CA2861722C - Method and device for fast dissolution of solid protein composition - Google Patents

Method and device for fast dissolution of solid protein composition Download PDF

Info

Publication number
CA2861722C
CA2861722C CA2861722A CA2861722A CA2861722C CA 2861722 C CA2861722 C CA 2861722C CA 2861722 A CA2861722 A CA 2861722A CA 2861722 A CA2861722 A CA 2861722A CA 2861722 C CA2861722 C CA 2861722C
Authority
CA
Canada
Prior art keywords
fibrinogen
solid
syringe
container
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2861722A
Other languages
English (en)
French (fr)
Other versions
CA2861722A1 (en
Inventor
Erez Ilan
Kfir Regev
Dana LEITMAN
Israel Nur
Moti Meron
John Goodman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omrix Biopharmaceuticals Ltd
Original Assignee
Omrix Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL217273A external-priority patent/IL217273A0/en
Application filed by Omrix Biopharmaceuticals Ltd filed Critical Omrix Biopharmaceuticals Ltd
Priority to CA3078563A priority Critical patent/CA3078563A1/en
Publication of CA2861722A1 publication Critical patent/CA2861722A1/en
Application granted granted Critical
Publication of CA2861722C publication Critical patent/CA2861722C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
    • B01F25/4512—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture with reciprocating pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/25—Mixers with loose mixing elements, e.g. loose balls in a receptacle
    • B01F33/251—Mixers with loose mixing elements, e.g. loose balls in a receptacle using balls as loose mixing element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B01F33/50112—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held of the syringe or cartridge type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7163—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected in a mouth-to-mouth, end-to-end disposition, i.e. the openings are juxtaposed before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/718—Feed mechanisms characterised by the means for feeding the components to the mixer using vacuum, under pressure in a closed receptacle or circuit system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA2861722A 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition Expired - Fee Related CA2861722C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3078563A CA3078563A1 (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
IL217273A IL217273A0 (en) 2011-12-29 2011-12-29 Fast dissolution of solid fibrinogen
IL217273 2011-12-29
US201261582524P 2012-01-03 2012-01-03
US61/582,524 2012-01-03
US201261677048P 2012-07-30 2012-07-30
IL221180 2012-07-30
US61/677,048 2012-07-30
IL22118012 2012-07-30
PCT/IL2012/000393 WO2013098805A1 (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3078563A Division CA3078563A1 (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition

Publications (2)

Publication Number Publication Date
CA2861722A1 CA2861722A1 (en) 2013-07-04
CA2861722C true CA2861722C (en) 2020-06-30

Family

ID=48696437

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3078563A Abandoned CA3078563A1 (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition
CA2861722A Expired - Fee Related CA2861722C (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA3078563A Abandoned CA3078563A1 (en) 2011-12-29 2012-12-20 Method and device for fast dissolution of solid protein composition

Country Status (13)

Country Link
US (2) US10618950B2 (Sortimente)
EP (1) EP2797681B1 (Sortimente)
JP (1) JP6223999B2 (Sortimente)
KR (1) KR102109317B1 (Sortimente)
AU (1) AU2012360048B2 (Sortimente)
BR (1) BR112014016193A8 (Sortimente)
CA (2) CA3078563A1 (Sortimente)
ES (1) ES2621363T3 (Sortimente)
IL (1) IL233361B (Sortimente)
IN (1) IN2014DN05901A (Sortimente)
MX (1) MX351980B (Sortimente)
RU (1) RU2605710C2 (Sortimente)
WO (1) WO2013098805A1 (Sortimente)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102109317B1 (ko) 2011-12-29 2020-05-29 옴릭스 바이오파머슈티컬스 리미티드 고체 단백질 조성물의 신속한 용해를 위한 방법 및 장치
KR102325240B1 (ko) 2014-01-20 2021-11-11 유씨비 바이오파마 에스알엘 고체 형태의 약학 조성물의 재형성 방법
US20170274012A1 (en) * 2014-09-03 2017-09-28 Entegrion, Inc. Acceleration of Reconstitution of Plasma Powder by Mixing with Small Beads
US11229702B1 (en) 2015-10-28 2022-01-25 Coherus Biosciences, Inc. High concentration formulations of adalimumab
US10918790B2 (en) * 2015-12-22 2021-02-16 Guangzhou Bioseal Biotech Co., Ltd. Dual syringe with funnel feeding kit
USD877890S1 (en) 2015-12-22 2020-03-10 Guangzhou Bioseal Biotech Co., Ltd. Reconstitution device
USD829888S1 (en) * 2015-12-22 2018-10-02 Guangzhou Bioseal Biotech Co., Ltd. Reconstitution and delivery device
USD877891S1 (en) 2015-12-22 2020-03-10 Guangzhou Bioseal Biotech Co., Ltd. Reconstitution and delivery device
IL244922A0 (en) * 2016-04-05 2016-07-31 Omrix Biopharmaceuticals Ltd Device and method for sample preparation
WO2017184880A1 (en) 2016-04-20 2017-10-26 Coherus Biosciences, Inc. A method of filling a container with no headspace
US10150115B2 (en) * 2016-07-21 2018-12-11 Spacepharma SA System and method for rehydrating powder and delivering the rehydrated powder to a reactor
WO2018150375A1 (en) * 2017-02-17 2018-08-23 Baxter International Inc. Devices and methods for forming and delivering a tissue sealant
AU2018204933B2 (en) 2017-07-06 2024-08-22 Plas-Tech Engineering, Inc. Systems and methods related to fluid pumping
WO2023119277A1 (en) 2021-12-21 2023-06-29 Omrix Biopharmaceuticals Ltd. Highly soluble fibrinogen compositions

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3052240A (en) * 1959-01-29 1962-09-04 Silver Disposable hypodermic syringe
US3405712A (en) * 1966-02-07 1968-10-15 Richard L. Pierick Desiccative syringe
AT366916B (de) * 1980-04-02 1982-05-25 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen
AT371719B (de) 1980-08-25 1983-07-25 Immuno Ag Verfahren und vorrichtung zur beschleunigung des aufloesens von schwerloeslichen lyophilisierten arzneimitteln
DE3203775A1 (de) 1982-02-04 1983-08-11 Behringwerke Ag, 3550 Marburg Fibrinogenzubereitung, verfahen zu ihrer herstellungund ihre verwendung
US4610666A (en) * 1985-06-24 1986-09-09 Pizzino Joanne L Dual syringe
US4742128A (en) * 1985-10-15 1988-05-03 Stamicarbon B.V. Process for preparing a polymer alloy, molded product, and reaction injection molded products
US4978336A (en) * 1987-09-29 1990-12-18 Hemaedics, Inc. Biological syringe system
AT397203B (de) 1988-05-31 1994-02-25 Immuno Ag Gewebeklebstoff
AT392972B (de) 1988-08-16 1991-07-25 Chemiefaser Lenzing Ag Verfahren zur herstellung von loesungen von cellulose sowie einrichtung zur durchfuehrung des verfahrens
SU1697836A1 (ru) 1989-01-24 1991-12-15 Московский научно-исследовательский онкологический институт им.П.А.Герцена Устройство дл смешивани и введени жидких быстроструктурирующихс компонентов
US5122117A (en) * 1990-06-05 1992-06-16 Habley Medical Technology Corp. Component mixing syringe
US5181909A (en) * 1991-05-15 1993-01-26 Mcfarlane Richard H Ampule-container medical syringe and methods
US5792835A (en) * 1991-09-05 1998-08-11 Baxter International Inc. Method of preparing a topical fibrinogen complex
EP0534178B1 (en) 1991-09-27 2001-04-18 Omrix Biopharmaceuticals S.A. Improved tissue glue prepared by using cryoprecipitate
JP3063935B2 (ja) 1992-05-12 2000-07-12 宇部興産株式会社 接着性、耐熱性および耐カ−ル性を兼ね備えたポリイミドシロキサン組成物
US5599790A (en) * 1992-06-11 1997-02-04 The Scripps Research Institute Fibrinogen γ chain polypeptide and compositions thereof
US5330974A (en) * 1993-03-01 1994-07-19 Fibratek, Inc. Therapeutic fibrinogen compositions
AT400675B (de) * 1993-10-18 1996-02-26 Immuno Ag Spritzengarnitur zur aufbewahrung und applikation eines mehrkomponentenmaterials, spritzenvorrichtung und betätigungseinrichtung hiefür sowie verfahren zum herstellen einer befüllten, sterilen spritzenvorrichtung
US6965014B1 (en) * 1996-01-16 2005-11-15 Baxter International Inc. Fibrin material and method for producing and using the same
US6599515B1 (en) * 1995-01-16 2003-07-29 Baxter International Inc. Fibrin porous structure
WO1997033633A1 (en) 1996-03-15 1997-09-18 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Tissue adhesive applied with spray
DE19617369A1 (de) 1996-04-30 1997-11-06 Immuno Ag Lagerstabile Fibrinogen-Präparate
FR2749169B1 (fr) 1996-06-04 1998-08-21 Delab Procede pour constituer une preparation injectable et dispositif pour la mise en oeuvre de ce procede
JP3420892B2 (ja) * 1996-07-25 2003-06-30 高橋 宏嘉 指圧代用刺激具及びその製造方法
JP3063935U (ja) 1999-05-17 1999-12-10 川澄化学工業株式会社 二液同時混合注出器及びプランジャ結合部材
WO2002018546A2 (en) * 2000-09-01 2002-03-07 Virginia Commonwealth University Intellectual Property Foundation Plasma-derived-fibrin-based matrices and tissue
IL158754A0 (en) 2001-05-21 2004-05-12 Omrix Biopharm Sa Removal of plasmin(ogen) from protein solutions
DE10211227A1 (de) 2002-03-13 2003-10-02 Aventis Behring Gmbh Verfahren zur Rekonstitution von Iyophilisierten Proteinen
ATE345277T1 (de) * 2002-08-21 2006-12-15 Pharmacia Corp Injizierbare pharmazeutische suspension in einer phiole mit zwei kammern
DE20216631U1 (de) 2002-10-28 2004-03-11 Haindl, Hans, Dr.med. Selbstentlüftende Spritze für das Mischen von flüssigen und pulverförmigen Substanzen
WO2004067704A2 (en) * 2003-01-30 2004-08-12 Prochon Biotech Ltd. Freeze-dried fibrin matrices and methods for preparation thereof
US6669667B1 (en) * 2003-04-11 2003-12-30 Jih-Hsiung Yang Safety syringe
HRP20140442T1 (hr) * 2003-06-23 2014-07-04 Kiacta Sàrl Metoda za pripremu spoja 1,3-propan disulfonske kiseline
DE102005017985A1 (de) * 2005-04-19 2006-10-26 Theo Arnitz Verfahren und Vorrichtungen zum Auflösen von Medikamenten für Injektionen
EP1888145A1 (en) * 2005-05-16 2008-02-20 Mallinckrodt Inc. Multi-barrel syringe having integral manifold
RU2429056C2 (ru) * 2006-01-17 2011-09-20 Бакстер Интернэшнл Инк. Устройство, система и способ смешивания
DE102006009611A1 (de) 2006-03-02 2007-09-06 Bernd Hansen System zum Zubereiten und Bereitstellen eines durch Vermischen einer Trockensubstanz mit einem Fluid gebildeten fließfähigen Mediums
CA2667969C (en) * 2006-11-02 2014-10-14 Omrix Biopharmaceuticals Ltd. Method of micronization
US20080221584A1 (en) * 2007-03-06 2008-09-11 Downer David A Lens Delivery System
JP5393447B2 (ja) 2007-03-22 2014-01-22 一般財団法人化学及血清療法研究所 固体状フィブリノゲン製剤
DE102008003103A1 (de) 2008-01-01 2009-07-02 Lts Lohmann Therapie-Systeme Ag Einweginjektor mit zweikolbigem Zweikammersystem
US20090198211A1 (en) * 2008-02-06 2009-08-06 Intravena, Llc Convenience IV kits and methods of use
US8512740B2 (en) * 2008-03-26 2013-08-20 Baxter International Inc. Fibrin foam and process for making
JP5264545B2 (ja) 2008-06-16 2013-08-14 テルモ株式会社 液体混合方法
JP5318684B2 (ja) 2009-07-14 2013-10-16 テルモ株式会社 シリンジおよびシリンジ連結体
WO2011031783A1 (en) * 2009-09-08 2011-03-17 Baxter International Inc. Reconstitution and applicator system for wound sealant product
KR102109317B1 (ko) 2011-12-29 2020-05-29 옴릭스 바이오파머슈티컬스 리미티드 고체 단백질 조성물의 신속한 용해를 위한 방법 및 장치

Also Published As

Publication number Publication date
KR102109317B1 (ko) 2020-05-29
MX351980B (es) 2017-11-03
JP6223999B2 (ja) 2017-11-01
AU2012360048A1 (en) 2014-08-14
IN2014DN05901A (Sortimente) 2015-06-05
JP2015509084A (ja) 2015-03-26
IL233361B (en) 2018-06-28
US10618950B2 (en) 2020-04-14
CA2861722A1 (en) 2013-07-04
BR112014016193A8 (pt) 2017-07-04
US20130312868A1 (en) 2013-11-28
EP2797681B1 (en) 2017-02-01
ES2621363T3 (es) 2017-07-03
IL233361A0 (en) 2014-08-31
US20200262892A1 (en) 2020-08-20
RU2605710C2 (ru) 2016-12-27
MX2014008033A (es) 2014-12-08
WO2013098805A1 (en) 2013-07-04
AU2012360048B2 (en) 2017-05-25
RU2014131276A (ru) 2016-02-20
CA3078563A1 (en) 2013-07-04
KR20140108709A (ko) 2014-09-12
CN104144742A (zh) 2014-11-12
EP2797681A1 (en) 2014-11-05
HK1203438A1 (en) 2015-10-30
BR112014016193A2 (pt) 2017-06-13
US11634473B2 (en) 2023-04-25

Similar Documents

Publication Publication Date Title
US11634473B2 (en) Method and device for fast dissolution of solid protein composition
KR101288174B1 (ko) 용기 폐쇄 전달 시스템
CA2118034C (en) Injection cartridge arrangement
AU2002240070B2 (en) Reconstitution device and method of use
CN104582761B (zh) 具有旁路的多隔室预填充混合注射器
CN1378466A (zh) 重新配制医疗用溶液、悬浮液或分散液的装置
JP2014195704A (ja) 凍結乾燥薬剤から薬液を形成するための移送システム
AU2002240070A1 (en) Reconstitution device and method of use
WO2012115619A1 (en) Loading system for an encapsulation device
US8871526B1 (en) Apparatus for obtaining growth factors
JP2018515178A (ja) 点眼薬用投与器具
JP4960259B2 (ja) 密閉容器送出システム
KR20080039882A (ko) 2상 화합물, 특히 2성분의 아크릴 수지를 무균 상태에서혼합하는 카트리지
HK1203438B (en) Method and device for fast dissolution of solid protein composition
CN104144742B (zh) 用于固体蛋白质组合物的快速溶解的方法和装置
WO2015011504A1 (en) Novel reconstitution assembly
JP7557928B2 (ja) 薬物混合注射システム用アダプタ

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20171218

MKLA Lapsed

Effective date: 20201221