CA2862171C - Dispositifs, appareil, trousse et procede pour traiter un echantillon biologique - Google Patents
Dispositifs, appareil, trousse et procede pour traiter un echantillon biologique Download PDFInfo
- Publication number
- CA2862171C CA2862171C CA2862171A CA2862171A CA2862171C CA 2862171 C CA2862171 C CA 2862171C CA 2862171 A CA2862171 A CA 2862171A CA 2862171 A CA2862171 A CA 2862171A CA 2862171 C CA2862171 C CA 2862171C
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- CA
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- Prior art keywords
- filter
- hollow device
- inner chamber
- hollow
- cavity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 title claims abstract description 33
- 239000012472 biological sample Substances 0.000 title claims abstract description 6
- 239000000523 sample Substances 0.000 claims abstract description 41
- 239000011148 porous material Substances 0.000 claims abstract description 33
- 239000007788 liquid Substances 0.000 claims abstract description 24
- 239000002245 particle Substances 0.000 claims description 28
- 239000000463 material Substances 0.000 claims description 23
- 230000008878 coupling Effects 0.000 claims description 8
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- 238000003780 insertion Methods 0.000 claims description 7
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- 230000003321 amplification Effects 0.000 claims description 6
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- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 150000007523 nucleic acids Chemical class 0.000 claims description 3
- 239000011344 liquid material Substances 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 229920003023 plastic Polymers 0.000 claims description 2
- 244000043261 Hevea brasiliensis Species 0.000 claims 1
- 239000013013 elastic material Substances 0.000 claims 1
- 229920003052 natural elastomer Polymers 0.000 claims 1
- 229920001194 natural rubber Polymers 0.000 claims 1
- 229920001059 synthetic polymer Polymers 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 14
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- 210000004027 cell Anatomy 0.000 description 13
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- 108020004414 DNA Proteins 0.000 description 7
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- 229920006393 polyether sulfone Polymers 0.000 description 6
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- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
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- 229920000573 polyethylene Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 2
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5021—Test tubes specially adapted for centrifugation purposes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/042—Caps; Plugs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
- G01N2001/4088—Concentrating samples by other techniques involving separation of suspended solids filtration
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Sampling And Sample Adjustment (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La présente invention concerne une procédé permettant le traitement d'un échantillon biologique (B) comportant au moins une cellule (C) et un composant liquide (D); selon le procédé, une force est appliquée à l'échantillon (B) introduit dans une chambre intérieure (3) d'un dispositif creux (2) en direction d'un filtre (9) qui comporte des pores ayant des diamètres compris entre 2 nm et 1 um, de sorte qu'au moins une partie du composant liquide (D) passe à travers le filtre (9) et que la cellule (C) reste dans la chambre intérieure (3), permettant ainsi l'obtention d'un échantillon concentré (A); le filtre présente une surface inférieure à 12,6 mm2située en face de la chambre intérieure (3).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000766A ITBO20110766A1 (it) | 2011-12-28 | 2011-12-28 | Dispositivi, apparato, kit e metodo per il trattamento di un campione biologico |
ITBO2011A000766 | 2011-12-28 | ||
PCT/IB2012/057797 WO2013098792A1 (fr) | 2011-12-28 | 2012-12-28 | Dispositifs, appareil, trousse et procédé pour traiter un échantillon biologique |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2862171A1 CA2862171A1 (fr) | 2013-07-04 |
CA2862171C true CA2862171C (fr) | 2020-11-10 |
Family
ID=45922746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2862171A Active CA2862171C (fr) | 2011-12-28 | 2012-12-28 | Dispositifs, appareil, trousse et procede pour traiter un echantillon biologique |
Country Status (11)
Country | Link |
---|---|
US (1) | US10376878B2 (fr) |
EP (1) | EP2797696B1 (fr) |
JP (1) | JP6301264B2 (fr) |
KR (2) | KR102184522B1 (fr) |
CN (1) | CN104136126B (fr) |
CA (1) | CA2862171C (fr) |
ES (1) | ES2926499T3 (fr) |
IT (1) | ITBO20110766A1 (fr) |
PL (1) | PL2797696T3 (fr) |
SG (2) | SG11201403675UA (fr) |
WO (1) | WO2013098792A1 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITTO20070771A1 (it) | 2007-10-29 | 2009-04-30 | Silicon Biosystems Spa | Metodo e apparato per la identificazione e manipolazione di particelle |
IT1391619B1 (it) | 2008-11-04 | 2012-01-11 | Silicon Biosystems Spa | Metodo per l'individuazione, selezione e analisi di cellule tumorali |
US10895575B2 (en) | 2008-11-04 | 2021-01-19 | Menarini Silicon Biosystems S.P.A. | Method for identification, selection and analysis of tumour cells |
AU2013202805B2 (en) * | 2013-03-14 | 2015-07-16 | Gen-Probe Incorporated | System and method for extending the capabilities of a diagnostic analyzer |
CN105985903A (zh) * | 2015-02-12 | 2016-10-05 | 谭巍 | 细胞收集装置及其应用 |
SG11201707461YA (en) * | 2015-03-17 | 2017-10-30 | Mbs Co Ltd | Sample collection and separation device |
CN105935607A (zh) * | 2016-06-28 | 2016-09-14 | 江阴市正中科教器材有限公司 | 一种定量加注试管 |
EP3480577A4 (fr) * | 2016-06-30 | 2020-07-29 | Shimadzu Corporation | Ensemble de récipients et procédé de préparation d'échantillon l'utilisant |
WO2020049569A2 (fr) | 2018-09-05 | 2020-03-12 | Hero Scientific Ltd. | Détection de particules |
GB201703383D0 (en) | 2017-03-02 | 2017-04-19 | Gargle Tech Ltd | Testing for particulates |
US10137447B1 (en) | 2017-05-17 | 2018-11-27 | Biotix, Inc. | Ergonomic fluid handling tubes |
IT201700105911A1 (it) * | 2017-09-21 | 2019-03-21 | Menarini Silicon Biosystems Spa | Metodo ed apparato per la riduzione del volume di un campione |
USD882113S1 (en) * | 2017-11-30 | 2020-04-21 | Biotix, Inc. | Fluid handling tube |
USD881410S1 (en) * | 2018-01-19 | 2020-04-14 | Biotix, Inc. | Fluid handling tube |
CN108871908B9 (zh) * | 2018-09-06 | 2024-07-26 | 杭州优思达生物技术股份有限公司 | 生物样本处理装置 |
USD954296S1 (en) * | 2020-10-21 | 2022-06-07 | Michael Thomas Hendrikx | Laboratory utensil |
WO2022149135A2 (fr) | 2021-01-06 | 2022-07-14 | Hero Scientific Ltd. | Dispositifs d'échantillonnage à filtration |
USD1014780S1 (en) | 2022-04-15 | 2024-02-13 | Instrumentation Laboratory Co. | Cuvette |
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2011
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- 2012-12-28 WO PCT/IB2012/057797 patent/WO2013098792A1/fr active Application Filing
- 2012-12-28 JP JP2014549623A patent/JP6301264B2/ja active Active
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- 2012-12-28 KR KR1020207004696A patent/KR102184522B1/ko active IP Right Grant
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- 2012-12-28 ES ES12826572T patent/ES2926499T3/es active Active
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- 2012-12-28 KR KR1020147020961A patent/KR20140125367A/ko active Application Filing
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Also Published As
Publication number | Publication date |
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CN104136126B (zh) | 2016-12-28 |
US20150031040A1 (en) | 2015-01-29 |
WO2013098792A1 (fr) | 2013-07-04 |
EP2797696A1 (fr) | 2014-11-05 |
CA2862171A1 (fr) | 2013-07-04 |
JP2015509703A (ja) | 2015-04-02 |
KR102184522B1 (ko) | 2020-12-01 |
SG11201403675UA (en) | 2014-10-30 |
ES2926499T3 (es) | 2022-10-26 |
KR20200020983A (ko) | 2020-02-26 |
JP6301264B2 (ja) | 2018-03-28 |
CN104136126A (zh) | 2014-11-05 |
PL2797696T3 (pl) | 2022-11-07 |
KR20140125367A (ko) | 2014-10-28 |
ITBO20110766A1 (it) | 2013-06-29 |
EP2797696B1 (fr) | 2022-06-22 |
US10376878B2 (en) | 2019-08-13 |
SG10201911824TA (en) | 2020-02-27 |
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