CA2829189A1 - Charge-enhanced neural electric stimulation system - Google Patents
Charge-enhanced neural electric stimulation system Download PDFInfo
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- CA2829189A1 CA2829189A1 CA2829189A CA2829189A CA2829189A1 CA 2829189 A1 CA2829189 A1 CA 2829189A1 CA 2829189 A CA2829189 A CA 2829189A CA 2829189 A CA2829189 A CA 2829189A CA 2829189 A1 CA2829189 A1 CA 2829189A1
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Applications Claiming Priority (5)
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| US31631910P | 2010-03-22 | 2010-03-22 | |
| US61/316,319 | 2010-03-22 | ||
| USPCT/US2010/053720 | 2010-10-22 | ||
| PCT/US2010/053720 WO2011050255A2 (en) | 2009-10-22 | 2010-10-22 | Dipole electrical stimulation employing direct current for recovery from spinal cord injury |
| PCT/US2011/022283 WO2011119251A2 (en) | 2010-03-22 | 2011-01-24 | Charge-enhanced neural electric stimulation system |
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| CA2829189A1 true CA2829189A1 (en) | 2011-09-29 |
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| US9008781B2 (en) | 2009-10-22 | 2015-04-14 | The Research Foundation Of The City University Of New York | Method and system for treatment of mobility dysfunction |
| US20130053922A1 (en) | 2009-10-22 | 2013-02-28 | Zaghloul Ahmed | Dipole electrical stimulation employing direct current for recovery from spinal cord injury |
| WO2012051495A2 (en) | 2010-10-15 | 2012-04-19 | The Research Foundation Of State University Of New York | Compositions and methods for enhancing the biological response to chemical agents and physical stimuli |
| CA2823592C (en) | 2011-01-03 | 2021-11-23 | The Regents Of The University Of California | High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury |
| CN107361741B (zh) | 2011-03-24 | 2021-03-09 | 加利福尼亚理工学院 | 神经刺激器装置 |
| US9974455B2 (en) | 2011-05-13 | 2018-05-22 | Saluda Medical Pty Ltd. | Method and apparatus for estimating neural recruitment |
| US10568559B2 (en) | 2011-05-13 | 2020-02-25 | Saluda Medical Pty Ltd | Method and apparatus for measurement of neural response |
| US9872990B2 (en) | 2011-05-13 | 2018-01-23 | Saluda Medical Pty Limited | Method and apparatus for application of a neural stimulus |
| WO2012155190A1 (en) | 2011-05-13 | 2012-11-22 | National Ict Australia Ltd | Method and apparatus for measurement of neural response |
| JP6096759B2 (ja) | 2011-05-13 | 2017-03-15 | サルーダ・メディカル・ピーティーワイ・リミテッド | 神経応答の測定のための方法および装置 |
| WO2013071307A1 (en) | 2011-11-11 | 2013-05-16 | Edgerton Victor Reggie | Non invasive neuromodulation device for enabling recovery of motor, sensory, autonomic, sexual, vasomotor and cognitive function |
| US10092750B2 (en) | 2011-11-11 | 2018-10-09 | Neuroenabling Technologies, Inc. | Transcutaneous neuromodulation system and methods of using same |
| CA2876297C (en) | 2012-06-15 | 2019-02-26 | Case Western Reserve University | Therapy delivery devices and methods for non-damaging neural tissue conduction block |
| US10195434B2 (en) | 2012-06-15 | 2019-02-05 | Case Western Reserve University | Treatment of pain using electrical nerve conduction block |
| US9833614B1 (en) | 2012-06-22 | 2017-12-05 | Nevro Corp. | Autonomic nervous system control via high frequency spinal cord modulation, and associated systems and methods |
| DE102012013534B3 (de) | 2012-07-05 | 2013-09-19 | Tobias Sokolowski | Vorrichtung für repetitive Nervenstimulation zum Abbau von Fettgewebe mittels induktiver Magnetfelder |
| CN102886102B (zh) * | 2012-09-25 | 2014-12-10 | 深圳英智科技有限公司 | 镜像运动神经调制系统 |
| DK2908905T3 (da) | 2012-11-06 | 2020-12-14 | Saluda Medical Pty Ltd | System til at kontrollere elektriske forhold i væv |
| WO2014071445A1 (en) | 2012-11-06 | 2014-05-15 | Saluda Medical Pty Ltd | Method and system for controlling electrical conditions of tissue |
| CN103099677B (zh) * | 2013-01-17 | 2016-05-11 | 杨明亮 | 一种在生物体内构建网络及通过网络释放周期信号的方法 |
| US12453853B2 (en) * | 2013-01-21 | 2025-10-28 | Cala Health, Inc. | Multi-modal stimulation for treating tremor |
| CN105142714B (zh) | 2013-01-21 | 2018-02-16 | 卡拉健康公司 | 用于控制震颤的设备和方法 |
| DK2964315T3 (da) * | 2013-03-07 | 2019-01-02 | Univ City New York Res Found | System til behandling af neuromotorisk dysfunktion |
| EP3878507A1 (en) | 2013-03-15 | 2021-09-15 | The Regents Of The University Of California | Multi-site transcutaneous electrical stimulation of the spinal cord for facilitation of locomotion |
| US20150238764A1 (en) | 2013-05-10 | 2015-08-27 | Case Western Reserve University | Systems and methods for preventing noise in an electric waveform for neural stimulation, block, or sensing |
| JP6210363B2 (ja) * | 2013-05-24 | 2017-10-11 | 株式会社安川電機 | 訓練装置 |
| JP6210364B2 (ja) * | 2013-05-24 | 2017-10-11 | 株式会社安川電機 | 訓練装置 |
| US11229789B2 (en) | 2013-05-30 | 2022-01-25 | Neurostim Oab, Inc. | Neuro activator with controller |
| PL3003473T3 (pl) | 2013-05-30 | 2019-05-31 | Neurostim Solutions LLC | Miejscowa stymulacja neurologiczna |
| CN103495260B (zh) * | 2013-06-04 | 2016-05-25 | 东南大学 | 一种基于肌电信号和传感器信号实现精细实时运动的控制方法 |
| KR101540273B1 (ko) * | 2013-08-07 | 2015-07-31 | 한국과학기술연구원 | 멀티채널 촉각 유도 뇌 자극 |
| EP3049148B1 (en) | 2013-09-27 | 2020-05-20 | The Regents Of The University Of California | Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects |
| EP3065636B1 (en) * | 2013-11-07 | 2023-08-30 | SafeOp Surgical, Inc. | Systems and methods for detecting nerve function |
| ES3033225T3 (en) * | 2013-11-15 | 2025-07-31 | Closed Loop Medical Pty Ltd | Monitoring brain neural potentials |
| CN105848574B9 (zh) | 2013-11-22 | 2020-01-21 | 萨鲁达医疗有限公司 | 用于检测神经测量值中的神经反应的方法和装置 |
| CN109432596B (zh) | 2013-12-22 | 2022-05-17 | 纽约城市大学研究基金会 | 经脊髓直流电调节系统 |
| US9707391B2 (en) | 2013-12-22 | 2017-07-18 | The Research Foundation Of The City University Of New York | Method for modulation of effector organs |
| US9707390B2 (en) * | 2013-12-22 | 2017-07-18 | The Research Foundation Of The City University Of New York | Apparatus for modulation of effector organs |
| US20150217120A1 (en) | 2014-01-13 | 2015-08-06 | Mandheerej Nandra | Neuromodulation systems and methods of using same |
| WO2015143509A1 (en) | 2014-03-28 | 2015-10-01 | Saluda Medical Pty Ltd | Assessing neural state from action potentials |
| AU2015255631B2 (en) | 2014-05-05 | 2020-02-06 | Saluda Medical Pty Ltd | Improved neural measurement |
| WO2015187712A1 (en) * | 2014-06-02 | 2015-12-10 | Cala Health, Inc. | Systems and methods for peripheral nerve stimulation to treat tremor |
| AU2015292272B2 (en) | 2014-07-25 | 2020-11-12 | Saluda Medical Pty Ltd | Neural stimulation dosing |
| KR101523715B1 (ko) * | 2014-07-30 | 2015-05-29 | 한국과학기술연구원 | 하이브리드 자극을 이용한 생체 신경 기능 조절 시스템 |
| KR101465593B1 (ko) * | 2014-09-03 | 2014-11-27 | (주)와이브레인 | 경두개 직류 자극(tDCS) 장치 |
| CN104436447B (zh) * | 2014-10-11 | 2017-01-11 | 中国科学院苏州生物医学工程技术研究所 | 一种用于脊髓功能调控的闭环光刺激系统 |
| WO2016077882A1 (en) | 2014-11-17 | 2016-05-26 | Saluda Medical Pty Ltd | Method and device for detecting a neural response in neural measurements |
| WO2016090420A1 (en) | 2014-12-11 | 2016-06-16 | Saluda Medical Pty Ltd | Implantable electrode positioning |
| AU2015362091B2 (en) | 2014-12-11 | 2020-11-26 | Saluda Medical Pty Ltd | Method and device for feedback control of neural stimulation |
| KR101653889B1 (ko) | 2014-12-31 | 2016-09-09 | 영남대학교 산학협력단 | 능동형 생체이식 경천추 경막외 척수신경 자극을 위한 카테터용 박동성 고주파 자극장치 |
| KR101653888B1 (ko) | 2014-12-31 | 2016-09-02 | 영남대학교 산학협력단 | 수동형 생체이식 경천추 경막외 척수신경 자극을 위한 카테터용 박동성 고주파 자극장치 |
| EP3229893B1 (en) | 2015-01-19 | 2020-06-17 | Saluda Medical Pty Ltd | Method and device for neural implant communication |
| US9962547B2 (en) | 2015-02-05 | 2018-05-08 | Stimgenics, Llc | Method and apparatus for multimodal electrical modulation of pain |
| US10195424B2 (en) * | 2015-02-20 | 2019-02-05 | The Research Foundation Of The City University Of New York | Methods and systems for treatment of spinal disorders using trans-spinal direct current stimulation |
| US11077301B2 (en) | 2015-02-21 | 2021-08-03 | NeurostimOAB, Inc. | Topical nerve stimulator and sensor for bladder control |
| US10434311B2 (en) | 2015-03-20 | 2019-10-08 | Stimgenics, Llc | Method and apparatus for multimodal electrical modulation of pain |
| US10675466B2 (en) | 2015-03-20 | 2020-06-09 | Stimgenics, Llc | Method and apparatus for multimodal electrical modulation of pain using composite electromagnetic fields |
| US11167139B2 (en) | 2015-03-20 | 2021-11-09 | Medtronic Sg, Llc | Method and apparatus for multi modal electrical modulation of pain using composite electromagnetic fields |
| US12311177B2 (en) | 2015-03-20 | 2025-05-27 | Medtronic Sg, Llc | Method and apparatus for multi modal electrical modulation of pain using composite electromagnetic fields |
| US10850102B2 (en) | 2015-03-20 | 2020-12-01 | Medtronic Sg, Llc | Method and apparatus for multimodal electrical modulation of pain |
| CN107530543B (zh) | 2015-04-09 | 2021-03-02 | 萨鲁达医疗有限公司 | 电极到神经距离估计 |
| US11491342B2 (en) | 2015-07-01 | 2022-11-08 | Btl Medical Solutions A.S. | Magnetic stimulation methods and devices for therapeutic treatments |
| CA2983336C (en) | 2015-05-31 | 2024-05-28 | Saluda Medical Pty Ltd | Monitoring brain neural activity |
| CA2983333C (en) | 2015-05-31 | 2023-09-19 | Saluda Medical Pty Ltd | Brain neurostimulator electrode fitting |
| CN107613861B (zh) | 2015-06-01 | 2021-10-26 | 闭环医疗私人有限公司 | 运动纤维神经调节 |
| DE102015108861A1 (de) * | 2015-06-03 | 2016-12-08 | Cortec Gmbh | Verfahren und Vorrichtung zur Neurostimulation |
| EP4342516A3 (en) | 2015-06-10 | 2024-07-10 | Cala Health, Inc. | Systems and methods for peripheral nerve stimulation to treat tremor with detachable therapy and monitoring units |
| DE102015109988B4 (de) * | 2015-06-22 | 2017-04-27 | Forschungszentrum Jülich GmbH | Vorrichtung zur effektiven invasiven Zwei-Stufen-Neurostimulation |
| JP6796089B2 (ja) * | 2015-06-22 | 2020-12-02 | リサーチ ファウンデーション オブ ザ シティー ユニバーシティ オブ ニューヨークＲｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ Ｏｆ Ｔｈｅ Ｃｉｔｙ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｅｗ Ｙｏｒｋ | 効果器を調節するための方法および装置 |
| US11266850B2 (en) | 2015-07-01 | 2022-03-08 | Btl Healthcare Technologies A.S. | High power time varying magnetic field therapy |
| US10695575B1 (en) | 2016-05-10 | 2020-06-30 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
| US20180001107A1 (en) | 2016-07-01 | 2018-01-04 | Btl Holdings Limited | Aesthetic method of biological structure treatment by magnetic field |
| US10603482B2 (en) | 2015-09-23 | 2020-03-31 | Cala Health, Inc. | Systems and methods for peripheral nerve stimulation in the finger or hand to treat hand tremors |
| AU2016335931B2 (en) | 2015-10-06 | 2019-06-27 | Case Western Reserve University | High-charge capacity electrodes to deliver direct current nerve conduction block |
| US11036294B2 (en) | 2015-10-07 | 2021-06-15 | The Governing Council Of The University Of Toronto | Wireless power and data transmission system for wearable and implantable devices |
| US11253717B2 (en) | 2015-10-29 | 2022-02-22 | Btl Healthcare Technologies A.S. | Aesthetic method of biological structure treatment by magnetic field |
| US10864373B2 (en) | 2015-12-15 | 2020-12-15 | Case Western Reserve University | Systems for treatment of a neurological disorder using electrical nerve conduction block |
| CN108778411B (zh) | 2016-01-21 | 2022-06-03 | 卡拉健康公司 | 用来治疗与膀胱过动症相关的疾病的用于外周神经调制的系统、方法和装置 |
| ES2888773T3 (es) | 2016-04-05 | 2022-01-07 | Saluda Medical Pty Ltd | Control de retroalimentación de la neuromodulación mejorado |
| US11464993B2 (en) | 2016-05-03 | 2022-10-11 | Btl Healthcare Technologies A.S. | Device including RF source of energy and vacuum system |
| US11247039B2 (en) | 2016-05-03 | 2022-02-15 | Btl Healthcare Technologies A.S. | Device including RF source of energy and vacuum system |
| US11534619B2 (en) | 2016-05-10 | 2022-12-27 | Btl Medical Solutions A.S. | Aesthetic method of biological structure treatment by magnetic field |
| US10583287B2 (en) | 2016-05-23 | 2020-03-10 | Btl Medical Technologies S.R.O. | Systems and methods for tissue treatment |
| CN109561849B (zh) * | 2016-06-24 | 2023-01-13 | 萨鲁达医疗有限公司 | 伪像减少的神经刺激 |
| US10556122B1 (en) | 2016-07-01 | 2020-02-11 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
| US10953230B2 (en) | 2016-07-20 | 2021-03-23 | The Governing Council Of The University Of Toronto | Neurostimulator and method for delivering a stimulation in response to a predicted or detected neurophysiological condition |
| CN109689156B (zh) | 2016-08-08 | 2023-08-01 | 深部脑刺激技术有限公司 | 用于监测神经活动的系统和方法 |
| US11141219B1 (en) | 2016-08-16 | 2021-10-12 | BTL Healthcare Technologies, a.s. | Self-operating belt |
| CN109803717B (zh) | 2016-08-25 | 2024-01-09 | 卡拉健康公司 | 通过周围神经刺激治疗心脏机能障碍的系统和方法 |
| EP3679979B1 (en) * | 2016-10-05 | 2021-06-16 | Tesla Medical s.r.o. | A device for neuromodulation treatment |
| WO2018101986A1 (en) | 2016-12-01 | 2018-06-07 | Thimble Bioelectronics, Inc. d/b/a Enso | Neuromodulation device and method for use |
| US20180272132A1 (en) | 2017-01-19 | 2018-09-27 | Nevro Corp. | High frequency stimulation for treating sensory and/or motor deficits in patients with spinal cord injuries and/or peripheral polyneuropathy, and associated systems and methods |
| US11235154B2 (en) | 2017-02-17 | 2022-02-01 | The University Of British Columbia | Apparatus and methods for maintaining physiological functions |
| CA3058786A1 (en) | 2017-04-03 | 2018-10-11 | Cala Health, Inc. | Systems, methods and devices for peripheral neuromodulation for treating diseases related to overactive bladder |
| WO2018187237A1 (en) | 2017-04-03 | 2018-10-11 | Presidio Medical, Inc. | Systems and methods for direct current nerve conduction block |
| US11298070B2 (en) | 2017-05-22 | 2022-04-12 | Deep Brain Stimulation Technologies Pty Ltd | Systems and methods for monitoring neural activity |
| WO2018217791A1 (en) | 2017-05-23 | 2018-11-29 | The Regents Of The University Of California | Accessing spinal networks to address sexual dysfunction |
| EP3974021B1 (en) | 2017-06-30 | 2023-06-14 | ONWARD Medical N.V. | A system for neuromodulation |
| WO2019050896A2 (en) * | 2017-09-05 | 2019-03-14 | University Of Florida Research Foundation, Inc. | STIMULATION OF NEURONES MOTORS OF SPINAL CORD BY ELECTRICAL SIGNALS |
| EP3691744B1 (en) * | 2017-10-04 | 2021-07-28 | Boston Scientific Neuromodulation Corporation | Adjustment of stimulation in a stimulator using detected evoked compound action potentials |
| WO2019094365A1 (en) | 2017-11-07 | 2019-05-16 | Neurostim Oab, Inc. | Non-invasive nerve activator with adaptive circuit |
| US11986645B2 (en) | 2017-11-07 | 2024-05-21 | Neurostim Technologies Llc | Restless legs syndrome treatment system |
| EP3720338B1 (en) | 2017-12-05 | 2025-09-24 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | A system for planning and/or providing neuromodulation |
| US12357828B2 (en) | 2017-12-05 | 2025-07-15 | Ecole Polytechnique Federale De Lausanne (Epfl) | System for planning and/or providing neuromodulation |
| EP3740274A4 (en) | 2018-01-17 | 2021-10-27 | Cala Health, Inc. | SYSTEMS AND METHODS FOR TREATING INFLAMMATORY INTESTINAL DISEASE USING PERIPHERAL NERVE STIMULATION |
| US12465260B2 (en) | 2018-02-09 | 2025-11-11 | Presidio Medical, Inc. | Systems and methods for cardiac conduction block |
| CN119607410A (zh) | 2018-02-20 | 2025-03-14 | 普雷西迪奥医学有限公司 | 用于神经传导阻滞的方法和系统 |
| US11986659B2 (en) | 2018-03-22 | 2024-05-21 | Research Foundation Of The City University Of New York | Modulation of neuronal NKCC1 as a therapeutic strategy for spasticity and related disorders |
| US11617887B2 (en) * | 2018-04-19 | 2023-04-04 | University of Washington and Seattle Children's Hospital Children's Research Institute | Systems and methods for brain stimulation for recovery from brain injury, such as stroke |
| EP4434461A3 (en) | 2018-04-27 | 2025-03-05 | Saluda Medical Pty Ltd | Neurostimulation of mixed nerves |
| AU2019299334B2 (en) | 2018-07-01 | 2025-03-20 | Presidio Medical, Inc. | Systems and methods for nerve conduction block |
| CA3110463A1 (en) | 2018-08-23 | 2020-02-27 | The Regents Of The University Of California | Non-invasive spinal cord stimulation for nerve root palsy, cauda equina syndrome, and restoration of upper extremity function |
| CN109173056B (zh) * | 2018-10-19 | 2022-03-22 | 南通大学 | 一种大鼠脊髓神经信号检测与评估系统及方法 |
| DE18205817T1 (de) | 2018-11-13 | 2020-12-24 | Gtx Medical B.V. | Sensor in bekleidung von gliedmassen oder schuhwerk |
| KR102412194B1 (ko) * | 2018-11-13 | 2022-06-23 | 한국과학기술연구원 | 자폐 스펙트럼 장애의 치료방법, 자폐 스펙트럼 장애 모니터링용 마우스, 및 자폐 스펙트럼 장애 예방 또는 치료용 후보물질의 스크리닝 방법 |
| ES2911465T3 (es) | 2018-11-13 | 2022-05-19 | Onward Medical N V | Sistema de control para la reconstrucción y/o restauración del movimiento de un paciente |
| EP3695878B1 (en) | 2019-02-12 | 2023-04-19 | ONWARD Medical N.V. | A system for neuromodulation |
| DE202020005828U1 (de) | 2019-04-11 | 2022-09-06 | BTL Medical Solutions as. | Vorrichtungen zur Schönheitsbehandlung biologischer Strukturen durch Hochfrequenz- und Magnetenergie |
| US12156689B2 (en) | 2019-04-11 | 2024-12-03 | Btl Medical Solutions A.S. | Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy |
| US11918811B2 (en) | 2019-05-06 | 2024-03-05 | Medtronic Sg, Llc | Method and apparatus for multi modal or multiplexed electrical modulation of pain using composite electromagnetic fields |
| CN110262336B (zh) * | 2019-06-18 | 2021-02-02 | 中国科学院自动化研究所 | 电流输出电路及包括其的经颅电刺激设备 |
| KR20220025834A (ko) | 2019-06-26 | 2022-03-03 | 뉴로스팀 테크놀로지스 엘엘씨 | 적응적 회로를 갖는 비침습적 신경 활성화기 |
| US12251560B1 (en) | 2019-08-13 | 2025-03-18 | Cala Health, Inc. | Connection quality determination for wearable neurostimulation systems |
| GB2591429A (en) * | 2019-09-06 | 2021-08-04 | Imp College Innovations Ltd | Apparatus and method |
| US11890468B1 (en) | 2019-10-03 | 2024-02-06 | Cala Health, Inc. | Neurostimulation systems with event pattern detection and classification |
| CA3159295A1 (en) | 2019-11-24 | 2021-05-27 | Douglas Michael Ackermann | Current bias as a control mechanism for electrode operation |
| EP4061476A4 (en) | 2019-11-24 | 2023-12-13 | Presidio Medical, Inc. | Pulse generation and stimulation engine systems |
| DE19211698T1 (de) | 2019-11-27 | 2021-09-02 | Onward Medical B.V. | Neuromodulation system |
| EP3827875B1 (en) | 2019-11-27 | 2023-07-05 | ONWARD Medical N.V. | Neuromodulation system |
| CN110946577A (zh) * | 2019-12-03 | 2020-04-03 | 南京航空航天大学 | 一种采集手臂肌电信号的柔性电路板装置 |
| JP2023506713A (ja) | 2019-12-16 | 2023-02-20 | ニューロスティム テクノロジーズ エルエルシー | 昇圧電荷送達を用いた非侵襲性神経アクティベータ |
| CN111481438A (zh) * | 2020-04-23 | 2020-08-04 | 四川大学华西医院 | 一种治疗脑出血继发性神经损伤的电针仪 |
| US11878167B2 (en) | 2020-05-04 | 2024-01-23 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
| BR112022022112A2 (pt) | 2020-05-04 | 2022-12-13 | Btl Healthcare Technologies As | Dispositivo para tratamento não assistido do paciente |
| US12208266B2 (en) | 2020-05-26 | 2025-01-28 | Research Foundation Of The City University Of New York | Multi-site neuromodulation for treatment of ALS and related disorders |
| KR20220055231A (ko) | 2020-10-26 | 2022-05-03 | 주식회사 에이치엘메디텍 | 능동형 생체이식 경천추 경막외 척수신경 자극을 위한 카테터용 박동성 고주파 자극장치 |
| CA3200200A1 (en) * | 2020-12-03 | 2022-06-09 | REHABILITATION INSTITUTE OF CHICAGO d/b/a Shirley Ryan AbilityLab | Systems and methods for facilitating multisite paired corticospinal-motoneuronal stimulation therapy |
| CA3260012A1 (en) | 2021-10-13 | 2023-04-20 | Btl Medical Solutions A.S. | AESTHETIC TREATMENT DEVICES FOR BIOLOGICAL STRUCTURES USING RADIOFREQUENCY AND MAGNETIC ENERGY |
| US11896816B2 (en) | 2021-11-03 | 2024-02-13 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
| KR102873191B1 (ko) | 2022-02-23 | 2025-10-17 | 충북대학교 산학협력단 | 중뇌수도관 주변 회백질 내 신경세포의 광유전학적 자극을 통한 삼차신경통 저해 방법 |
| KR102805604B1 (ko) | 2022-02-23 | 2025-05-09 | 충북대학교 산학협력단 | 전두대상피질 내 신경세포의 광유전학적 자극을 통한 좌골신경통 억제 방법 |
| CN114886545B (zh) * | 2022-05-07 | 2023-11-28 | 宇寿医疗科技(无锡)有限公司 | 一种同步双极性短脉冲肿瘤消融方法与装置 |
| CN114886546B (zh) * | 2022-05-09 | 2023-11-28 | 宇寿医疗科技(无锡)有限公司 | 一种同步双极性短脉冲肿瘤消融方法与系统 |
| US11986657B2 (en) | 2022-07-01 | 2024-05-21 | Nevro Corp. | Neurostimulation for treating sensory deficits, and associated systems and methods |
| CN117679636B (zh) * | 2023-12-25 | 2025-11-28 | 东南大学 | 一种抑郁症穿戴式颅内荷电弥散电刺激装置 |
| CN117653908B (zh) * | 2024-01-17 | 2024-05-28 | 湖北文理学院 | 一种基于电刺激的神经肌肉康复设备及其使用方法 |
| CN119113391B (zh) * | 2024-08-28 | 2025-05-06 | 北京领创医谷科技发展有限责任公司 | 向电极施加电流的方法和装置 |
| CN120437491A (zh) * | 2024-11-28 | 2025-08-08 | 西安穹顶医疗科技有限公司 | 极性可调的无创脑深部电刺激系统 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5047005A (en) * | 1987-01-28 | 1991-09-10 | Cadwell Industries, Inc. | Method and apparatus for magnetically stimulating neurons |
| US6839594B2 (en) * | 2001-04-26 | 2005-01-04 | Biocontrol Medical Ltd | Actuation and control of limbs through motor nerve stimulation |
| JP2004321242A (ja) * | 2003-04-21 | 2004-11-18 | Matsushita Electric Works Ltd | 脳脊髄液循環促進装置及び該方法並びにぼけ遅行装置 |
| US7422555B2 (en) * | 2003-12-30 | 2008-09-09 | Jacob Zabara | Systems and methods for therapeutically treating neuro-psychiatric disorders and other illnesses |
| US20060052836A1 (en) * | 2004-09-08 | 2006-03-09 | Kim Daniel H | Neurostimulation system |
| US20060116720A1 (en) * | 2004-12-01 | 2006-06-01 | Penny Knoblich | Method and apparatus for improving renal function |
| US7844340B2 (en) * | 2007-01-31 | 2010-11-30 | Pawlowicz Iii John S | Devices and methods for transcutaneous electrical neural stimulation |
| US7949403B2 (en) * | 2007-02-27 | 2011-05-24 | Accelerated Care Plus Corp. | Electrical stimulation device and method for the treatment of neurological disorders |
-
2011
- 2011-01-24 KR KR1020127027536A patent/KR101866252B1/ko not_active Expired - Fee Related
- 2011-01-24 US US13/635,929 patent/US20130035745A1/en not_active Abandoned
- 2011-01-24 MX MX2012010841A patent/MX2012010841A/es active IP Right Grant
- 2011-01-24 WO PCT/US2011/022283 patent/WO2011119251A2/en not_active Ceased
- 2011-01-24 CN CN201610029272.3A patent/CN105477782B/zh not_active Expired - Fee Related
- 2011-01-24 CA CA2829189A patent/CA2829189A1/en not_active Abandoned
- 2011-01-24 MX MX2015017515A patent/MX350386B/es unknown
- 2011-01-24 CN CN201180025486.9A patent/CN102905757B/zh not_active Expired - Fee Related
- 2011-01-24 JP JP2013501261A patent/JP5726285B2/ja active Active
-
2012
- 2012-09-20 IL IL222033A patent/IL222033A/en not_active IP Right Cessation
-
2015
- 2015-03-31 JP JP2015071611A patent/JP6062990B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20130020669A (ko) | 2013-02-27 |
| JP2015123376A (ja) | 2015-07-06 |
| KR101866252B1 (ko) | 2018-06-11 |
| JP5726285B2 (ja) | 2015-05-27 |
| WO2011119251A3 (en) | 2011-12-22 |
| JP6062990B2 (ja) | 2017-01-18 |
| US20130035745A1 (en) | 2013-02-07 |
| JP2013521979A (ja) | 2013-06-13 |
| WO2011119251A2 (en) | 2011-09-29 |
| IL222033A (en) | 2015-07-30 |
| CN102905757A (zh) | 2013-01-30 |
| MX2012010841A (es) | 2013-01-29 |
| MX350386B (es) | 2017-09-05 |
| CN105477782A (zh) | 2016-04-13 |
| CN105477782B (zh) | 2019-01-04 |
| CN102905757B (zh) | 2016-02-17 |
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