CA2806008C - Arylcyclopropylamine based demethylase inhibitors of lsd1 and their medical use - Google Patents

Arylcyclopropylamine based demethylase inhibitors of lsd1 and their medical use Download PDF

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CA2806008C
CA2806008C CA2806008A CA2806008A CA2806008C CA 2806008 C CA2806008 C CA 2806008C CA 2806008 A CA2806008 A CA 2806008A CA 2806008 A CA2806008 A CA 2806008A CA 2806008 C CA2806008 C CA 2806008C
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compound
trans
phenyl
methyl
amine
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CA2806008A1 (en
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Alberto Ortega Munoz
Matthew Colin Thor Fyfe
Marc Martinell Pedemonte
Inigo Tirapu Fernandez De La Cuesta
Maria De Los Angeles Estiarte-Martinez
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Oryzon Genomics SA
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Oryzon Genomics SA
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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