CA2894170C - Lfa-1 inhibitor formulations - Google Patents

Lfa-1 inhibitor formulations Download PDF

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Publication number
CA2894170C
CA2894170C CA2894170A CA2894170A CA2894170C CA 2894170 C CA2894170 C CA 2894170C CA 2894170 A CA2894170 A CA 2894170A CA 2894170 A CA2894170 A CA 2894170A CA 2894170 C CA2894170 C CA 2894170C
Authority
CA
Canada
Prior art keywords
composition
compound
formula
months
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2894170A
Other languages
English (en)
French (fr)
Other versions
CA2894170A1 (en
Inventor
Mary Newman
William Hunke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bausch and Lomb Ireland Ltd
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50979140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2894170(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of CA2894170A1 publication Critical patent/CA2894170A1/en
Application granted granted Critical
Publication of CA2894170C publication Critical patent/CA2894170C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA2894170A 2012-12-19 2013-12-18 Lfa-1 inhibitor formulations Active CA2894170C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261739609P 2012-12-19 2012-12-19
US61/739,609 2012-12-19
US201361758147P 2013-01-29 2013-01-29
US61/758,147 2013-01-29
PCT/US2013/076041 WO2014100135A1 (en) 2012-12-19 2013-12-18 Lfa-1 inhibitor formulations

Publications (2)

Publication Number Publication Date
CA2894170A1 CA2894170A1 (en) 2014-06-26
CA2894170C true CA2894170C (en) 2021-08-10

Family

ID=50979140

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2894170A Active CA2894170C (en) 2012-12-19 2013-12-18 Lfa-1 inhibitor formulations

Country Status (20)

Country Link
US (2) US11058677B2 (enExample)
EP (2) EP3827823A1 (enExample)
JP (1) JP6373867B2 (enExample)
KR (1) KR101891144B1 (enExample)
CN (1) CN104955453B (enExample)
AU (1) AU2013361579B2 (enExample)
BR (1) BR112015014367B1 (enExample)
CA (1) CA2894170C (enExample)
DK (1) DK2934510T3 (enExample)
EA (2) EA201791321A1 (enExample)
ES (1) ES2846724T3 (enExample)
HU (1) HUE052299T2 (enExample)
IL (1) IL239490B (enExample)
MX (2) MX391620B (enExample)
NZ (1) NZ708821A (enExample)
PL (1) PL2934510T3 (enExample)
PT (1) PT2934510T (enExample)
SI (1) SI2934510T1 (enExample)
WO (1) WO2014100135A1 (enExample)
ZA (2) ZA201504404B (enExample)

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WO2019171260A1 (en) * 2018-03-09 2019-09-12 Mankind Pharma Ltd. Pharmaceutical composition of lifitegrast
WO2020212755A1 (en) * 2019-04-18 2020-10-22 Azura Ophthalmics Ltd. Compounds and methods for the treatment of ocular disorders
EP3842032A1 (en) 2019-12-24 2021-06-30 Warszawskie Zaklady Farmaceutyczne Polfa S.A. A pharmaceutical formulation
CN116635032A (zh) * 2020-10-21 2023-08-22 阿祖拉眼科有限公司 用于治疗眼部病症的化合物和方法
CN116211796A (zh) * 2022-12-30 2023-06-06 新领先(重庆)医药科技有限公司 一种立他司特滴眼液及其制备方法
KR20240109779A (ko) * 2023-01-05 2024-07-12 주식회사 종근당 리피테그라스트와 토코페롤을 함유하는 건성안 예방 또는 치료용 약제학적 조성물
KR20250033790A (ko) 2023-09-01 2025-03-10 주식회사 와이에스생명과학 리피테그라스트 함유 점안 조성물
KR20260109029A (ko) 2023-11-02 2026-07-09 노바리크 게엠베하 리피테그라스트를 포함하는 세미플루오르화 알칸 조성물
CN122349415A (zh) * 2023-11-17 2026-07-07 博士伦爱尔兰有限公司 用于治疗眼部病症的半氟化烷烃小分子lfa-1拮抗剂复方组合物
CN117771174B (zh) * 2023-12-29 2025-07-29 鲁南贝特制药有限公司 一种立他司特滴眼液及其制备方法

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WO2005065069A2 (en) * 2003-07-11 2005-07-21 Myriad Genetics, Inc. Pharmaceutical methods, dosing regimes and dosage forms for the treatment of alzheimer's disease
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US20060073172A1 (en) * 2004-10-01 2006-04-06 Schneider L W Stabilized ophthalmic solution for the treatment of glaucoma and lowering intraocular pressure
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KR20120085330A (ko) * 2009-11-23 2012-07-31 알러간, 인코포레이티드 결정형 ｉｉ의 ７?〔３,５?다이하이드록시?２?(３?하이드록시?５?페닐?펜트?１?에닐)?사이클로펜틸〕?ｎ?에틸?헵트?５?엔아마이드(비마토프로스트), 그의 제조방법 및 이용방법
US20120190653A1 (en) * 2011-01-20 2012-07-26 Dow Pharmaceutical Sciences, Inc. Therapeutic eye drop comprising doxycycline and a stabilizer
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Also Published As

Publication number Publication date
PT2934510T (pt) 2021-01-13
EP2934510A4 (en) 2016-08-17
HK1214963A1 (en) 2016-08-12
MX368876B (es) 2019-10-21
ES2846724T3 (es) 2021-07-29
EP3827823A1 (en) 2021-06-02
IL239490B (en) 2018-12-31
JP2016503058A (ja) 2016-02-01
US20220000859A1 (en) 2022-01-06
EA028008B1 (ru) 2017-09-29
CN104955453B (zh) 2018-09-18
CN104955453A (zh) 2015-09-30
BR112015014367B1 (pt) 2022-11-22
IL239490A0 (en) 2015-08-31
ZA201608069B (en) 2017-11-29
KR101891144B1 (ko) 2018-08-23
WO2014100135A1 (en) 2014-06-26
HK1214536A1 (zh) 2016-07-29
AU2013361579A1 (en) 2015-06-18
EP2934510B1 (en) 2020-10-28
PL2934510T3 (pl) 2021-07-05
EA201791321A1 (ru) 2018-04-30
US20150320737A1 (en) 2015-11-12
CA2894170A1 (en) 2014-06-26
SI2934510T1 (sl) 2021-02-26
JP6373867B2 (ja) 2018-08-15
BR112015014367A2 (pt) 2017-07-11
US11058677B2 (en) 2021-07-13
KR20150100763A (ko) 2015-09-02
DK2934510T3 (da) 2021-01-25
ZA201504404B (en) 2020-01-29
EA201591180A1 (ru) 2015-12-30
MX391620B (es) 2025-03-19
NZ708821A (en) 2020-03-27
MX2019012375A (es) 2020-01-20
MX2015007540A (es) 2016-04-13
AU2013361579B2 (en) 2018-05-24
HUE052299T2 (hu) 2021-04-28
EP2934510A1 (en) 2015-10-28

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