CA2858025C - 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene as an intermediate to prepare a catechol-o-methyltransferase inhibitor - Google Patents

5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene as an intermediate to prepare a catechol-o-methyltransferase inhibitor Download PDF

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Publication number
CA2858025C
CA2858025C CA2858025A CA2858025A CA2858025C CA 2858025 C CA2858025 C CA 2858025C CA 2858025 A CA2858025 A CA 2858025A CA 2858025 A CA2858025 A CA 2858025A CA 2858025 C CA2858025 C CA 2858025C
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Prior art keywords
formula
compound
reaction
mixture
acid
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English (en)
French (fr)
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CA2858025A1 (en
Inventor
Domenico Russo
Laszlo Erno Kiss
Jorge Bruno Reis Wahnon
David Alexander Learmonth
Tibor Eszenyi
Axel Zimmermann
Bjoern Schlummer
Michael Kreis
Klaus Reiter
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Bial Portela and Cia SA
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Bial Portela and Cia SA
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48612903&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2858025(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB1121413.7A external-priority patent/GB201121413D0/en
Priority claimed from GBGB1201758.8A external-priority patent/GB201201758D0/en
Application filed by Bial Portela and Cia SA filed Critical Bial Portela and Cia SA
Priority to CA3088684A priority Critical patent/CA3088684C/en
Publication of CA2858025A1 publication Critical patent/CA2858025A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CA2858025A 2011-12-13 2012-12-12 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene as an intermediate to prepare a catechol-o-methyltransferase inhibitor Active CA2858025C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3088684A CA3088684C (en) 2011-12-13 2012-12-12 Compound 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-3-nitrobenzene-1,2-diol in microparticulate form and its use in the treatment of parkinson's disease

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201161570141P 2011-12-13 2011-12-13
GBGB1121413.7A GB201121413D0 (en) 2011-12-13 2011-12-13 Chemical compounds and processes
GB1121413.7 2011-12-13
US61/570,141 2011-12-13
US201261593625P 2012-02-01 2012-02-01
GBGB1201758.8A GB201201758D0 (en) 2012-02-01 2012-02-01 Chemical compounds and processes
US61/593,625 2012-02-01
GB1201758.8 2012-02-01
US201261718589P 2012-10-25 2012-10-25
US61/718,589 2012-10-25
PCT/PT2012/000048 WO2013089573A1 (en) 2011-12-13 2012-12-12 Chemical compound useful as intermediate for preparing a catechol-o-methyltransferase inhibitor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3088684A Division CA3088684C (en) 2011-12-13 2012-12-12 Compound 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-3-nitrobenzene-1,2-diol in microparticulate form and its use in the treatment of parkinson's disease

Publications (2)

Publication Number Publication Date
CA2858025A1 CA2858025A1 (en) 2013-06-20
CA2858025C true CA2858025C (en) 2020-09-22

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Family Applications (2)

Application Number Title Priority Date Filing Date
CA2858025A Active CA2858025C (en) 2011-12-13 2012-12-12 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene as an intermediate to prepare a catechol-o-methyltransferase inhibitor
CA3088684A Active CA3088684C (en) 2011-12-13 2012-12-12 Compound 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-3-nitrobenzene-1,2-diol in microparticulate form and its use in the treatment of parkinson's disease

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3088684A Active CA3088684C (en) 2011-12-13 2012-12-12 Compound 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-3-nitrobenzene-1,2-diol in microparticulate form and its use in the treatment of parkinson's disease

Country Status (15)

Country Link
US (2) US9126988B2 (https=)
EP (2) EP2791134B1 (https=)
JP (3) JP6456143B2 (https=)
BR (1) BR112014014341A2 (https=)
CA (2) CA2858025C (https=)
CY (1) CY1122580T1 (https=)
DK (1) DK2791134T3 (https=)
ES (2) ES2960805T3 (https=)
HR (1) HRP20192133T8 (https=)
HU (1) HUE047856T2 (https=)
PL (1) PL2791134T3 (https=)
PT (2) PT3604299T (https=)
RS (1) RS59666B1 (https=)
SI (1) SI2791134T1 (https=)
WO (1) WO2013089573A1 (https=)

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CN113292489B (zh) * 2021-06-16 2022-08-30 泓博智源(开原)药业有限公司 二氯代二烷基烟腈的制备方法
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Publication number Publication date
JP6721558B2 (ja) 2020-07-15
US9126988B2 (en) 2015-09-08
EP2791134A1 (en) 2014-10-22
PT3604299T (pt) 2023-10-31
JP2018052949A (ja) 2018-04-05
SI2791134T1 (sl) 2020-01-31
PT2791134T (pt) 2019-12-18
HRP20192133T8 (hr) 2021-02-19
JP2020059729A (ja) 2020-04-16
CA3088684A1 (en) 2013-06-20
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