CA2847293C - Solid forms of a transthyretin dissociation inhibitor - Google Patents

Solid forms of a transthyretin dissociation inhibitor Download PDF

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Publication number
CA2847293C
CA2847293C CA2847293A CA2847293A CA2847293C CA 2847293 C CA2847293 C CA 2847293C CA 2847293 A CA2847293 A CA 2847293A CA 2847293 A CA2847293 A CA 2847293A CA 2847293 C CA2847293 C CA 2847293C
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CA
Canada
Prior art keywords
crystalline form
compound
solid
carboxy
peaks
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2847293A
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English (en)
French (fr)
Other versions
CA2847293A1 (en
Inventor
Richard Frederic Labaudiniere
Michael Henry O'NEILL
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Pfizer Inc
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Pfizer Inc
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Publication of CA2847293A1 publication Critical patent/CA2847293A1/en
Application granted granted Critical
Publication of CA2847293C publication Critical patent/CA2847293C/en
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA2847293A 2011-09-16 2012-09-12 Solid forms of a transthyretin dissociation inhibitor Expired - Fee Related CA2847293C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161535551P 2011-09-16 2011-09-16
US61/535,551 2011-09-16
PCT/IB2012/054748 WO2013038351A1 (en) 2011-09-16 2012-09-12 Solid forms of a transthyretin dissociation inhibitor

Publications (2)

Publication Number Publication Date
CA2847293A1 CA2847293A1 (en) 2013-03-21
CA2847293C true CA2847293C (en) 2017-03-28

Family

ID=47116132

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2847293A Expired - Fee Related CA2847293C (en) 2011-09-16 2012-09-12 Solid forms of a transthyretin dissociation inhibitor

Country Status (16)

Country Link
US (2) US9249112B2 (enExample)
EP (1) EP2755961A1 (enExample)
JP (2) JP5869677B2 (enExample)
KR (1) KR20140054231A (enExample)
CN (1) CN103781770B (enExample)
AR (1) AR088755A1 (enExample)
AU (1) AU2012310157B2 (enExample)
BR (1) BR112014005810A2 (enExample)
CA (1) CA2847293C (enExample)
IL (1) IL231472A0 (enExample)
MX (1) MX2014003043A (enExample)
RU (1) RU2586330C2 (enExample)
SG (1) SG2014013270A (enExample)
TW (2) TWI476185B (enExample)
WO (1) WO2013038351A1 (enExample)
ZA (1) ZA201401202B (enExample)

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WO2013038351A1 (en) * 2011-09-16 2013-03-21 Pfizer Inc. Solid forms of a transthyretin dissociation inhibitor
EP2764866A1 (en) 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibitors of nedd8-activating enzyme
HUE056583T2 (hu) * 2014-09-08 2022-02-28 Pfizer 6-Karboxi-2-(3,5-diklórfenil)-benzoxazol kristályos szilárd formái
CN107344927A (zh) * 2016-05-05 2017-11-14 苏州晶云药物科技有限公司 Tafamidis葡甲胺盐的晶型E及其制备方法和用途
GB2571950A (en) * 2018-03-13 2019-09-18 Azad Pharma Ag New polymorph and new path to synthesize tafamidis
WO2020128816A2 (en) 2018-12-20 2020-06-25 Pfizer Inc. Pharmaceutical compositions and methods comprising a combination of a benzoxazole transthyretin stabilizer and an additional therapeutic agent
US12116352B2 (en) 2019-04-11 2024-10-15 Inke, S.A. Process for preparing 1-deoxy-1-methylamino-d-glucitol 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylate
HRP20250159T1 (hr) 2019-05-16 2025-03-28 Assia Chemical Industries Ltd. Kruti oblici tafamidisa i njegovih soli
MX2021014682A (es) * 2019-05-31 2022-04-06 Plex Pharmaceuticals Inc Agentes farmacológicos para tratar enfermedades de agregación de proteínas de los ojos.
WO2021019448A1 (en) * 2019-08-01 2021-02-04 Honour (R&D) Process for the preparation of transthyretin dissociation inhibitor
EP4059926A4 (en) * 2019-11-15 2022-12-14 Crystal Pharmaceutical (Suzhou) Co., Ltd. CRYSTALLINE FORM OF TAFAMIDIS AND PROCESS FOR PRODUCTION AND USE THEREOF
HRP20251570T1 (hr) 2019-12-20 2026-01-30 Pfizer Ireland Pharmaceuticals Unlimited Company Djelotvoran postupak dobivanja derivata 6-karboksibenzoksazola
WO2021232619A1 (zh) * 2020-05-19 2021-11-25 苏州科睿思制药有限公司 一种他发米帝司游离酸的晶型及其制备方法和用途
WO2022009221A1 (en) * 2020-07-04 2022-01-13 Nuray Chemicals Private Limited Solid state forms of 6-carboxy-2-(3, 5-dichlorophenyl)-benzoxazole of formula-i and pharmaceutically acceptable salts thereof
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WO2022084790A1 (en) * 2020-10-19 2022-04-28 Glenmark Life Sciences Limited Process for preparation of tafamidis and salts thereof
WO2022112919A1 (en) 2020-11-25 2022-06-02 Pfizer Inc. (aza)benzothiazolyl substituted pyrazole compounds
EP4083027A1 (en) 2021-04-26 2022-11-02 Química Sintética, S.A. A solid state form of tafamidis and a process for its preparation
WO2023020762A1 (en) 2021-08-16 2023-02-23 Synthon B.V. Crystalline forms of tafamidis nicotinamide adduct
WO2023091534A1 (en) 2021-11-17 2023-05-25 Teva Pharmaceuticals International Gmbh Solid state form of tafamidis

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Also Published As

Publication number Publication date
HK1197239A1 (zh) 2015-01-09
CA2847293A1 (en) 2013-03-21
MX2014003043A (es) 2015-02-05
JP5869677B2 (ja) 2016-02-24
AR088755A1 (es) 2014-07-02
NZ621194A (en) 2016-02-26
JP2016128444A (ja) 2016-07-14
IL231472A0 (en) 2014-04-30
TW201516039A (zh) 2015-05-01
CN103781770A (zh) 2014-05-07
US20160185739A1 (en) 2016-06-30
JP2014526498A (ja) 2014-10-06
AU2012310157A1 (en) 2014-04-03
TW201315720A (zh) 2013-04-16
ZA201401202B (en) 2016-01-27
BR112014005810A2 (pt) 2017-03-28
TWI476185B (zh) 2015-03-11
KR20140054231A (ko) 2014-05-08
RU2014109676A (ru) 2015-10-27
TWI538909B (zh) 2016-06-21
SG2014013270A (en) 2014-05-29
AU2012310157B2 (en) 2015-11-12
RU2586330C2 (ru) 2016-06-10
EP2755961A1 (en) 2014-07-23
US9249112B2 (en) 2016-02-02
WO2013038351A1 (en) 2013-03-21
CN103781770B (zh) 2016-04-13
US20150031735A1 (en) 2015-01-29

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