CA2870316C - Hydroxypropyl beta cyclodextrin in the treatment of a proteinuric glomerural disease - Google Patents
Hydroxypropyl beta cyclodextrin in the treatment of a proteinuric glomerural disease Download PDFInfo
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- CA2870316C CA2870316C CA2870316A CA2870316A CA2870316C CA 2870316 C CA2870316 C CA 2870316C CA 2870316 A CA2870316 A CA 2870316A CA 2870316 A CA2870316 A CA 2870316A CA 2870316 C CA2870316 C CA 2870316C
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- beta cyclodextrin
- hydroxypropyl beta
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| US201261624087P | 2012-04-13 | 2012-04-13 | |
| US61/624,087 | 2012-04-13 | ||
| PCT/US2013/036484 WO2013155485A2 (en) | 2012-04-13 | 2013-04-12 | Method of using cyclodextrin |
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| CA2870316A1 CA2870316A1 (en) | 2013-10-17 |
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| CA2870316A Active CA2870316C (en) | 2012-04-13 | 2013-04-12 | Hydroxypropyl beta cyclodextrin in the treatment of a proteinuric glomerural disease |
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| EP2968083B1 (en) | 2013-03-12 | 2021-09-22 | Primal Therapies, Inc. | Dental composition comprising chelator and base |
| JP6418911B2 (ja) * | 2014-11-18 | 2018-11-07 | 学校法人中部大学 | Ｇｌｐ−１分泌促進剤 |
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| CN105395549A (zh) * | 2015-11-03 | 2016-03-16 | 天津医科大学总医院 | 烟酸的新用途 |
| EP3515501A1 (en) * | 2016-09-19 | 2019-07-31 | Aten Porus Lifesciences | Cyclodextrin based polymers, methods, compositions and applications thereof |
| WO2018075622A1 (en) * | 2016-10-19 | 2018-04-26 | University Of Miami | Materials and methods for modulating insulin signaling and preserving podocyte function |
| CN107982546A (zh) * | 2017-12-05 | 2018-05-04 | 中国药科大学 | 基于主客体相互作用的酸敏感超分子纳米粒及其应用 |
| US11925659B2 (en) | 2018-10-29 | 2024-03-12 | Cyclo Therapeutics, Inc. | Methods for treating Alzheimer's disease |
| AU2020204925B2 (en) | 2019-01-03 | 2025-11-20 | Cyclarity Therapeutics, Inc. | Cyclodextrin dimers, compositions thereof, and uses thereof |
| PH12021552553A1 (en) * | 2019-04-16 | 2022-06-20 | Celagenex Res India Pvt Ltd | Synergistic lipid controlling compositions |
| KR20220098009A (ko) * | 2019-11-11 | 2022-07-08 | 아츠오 오치 | 체세포를 재프로그래밍하기 위한 방법 및 키트 |
| US12226431B2 (en) | 2021-09-11 | 2025-02-18 | Porosome Therapeutics, Inc. | Aerosol and topical administration of a formulation containing cyclodextrin, quercetin and zinc, in combination or separately, to mitigate infection by enveloped viruses |
| PE20231169A1 (es) * | 2020-08-27 | 2023-07-26 | Beren Therapeutics P B C | Metodos para el tratamiento de enfermedades cardiovasculares con ciclodextrinas |
| WO2022047241A1 (en) * | 2020-08-27 | 2022-03-03 | Beren Therapeutics P.B.C. | Methods for the treatment of cholesterol crystal embolization with cyclodextrins |
| EP4203973A4 (en) * | 2020-08-27 | 2024-08-21 | Beren Therapeutics P.B.C. | METHOD FOR PREVENTING CHOLESTEROL CRYSTAL EMBOLISATION WITH CYCLODEXTRINS |
| CN112089843B (zh) * | 2020-10-13 | 2022-11-04 | 合肥工业大学 | 一种抗心力衰竭的联用组合药物及其在制备抗心力衰竭药物中的应用 |
| WO2022178318A1 (en) * | 2021-02-18 | 2022-08-25 | Beren Therapeutics P.B.C. | Methods for the treatment of familial heterozygous and homozygous hypercholesterolemia with cyclodextrins |
| CN113295793B (zh) * | 2021-05-20 | 2022-11-04 | 复旦大学附属中山医院 | 预测早期糖尿病以及糖尿病发生的生物标志物、其检测方法与应用 |
| EP4198061A4 (en) * | 2021-09-01 | 2024-10-23 | Renatus Inc. | PHARMACEUTICAL COMPOSITION COMPRISING A GAMMA-CYCLODEXTRIN POLYMER AND ITS USE |
| KR20240160120A (ko) | 2022-02-18 | 2024-11-08 | 베렌 테라퓨틱스 피.비.씨. | 하이드록시프로필-베타-사이클로덱스트린의 조성물 및 이의 정제 방법 |
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| US9200245B2 (en) | 2003-06-26 | 2015-12-01 | Seng Enterprises Ltd. | Multiwell plate |
| US7393826B2 (en) * | 2003-07-03 | 2008-07-01 | Lipid Sciences, Inc. | Methods and apparatus for creating particle derivatives of HDL with reduced lipid content |
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| AU2007325576B2 (en) * | 2006-10-20 | 2013-01-10 | Icos Corporation | Compositions of Chk1 inhibitors |
| EP1920785A1 (en) | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
| WO2010042202A1 (en) | 2008-10-07 | 2010-04-15 | Fibrogen, Inc. | Methods for treatment of podocyte injury |
| US20100189653A1 (en) * | 2008-10-10 | 2010-07-29 | Wendye Robbins | Pyrone analogs for therapeutic treatment |
| US8202702B2 (en) | 2008-10-14 | 2012-06-19 | Seahorse Bioscience | Method and device for measuring extracellular acidification and oxygen consumption rate with higher precision |
| US8263413B1 (en) | 2008-10-17 | 2012-09-11 | Andrew S Hansen | Methods for analyzing lipids and membrane proteins in biological matter using stable isotopes and mass spectrometry |
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| US8975241B2 (en) * | 2009-10-08 | 2015-03-10 | Song Ho Biomed Co., Ltd. | Composition for treating and preventing obesity including high water-soluble 2-hydroxypropyl-betacyclodextrin as effective component |
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