AU2011265184B2 - Multivalent glycopeptide constructs and uses thereof - Google Patents

Multivalent glycopeptide constructs and uses thereof Download PDF

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Publication number
AU2011265184B2
AU2011265184B2 AU2011265184A AU2011265184A AU2011265184B2 AU 2011265184 B2 AU2011265184 B2 AU 2011265184B2 AU 2011265184 A AU2011265184 A AU 2011265184A AU 2011265184 A AU2011265184 A AU 2011265184A AU 2011265184 B2 AU2011265184 B2 AU 2011265184B2
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AU
Australia
Prior art keywords
cancer
carbamate
certain embodiments
carbohydrate
patients
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2011265184A
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English (en)
Other versions
AU2011265184A1 (en
Inventor
Samuel J. Danishefsky
Karthik Iyer
Philip O. Livingston
Govind Ragupathi
David R. Spriggs
Guangbin Yang
Jianglong Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memorial Sloan Kettering Cancer Center
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of AU2011265184A1 publication Critical patent/AU2011265184A1/en
Application granted granted Critical
Publication of AU2011265184B2 publication Critical patent/AU2011265184B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/001171—Gangliosides, e.g. GM2, GD2 or GD3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2011265184A 2010-06-11 2011-06-10 Multivalent glycopeptide constructs and uses thereof Ceased AU2011265184B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35372210P 2010-06-11 2010-06-11
US61/353,722 2010-06-11
PCT/US2011/040074 WO2011156774A2 (en) 2010-06-11 2011-06-10 Multivalent glycopeptide constructs and uses thereof

Publications (2)

Publication Number Publication Date
AU2011265184A1 AU2011265184A1 (en) 2013-01-10
AU2011265184B2 true AU2011265184B2 (en) 2016-08-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011265184A Ceased AU2011265184B2 (en) 2010-06-11 2011-06-10 Multivalent glycopeptide constructs and uses thereof

Country Status (8)

Country Link
US (1) US9493580B2 (enExample)
EP (1) EP2579893A4 (enExample)
JP (1) JP6050227B2 (enExample)
CN (1) CN103108654A (enExample)
AU (1) AU2011265184B2 (enExample)
CA (1) CA2801922A1 (enExample)
NZ (1) NZ604089A (enExample)
WO (1) WO2011156774A2 (enExample)

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US9598466B2 (en) 2008-07-11 2017-03-21 Sloan-Kettering Institute For Cancer Research Glycopeptide constructs and uses thereof
US8900635B2 (en) 2010-11-15 2014-12-02 Humanetics Corporation Nanoparticle isoflavone compositions and methods of making and using the same
BR112015007126A2 (pt) * 2012-10-02 2017-08-08 Glaxosmithkline Biologicals Sa composição, método para induzir uma resposta imune, e, uso de uma composição
CN111499679B (zh) * 2013-01-04 2021-07-06 台湾浩鼎生技股份有限公司 具有较高碳水化合物抗原密度的疫苗及新颖皂素佐剂
NZ714555A (en) 2013-09-17 2020-03-27 Obi Pharma Inc Compositions of a carbohydrate vaccine for inducing immune responses and uses thereof in cancer treatment
WO2015048408A1 (en) * 2013-09-27 2015-04-02 Virginia Tech Intellectual Properties, Inc. Cross-metathesized polysaccharide derivatives and processes for preparing them
US9084726B2 (en) * 2013-11-26 2015-07-21 Humanetics Corporation Suspension compositions of physiologically active phenolic compounds and methods of making and using the same
RU2760005C2 (ru) 2014-03-13 2021-11-22 Университет Базель УГЛЕВОДНЫЕ ЛИГАНДЫ, КОТОРЫЕ СВЯЗЫВАЮТСЯ С IgM АНТИТЕЛАМИ ПРОТИВ МИЕЛИН-АССОЦИИРОВАННОГО ГЛИКОПРОТЕИНА
WO2015139029A2 (en) 2014-03-14 2015-09-17 Virginia Tech Intellectual Properties, Inc. Polysaccharide derivatives and cross-metathesis processes for preparing them
TWI681972B (zh) 2014-03-19 2020-01-11 財團法人臺灣基督長老教會馬偕紀念社會事業基金會馬偕紀念醫院 抗免疫原性醣肽之抗體，包含彼等之組合物及其用途
JP6590474B2 (ja) * 2014-09-25 2019-10-16 国立大学法人埼玉大学 化学架橋ペプチドの作製方法、その方法を用いて作製した化学架橋ペプチド及びそのペプチドを用いて構築したｃＤＮＡディスプレイ法によるペプチドライブラリ
AR105910A1 (es) 2015-09-04 2017-11-22 Obi Pharma Inc Matrices de glicano y método de uso
AU2016323377B2 (en) 2015-09-16 2021-04-15 Universität Basel Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
EP3436482A4 (en) 2016-03-29 2020-03-11 OBI Pharma, Inc. ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS
CA3021548A1 (en) 2016-04-22 2017-10-26 Obi Pharma, Inc. Cancer immunotherapy by immune activation or immune modulation via globo series antigens
WO2018022933A1 (en) 2016-07-27 2018-02-01 Obi Pharma, Inc. Immunogenic/therapeutic glycan compositions and uses thereof
KR102528998B1 (ko) 2016-07-29 2023-05-03 오비아이 파머 인코퍼레이티드 인간 항체, 제약 조성물 및 방법
CN110290800A (zh) 2016-11-21 2019-09-27 台湾浩鼎生技股份有限公司 缀合生物分子、医药组合物及方法
WO2020006176A1 (en) 2018-06-27 2020-01-02 Obi Pharma, Inc. Glycosynthase variants for glycoprotein engineering and methods of use

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WO2010006343A2 (en) * 2008-07-11 2010-01-14 Sloan-Kettering Institute For Cancer Research Glycopeptide constructs and uses thereof

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Patent Citations (2)

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US20030153492A1 (en) * 1999-08-20 2003-08-14 Danishefsky Samuel J. Novel glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof
WO2010006343A2 (en) * 2008-07-11 2010-01-14 Sloan-Kettering Institute For Cancer Research Glycopeptide constructs and uses thereof

Also Published As

Publication number Publication date
EP2579893A4 (en) 2014-01-01
WO2011156774A3 (en) 2012-04-19
AU2011265184A1 (en) 2013-01-10
US20130095173A1 (en) 2013-04-18
JP6050227B2 (ja) 2016-12-21
WO2011156774A2 (en) 2011-12-15
NZ604089A (en) 2015-03-27
CA2801922A1 (en) 2011-12-15
CN103108654A (zh) 2013-05-15
EP2579893A2 (en) 2013-04-17
JP2013528229A (ja) 2013-07-08
US9493580B2 (en) 2016-11-15

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Legal Events

Date Code Title Description
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ DANISHEFSKY, SAMUEL J.; RAGUPATHI, GOVIND; LIVINGSTON, PHILIP O.; ZHU, JIANGLONG; IYAMENDMENTS ER, KARTHIK; YANG, GUANGBIN AND SPRIGGS, DAVID R. .

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ DANISHEFSKY, SAMUEL J.; RAGUPATHI, GOVIND; LIVINGSTON, PHILIP O.; ZHU, JIANGLONG; IYER, KARTHIK; YANG, GUANGBIN AND SPRIGGS, DAVID R.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired