDH3 in CD3 |
| SG10202002131PA (en) | 2015-05-21 | 2020-05-28 | Harpoon Therapeutics Inc | Trispecific binding proteins and methods of use |
| MX2017015380A (es) | 2015-05-29 | 2018-03-28 | Amphivena Therapeutics Inc | Metodos para utilizar proteinas de enlace biespecificas cd3 y cd33. |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白 |
| FR3038517B1 (fr) * | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| TW202346349A (zh) | 2015-07-31 | 2023-12-01 | 德商安美基研究（慕尼黑）公司 | Dll3及cd3抗體構築體 |
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| CN104302665B (zh) | 2011-12-21 | 2019-04-23 | 安姆根有限公司 | 与新生儿Fc受体的结合增强的变体Fc多肽 |
| EP2938637A2 (en) | 2012-12-28 | 2015-11-04 | AbbVie Inc. | Multivalent binding protein compositions |
| SG11201507413XA (en) * | 2013-03-15 | 2015-10-29 | Amgen Inc | Myostatin antagonism in human subjects |
| LT2951203T (lt) | 2013-03-15 | 2019-09-10 | Xencor, Inc. | Heterodimeriniai baltymai |
| US20140308285A1 (en) * | 2013-03-15 | 2014-10-16 | Amgen Inc. | Heterodimeric bispecific antibodies |
| US20140302037A1 (en) * | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
| WO2015048272A1 (en) * | 2013-09-25 | 2015-04-02 | Amgen Inc. | V-c-fc-v-c antibody |
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2015
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| AU2014236769A1 (en) | 2015-09-10 |
| EP2970484B2 (en) | 2022-09-21 |
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| CA2903258A1 (en) | 2014-09-25 |
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| WO2014151910A1 (en) | 2014-09-25 |
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| AU2014236769B2 (en) | 2018-09-27 |
| MX2015012439A (es) | 2016-04-19 |
| EP2970484A1 (en) | 2016-01-20 |
| TW201439117A (zh) | 2014-10-16 |
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