CA2801922A1 - Multivalent glycopeptide constructs and uses thereof - Google Patents
Multivalent glycopeptide constructs and uses thereof Download PDFInfo
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- CA2801922A1 CA2801922A1 CA2801922A CA2801922A CA2801922A1 CA 2801922 A1 CA2801922 A1 CA 2801922A1 CA 2801922 A CA2801922 A CA 2801922A CA 2801922 A CA2801922 A CA 2801922A CA 2801922 A1 CA2801922 A1 CA 2801922A1
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- glycopeptide
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- carbohydrate
- cancer
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Classifications
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- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001169—Tumor associated carbohydrates
- A61K39/001171—Gangliosides, e.g. GM2, GD2 or GD3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
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- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/US2011/040074 WO2011156774A2 (en) | 2010-06-11 | 2011-06-10 | Multivalent glycopeptide constructs and uses thereof |
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| CA2801922A1 true CA2801922A1 (en) | 2011-12-15 |
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| ATE325803T1 (de) | 1999-08-20 | 2006-06-15 | Sloan Kettering Inst Cancer | Glycokonjugate, glycoaminosäure, deren zwischenprodukte, und ihre verwendung |
| WO2010006343A2 (en) | 2008-07-11 | 2010-01-14 | Sloan-Kettering Institute For Cancer Research | Glycopeptide constructs and uses thereof |
| US8900635B2 (en) | 2010-11-15 | 2014-12-02 | Humanetics Corporation | Nanoparticle isoflavone compositions and methods of making and using the same |
| MX2015004171A (es) * | 2012-10-02 | 2015-10-22 | Glaxosmithkline Biolog Sa | Conjugados de sacaridos no lineales. |
| CA2897084C (en) * | 2013-01-04 | 2019-07-16 | Cheng Der Tony Yu | Vaccines with higher carbohydrate antigen density and novel saponin adjuvant |
| EP3046588B1 (en) * | 2013-09-17 | 2022-03-02 | OBI Pharma, Inc. | Compositions of a carbohydrate vaccine for inducing immune responses and uses thereof in cancer treatment |
| WO2015048408A1 (en) * | 2013-09-27 | 2015-04-02 | Virginia Tech Intellectual Properties, Inc. | Cross-metathesized polysaccharide derivatives and processes for preparing them |
| US9084726B2 (en) * | 2013-11-26 | 2015-07-21 | Humanetics Corporation | Suspension compositions of physiologically active phenolic compounds and methods of making and using the same |
| PL3116887T3 (pl) | 2014-03-13 | 2021-09-06 | Universität Basel | Ligandy węglowodanowe, które wiążą się z przeciwciałami igm przeciwko glikoproteinie związanej z mieliną |
| WO2015139029A2 (en) | 2014-03-14 | 2015-09-17 | Virginia Tech Intellectual Properties, Inc. | Polysaccharide derivatives and cross-metathesis processes for preparing them |
| TW201622743A (zh) | 2014-03-19 | 2016-07-01 | 財團法人臺灣基督長老教會馬偕紀念社會事業基金會馬偕紀念醫院 | 免疫原醣肽、包含該醣肽之組合物及其用途 |
| JP6590474B2 (ja) * | 2014-09-25 | 2019-10-16 | 国立大学法人埼玉大学 | 化学架橋ペプチドの作製方法、その方法を用いて作製した化学架橋ペプチド及びそのペプチドを用いて構築したｃＤＮＡディスプレイ法によるペプチドライブラリ |
| EP3344806A4 (en) * | 2015-09-04 | 2019-03-20 | OBI Pharma, Inc. | GLYCANARRAYS AND METHOD OF USE |
| CN108026134A (zh) * | 2015-09-16 | 2018-05-11 | 巴塞尔大学 | 结合抗糖鞘脂糖蛋白表位抗体的碳水化合物配体 |
| AU2017239637A1 (en) | 2016-03-29 | 2018-11-15 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| IL262296B2 (en) | 2016-04-22 | 2024-09-01 | Obi Pharma Inc | Cancer immunotherapy by immune activation or immune modulation via globo series antigens |
| KR20190067765A (ko) | 2016-07-27 | 2019-06-17 | 오비아이 파머 인코퍼레이티드 | 면역원성/치료 글리칸 조성물 및 그의 용도 |
| KR102528998B1 (ko) | 2016-07-29 | 2023-05-03 | 오비아이 파머 인코퍼레이티드 | 인간 항체, 제약 조성물 및 방법 |
| WO2018094414A1 (en) | 2016-11-21 | 2018-05-24 | Obi Pharma, Inc. | Conjugated biological molecules, pharmaceutical compositions and methods |
| TW202504930A (zh) | 2018-06-27 | 2025-02-01 | 台灣浩鼎生技股份有限公司 | 用於糖蛋白工程的糖苷合成酶變體及其使用方法 |
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| JPS5576894A (en) | 1978-12-05 | 1980-06-10 | Towa Kasei Kogyo Kk | Epimerization of aldose |
| ES2097840T3 (es) | 1987-11-03 | 1997-04-16 | Syntex Inc | Adyuvante de vacuna que comprende un tetrapoliol. |
| US6303120B1 (en) | 1994-03-15 | 2001-10-16 | Memorial Sloan-Kettering Institute For Cancer Research | Synthesis of glycoconjugates of the lewis y epitope and uses thereof |
| US5708163A (en) | 1994-03-15 | 1998-01-13 | Sloan-Kettering Institute Of Cancer Research | Synthesis of the breast tumor-associated antigen defined by monoclonalantibody MBRL and uses thereof |
| US6184344B1 (en) | 1995-05-04 | 2001-02-06 | The Scripps Research Institute | Synthesis of proteins by native chemical ligation |
| CA2277867A1 (en) | 1997-01-13 | 1998-07-16 | Sloan-Kettering Institute For Cancer Research | Colon cancer kh-1 and n3 antigens |
| EP0996455B1 (en) | 1997-04-16 | 2009-12-16 | Sloan-Kettering Institute For Cancer Research | Alpha-o-linked glycoconjugates with clustered (2,6)-st epitopes, methods of preparation and uses thereof |
| US7550146B2 (en) | 1997-04-16 | 2009-06-23 | Sloan-Kettering Institute For Cancer Research | Glycopeptide conjugates and uses thereof |
| US6080725A (en) | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| NZ500779A (en) | 1997-05-20 | 2001-06-29 | Galenica Pharmaceuticals Inc | Triterpene saponin analogs having adjuvant and immunostimulatory activity |
| JPH1135594A (ja) | 1997-07-24 | 1999-02-09 | Meiji Milk Prod Co Ltd | ムチン型糖鎖合成中間体 |
| AU745555B2 (en) | 1997-09-25 | 2002-03-21 | Sloan-Kettering Institute For Cancer Research | Fucosyl GM1-KLH conjugate vaccine against small cell lung cancer |
| DE19802748A1 (de) | 1998-01-26 | 1999-07-29 | Chemtec Leuna Ges Fuer Chemie | Verfahren zur enzymatischen Synthese von Glycoaminosäurederivaten |
| US7018637B2 (en) | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
| EP1091751A4 (en) | 1998-03-25 | 2005-01-19 | Sloan Kettering Institutefor C | TRIMERIC OXYGENIC BINDING GLYCOPEPTIDE CONJUGATES, METHODS OF PREPARATION AND USE THEREOF |
| WO1999061916A1 (en) | 1998-05-29 | 1999-12-02 | Epimmune, Inc. | Identification of broadly reactive dr restricted epitopes |
| US7854934B2 (en) * | 1999-08-20 | 2010-12-21 | Sloan-Kettering Institute For Cancer Research | Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof |
| ATE325803T1 (de) | 1999-08-20 | 2006-06-15 | Sloan Kettering Inst Cancer | Glycokonjugate, glycoaminosäure, deren zwischenprodukte, und ihre verwendung |
| US7824687B2 (en) | 1999-08-20 | 2010-11-02 | Sloan-Kettering Institute For Cancer Research | Clustered multi-antigenic carbohydrate constructs, methods for their preparation, and uses thereof |
| US7118737B2 (en) | 2000-09-08 | 2006-10-10 | Amylin Pharmaceuticals, Inc. | Polymer-modified synthetic proteins |
| WO2003003985A2 (en) * | 2001-07-06 | 2003-01-16 | Sloan-Kettering Institute For Cancer Research | Polyvalent conjugate vaccine for cancer |
| WO2004050711A2 (en) | 2002-12-03 | 2004-06-17 | Sloan-Kettering Institute For Cancer Research | Gp120 specific antigens, conjugates thereof, methods for their preparation and uses thereof |
| WO2004060915A2 (en) | 2002-12-03 | 2004-07-22 | Sloan-Kettering Institute For Cancer Research | Prostate specific antigens, conjugates thereof, methods for their preparation and uses thereof. |
| JP2007527864A (ja) | 2003-09-05 | 2007-10-04 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | 自然に起こる化学的連結による、多官能化ペプチドおよび／またはタンパク質の調製方法 |
| WO2007079448A2 (en) | 2006-01-03 | 2007-07-12 | University Of Georgia Research Foundation, Inc. | Three component carbohydrate vaccine |
| AU2007258550B2 (en) | 2006-06-08 | 2013-09-19 | University Of Georgia Research Foundation, Inc. | Liposome-mediated native chemical ligation |
| JP2011524375A (ja) * | 2008-06-16 | 2011-09-01 | アカデミア シニカ | ＧｌｏｂｏＨおよびＳＳＥＡ３に特異的な免疫反応を誘起する組成物および癌治療におけるその使用 |
| WO2010006343A2 (en) * | 2008-07-11 | 2010-01-14 | Sloan-Kettering Institute For Cancer Research | Glycopeptide constructs and uses thereof |
-
2011
- 2011-06-10 CA CA2801922A patent/CA2801922A1/en not_active Abandoned
- 2011-06-10 US US13/703,563 patent/US9493580B2/en not_active Expired - Fee Related
- 2011-06-10 EP EP11793286.3A patent/EP2579893A4/en not_active Withdrawn
- 2011-06-10 AU AU2011265184A patent/AU2011265184B2/en not_active Ceased
- 2011-06-10 JP JP2013514400A patent/JP6050227B2/ja not_active Expired - Fee Related
- 2011-06-10 NZ NZ604089A patent/NZ604089A/en not_active IP Right Cessation
- 2011-06-10 WO PCT/US2011/040074 patent/WO2011156774A2/en not_active Ceased
- 2011-06-10 CN CN2011800392591A patent/CN103108654A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US9493580B2 (en) | 2016-11-15 |
| AU2011265184B2 (en) | 2016-08-04 |
| JP6050227B2 (ja) | 2016-12-21 |
| WO2011156774A3 (en) | 2012-04-19 |
| EP2579893A2 (en) | 2013-04-17 |
| WO2011156774A2 (en) | 2011-12-15 |
| US20130095173A1 (en) | 2013-04-18 |
| CN103108654A (zh) | 2013-05-15 |
| NZ604089A (en) | 2015-03-27 |
| AU2011265184A1 (en) | 2013-01-10 |
| EP2579893A4 (en) | 2014-01-01 |
| JP2013528229A (ja) | 2013-07-08 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20160608 |
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| FZDE | Discontinued |
Effective date: 20181019 |