BR112023003490A2 - Métodos para prevenção de embolização de cristais de colesterol com ciclodextrinas - Google Patents
Métodos para prevenção de embolização de cristais de colesterol com ciclodextrinasInfo
- Publication number
- BR112023003490A2 BR112023003490A2 BR112023003490A BR112023003490A BR112023003490A2 BR 112023003490 A2 BR112023003490 A2 BR 112023003490A2 BR 112023003490 A BR112023003490 A BR 112023003490A BR 112023003490 A BR112023003490 A BR 112023003490A BR 112023003490 A2 BR112023003490 A2 BR 112023003490A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- embolization
- cholesterol crystals
- cyclodextrins
- prevention
- Prior art date
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 10
- 235000012000 cholesterol Nutrition 0.000 title abstract 5
- 239000013078 crystal Substances 0.000 title abstract 5
- 230000010102 embolization Effects 0.000 title abstract 3
- 229920000858 Cyclodextrin Polymers 0.000 title abstract 2
- 229940097362 cyclodextrins Drugs 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 210000002381 plasma Anatomy 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
MÉTODOS PARA PREVENÇÃO DE EMBOLIZAÇÃO DE CRISTAIS DE COLESTEROL COM CICLODEXTRINAS. Trata-se de métodos para prevenir ou reduzir o risco de desenvolver e/ou prevenir ou reduzir o risco de um aumento em uma quantidade e/ou um tamanho, e/ou mudar o formato, de cristais de colesterol circulante (por exemplo, sangue, soro, plasma) (e/ou coágulos que compreendem cristais de colesterol) em um indivíduo. Além disso, são divulgados no presente documento métodos para prevenir ou reduzir o risco de embolização de cristais de colesterol (CCE) e/ou um sintoma dessa doença em um indivíduo. Os métodos envolvem geralmente administrar uma quantidade terapeuticamente eficaz de 2-hidroxipropipropil-beta-ciclodextrina ao indivíduo. No presente documento, também são fornecidas composições farmacêuticas que compreendem uma quantidade terapeuticamente eficaz de 2-hidroxipropipropil-beta-ciclodextrina e um excipiente farmaceuticamente aceitável.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063071243P | 2020-08-27 | 2020-08-27 | |
PCT/US2021/048075 WO2022047244A1 (en) | 2020-08-27 | 2021-08-27 | Methods for the prevention of cholesterol crystal embolization with cyclodextrins |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023003490A2 true BR112023003490A2 (pt) | 2023-05-09 |
Family
ID=80352440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023003490A BR112023003490A2 (pt) | 2020-08-27 | 2021-08-27 | Métodos para prevenção de embolização de cristais de colesterol com ciclodextrinas |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230302042A1 (pt) |
EP (1) | EP4203973A1 (pt) |
JP (1) | JP2023543132A (pt) |
KR (1) | KR20230096976A (pt) |
CN (1) | CN116635007A (pt) |
AU (1) | AU2021331485A1 (pt) |
BR (1) | BR112023003490A2 (pt) |
CA (1) | CA3190764A1 (pt) |
IL (1) | IL300881A (pt) |
MX (1) | MX2023002420A (pt) |
WO (1) | WO2022047244A1 (pt) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4877778A (en) * | 1987-07-01 | 1989-10-31 | The Children's Medical Center Corporation | Method of enhancing lipophile transport using cyclodextrin derivatives |
MX371073B (es) * | 2012-04-13 | 2020-01-15 | L&F Res Llc | Método para utilizar ciclodextrina. |
-
2021
- 2021-08-27 US US18/043,009 patent/US20230302042A1/en active Pending
- 2021-08-27 JP JP2023513678A patent/JP2023543132A/ja active Pending
- 2021-08-27 BR BR112023003490A patent/BR112023003490A2/pt unknown
- 2021-08-27 EP EP21862878.2A patent/EP4203973A1/en active Pending
- 2021-08-27 WO PCT/US2021/048075 patent/WO2022047244A1/en active Application Filing
- 2021-08-27 AU AU2021331485A patent/AU2021331485A1/en active Pending
- 2021-08-27 KR KR1020237010391A patent/KR20230096976A/ko unknown
- 2021-08-27 MX MX2023002420A patent/MX2023002420A/es unknown
- 2021-08-27 CN CN202180066571.3A patent/CN116635007A/zh active Pending
- 2021-08-27 IL IL300881A patent/IL300881A/en unknown
- 2021-08-27 CA CA3190764A patent/CA3190764A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
IL300881A (en) | 2023-04-01 |
AU2021331485A1 (en) | 2023-03-23 |
WO2022047244A1 (en) | 2022-03-03 |
CN116635007A (zh) | 2023-08-22 |
JP2023543132A (ja) | 2023-10-13 |
US20230302042A1 (en) | 2023-09-28 |
MX2023002420A (es) | 2023-07-11 |
EP4203973A1 (en) | 2023-07-05 |
CA3190764A1 (en) | 2022-03-03 |
KR20230096976A (ko) | 2023-06-30 |
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