CA2859569C - Tooth whitening strip providing perhydrolase-catalyzed peracid formation - Google Patents

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Publication number

CA2859569C

CA2859569C CA2859569A CA2859569A CA2859569C CA 2859569 C CA2859569 C CA 2859569C CA 2859569 A CA2859569 A CA 2859569A CA 2859569 A CA2859569 A CA 2859569A CA 2859569 C CA2859569 C CA 2859569C

Authority

CA

Canada

Prior art keywords

gly

pro

ala

leu

glu

Prior art date

2011-12-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 230000002087 whitening effect Effects 0.000 title claims abstract description 107
• 150000004965 peroxy acids Chemical class 0.000 title claims abstract description 33
• 230000015572 biosynthetic process Effects 0.000 title description 7
• 102000004190 Enzymes Human genes 0.000 claims abstract description 108
• 108090000790 Enzymes Proteins 0.000 claims abstract description 108
• 239000004615 ingredient Substances 0.000 claims abstract description 73
• 239000002313 adhesive film Substances 0.000 claims abstract description 63
• 238000004061 bleaching Methods 0.000 claims abstract description 59
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 58
• 239000000758 substrate Substances 0.000 claims abstract description 36
• 125000002252 acyl group Chemical group 0.000 claims abstract description 23
• 230000036571 hydration Effects 0.000 claims abstract description 16
• 238000006703 hydration reaction Methods 0.000 claims abstract description 16
• 239000007844 bleaching agent Substances 0.000 claims abstract description 12
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 72
• URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical group CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims description 43
• 210000000214 mouth Anatomy 0.000 claims description 33
• 239000008187 granular material Substances 0.000 claims description 30
• 229920002125 Sokalan® Polymers 0.000 claims description 28
• 235000013773 glyceryl triacetate Nutrition 0.000 claims description 25
• 239000002245 particle Substances 0.000 claims description 25
• 150000002978 peroxides Chemical class 0.000 claims description 25
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
• -1 peroxide salts Chemical class 0.000 claims description 24
• 229920000642 polymer Polymers 0.000 claims description 22
• 229920002689 polyvinyl acetate Polymers 0.000 claims description 21
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 19
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 17
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 17
• 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 16
• AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims description 16
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 15
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 15
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 15
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 15
• 229910052739 hydrogen Inorganic materials 0.000 claims description 13
• 239000001257 hydrogen Substances 0.000 claims description 13
• 108010010803 Gelatin Proteins 0.000 claims description 11
• 229920000159 gelatin Polymers 0.000 claims description 11
• 239000008273 gelatin Substances 0.000 claims description 11
• 235000019322 gelatine Nutrition 0.000 claims description 11
• 235000011852 gelatine desserts Nutrition 0.000 claims description 11
• 229920001282 polysaccharide Polymers 0.000 claims description 11
• 239000005017 polysaccharide Substances 0.000 claims description 11
• 239000007787 solid Substances 0.000 claims description 11
• 239000004373 Pullulan Substances 0.000 claims description 10
• 229920001218 Pullulan Polymers 0.000 claims description 10
• 229920003086 cellulose ether Polymers 0.000 claims description 10
• 235000019423 pullulan Nutrition 0.000 claims description 10
• 229920003169 water-soluble polymer Polymers 0.000 claims description 9
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 8
• 238000004806 packaging method and process Methods 0.000 claims description 8
• 229920002451 polyvinyl alcohol Polymers 0.000 claims description 8
• 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 8
• 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 7
• 239000011248 coating agent Substances 0.000 claims description 7
• 238000000576 coating method Methods 0.000 claims description 7
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 7
• 235000013772 propylene glycol Nutrition 0.000 claims description 7
• 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 6
• 229920000881 Modified starch Polymers 0.000 claims description 6
• 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 6
• 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 6
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 5
• 241000251468 Actinopterygii Species 0.000 claims description 5
• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 5
• 241001465754 Metazoa Species 0.000 claims description 5
• 229940072056 alginate Drugs 0.000 claims description 5
• 229920000615 alginic acid Polymers 0.000 claims description 5
• 235000010443 alginic acid Nutrition 0.000 claims description 5
• 239000001768 carboxy methyl cellulose Substances 0.000 claims description 5
• 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 5
• 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 5
• 239000005018 casein Substances 0.000 claims description 5
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 5
• 235000021240 caseins Nutrition 0.000 claims description 5
• 229920001577 copolymer Polymers 0.000 claims description 5
• 238000004090 dissolution Methods 0.000 claims description 5
• MPNNOLHYOHFJKL-UHFFFAOYSA-K peroxyphosphate Chemical compound [O-]OP([O-])([O-])=O MPNNOLHYOHFJKL-UHFFFAOYSA-K 0.000 claims description 5
• 229920000058 polyacrylate Polymers 0.000 claims description 5
• 229920001285 xanthan gum Polymers 0.000 claims description 5
• 239000000230 xanthan gum Substances 0.000 claims description 5
• 235000010493 xanthan gum Nutrition 0.000 claims description 5
• 229940082509 xanthan gum Drugs 0.000 claims description 5
• 239000004343 Calcium peroxide Substances 0.000 claims description 4
• LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 claims description 4
• 235000019402 calcium peroxide Nutrition 0.000 claims description 4
• DLINORNFHVEIFE-UHFFFAOYSA-N hydrogen peroxide;zinc Chemical compound [Zn].OO DLINORNFHVEIFE-UHFFFAOYSA-N 0.000 claims description 4
• WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical class Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 claims description 4
• 150000004972 metal peroxides Chemical class 0.000 claims description 4
• MMCOUVMKNAHQOY-UHFFFAOYSA-L oxido carbonate Chemical compound [O-]OC([O-])=O MMCOUVMKNAHQOY-UHFFFAOYSA-L 0.000 claims description 4
• JRKICGRDRMAZLK-UHFFFAOYSA-L persulfate group Chemical class S(=O)(=O)([O-])OOS(=O)(=O)[O-] JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 claims description 4
• 239000004014 plasticizer Substances 0.000 claims description 4
• USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 claims description 4
• 229960001922 sodium perborate Drugs 0.000 claims description 4
• YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 claims description 4
• MSLRPWGRFCKNIZ-UHFFFAOYSA-J tetrasodium;hydrogen peroxide;dicarbonate Chemical compound [Na+].[Na+].[Na+].[Na+].OO.OO.OO.[O-]C([O-])=O.[O-]C([O-])=O MSLRPWGRFCKNIZ-UHFFFAOYSA-J 0.000 claims description 4
• SYMVZGYNJDKIPL-UHFFFAOYSA-H tricalcium;oxido phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]OP([O-])([O-])=O.[O-]OP([O-])([O-])=O SYMVZGYNJDKIPL-UHFFFAOYSA-H 0.000 claims description 4
• VBIJGJLWKWLWHQ-UHFFFAOYSA-K trisodium;oxido phosphate Chemical compound [Na+].[Na+].[Na+].[O-]OP([O-])([O-])=O VBIJGJLWKWLWHQ-UHFFFAOYSA-K 0.000 claims description 4
• 229940105296 zinc peroxide Drugs 0.000 claims description 4
• VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 claims description 3
• 230000002401 inhibitory effect Effects 0.000 claims description 3
• 229940045872 sodium percarbonate Drugs 0.000 claims description 3
• 150000004676 glycans Chemical class 0.000 claims 1
• 238000000034 method Methods 0.000 abstract description 48
• 230000000694 effects Effects 0.000 abstract description 44
• 239000003054 catalyst Substances 0.000 abstract description 18
• 108090000765 processed proteins & peptides Proteins 0.000 description 93
• XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Chemical compound NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 description 77
• XBGGUPMXALFZOT-UHFFFAOYSA-N glycyl-L-tyrosine hemihydrate Natural products NCC(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 XBGGUPMXALFZOT-UHFFFAOYSA-N 0.000 description 45
• KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 42
• 239000000203 mixture Substances 0.000 description 41
• KOSRFJWDECSPRO-UHFFFAOYSA-N alpha-L-glutamyl-L-glutamic acid Natural products OC(=O)CCC(N)C(=O)NC(CCC(O)=O)C(O)=O KOSRFJWDECSPRO-UHFFFAOYSA-N 0.000 description 39
• 108010060035 arginylproline Proteins 0.000 description 35
• 108010055341 glutamyl-glutamic acid Proteins 0.000 description 33
• 108010064235 lysylglycine Proteins 0.000 description 33
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 32
• 108010080434 cephalosporin-C deacetylase Proteins 0.000 description 32
• JBCLFWXMTIKCCB-UHFFFAOYSA-N H-Gly-Phe-OH Natural products NCC(=O)NC(C(O)=O)CC1=CC=CC=C1 JBCLFWXMTIKCCB-UHFFFAOYSA-N 0.000 description 31
• KZNQNBZMBZJQJO-UHFFFAOYSA-N N-glycyl-L-proline Natural products NCC(=O)N1CCCC1C(O)=O KZNQNBZMBZJQJO-UHFFFAOYSA-N 0.000 description 30
• 238000006243 chemical reaction Methods 0.000 description 30
• 108010093581 aspartyl-proline Proteins 0.000 description 29
• 150000001720 carbohydrates Chemical class 0.000 description 26
• 108010067216 glycyl-glycyl-glycine Proteins 0.000 description 26
• 108010081551 glycylphenylalanine Proteins 0.000 description 25
• 235000001014 amino acid Nutrition 0.000 description 24
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 24
• 229940024606 amino acid Drugs 0.000 description 23
• 150000001413 amino acids Chemical class 0.000 description 23
• 108010087823 glycyltyrosine Proteins 0.000 description 23
• SOEGEPHNZOISMT-BYPYZUCNSA-N Gly-Ser-Gly Chemical compound NCC(=O)N[C@@H](CO)C(=O)NCC(O)=O SOEGEPHNZOISMT-BYPYZUCNSA-N 0.000 description 22
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 21
• 108010093941 acetylxylan esterase Proteins 0.000 description 21
• 239000010410 layer Substances 0.000 description 21
• 150000007523 nucleic acids Chemical group 0.000 description 21
• 108010003137 tyrosyltyrosine Proteins 0.000 description 21
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 20
• 108020004707 nucleic acids Proteins 0.000 description 20
• 102000039446 nucleic acids Human genes 0.000 description 20
• SOBIAADAMRHGKH-CIUDSAMLSA-N Ala-Leu-Ser Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O SOBIAADAMRHGKH-CIUDSAMLSA-N 0.000 description 19
• MMEDVBWCMGRKKC-GARJFASQSA-N Leu-Asp-Pro Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@@H]1C(=O)O)N MMEDVBWCMGRKKC-GARJFASQSA-N 0.000 description 19
• AJHCSUXXECOXOY-UHFFFAOYSA-N N-glycyl-L-tryptophan Natural products C1=CC=C2C(CC(NC(=O)CN)C(O)=O)=CNC2=C1 AJHCSUXXECOXOY-UHFFFAOYSA-N 0.000 description 19
• KQNDIKOYWZTZIX-FXQIFTODSA-N Ser-Ser-Arg Chemical compound OC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(O)=O)CCCNC(N)=N KQNDIKOYWZTZIX-FXQIFTODSA-N 0.000 description 19
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• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 18
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