CA2889584C - Methods for controlling blood pressure and reducing dyspnea in heart failure - Google Patents
Methods for controlling blood pressure and reducing dyspnea in heart failure Download PDFInfo
- Publication number
- CA2889584C CA2889584C CA2889584A CA2889584A CA2889584C CA 2889584 C CA2889584 C CA 2889584C CA 2889584 A CA2889584 A CA 2889584A CA 2889584 A CA2889584 A CA 2889584A CA 2889584 C CA2889584 C CA 2889584C
- Authority
- CA
- Canada
- Prior art keywords
- clevidipine
- blood pressure
- patient
- mmhg
- patients
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261719127P | 2012-10-26 | 2012-10-26 | |
| US61/719,127 | 2012-10-26 | ||
| PCT/US2013/066990 WO2014066870A1 (en) | 2012-10-26 | 2013-10-26 | Methods for controlling blood pressure and reducing dyspnea in heart failure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2889584A1 CA2889584A1 (en) | 2014-05-01 |
| CA2889584C true CA2889584C (en) | 2018-08-14 |
Family
ID=50545374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2889584A Active CA2889584C (en) | 2012-10-26 | 2013-10-26 | Methods for controlling blood pressure and reducing dyspnea in heart failure |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US10881645B2 (https=) |
| EP (1) | EP2925128B1 (https=) |
| JP (2) | JP6329957B2 (https=) |
| KR (1) | KR102299073B1 (https=) |
| CN (2) | CN104968199A (https=) |
| AU (1) | AU2013334081B2 (https=) |
| BR (1) | BR112015009291B1 (https=) |
| CA (1) | CA2889584C (https=) |
| EA (1) | EA030354B1 (https=) |
| ES (1) | ES2671639T3 (https=) |
| IL (1) | IL238462A0 (https=) |
| MX (1) | MX359768B (https=) |
| NZ (1) | NZ708511A (https=) |
| PL (1) | PL2925128T3 (https=) |
| TR (1) | TR201807636T4 (https=) |
| UA (1) | UA117571C2 (https=) |
| WO (1) | WO2014066870A1 (https=) |
| ZA (1) | ZA201503741B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2947486C (en) * | 2014-05-19 | 2023-09-26 | The Medicines Company | Clevidipine nanoparticles and pharmaceutical compositions thereof |
| MX2021010483A (es) * | 2019-03-05 | 2021-10-01 | Windtree Therapeutics Inc | Formulacion intravenosa que contiene istaroxima para el tratamiento de insuficiencia cardiaca aguda (ahf). |
| CN114966056B (zh) * | 2022-06-08 | 2024-07-02 | 四川大学华西医院 | 筛查急性主动脉夹层的试剂盒和系统 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9303657D0 (sv) | 1993-11-05 | 1993-11-05 | Astra Ab | Short-acting dihydropyridines |
| SE9303744D0 (sv) | 1993-11-12 | 1993-11-12 | Astra Ab | Pharmaceutical emulsion |
| SE9804002D0 (sv) | 1998-11-23 | 1998-11-23 | Astra Ab | New manufacturing process |
| CA2724540C (en) | 2008-05-16 | 2014-07-08 | Corthera, Inc. | Treating dyspnea associated with acute heart failure with relaxin |
| CN102186351A (zh) | 2008-08-01 | 2011-09-14 | 医药公司 | 药物组合物和用于稳定药物组合物的方法 |
| WO2010014727A1 (en) | 2008-08-01 | 2010-02-04 | The Medicines Company | Pharmaceutical compositions and methods for producing low impurity concentrations of the same |
| BR112012011298B1 (pt) * | 2009-11-11 | 2021-12-14 | Chiesi Farmaceutici S.P.A. | Uso de cangrelor e/ou bivalirudina na preparação de medicamentos e combinação de medicamentos |
| TW201215392A (en) | 2010-06-16 | 2012-04-16 | Gilead Sciences Inc | Use of ranolazine for treating pulmonary hypertension |
| PL2627173T5 (pl) * | 2010-10-12 | 2019-11-29 | Chiesi Farm Spa | Formulacje emulsyjne klewidypiny zawierające środki przeciw mikrobom |
| CA2832066C (en) | 2011-04-01 | 2023-04-18 | The Medicines Company | Short-acting dihydropyridines (clevidipine) for use in reducing stroke damage |
-
2013
- 2013-10-26 KR KR1020157013890A patent/KR102299073B1/ko active Active
- 2013-10-26 WO PCT/US2013/066990 patent/WO2014066870A1/en not_active Ceased
- 2013-10-26 AU AU2013334081A patent/AU2013334081B2/en active Active
- 2013-10-26 CN CN201380068074.2A patent/CN104968199A/zh active Pending
- 2013-10-26 UA UAA201505170A patent/UA117571C2/uk unknown
- 2013-10-26 NZ NZ708511A patent/NZ708511A/en unknown
- 2013-10-26 CA CA2889584A patent/CA2889584C/en active Active
- 2013-10-26 CN CN201911070111.9A patent/CN110840890A/zh active Pending
- 2013-10-26 BR BR112015009291-8A patent/BR112015009291B1/pt active IP Right Grant
- 2013-10-26 MX MX2015005341A patent/MX359768B/es active IP Right Grant
- 2013-10-26 PL PL13848937T patent/PL2925128T3/pl unknown
- 2013-10-26 ES ES13848937.2T patent/ES2671639T3/es active Active
- 2013-10-26 US US14/064,137 patent/US10881645B2/en active Active
- 2013-10-26 EA EA201590825A patent/EA030354B1/ru unknown
- 2013-10-26 TR TR2018/07636T patent/TR201807636T4/tr unknown
- 2013-10-26 EP EP13848937.2A patent/EP2925128B1/en active Active
- 2013-10-26 JP JP2015539879A patent/JP6329957B2/ja active Active
-
2015
- 2015-04-26 IL IL238462A patent/IL238462A0/en active IP Right Grant
- 2015-05-26 ZA ZA2015/03741A patent/ZA201503741B/en unknown
-
2018
- 2018-01-31 JP JP2018014665A patent/JP2018065875A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US10881645B2 (en) | 2021-01-05 |
| AU2013334081A1 (en) | 2015-06-11 |
| ZA201503741B (en) | 2022-09-28 |
| AU2013334081B2 (en) | 2017-05-18 |
| EP2925128A4 (en) | 2016-06-08 |
| MX359768B (es) | 2018-10-10 |
| US20140121247A1 (en) | 2014-05-01 |
| IL238462A0 (en) | 2015-06-30 |
| JP6329957B2 (ja) | 2018-05-23 |
| WO2014066870A1 (en) | 2014-05-01 |
| EA201590825A1 (ru) | 2015-09-30 |
| BR112015009291B1 (pt) | 2021-03-16 |
| EA030354B1 (ru) | 2018-07-31 |
| BR112015009291A2 (pt) | 2017-07-04 |
| ES2671639T3 (es) | 2018-06-07 |
| NZ708511A (en) | 2018-11-30 |
| EP2925128B1 (en) | 2018-04-11 |
| CA2889584A1 (en) | 2014-05-01 |
| JP2018065875A (ja) | 2018-04-26 |
| CN110840890A (zh) | 2020-02-28 |
| JP2015535258A (ja) | 2015-12-10 |
| CN104968199A (zh) | 2015-10-07 |
| KR20150104084A (ko) | 2015-09-14 |
| MX2015005341A (es) | 2016-05-24 |
| PL2925128T3 (pl) | 2018-10-31 |
| UA117571C2 (uk) | 2018-08-27 |
| EP2925128A1 (en) | 2015-10-07 |
| TR201807636T4 (tr) | 2018-06-21 |
| KR102299073B1 (ko) | 2021-09-09 |
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| CA2889584C (en) | Methods for controlling blood pressure and reducing dyspnea in heart failure | |
| CN114222566A (zh) | 用于改善癌症患者的结果的方法和组合物 | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20161026 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 11TH ANNIV.) - STANDARD Year of fee payment: 11 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20241018 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT Effective date: 20241018 Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20241018 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 12TH ANNIV.) - STANDARD Year of fee payment: 12 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20251017 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20251017 |