CA2801922A1 - Multivalent glycopeptide constructs and uses thereof - Google Patents
Multivalent glycopeptide constructs and uses thereof Download PDFInfo
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- CA2801922A1 CA2801922A1 CA2801922A CA2801922A CA2801922A1 CA 2801922 A1 CA2801922 A1 CA 2801922A1 CA 2801922 A CA2801922 A CA 2801922A CA 2801922 A CA2801922 A CA 2801922A CA 2801922 A1 CA2801922 A1 CA 2801922A1
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- glycopeptide
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- carbohydrate
- cancer
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Classifications
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- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001169—Tumor associated carbohydrates
- A61K39/001171—Gangliosides, e.g. GM2, GD2 or GD3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Molecular Biology (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
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| PCT/US2011/040074 WO2011156774A2 (en) | 2010-06-11 | 2011-06-10 | Multivalent glycopeptide constructs and uses thereof |
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| HK1048819B (en) | 1999-08-20 | 2006-11-10 | Sloan-Kettering Institute For Cancer Research | Glycoconjugates, glycoamino, acids, intermediates thereto, and uses thereof |
| AU2009268349C1 (en) | 2008-07-11 | 2015-01-22 | Sloan-Kettering Institute For Cancer Research | Glycopeptide constructs and uses thereof |
| US8900635B2 (en) | 2010-11-15 | 2014-12-02 | Humanetics Corporation | Nanoparticle isoflavone compositions and methods of making and using the same |
| KR20150060986A (ko) * | 2012-10-02 | 2015-06-03 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 비선형 사카라이드 컨주게이트 |
| CN111499679B (zh) * | 2013-01-04 | 2021-07-06 | 台湾浩鼎生技股份有限公司 | 具有较高碳水化合物抗原密度的疫苗及新颖皂素佐剂 |
| HK1222569A1 (zh) * | 2013-09-17 | 2017-07-07 | Obi Pharma, Inc. | 用於诱导免疫反应的糖疫苗组合物及其治疗癌症的用途 |
| WO2015048408A1 (en) * | 2013-09-27 | 2015-04-02 | Virginia Tech Intellectual Properties, Inc. | Cross-metathesized polysaccharide derivatives and processes for preparing them |
| US9084726B2 (en) | 2013-11-26 | 2015-07-21 | Humanetics Corporation | Suspension compositions of physiologically active phenolic compounds and methods of making and using the same |
| ES2865148T3 (es) | 2014-03-13 | 2021-10-15 | Univ Basel | Ligandos de carbohidratos que se unen a los anticuerpos IgM contra la glucoproteína asociada a mielina |
| US10851179B2 (en) | 2014-03-14 | 2020-12-01 | Virginia Tech Intellectual Properties, Inc. | Polysaccharide derivatives and cross-metathesis processes for preparing them |
| US20170143810A1 (en) | 2014-03-19 | 2017-05-25 | Mackay Medical Foundation The Presbyterian Church In Taiwan Mackay Memorial Hospital | Immunogenic glycopeptides, composition comprising the glycopeptides and use thereof |
| JP6590474B2 (ja) * | 2014-09-25 | 2019-10-16 | 国立大学法人埼玉大学 | 化学架橋ペプチドの作製方法、その方法を用いて作製した化学架橋ペプチド及びそのペプチドを用いて構築したｃＤＮＡディスプレイ法によるペプチドライブラリ |
| AR105910A1 (es) * | 2015-09-04 | 2017-11-22 | Obi Pharma Inc | Matrices de glicano y método de uso |
| HK1252262A1 (zh) | 2015-09-16 | 2019-05-24 | 巴塞尔大学 | 结合抗糖鞘脂糖蛋白表位抗体的碳水化合物配体 |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| BR112018070097A2 (pt) | 2016-03-29 | 2019-02-12 | Obi Pharma, Inc. | anticorpo, hibridoma, composição farmacêutica, método para tratar câncer em um indivíduo, método para inibir a proliferação de células cancerígenas, método para diagnosticar o câncer em um indivíduo, método para tratar um paciente humano, método para fazer imagens de um indivíduo, conjugado de fármaco-anticorpo (adc), método para tratar câncer, anticorpo biespecífico e método para preparar uma população de anticorpos homogêneos |
| TWI697333B (zh) | 2016-04-22 | 2020-07-01 | 台灣浩鼎生技股份有限公司 | 經由Globo系列抗原之免疫活化或免疫調節之癌症免疫療法 |
| JP2019527690A (ja) * | 2016-07-27 | 2019-10-03 | オービーアイ ファーマ，インコーポレイテッド | 免疫原性／治療用グリカン組成物およびその使用 |
| JP7121724B2 (ja) | 2016-07-29 | 2022-08-18 | オービーアイ ファーマ，インコーポレイテッド | ヒト抗体、医薬組成物及び方法 |
| WO2018094414A1 (en) | 2016-11-21 | 2018-05-24 | Obi Pharma, Inc. | Conjugated biological molecules, pharmaceutical compositions and methods |
| WO2020006176A1 (en) | 2018-06-27 | 2020-01-02 | Obi Pharma, Inc. | Glycosynthase variants for glycoprotein engineering and methods of use |
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| JPS5576894A (en) | 1978-12-05 | 1980-06-10 | Towa Kasei Kogyo Kk | Epimerization of aldose |
| ZA888209B (en) | 1987-11-03 | 1990-07-25 | Syntex Inc | Vaccine adjuvant |
| US5708163A (en) | 1994-03-15 | 1998-01-13 | Sloan-Kettering Institute Of Cancer Research | Synthesis of the breast tumor-associated antigen defined by monoclonalantibody MBRL and uses thereof |
| US6303120B1 (en) | 1994-03-15 | 2001-10-16 | Memorial Sloan-Kettering Institute For Cancer Research | Synthesis of glycoconjugates of the lewis y epitope and uses thereof |
| US6184344B1 (en) | 1995-05-04 | 2001-02-06 | The Scripps Research Institute | Synthesis of proteins by native chemical ligation |
| CA2277867A1 (en) | 1997-01-13 | 1998-07-16 | Sloan-Kettering Institute For Cancer Research | Colon cancer kh-1 and n3 antigens |
| US7550146B2 (en) | 1997-04-16 | 2009-06-23 | Sloan-Kettering Institute For Cancer Research | Glycopeptide conjugates and uses thereof |
| WO1998046246A1 (en) | 1997-04-16 | 1998-10-22 | Sloan-Kettering Institute For Cancer Research | α-O-LINKED GLYCOCONJUGATES WITH CLUSTERED (2,6)-ST EPITOPES, METHODS OF PREPARATION AND USES THEREOF |
| US6080725A (en) | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| EP0996451B1 (en) | 1997-05-20 | 2005-01-05 | Galenica Pharmaceuticals, Inc. | Triterpene saponin analogs having adjuvant and immunostimulatory activity |
| JPH1135594A (ja) | 1997-07-24 | 1999-02-09 | Meiji Milk Prod Co Ltd | ムチン型糖鎖合成中間体 |
| CA2304599A1 (en) | 1997-09-25 | 1999-04-01 | Sloan-Kettering Institute For Cancer Research | Fucosyl gm1-klh conjugate vaccine against small cell lung cancer |
| DE19802748A1 (de) | 1998-01-26 | 1999-07-29 | Chemtec Leuna Ges Fuer Chemie | Verfahren zur enzymatischen Synthese von Glycoaminosäurederivaten |
| US7018637B2 (en) | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
| EP1091751A4 (en) | 1998-03-25 | 2005-01-19 | Sloan Kettering Institutefor C | TRIMERIC OXYGENIC BINDING GLYCOPEPTIDE CONJUGATES, METHODS OF PREPARATION AND USE THEREOF |
| CA2332786A1 (en) | 1998-05-29 | 1999-12-02 | Epimmune Inc. | Identification of broadly reactive dr restricted epitopes |
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| US7824687B2 (en) | 1999-08-20 | 2010-11-02 | Sloan-Kettering Institute For Cancer Research | Clustered multi-antigenic carbohydrate constructs, methods for their preparation, and uses thereof |
| HK1048819B (en) | 1999-08-20 | 2006-11-10 | Sloan-Kettering Institute For Cancer Research | Glycoconjugates, glycoamino, acids, intermediates thereto, and uses thereof |
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| WO2004060915A2 (en) | 2002-12-03 | 2004-07-22 | Sloan-Kettering Institute For Cancer Research | Prostate specific antigens, conjugates thereof, methods for their preparation and uses thereof. |
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| AU2009268349C1 (en) * | 2008-07-11 | 2015-01-22 | Sloan-Kettering Institute For Cancer Research | Glycopeptide constructs and uses thereof |
-
2011
- 2011-06-10 NZ NZ604089A patent/NZ604089A/en not_active IP Right Cessation
- 2011-06-10 JP JP2013514400A patent/JP6050227B2/ja not_active Expired - Fee Related
- 2011-06-10 CA CA2801922A patent/CA2801922A1/en not_active Abandoned
- 2011-06-10 CN CN2011800392591A patent/CN103108654A/zh active Pending
- 2011-06-10 WO PCT/US2011/040074 patent/WO2011156774A2/en not_active Ceased
- 2011-06-10 AU AU2011265184A patent/AU2011265184B2/en not_active Ceased
- 2011-06-10 US US13/703,563 patent/US9493580B2/en not_active Expired - Fee Related
- 2011-06-10 EP EP11793286.3A patent/EP2579893A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN103108654A (zh) | 2013-05-15 |
| JP2013528229A (ja) | 2013-07-08 |
| AU2011265184B2 (en) | 2016-08-04 |
| EP2579893A2 (en) | 2013-04-17 |
| US9493580B2 (en) | 2016-11-15 |
| EP2579893A4 (en) | 2014-01-01 |
| WO2011156774A3 (en) | 2012-04-19 |
| JP6050227B2 (ja) | 2016-12-21 |
| WO2011156774A2 (en) | 2011-12-15 |
| AU2011265184A1 (en) | 2013-01-10 |
| US20130095173A1 (en) | 2013-04-18 |
| NZ604089A (en) | 2015-03-27 |
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