KR102196374B1 - Cxcr7 길항제 - Google Patents
Cxcr7 길항제 Download PDFInfo
- Publication number
- KR102196374B1 KR102196374B1 KR1020157017200A KR20157017200A KR102196374B1 KR 102196374 B1 KR102196374 B1 KR 102196374B1 KR 1020157017200 A KR1020157017200 A KR 1020157017200A KR 20157017200 A KR20157017200 A KR 20157017200A KR 102196374 B1 KR102196374 B1 KR 102196374B1
- Authority
- KR
- South Korea
- Prior art keywords
- mmol
- compound
- mixture
- added
- pyrazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *C(CO)(CC1)CN1c1ncc[n]2c1ncc2 Chemical compound *C(CO)(CC1)CN1c1ncc[n]2c1ncc2 0.000 description 3
- RLXREJLLZLVGGK-ZETCQYMHSA-N N[C@@H](CC1)CN1c1ncc[n]2c1nnc2 Chemical compound N[C@@H](CC1)CN1c1ncc[n]2c1nnc2 RLXREJLLZLVGGK-ZETCQYMHSA-N 0.000 description 3
- DQQJBEAXSOOCPG-UHFFFAOYSA-N CC(C)(C)OC(NC1CNCC1)=O Chemical compound CC(C)(C)OC(NC1CNCC1)=O DQQJBEAXSOOCPG-UHFFFAOYSA-N 0.000 description 2
- IYQDUYYYAKDYLJ-UHFFFAOYSA-N NC(CO)(CC1)CN1c1ncc[n]2c1ncc2 Chemical compound NC(CO)(CC1)CN1c1ncc[n]2c1ncc2 IYQDUYYYAKDYLJ-UHFFFAOYSA-N 0.000 description 2
- ORAXRJZMNYAONE-QMMMGPOBSA-N N[C@@H](CC1)CN1c1ncc[n]2c1ncc2 Chemical compound N[C@@H](CC1)CN1c1ncc[n]2c1ncc2 ORAXRJZMNYAONE-QMMMGPOBSA-N 0.000 description 2
- NWGGOBKNPWXKON-UHFFFAOYSA-N OC(CC1)CCN1c1nc(C(O)=O)c[s]1 Chemical compound OC(CC1)CCN1c1nc(C(O)=O)c[s]1 NWGGOBKNPWXKON-UHFFFAOYSA-N 0.000 description 2
- UOCYDEIYBDEANP-UHFFFAOYSA-N C=C1C(Cc2nc(C(O)=O)n[n]2-c2ccccc2)CC1 Chemical compound C=C1C(Cc2nc(C(O)=O)n[n]2-c2ccccc2)CC1 UOCYDEIYBDEANP-UHFFFAOYSA-N 0.000 description 1
- OKXMGVHRDZMSHD-UHFFFAOYSA-N CC(C)(C)OC(NC(CC1)CN1c1ncc[n]2c1ncc2)=O Chemical compound CC(C)(C)OC(NC(CC1)CN1c1ncc[n]2c1ncc2)=O OKXMGVHRDZMSHD-UHFFFAOYSA-N 0.000 description 1
- BPHSXKIDCQRBTE-UHFFFAOYSA-N CC(C)(C)OC(NC(CC1)CN1c1ncc[n]2c1nnc2)=O Chemical compound CC(C)(C)OC(NC(CC1)CN1c1ncc[n]2c1nnc2)=O BPHSXKIDCQRBTE-UHFFFAOYSA-N 0.000 description 1
- AXNAHFQBVPFTPL-UHFFFAOYSA-N CC(C)(C)OC(NC1(CO)CNCC1)=O Chemical compound CC(C)(C)OC(NC1(CO)CNCC1)=O AXNAHFQBVPFTPL-UHFFFAOYSA-N 0.000 description 1
- YGEXXNAHZIXERI-LBPRGKRZSA-N CC(C)(C)OC(N[C@@H](CC1)CN1c1ncc[n]2c1ccc2)=O Chemical compound CC(C)(C)OC(N[C@@H](CC1)CN1c1ncc[n]2c1ccc2)=O YGEXXNAHZIXERI-LBPRGKRZSA-N 0.000 description 1
- DSVGMNRERUUNAT-UHFFFAOYSA-N CCOC(c1n[n](-c2ccccc2)nn1)=O Chemical compound CCOC(c1n[n](-c2ccccc2)nn1)=O DSVGMNRERUUNAT-UHFFFAOYSA-N 0.000 description 1
- MUJOCXSTKFXWJK-UHFFFAOYSA-N CC[O](C)C(c(nc1)n[n]1-c(cc1)ccc1Cl)=O Chemical compound CC[O](C)C(c(nc1)n[n]1-c(cc1)ccc1Cl)=O MUJOCXSTKFXWJK-UHFFFAOYSA-N 0.000 description 1
- JRHPOFJADXHYBR-HTQZYQBOSA-N CN[C@H](CCCC1)[C@@H]1NC Chemical compound CN[C@H](CCCC1)[C@@H]1NC JRHPOFJADXHYBR-HTQZYQBOSA-N 0.000 description 1
- XUDVXELGDYURNP-UHFFFAOYSA-N COC(c(cc1)n[n]1-c1c(CC#N)cccc1)=O Chemical compound COC(c(cc1)n[n]1-c1c(CC#N)cccc1)=O XUDVXELGDYURNP-UHFFFAOYSA-N 0.000 description 1
- ORUCTBNNYKZMSK-UHFFFAOYSA-N COC(c1n[nH]cc1)=O Chemical compound COC(c1n[nH]cc1)=O ORUCTBNNYKZMSK-UHFFFAOYSA-N 0.000 description 1
- UZVDHXKBVIXTIT-UHFFFAOYSA-N Cc(cc(cc1)-[n](cc2)nc2C(NC(CO)(CC2)CN2c2ncc[n]3c2ncc3)=O)c1F Chemical compound Cc(cc(cc1)-[n](cc2)nc2C(NC(CO)(CC2)CN2c2ncc[n]3c2ncc3)=O)c1F UZVDHXKBVIXTIT-UHFFFAOYSA-N 0.000 description 1
- GZNIUVUDCWZALD-HNNXBMFYSA-N Cc(cc1)c2[n]1ccnc2N(CC1)C[C@H]1NC(c1c[s]c(N(CC2)CCC2O)n1)=O Chemical compound Cc(cc1)c2[n]1ccnc2N(CC1)C[C@H]1NC(c1c[s]c(N(CC2)CCC2O)n1)=O GZNIUVUDCWZALD-HNNXBMFYSA-N 0.000 description 1
- PQIMBXFGSGKRTI-AWEZNQCLSA-N Cc(cc1)cc2c1nc(C(N[C@@H](CC1)CN1c1ncc[n]3c1nnc3)=O)nc2 Chemical compound Cc(cc1)cc2c1nc(C(N[C@@H](CC1)CN1c1ncc[n]3c1nnc3)=O)nc2 PQIMBXFGSGKRTI-AWEZNQCLSA-N 0.000 description 1
- DBUFGLULXNKLMX-UHFFFAOYSA-N Cc(cccc1)c1-[n](cc1)nc1C(O)=O Chemical compound Cc(cccc1)c1-[n](cc1)nc1C(O)=O DBUFGLULXNKLMX-UHFFFAOYSA-N 0.000 description 1
- YDQURWXDXKOPNV-HNNXBMFYSA-N Cc1ccccc1-[n](cc1)nc1C(N[C@@H](CC1)CN1c1ncc[n]2c1nnc2)=O Chemical compound Cc1ccccc1-[n](cc1)nc1C(N[C@@H](CC1)CN1c1ncc[n]2c1nnc2)=O YDQURWXDXKOPNV-HNNXBMFYSA-N 0.000 description 1
- GXNLHIOTOUQJHS-UHFFFAOYSA-N Cc1ncc[n]2c1ncc2 Chemical compound Cc1ncc[n]2c1ncc2 GXNLHIOTOUQJHS-UHFFFAOYSA-N 0.000 description 1
- PREWHWRWNMLCNH-UHFFFAOYSA-N Clc1ncc[n]2c1ncc2 Chemical compound Clc1ncc[n]2c1ncc2 PREWHWRWNMLCNH-UHFFFAOYSA-N 0.000 description 1
- VKZJRJVVFDDJKP-UHFFFAOYSA-N Clc1ncc[n]2c1nnc2 Chemical compound Clc1ncc[n]2c1nnc2 VKZJRJVVFDDJKP-UHFFFAOYSA-N 0.000 description 1
- BVCOJESIQPNOIF-UHFFFAOYSA-N N#CCc(cccc1)c1Br Chemical compound N#CCc(cccc1)c1Br BVCOJESIQPNOIF-UHFFFAOYSA-N 0.000 description 1
- WVDJKSUDLKUOGF-UHFFFAOYSA-N N#CCc1ccccc1-[n](cc1)nc1C(O)=O Chemical compound N#CCc1ccccc1-[n](cc1)nc1C(O)=O WVDJKSUDLKUOGF-UHFFFAOYSA-N 0.000 description 1
- QJAWHSQGWANHCM-UHFFFAOYSA-N NC(CC1)CN1c1ncc[n]2c1ccc2 Chemical compound NC(CC1)CN1c1ncc[n]2c1ccc2 QJAWHSQGWANHCM-UHFFFAOYSA-N 0.000 description 1
- UEPSPNNKZCKUHL-QMMMGPOBSA-N N[C@@H](CC1)CN1c1ncc[n]2nccc12 Chemical compound N[C@@H](CC1)CN1c1ncc[n]2nccc12 UEPSPNNKZCKUHL-QMMMGPOBSA-N 0.000 description 1
- QSNSCYSYFYORTR-UHFFFAOYSA-N Nc(cc1)ccc1Cl Chemical compound Nc(cc1)ccc1Cl QSNSCYSYFYORTR-UHFFFAOYSA-N 0.000 description 1
- ODYSXAOZKCELAL-UHFFFAOYSA-N O=C(c(nc1)n[n]1-c(cc1)ccc1Cl)NCC(CC1)CN1c1ncc[n]2c1ccc2 Chemical compound O=C(c(nc1)n[n]1-c(cc1)ccc1Cl)NCC(CC1)CN1c1ncc[n]2c1ccc2 ODYSXAOZKCELAL-UHFFFAOYSA-N 0.000 description 1
- QPEDKZAZXMYGPX-UHFFFAOYSA-N O=C(c(nc1)n[n]1-c1ccccc1)NC(CC1)CN1c1ncc[n]2c1nnc2 Chemical compound O=C(c(nc1)n[n]1-c1ccccc1)NC(CC1)CN1c1ncc[n]2c1nnc2 QPEDKZAZXMYGPX-UHFFFAOYSA-N 0.000 description 1
- ONIMSZJFFFNZHA-AWEZNQCLSA-N O=C(c(nc1)n[n]1-c1ccccc1)N[C@@H](CC1)CN1c1ncc[n]2c1ncc2 Chemical compound O=C(c(nc1)n[n]1-c1ccccc1)N[C@@H](CC1)CN1c1ncc[n]2c1ncc2 ONIMSZJFFFNZHA-AWEZNQCLSA-N 0.000 description 1
- OXXMSNZMCFUGFS-HNNXBMFYSA-N O=C(c1c[o]c(-c2ccccc2)n1)N[C@@H](CC1)CN1c1ncc[n]2c1ncc2 Chemical compound O=C(c1c[o]c(-c2ccccc2)n1)N[C@@H](CC1)CN1c1ncc[n]2c1ncc2 OXXMSNZMCFUGFS-HNNXBMFYSA-N 0.000 description 1
- ZNGOIVPALFVBDD-AWEZNQCLSA-N O=C(c1c[s]c(-c2ccccc2)n1)N[C@@H](CC1)CN1c1ncc[n]2c1nnc2 Chemical compound O=C(c1c[s]c(-c2ccccc2)n1)N[C@@H](CC1)CN1c1ncc[n]2c1nnc2 ZNGOIVPALFVBDD-AWEZNQCLSA-N 0.000 description 1
- WIPGFFGFVALIQM-KRWDZBQOSA-N O=C(c1ncc(C2CCCC2)cn1)N[C@@H](CC1)CN1c1ncc[n]2c1ccc2 Chemical compound O=C(c1ncc(C2CCCC2)cn1)N[C@@H](CC1)CN1c1ncc[n]2c1ccc2 WIPGFFGFVALIQM-KRWDZBQOSA-N 0.000 description 1
- IEYSGPZUULPJPQ-UHFFFAOYSA-N O=Nc(cc1)ccc1Cl Chemical compound O=Nc(cc1)ccc1Cl IEYSGPZUULPJPQ-UHFFFAOYSA-N 0.000 description 1
- OYGSDSZQKGMLJZ-UHFFFAOYSA-N OC(c(cc1)n[n]1-c(cc1)ccc1F)=O Chemical compound OC(c(cc1)n[n]1-c(cc1)ccc1F)=O OYGSDSZQKGMLJZ-UHFFFAOYSA-N 0.000 description 1
- NQFZERHPFJLLFU-UHFFFAOYSA-N OC(c(nc1)n[n]1-c(cc1)ccc1Cl)=O Chemical compound OC(c(nc1)n[n]1-c(cc1)ccc1Cl)=O NQFZERHPFJLLFU-UHFFFAOYSA-N 0.000 description 1
- ACFQGTMTFLDFLP-UHFFFAOYSA-N OC(c(nc1)n[n]1-c1ccccc1)=O Chemical compound OC(c(nc1)n[n]1-c1ccccc1)=O ACFQGTMTFLDFLP-UHFFFAOYSA-N 0.000 description 1
- KQRWYYSDIFOTTP-UHFFFAOYSA-N OC(c1c[o]c(-c2ccccc2)n1)=O Chemical compound OC(c1c[o]c(-c2ccccc2)n1)=O KQRWYYSDIFOTTP-UHFFFAOYSA-N 0.000 description 1
- IBUSLNJQKLZPNR-UHFFFAOYSA-N OC(c1c[s]c(-c2ccccc2)n1)=O Chemical compound OC(c1c[s]c(-c2ccccc2)n1)=O IBUSLNJQKLZPNR-UHFFFAOYSA-N 0.000 description 1
- RHFHOOINLIRPDW-FQEVSTJZSA-N OC[C@](CC1)(CN1c1ncc[n]2c1ncc2)NC(c1c[s]c(N(CC2)CCC2O)n1)=O Chemical compound OC[C@](CC1)(CN1c1ncc[n]2c1ncc2)NC(c1c[s]c(N(CC2)CCC2O)n1)=O RHFHOOINLIRPDW-FQEVSTJZSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
- G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
- G01N2333/7158—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Pain & Pain Management (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261731463P | 2012-11-29 | 2012-11-29 | |
| US61/731,463 | 2012-11-29 | ||
| PCT/US2013/072067 WO2014085490A1 (en) | 2012-11-29 | 2013-11-26 | Cxcr7 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20160002667A KR20160002667A (ko) | 2016-01-08 |
| KR102196374B1 true KR102196374B1 (ko) | 2020-12-31 |
Family
ID=50825654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157017200A Active KR102196374B1 (ko) | 2012-11-29 | 2013-11-26 | Cxcr7 길항제 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US9169261B2 (https=) |
| EP (1) | EP2925745B1 (https=) |
| JP (1) | JP6272897B2 (https=) |
| KR (1) | KR102196374B1 (https=) |
| CN (1) | CN105189484B (https=) |
| AU (1) | AU2013352304C1 (https=) |
| BR (1) | BR112015012366A8 (https=) |
| CA (1) | CA2892042C (https=) |
| DK (1) | DK2925745T3 (https=) |
| ES (1) | ES2681593T3 (https=) |
| IL (1) | IL238974B (https=) |
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| EP4302834A3 (en) | 2016-07-12 | 2024-07-17 | Revolution Medicines, Inc. | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors |
| MA45782B1 (fr) * | 2016-07-28 | 2021-12-31 | Idorsia Pharmaceuticals Ltd | Modulateurs du récepteur de cxcr7 pipéridine |
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| JP7240319B2 (ja) * | 2017-01-23 | 2023-03-15 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての二環式化合物 |
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| TW201930292A (zh) | 2017-10-12 | 2019-08-01 | 美商銳新醫藥公司 | 作為變構ｓｈｐ２抑制劑的吡啶、吡嗪和三嗪化合物 |
| EP3713934B1 (en) | 2017-11-23 | 2022-04-13 | Universita' degli Studi di Palermo | Oxadiazole derivatives for the treatment of genetic diseases due to nonsense mutations |
| JP7361693B2 (ja) | 2017-12-15 | 2023-10-16 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての多環式化合物 |
| WO2019145460A1 (en) * | 2018-01-26 | 2019-08-01 | Idorsia Pharmaceuticals Ltd | Crystalline forms of the cxcr7 receptor antagonist (3s,4s)-1-cyclopropylmethyl-4-{[5-(2,4-difluoro-phenyl)-isoxazole-3-carbonyl]-amino}-piperidine-3-carboxylic acid (1-pyrimidin-2-yl-cyclopropyl)-amide |
| CN108794484B (zh) * | 2018-04-28 | 2020-04-24 | 北京施安泰医药技术开发有限公司 | [1,2,4]三唑并[4,3-a]吡嗪衍生物、其药物组合物、制备方法和应用 |
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| CN110013483B (zh) * | 2019-05-10 | 2022-04-15 | 江苏师范大学 | 噻唑并[3,2-a]嘧啶-6-甲腈衍生物用于抗菌的用途 |
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| TWI879949B (zh) | 2020-04-27 | 2025-04-11 | 南韓商奧土擇破利悟股份有限公司 | 用於ｕｂｒ盒結構域配體之化合物、組成物以及醫藥組成物 |
| CN113105469B (zh) * | 2021-04-13 | 2022-04-22 | 中国科学院新疆理化技术研究所 | 一种三环呋喃并[2,3-d]嘧啶酮类化合物及用途 |
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