CA2884114C - Process for the reduction of nitro derivatives to amines by trichlorosilane in presence of an organic base - Google Patents
Process for the reduction of nitro derivatives to amines by trichlorosilane in presence of an organic base Download PDFInfo
- Publication number
- CA2884114C CA2884114C CA2884114A CA2884114A CA2884114C CA 2884114 C CA2884114 C CA 2884114C CA 2884114 A CA2884114 A CA 2884114A CA 2884114 A CA2884114 A CA 2884114A CA 2884114 C CA2884114 C CA 2884114C
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- CA
- Canada
- Prior art keywords
- process according
- nitro group
- group
- base
- reduction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
- C07C209/325—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups reduction by other means than indicated in C07C209/34 or C07C209/36
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C07B43/04—Formation or introduction of functional groups containing nitrogen of amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
- C07C209/34—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
- C07C209/36—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst
- C07C209/365—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst by reduction with preservation of halogen-atoms in compounds containing nitro groups and halogen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2012A001489 | 2012-09-06 | ||
| IT001489A ITMI20121489A1 (it) | 2012-09-06 | 2012-09-06 | Metodo per la riduzione di nitro derivati ad ammine |
| PCT/EP2013/068371 WO2014037444A1 (en) | 2012-09-06 | 2013-09-05 | Process for the reduction of nitro derivatives to amines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2884114A1 CA2884114A1 (en) | 2014-03-13 |
| CA2884114C true CA2884114C (en) | 2020-08-18 |
Family
ID=47046692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2884114A Active CA2884114C (en) | 2012-09-06 | 2013-09-05 | Process for the reduction of nitro derivatives to amines by trichlorosilane in presence of an organic base |
Country Status (18)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2933242A1 (en) * | 2014-04-16 | 2015-10-21 | Basf Se | Process for manufacturing amino compounds |
| JP2016117688A (ja) * | 2014-12-22 | 2016-06-30 | 東レ・ファインケミカル株式会社 | ジアミン化合物の製造方法 |
| CN108484522A (zh) * | 2018-04-25 | 2018-09-04 | 山东百诺医药股份有限公司 | 4-(1,2,4-噁二唑-3-基)苯胺的制备方法 |
| CN109053585B (zh) * | 2018-09-13 | 2020-10-23 | 暨明医药科技（苏州）有限公司 | 一种三氯苯达唑的合成方法 |
| CN111777576A (zh) * | 2019-04-05 | 2020-10-16 | 齐鲁制药有限公司 | 尼达尼布关键中间体的制备方法 |
| CN113354543A (zh) * | 2020-03-03 | 2021-09-07 | 深圳有为技术控股集团有限公司 | 若干硝基化合物的硅烷化学还原制备胺基产物及h-酸的新环保生产工艺 |
| CN112010801B (zh) * | 2020-10-16 | 2023-07-28 | 山东汇海医药化工有限公司 | 一种氨氯地平碱的制备方法 |
| US20230357125A1 (en) * | 2022-05-06 | 2023-11-09 | AMPAC Fine Chemicals | Process for Catalytic Reduction of Nitro Compounds to Amines |
| CN117164471A (zh) * | 2023-08-14 | 2023-12-05 | 河北圣雪大成制药有限责任公司 | 一种由9-氨基米诺环素制备替加环素的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3485875A (en) * | 1967-06-28 | 1969-12-23 | Texaco Inc | Production of primary amines |
| JPH1036300A (ja) * | 1996-07-18 | 1998-02-10 | Souzou Kagaku Kenkyusho:Kk | トリクロロシラン還元によるアルコールおよびアミンの製造方法 |
| US6162929A (en) * | 1997-12-23 | 2000-12-19 | Hoffmann-La Roche Inc. | Process for the manufacture of bisphosphine oxide and bisphosphonate compounds |
| JP2000256305A (ja) * | 1999-03-10 | 2000-09-19 | Sumitomo Chem Co Ltd | 光学活性アミン化合物の製造法 |
| JP2001270851A (ja) * | 2000-03-24 | 2001-10-02 | Tokuyama Corp | 含窒素化合物の製造方法 |
| JP2004307369A (ja) * | 2003-04-03 | 2004-11-04 | Seiko Epson Corp | ４−フェニルベンゾフェノン誘導体および４−フェニルベンゾフェノン誘導体の製造方法 |
| EP1747205B1 (en) * | 2004-05-11 | 2012-06-20 | The Hong Kong Polytechnic University | Chiral phosphine ligands, their preparation, catalysts thereof and their use |
| JP5008063B2 (ja) * | 2006-11-22 | 2012-08-22 | 独立行政法人産業技術総合研究所 | ジホスフィンコア型両親媒性デンドリマー、その製造方法、二座ホスフィン配位子及びその配位構造を有する含パラジウム錯体化合物 |
| EP2462106A2 (en) * | 2009-08-03 | 2012-06-13 | Helvetica Industries (P) Limited | Process for preparing pregabalin |
-
2012
- 2012-09-06 IT IT001489A patent/ITMI20121489A1/it unknown
-
2013
- 2013-09-05 US US14/426,221 patent/US9284258B2/en active Active
- 2013-09-05 KR KR1020157008317A patent/KR102074540B1/ko active Active
- 2013-09-05 EP EP13766240.9A patent/EP2892862B1/en active Active
- 2013-09-05 CN CN201380056114.1A patent/CN104822642B/zh active Active
- 2013-09-05 IN IN2567DEN2015 patent/IN2015DN02567A/en unknown
- 2013-09-05 SI SI201330516A patent/SI2892862T1/sl unknown
- 2013-09-05 HU HUE13766240A patent/HUE032256T2/en unknown
- 2013-09-05 MX MX2015003039A patent/MX373769B/es active IP Right Grant
- 2013-09-05 PL PL13766240T patent/PL2892862T3/pl unknown
- 2013-09-05 HR HRP20170204TT patent/HRP20170204T1/hr unknown
- 2013-09-05 PT PT137662409T patent/PT2892862T/pt unknown
- 2013-09-05 DK DK13766240.9T patent/DK2892862T3/en active
- 2013-09-05 CA CA2884114A patent/CA2884114C/en active Active
- 2013-09-05 ES ES13766240.9T patent/ES2614243T3/es active Active
- 2013-09-05 JP JP2015530387A patent/JP6147345B2/ja active Active
- 2013-09-05 WO PCT/EP2013/068371 patent/WO2014037444A1/en active Application Filing
-
2015
- 2015-03-08 IL IL237616A patent/IL237616A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| HUE032256T2 (en) | 2017-09-28 |
| KR20150060740A (ko) | 2015-06-03 |
| JP2015527381A (ja) | 2015-09-17 |
| US20150232412A1 (en) | 2015-08-20 |
| SI2892862T1 (sl) | 2017-06-30 |
| DK2892862T3 (en) | 2017-02-20 |
| IL237616A (en) | 2017-03-30 |
| PT2892862T (pt) | 2017-02-10 |
| ES2614243T3 (es) | 2017-05-30 |
| MX373769B (es) | 2020-04-10 |
| ITMI20121489A1 (it) | 2014-03-07 |
| WO2014037444A1 (en) | 2014-03-13 |
| KR102074540B1 (ko) | 2020-02-06 |
| CA2884114A1 (en) | 2014-03-13 |
| PL2892862T3 (pl) | 2017-07-31 |
| IL237616A0 (en) | 2015-04-30 |
| MX2015003039A (es) | 2015-09-21 |
| CN104822642B (zh) | 2016-08-24 |
| IN2015DN02567A (enrdf_load_stackoverflow) | 2015-09-11 |
| EP2892862B1 (en) | 2016-11-09 |
| HRP20170204T1 (hr) | 2017-06-02 |
| US9284258B2 (en) | 2016-03-15 |
| EP2892862A1 (en) | 2015-07-15 |
| JP6147345B2 (ja) | 2017-06-14 |
| CN104822642A (zh) | 2015-08-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20180727 |