SG11201504212WA - Cxcr7 antagonists - Google Patents

Cxcr7 antagonists

Info

Publication number
SG11201504212WA
SG11201504212WA SG11201504212WA SG11201504212WA SG11201504212WA SG 11201504212W A SG11201504212W A SG 11201504212WA SG 11201504212W A SG11201504212W A SG 11201504212WA SG 11201504212W A SG11201504212W A SG 11201504212WA SG 11201504212W A SG11201504212W A SG 11201504212WA
Authority
SG
Singapore
Prior art keywords
cxcr7 antagonists
cxcr7
antagonists
Prior art date
Application number
SG11201504212WA
Inventor
Junfa Fan
Antoni Krasinski
Christopher W Lange
Rebecca M Lui
Jeffrey P Mcmahon
Jay P Powers
Yibin Zeng
Penglie Zhang
Original Assignee
Chemocentryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemocentryx Inc filed Critical Chemocentryx Inc
Publication of SG11201504212WA publication Critical patent/SG11201504212WA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
    • G01N2333/7158Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for chemokines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG11201504212WA 2012-11-29 2013-11-26 Cxcr7 antagonists SG11201504212WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261731463P 2012-11-29 2012-11-29
PCT/US2013/072067 WO2014085490A1 (en) 2012-11-29 2013-11-26 Cxcr7 antagonists

Publications (1)

Publication Number Publication Date
SG11201504212WA true SG11201504212WA (en) 2015-06-29

Family

ID=50825654

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201504212WA SG11201504212WA (en) 2012-11-29 2013-11-26 Cxcr7 antagonists

Country Status (17)

Country Link
US (5) US9169261B2 (en)
EP (1) EP2925745B1 (en)
JP (1) JP6272897B2 (en)
KR (1) KR102196374B1 (en)
CN (1) CN105189484B (en)
AU (1) AU2013352304C1 (en)
BR (1) BR112015012366A8 (en)
CA (1) CA2892042C (en)
DK (1) DK2925745T3 (en)
ES (1) ES2681593T3 (en)
HK (1) HK1214264A1 (en)
IL (1) IL238974B (en)
MX (1) MX359651B (en)
PT (1) PT2925745T (en)
RU (1) RU2649004C2 (en)
SG (1) SG11201504212WA (en)
WO (1) WO2014085490A1 (en)

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TWI806832B (en) 2016-07-12 2023-07-01 美商銳新醫藥公司 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors
MY198113A (en) * 2016-07-28 2023-08-03 Idorsia Pharmaceuticals Ltd Piperidine cxcr7 receptor modulators
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EP3678703A1 (en) 2017-09-07 2020-07-15 Revolution Medicines, Inc. Shp2 inhibitor compositions and methods for treating cancer
RU2020115095A (en) 2017-10-12 2021-11-12 Революшн Медсинз, Инк. PYRIDINE, PYRAZINE AND TRIAZINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS
WO2019101709A1 (en) 2017-11-23 2019-05-31 Universita' Degli Studi Di Palermo Oxadiazole derivatives for the treatment of genetic diseases due to nonsense mutations
BR112020009757A2 (en) 2017-12-15 2020-11-03 Revolution Medicines, Inc. polycyclic compounds as allosteric inhibitors of shp2
SG11202006943TA (en) * 2018-01-26 2020-08-28 Idorsia Pharmaceuticals Ltd Crystalline forms of the cxcr7 receptor antagonist (3s,4s)-1-cyclopropylmethyl-4-{[5-(2,4-difluoro-phenyl)-isoxazole-3-carbonyl]-amino}-piperidine-3-carboxylic acid (1-pyrimidin-2-yl-cyclopropyl)-amide
CN108794484B (en) * 2018-04-28 2020-04-24 北京施安泰医药技术开发有限公司 [1,2,4] triazolo [4,3-a ] pyrazine derivative, pharmaceutical composition, preparation method and application thereof
CN113194956A (en) 2018-12-12 2021-07-30 凯莫森特里克斯股份有限公司 CXCR7 inhibitors for cancer treatment
CN110013483B (en) * 2019-05-10 2022-04-15 江苏师范大学 Use of thiazolo [3,2-a ] pyrimidine-6-carbonitrile derivatives for antibacterial purposes
JP2022539830A (en) 2019-07-10 2022-09-13 ケモセントリックス,インコーポレイティド Indane as a PD-L1 inhibitor
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CN113105469B (en) * 2021-04-13 2022-04-22 中国科学院新疆理化技术研究所 Tricyclic furo [2,3-d ] pyrimidone compound and application thereof
WO2024042480A1 (en) 2022-08-26 2024-02-29 Suven Life Sciences Limited Heteroaromatic compounds for the treatment of neurological disorders

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Also Published As

Publication number Publication date
HK1214264A1 (en) 2016-07-22
MX359651B (en) 2018-10-05
PT2925745T (en) 2018-08-08
AU2013352304A1 (en) 2015-06-04
RU2649004C2 (en) 2018-03-29
MX2015006412A (en) 2015-10-29
AU2013352304C1 (en) 2018-03-22
CA2892042A1 (en) 2014-06-05
IL238974B (en) 2019-03-31
US20180086766A1 (en) 2018-03-29
JP6272897B2 (en) 2018-01-31
ES2681593T3 (en) 2018-09-14
CN105189484A (en) 2015-12-23
RU2015125544A (en) 2017-01-10
KR102196374B1 (en) 2020-12-31
US20200095251A1 (en) 2020-03-26
DK2925745T3 (en) 2018-07-23
EP2925745B1 (en) 2018-04-04
BR112015012366A2 (en) 2017-07-11
IL238974A0 (en) 2015-07-30
US9169261B2 (en) 2015-10-27
US11834452B2 (en) 2023-12-05
CN105189484B (en) 2018-05-04
BR112015012366A8 (en) 2019-10-01
US10287292B2 (en) 2019-05-14
US9783544B2 (en) 2017-10-10
KR20160002667A (en) 2016-01-08
EP2925745A1 (en) 2015-10-07
JP2016502538A (en) 2016-01-28
CA2892042C (en) 2022-06-14
US20140154179A1 (en) 2014-06-05
WO2014085490A1 (en) 2014-06-05
US20160145259A1 (en) 2016-05-26
US20220127272A1 (en) 2022-04-28
EP2925745A4 (en) 2016-06-15
US11059825B2 (en) 2021-07-13
AU2013352304B2 (en) 2017-08-31

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