CA2892042C - Cxcr7 antagonists - Google Patents

Cxcr7 antagonists Download PDF

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Publication number
CA2892042C
CA2892042C CA2892042A CA2892042A CA2892042C CA 2892042 C CA2892042 C CA 2892042C CA 2892042 A CA2892042 A CA 2892042A CA 2892042 A CA2892042 A CA 2892042A CA 2892042 C CA2892042 C CA 2892042C
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Canada
Prior art keywords
mmol
compound
mixture
group
pyrazin
Prior art date
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Active
Application number
CA2892042A
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English (en)
French (fr)
Other versions
CA2892042A1 (en
Inventor
Junfa Fan
Antoni Krasinski
Christopher W. Lange
Rebecca M. LUI
Jeffrey P. Mcmahon
Jay P. Powers
Yibin Zeng
Penglie Zhang
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Chemocentryx Inc
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Chemocentryx Inc
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Publication of CA2892042A1 publication Critical patent/CA2892042A1/en
Application granted granted Critical
Publication of CA2892042C publication Critical patent/CA2892042C/en
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
    • G01N2333/7158—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for chemokines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Pain & Pain Management (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2892042A 2012-11-29 2013-11-26 Cxcr7 antagonists Active CA2892042C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261731463P 2012-11-29 2012-11-29
US61/731,463 2012-11-29
PCT/US2013/072067 WO2014085490A1 (en) 2012-11-29 2013-11-26 Cxcr7 antagonists

Publications (2)

Publication Number Publication Date
CA2892042A1 CA2892042A1 (en) 2014-06-05
CA2892042C true CA2892042C (en) 2022-06-14

Family

ID=50825654

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2892042A Active CA2892042C (en) 2012-11-29 2013-11-26 Cxcr7 antagonists

Country Status (16)

Country Link
US (5) US9169261B2 (https=)
EP (1) EP2925745B1 (https=)
JP (1) JP6272897B2 (https=)
KR (1) KR102196374B1 (https=)
CN (1) CN105189484B (https=)
AU (1) AU2013352304C1 (https=)
BR (1) BR112015012366A8 (https=)
CA (1) CA2892042C (https=)
DK (1) DK2925745T3 (https=)
ES (1) ES2681593T3 (https=)
IL (1) IL238974B (https=)
MX (1) MX359651B (https=)
PT (1) PT2925745T (https=)
RU (1) RU2649004C2 (https=)
SG (1) SG11201504212WA (https=)
WO (1) WO2014085490A1 (https=)

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TWI879949B (zh) 2020-04-27 2025-04-11 南韓商奧土擇破利悟股份有限公司 用於ｕｂｒ盒結構域配體之化合物、組成物以及醫藥組成物
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Also Published As

Publication number Publication date
CN105189484A (zh) 2015-12-23
KR20160002667A (ko) 2016-01-08
EP2925745A1 (en) 2015-10-07
MX2015006412A (es) 2015-10-29
US11834452B2 (en) 2023-12-05
EP2925745A4 (en) 2016-06-15
BR112015012366A2 (pt) 2017-07-11
IL238974B (en) 2019-03-31
US20200095251A1 (en) 2020-03-26
EP2925745B1 (en) 2018-04-04
SG11201504212WA (en) 2015-06-29
RU2015125544A (ru) 2017-01-10
AU2013352304B2 (en) 2017-08-31
US9169261B2 (en) 2015-10-27
US11059825B2 (en) 2021-07-13
IL238974A0 (en) 2015-07-30
DK2925745T3 (en) 2018-07-23
US10287292B2 (en) 2019-05-14
MX359651B (es) 2018-10-05
JP2016502538A (ja) 2016-01-28
AU2013352304C1 (en) 2018-03-22
US9783544B2 (en) 2017-10-10
US20180086766A1 (en) 2018-03-29
KR102196374B1 (ko) 2020-12-31
CA2892042A1 (en) 2014-06-05
CN105189484B (zh) 2018-05-04
US20160145259A1 (en) 2016-05-26
US20220127272A1 (en) 2022-04-28
WO2014085490A1 (en) 2014-06-05
HK1214264A1 (en) 2016-07-22
JP6272897B2 (ja) 2018-01-31
BR112015012366A8 (pt) 2019-10-01
RU2649004C2 (ru) 2018-03-29
US20140154179A1 (en) 2014-06-05
ES2681593T3 (es) 2018-09-14
AU2013352304A1 (en) 2015-06-04
PT2925745T (pt) 2018-08-08

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