CA2876542C - Method and device for monitoring an extracorporeal blood treatment of a patient - Google Patents

Method and device for monitoring an extracorporeal blood treatment of a patient Download PDF

Info

Publication number
CA2876542C
CA2876542C CA2876542A CA2876542A CA2876542C CA 2876542 C CA2876542 C CA 2876542C CA 2876542 A CA2876542 A CA 2876542A CA 2876542 A CA2876542 A CA 2876542A CA 2876542 C CA2876542 C CA 2876542C
Authority
CA
Canada
Prior art keywords
fluid
sample
intensity
polarization plane
anisotropy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2876542A
Other languages
English (en)
French (fr)
Other versions
CA2876542A1 (en
Inventor
Alfred Gagel
Andreas Maierhofer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius Medical Care Deutschland GmbH
Original Assignee
Fresenius Medical Care Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Medical Care Deutschland GmbH filed Critical Fresenius Medical Care Deutschland GmbH
Publication of CA2876542A1 publication Critical patent/CA2876542A1/en
Application granted granted Critical
Publication of CA2876542C publication Critical patent/CA2876542C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6866Extracorporeal blood circuits, e.g. dialysis circuits
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14558Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters by polarisation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4836Diagnosis combined with treatment in closed-loop systems or methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4848Monitoring or testing the effects of treatment, e.g. of medication
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7225Details of analogue processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601Control or regulation
    • A61M1/1603Regulation parameters
    • A61M1/1605Physical characteristics of the dialysate fluid
    • A61M1/1609Physical characteristics of the dialysate fluid after use, i.e. downstream of dialyser
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601Control or regulation
    • A61M1/1619Sampled collection of used dialysate, i.e. obviating the need for recovery of whole dialysate quantity for post-dialysis analysis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403Regulation parameters
    • A61M1/3406Physical characteristics of the filtrate, e.g. urea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3306Optical measuring means

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Signal Processing (AREA)
  • Psychiatry (AREA)
  • Power Engineering (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Physiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • External Artificial Organs (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CA2876542A 2012-06-15 2013-06-14 Method and device for monitoring an extracorporeal blood treatment of a patient Active CA2876542C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261660016P 2012-06-15 2012-06-15
US61/660,016 2012-06-15
EP12172251.6A EP2674103A1 (en) 2012-06-15 2012-06-15 Method and device for monitoring an extracorporeal blood treatment of a patient
EP12172251.6 2012-06-15
PCT/EP2013/062366 WO2013186357A1 (en) 2012-06-15 2013-06-14 Method and device for monitoring an extracorporeal blood treatment of a patient

Publications (2)

Publication Number Publication Date
CA2876542A1 CA2876542A1 (en) 2013-12-19
CA2876542C true CA2876542C (en) 2020-08-18

Family

ID=46465026

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2876542A Active CA2876542C (en) 2012-06-15 2013-06-14 Method and device for monitoring an extracorporeal blood treatment of a patient

Country Status (11)

Country Link
US (1) US10010289B2 (enExample)
EP (2) EP2674103A1 (enExample)
JP (1) JP6242883B2 (enExample)
KR (1) KR102058260B1 (enExample)
CN (1) CN104363820B (enExample)
AU (1) AU2013276453B2 (enExample)
BR (1) BR112014031407B1 (enExample)
CA (1) CA2876542C (enExample)
EA (1) EA028556B1 (enExample)
IN (1) IN2015DN00165A (enExample)
WO (1) WO2013186357A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9861733B2 (en) 2012-03-23 2018-01-09 Nxstage Medical Inc. Peritoneal dialysis systems, devices, and methods
CA2830085A1 (en) 2011-03-23 2012-09-27 Nxstage Medical, Inc. Peritoneal dialysis systems, devices, and methods
JP6303555B2 (ja) * 2014-02-04 2018-04-04 株式会社ジェイ・エム・エス アルブミン濃度測定装置及びアルブミン濃度測定方法
WO2016057982A1 (en) 2014-10-10 2016-04-14 Nxstage Medical, Inc. Flow balancing devices, methods, and systems
JP6595204B2 (ja) * 2015-04-24 2019-10-23 株式会社島津製作所 光学分析装置
EP3432785B1 (en) * 2016-03-25 2021-03-10 The General Hospital Corporation Polarization-based fluorescent nucleic acid detection
WO2018017623A1 (en) 2016-07-18 2018-01-25 Nxstage Medical, Inc. Flow balancing devices, methods, and systems
EP3506962B1 (en) 2016-08-30 2023-11-22 NxStage Medical, Inc. Parameter monitoring in medical treatment systems
US11826545B2 (en) * 2016-09-08 2023-11-28 Fresenius Medical Care Holdings, Inc. Optical blood detection system
US12048791B2 (en) 2017-06-24 2024-07-30 Nxstage Medical, Inc. Peritoneal dialysis fluid preparation and/or treatment devices methods and systems
DE102017114735B4 (de) * 2017-06-30 2019-07-04 Fresenius Medical Care Deutschland Gmbh Vorrichtung und Verfahren zur Desinfektion
US10948403B2 (en) * 2017-10-06 2021-03-16 Bio-Rad Laboratories, Inc. Protein quantitation device
JP6997582B2 (ja) * 2017-10-17 2022-01-17 日機装株式会社 血液浄化装置
US20190262526A1 (en) 2018-02-28 2019-08-29 Nxstage Medical, Inc. Fluid Preparation and Treatment Devices Methods and Systems
WO2020056808A1 (zh) * 2018-09-21 2020-03-26 北京大学深圳医院 血液中吲哚氰绿的检测装置及系统
WO2020237228A1 (en) 2019-05-23 2020-11-26 Nxstage Medical, Inc. Flow synchronization devices, methods and systems
EP3992617A4 (en) * 2019-06-26 2022-08-17 Asahi Kasei Medical Co., Ltd. Concentration calculation device and blood treatment system
CN110691153B (zh) * 2019-08-27 2020-09-22 珠海格力电器股份有限公司 一种显示模组及终端
US12228564B2 (en) 2020-01-10 2025-02-18 Fresenius Medical Care Holdings, Inc. Systems and methods for analyzing spent dialysate
EP4129356A4 (en) * 2020-03-31 2023-08-23 Asahi Kasei Medical Co., Ltd. BLOOD PURIFICATION SYSTEM, CONTROL METHOD, CONTROL PROGRAM, LEARNING DEVICE AND LEARNING METHOD
US12036344B2 (en) * 2020-11-13 2024-07-16 Fresenius Medical Care Holdings, Inc. Systems and methods for analyzing spent dialysate
DE102021113519A1 (de) * 2021-05-26 2022-12-01 B.Braun Avitum Ag Optischer Sensor zur Bestimmung einer Dialysedosis
JP7754735B2 (ja) * 2022-02-01 2025-10-15 日機装株式会社 透析排液用成分測定装置及び方法
US20240325615A1 (en) 2023-03-31 2024-10-03 Baxter International Inc. System featuring optical and electrical sensors for characterizing effluent from a peritoneal dialysis patient
CN116327188B (zh) * 2023-05-29 2023-09-08 深圳市亿米生命科技有限公司 一种基于指夹式血氧仪的血氧分析方法
CN117250178B (zh) * 2023-09-19 2024-09-13 北京艾锐精仪科技有限公司 一种荧光各向异性探测方法及其探测系统

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496722A (en) * 1981-05-01 1985-01-29 The Children's Medical Center Corporation Reporter compounds
US5515864A (en) * 1994-04-21 1996-05-14 Zuckerman; Ralph Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime
CA2332833A1 (en) * 1998-05-19 1999-11-25 Spectrx, Inc. Apparatus and method for determining tissue characteristics
JP2002098638A (ja) * 2000-09-26 2002-04-05 Shimadzu Corp 蛍光偏光度測定装置
JP4303125B2 (ja) 2002-01-28 2009-07-29 デビオテック ソシエテ アノニム 腹膜透析システム
US7326576B2 (en) 2003-04-09 2008-02-05 Prescient Medical, Inc. Raman spectroscopic monitoring of hemodialysis
DE102005001051B4 (de) * 2005-01-07 2007-10-31 Fresenius Medical Care Deutschland Gmbh Vorrichtung und Verfahren zur Erkennung von Komplikationen während einer extrakorporalen Blutbehandlung
DE102006029899B4 (de) 2006-06-29 2009-06-04 Fresenius Medical Care Deutschland Gmbh Spektroskopischer Detektor und Verfahren zur Bestimmung von Blut und biologischen Markersubstanzen in Flüssigkeiten
US20080225265A1 (en) * 2007-03-17 2008-09-18 Mi Research, Inc. Method and apparatus for finding macromolecule crystallization conditions
US20110188043A1 (en) * 2007-12-26 2011-08-04 Yissum, Research Development Company of The Hebrew University of Jerusalem, Ltd. Method and apparatus for monitoring processes in living cells
ATE524205T1 (de) 2009-02-11 2011-09-15 Braun B Avitum Ag Vorrichtung zur extrakorporalen blutbehandlung
US20130153474A1 (en) 2010-06-11 2013-06-20 B. Braun Avitum Ag Apparatus for extracorporeal blood treatment, comprising a measuring device for determining the luminescence of the spent dialysate

Also Published As

Publication number Publication date
CN104363820A (zh) 2015-02-18
KR102058260B1 (ko) 2019-12-20
EA201492106A1 (ru) 2015-05-29
EP2674103A1 (en) 2013-12-18
JP2015521492A (ja) 2015-07-30
US10010289B2 (en) 2018-07-03
US20140046150A1 (en) 2014-02-13
CN104363820B (zh) 2019-07-05
BR112014031407A2 (pt) 2017-06-27
WO2013186357A1 (en) 2013-12-19
EA028556B1 (ru) 2017-11-30
KR20150024405A (ko) 2015-03-06
BR112014031407B1 (pt) 2021-12-28
IN2015DN00165A (enExample) 2015-06-12
EP2861127A1 (en) 2015-04-22
CA2876542A1 (en) 2013-12-19
JP6242883B2 (ja) 2017-12-06
EP2861127B1 (en) 2020-09-09
AU2013276453B2 (en) 2017-08-17
AU2013276453A1 (en) 2015-01-22

Similar Documents

Publication Publication Date Title
CA2876542C (en) Method and device for monitoring an extracorporeal blood treatment of a patient
AU2012241983B2 (en) Method and apparatus for monitoring a treatment of a patient, preferably for monitoring hemodialysis, hemodiafiltration, and/or peritoneal dialysis
US20120115248A1 (en) Methods of determining the presence and/or concentration of an analyte in a sample
EP3111211B1 (en) Self calibrating blood chamber
US20130153474A1 (en) Apparatus for extracorporeal blood treatment, comprising a measuring device for determining the luminescence of the spent dialysate
JP2007505680A (ja) 血液透析、血液透析濾過、血液濾過または腹膜透析に関わる装置、システムおよび方法
EP2577270A1 (en) Method and device for measuring and monitoring concentration of substances in a biological fluid
Uhlin et al. Optical monitoring of dialysis dose
CN113588579B (zh) 血液离子浓度探测装置和方法、钙离子浓度探测方法
Filutowicz et al. Remarks on spectra-photometric monitoring of urea in dialysate
RU121373U1 (ru) Устройство для мониторинга процесса гемодиализа
Atanya The Effects of Acid-Base Parameters, Oxygen and Heparin on the Ability to Detect Changes in the Blood Status of End-Stage Renal Disease Patients Undergoing Hemodialysis Using Whole Blood-Based Optical Spectroscopy

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180613