CA2848711C - Galacto-rhamnogalacturonate compositions for the treatment of non-alcoholic steatohepatitis and non-alcoholic fatty liver disease - Google Patents
Galacto-rhamnogalacturonate compositions for the treatment of non-alcoholic steatohepatitis and non-alcoholic fatty liver disease Download PDFInfo
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- CA2848711C CA2848711C CA2848711A CA2848711A CA2848711C CA 2848711 C CA2848711 C CA 2848711C CA 2848711 A CA2848711 A CA 2848711A CA 2848711 A CA2848711 A CA 2848711A CA 2848711 C CA2848711 C CA 2848711C
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Classifications
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- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/732—Pectin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0087—Glucomannans or galactomannans; Tara or tara gum, i.e. D-mannose and D-galactose units, e.g. from Cesalpinia spinosa; Tamarind gum, i.e. D-galactose, D-glucose and D-xylose units, e.g. from Tamarindus indica; Gum Arabic, i.e. L-arabinose, L-rhamnose, D-galactose and D-glucuronic acid units, e.g. from Acacia Senegal or Acacia Seyal; Derivatives thereof
Landscapes
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- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US201161535655P | 2011-09-16 | 2011-09-16 | |
| US61/535,655 | 2011-09-16 | ||
| US201261656288P | 2012-06-06 | 2012-06-06 | |
| US61/656,288 | 2012-06-06 | ||
| PCT/US2012/055360 WO2013040324A1 (en) | 2011-09-16 | 2012-09-14 | Galacto-rhamnogalacturonate compositions for the treatment of non-alcoholic steatohepatitis and non-alcoholic fatty liver disease |
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| WO2008011216A2 (en) * | 2006-05-16 | 2008-01-24 | Pro-Pharmaceuticals, Inc. | Galactose-pronged polysaccharides in a formulation for antifibrotic therapies |
| KR101968370B1 (ko) | 2011-12-28 | 2019-04-11 | 갈렉틴 테라퓨틱스, 인크. | 인간 질환의 치료를 위한 신규 탄수화물 약물의 조성물 |
| ES2848538T3 (es) | 2012-06-06 | 2021-08-10 | Galectin Therapeutics Inc | Composiciones de galacto-ramnogalacturonato para el tratamiento de enfermedades asociadas con elevada óxido nítrico sintasa inducible |
| BR112015005772A2 (pt) * | 2012-09-17 | 2017-08-08 | Galectin Therapeutics Inc | método para a intensificação de imunoterapias específicas no tratamento de câncer |
| CA2924597A1 (en) | 2013-09-19 | 2015-03-26 | The Research Foundation For The State University Of New York | Methods and materials for treating diabetes or liver steatosis |
| US20170014446A1 (en) * | 2014-03-10 | 2017-01-19 | La Jolla Pharmaceutical Company | Compositions and methods for administering galectin antagonists |
| JP2017525702A (ja) * | 2014-08-18 | 2017-09-07 | ファーマジェネシス， インコーポレイテッド | ポリガラクツロナンラムノガラクツロナン（ｐｇｒｇ１）組成物 |
| MA41120A (fr) * | 2014-12-02 | 2017-10-10 | Afimmune Ltd | Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci |
| BR112017018882A2 (pt) * | 2015-03-03 | 2018-04-17 | Kohjin Life Sciences Co Ltd | composição para aperfeiçoamento ou prevenção de uma doença de fígado gorduroso não alcoólico |
| WO2016160594A1 (en) | 2015-03-27 | 2016-10-06 | The Research Foundation For The State University Of New York | Methods and materials for reducing amyloid beta levels within a mammal |
| JP2018524274A (ja) | 2015-05-13 | 2018-08-30 | ディーエス バイオファーマ リミテッド | １５−オキソ−ｅｐａまたは１５−オキソ−ｄｇｌａを含む組成物、ならびにその作製及び使用方法 |
| IL300476B2 (en) * | 2015-06-30 | 2024-07-01 | Eiger Group Int Inc | Use of chloroquine and clemizole compounds for treatment of inflammatory and cancerous conditions |
| WO2017109706A1 (en) * | 2015-12-22 | 2017-06-29 | Novartis Ag | Methods of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15) |
| MX394409B (es) * | 2016-03-04 | 2025-03-24 | Galectin Sciences Llc | Compuestos de seleno-galactosida para la prevención y el tratamiento de las enfermedades asociadas con galectina y el uso de los mismos. |
| FR3050112B1 (fr) | 2016-04-15 | 2020-09-04 | Soc Civ Immobiliere Gecinq | Utilisation de l'acide fenofibrique dans le traitement des maladies hepatiques |
| ES2966111T3 (es) * | 2016-06-03 | 2024-04-18 | Chemocentryx Inc | Pirrolo-piridinas y pirrolo-pirimidinas para su uso en el tratamiento de la fibrosis hepática |
| US10342785B2 (en) | 2016-11-04 | 2019-07-09 | Askat Inc. | Use of EP4 receptor antagonists for the treatment of NASH-associated liver cancer |
| MX2019012086A (es) | 2017-04-14 | 2021-01-08 | Gelesis Llc | Composiciones y métodos para tratar o prevenir trastornos relacionados con la permeabilidad intestinal. |
| CA3062648A1 (en) | 2017-05-12 | 2018-11-15 | Galectin Sciences, Llc | Compounds for the prevention and treatment of diseases and the use thereof |
| WO2019010024A1 (en) * | 2017-07-04 | 2019-01-10 | The Regents Of The University Of California | METHODS OF TREATING LIVER DISEASES ASSOCIATED WITH INFLAMMATION OF DOOR SPACE OR PERIODAL INFLAMMATION |
| CN111183360B (zh) * | 2017-07-19 | 2024-10-18 | 生物辐射欧洲有限公司 | 同时评估非酒精性脂肪性肝炎和肝纤维化状态的生物标志物组合 |
| GB201804922D0 (en) * | 2018-03-27 | 2018-05-09 | Ucl Business Plc | Traatment |
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| BR112022022737A2 (pt) * | 2020-05-22 | 2023-01-31 | Durect Corp | Tratamento de esteatose hepática não alcoólica (ehna) |
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| US6297229B1 (en) | 1994-11-14 | 2001-10-02 | Mayo Foundation For Medical Education And Research | Use of ursodeoxycholic acid to treat nonalcoholic steatohepatitis |
| US5760010A (en) | 1995-01-01 | 1998-06-02 | Klein; Ira | Method of treating liver disorders with a macrolide antibiotic |
| US6180139B1 (en) | 1998-12-04 | 2001-01-30 | Viva America Marketing, Inc. | Composition and method for treating nonalcoholic steatohepatitis |
| WO2000062076A1 (en) * | 1999-04-13 | 2000-10-19 | Hsu Daniel K | Galectin expression is induced in cirrhotic liver and hepatocellular carcinoma |
| US6592910B1 (en) | 1999-04-20 | 2003-07-15 | Board Of Trustees, Southern Illinois University | Methods of treating clinical diseases with isoflavones |
| CN1142272C (zh) | 2000-02-02 | 2004-03-17 | 中国人民解放军军事医学科学院百环生物医学研究中心 | 携带人肝细胞生长因子基因的重组腺病毒的用途 |
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| US6596762B2 (en) | 2001-05-17 | 2003-07-22 | The Regents Of The University Of Colorado | Antioxidant compositions and use for treatment of hepatic steatosis and steatohepatitis |
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| ATE555101T1 (de) | 2004-02-27 | 2012-05-15 | Asahi Kasei Pharma Corp | Neue benzothiazepin- und benzothiepinverbindungen |
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| RU2007148927A (ru) * | 2005-05-26 | 2009-07-10 | Метабэйзис Терапьютикс, Инк. (Us) | Новые тиреомиметики, содержащие фосфиновую кислоту |
| ATE450526T1 (de) | 2005-06-20 | 2009-12-15 | Schering Corp | Als antagonisten von histamin h3 geeignete piperidinderivate |
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| JP5105297B2 (ja) | 2006-05-25 | 2012-12-26 | 味の素株式会社 | Ｐｐａｒ活性調節剤 |
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| US20110313276A1 (en) * | 2008-11-18 | 2011-12-22 | Centre Hospitalier Universitaire D'angers | Non-invasive in vitro method for quantifying liver lesions |
| JP2010229099A (ja) * | 2009-03-27 | 2010-10-14 | Mochida Pharmaceut Co Ltd | 脂質異常症の改善または治療薬 |
| WO2011088404A1 (en) * | 2010-01-15 | 2011-07-21 | Infinity Pharmaceuticals , Inc | Treatment of fibrotic conditions using hedgehog inhibitors |
| KR101968370B1 (ko) * | 2011-12-28 | 2019-04-11 | 갈렉틴 테라퓨틱스, 인크. | 인간 질환의 치료를 위한 신규 탄수화물 약물의 조성물 |
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2012
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- 2012-09-14 WO PCT/US2012/055348 patent/WO2013040316A1/en not_active Ceased
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- 2012-09-14 AU AU2012308491A patent/AU2012308491B2/en active Active
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|---|---|
| ES2869884T3 (es) | 2021-10-26 |
| IL231512B (en) | 2019-02-28 |
| EP2755480B1 (en) | 2021-03-31 |
| KR101974675B1 (ko) | 2019-05-02 |
| BR112014006220A2 (pt) | 2017-04-11 |
| JP6185473B2 (ja) | 2017-08-23 |
| US8658787B2 (en) | 2014-02-25 |
| MX360979B (es) | 2018-11-22 |
| IL231512A0 (en) | 2014-04-30 |
| KR20140107180A (ko) | 2014-09-04 |
| MX2014003213A (es) | 2015-05-15 |
| AU2012308491B2 (en) | 2016-01-07 |
| CA2848711A1 (en) | 2013-03-21 |
| AU2012308491A1 (en) | 2014-04-03 |
| EP2755480A1 (en) | 2014-07-23 |
| WO2013040324A1 (en) | 2013-03-21 |
| WO2013040316A1 (en) | 2013-03-21 |
| JP2014526513A (ja) | 2014-10-06 |
| EP2755480A4 (en) | 2015-04-29 |
| US20130171151A1 (en) | 2013-07-04 |
| CN103945695A (zh) | 2014-07-23 |
| US20130259870A1 (en) | 2013-10-03 |
| CN103945695B (zh) | 2018-04-17 |
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