CA2842306A1

CA2842306A1 - Intraperitoneally-administered nanocarriers that release their therapeutic load based on the inflammatory environment of cancers

Intraperitoneally-administered nanocarriers that release their therapeutic load based on the inflammatory environment of cancers Download PDF

Info

Publication number: CA2842306A1
Authority: CA; Canada
Prior art keywords: composition; phosphatidyl; group; cancer; lipid bilayer
Prior art date: 2011-07-19
Legal status : Abandoned

Application number

CA2842306A

Other languages

English (en)

French (fr)

Inventor

Reema R. Zeineldin

Current Assignee

UNM Rainforest Innovations

Original Assignee

STC UNM

Priority date

2011-07-19

Filing date

2012-07-18

Publication date

2013-01-24

2012-07-18 Application filed by STC UNM filed Critical STC UNM

2013-01-24 Publication of CA2842306A1 publication Critical patent/CA2842306A1/en

Status Abandoned legal-status Critical Current

Links

239000002539 nanocarrier Substances 0.000 title claims abstract description 75
206010028980 Neoplasm Diseases 0.000 title claims abstract description 50
230000001225 therapeutic effect Effects 0.000 title abstract description 10
230000002757 inflammatory effect Effects 0.000 title description 9
239000000203 mixture Substances 0.000 claims abstract description 142
239000003642 reactive oxygen metabolite Substances 0.000 claims abstract description 74
239000000232 Lipid Bilayer Substances 0.000 claims abstract description 65
238000000034 method Methods 0.000 claims abstract description 27
201000011510 cancer Diseases 0.000 claims abstract description 24
238000007912 intraperitoneal administration Methods 0.000 claims abstract description 21
239000013543 active substance Substances 0.000 claims abstract description 17
238000011282 treatment Methods 0.000 claims abstract description 15
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 14
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 113
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 68
CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 claims description 59
239000000377 silicon dioxide Substances 0.000 claims description 56
239000002246 antineoplastic agent Substances 0.000 claims description 51
WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 45
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SNKAWJBJQDLSFF-NVKMUCNASA-N 1,2-dioleoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC SNKAWJBJQDLSFF-NVKMUCNASA-N 0.000 claims description 11
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TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 claims description 11
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229920001223 polyethylene glycol Polymers 0.000 claims description 11
229930182558 Sterol Natural products 0.000 claims description 10
OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 claims description 10
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YAYRGNWWLMLWJE-UHFFFAOYSA-L carboplatin Chemical compound O=C1O[Pt](N)(N)OC(=O)C11CCC1 YAYRGNWWLMLWJE-UHFFFAOYSA-L 0.000 claims description 10
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