CA2799969C - Degradable clostridial toxins - Google Patents

Degradable clostridial toxins Download PDF

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Publication number
CA2799969C
CA2799969C CA2799969A CA2799969A CA2799969C CA 2799969 C CA2799969 C CA 2799969C CA 2799969 A CA2799969 A CA 2799969A CA 2799969 A CA2799969 A CA 2799969A CA 2799969 C CA2799969 C CA 2799969C
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CA
Canada
Prior art keywords
seq
bont
domain
clostridial toxin
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2799969A
Other languages
English (en)
French (fr)
Other versions
CA2799969A1 (en
Inventor
Lance E. Steward
Sanjiv Ghanshani
Ester Fernandez-Salas
Marcella A. Gilmore
Joseph Francis
Kei Roger Aoki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of CA2799969A1 publication Critical patent/CA2799969A1/en
Application granted granted Critical
Publication of CA2799969C publication Critical patent/CA2799969C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
CA2799969A 2010-05-20 2011-05-19 Degradable clostridial toxins Expired - Fee Related CA2799969C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34657810P 2010-05-20 2010-05-20
US61/346,578 2010-05-20
PCT/US2011/037131 WO2011146704A1 (en) 2010-05-20 2011-05-19 Degradable clostridial toxins

Publications (2)

Publication Number Publication Date
CA2799969A1 CA2799969A1 (en) 2011-11-24
CA2799969C true CA2799969C (en) 2019-06-25

Family

ID=44484018

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2799969A Expired - Fee Related CA2799969C (en) 2010-05-20 2011-05-19 Degradable clostridial toxins

Country Status (21)

Country Link
US (13) US8512992B2 (de)
EP (3) EP2650003B1 (de)
JP (4) JP6148979B2 (de)
KR (4) KR102164166B1 (de)
CN (1) CN103228286B (de)
AR (1) AR081407A1 (de)
AU (1) AU2011255525B2 (de)
BR (1) BR112012029666A2 (de)
CA (1) CA2799969C (de)
DK (3) DK2571509T3 (de)
ES (3) ES2600463T3 (de)
HK (1) HK1180592A1 (de)
IL (1) IL223100B (de)
MX (2) MX2012013381A (de)
NZ (2) NZ703378A (de)
RU (1) RU2561465C2 (de)
SG (2) SG10201506567UA (de)
TW (1) TWI516594B (de)
UA (1) UA108646C2 (de)
WO (1) WO2011146704A1 (de)
ZA (1) ZA201208753B (de)

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Also Published As

Publication number Publication date
EP3106170B1 (de) 2020-04-08
US20160201046A1 (en) 2016-07-14
US8697413B2 (en) 2014-04-15
US20140227740A1 (en) 2014-08-14
DK2650003T3 (da) 2016-11-28
US20130196414A1 (en) 2013-08-01
ES2596128T3 (es) 2017-01-05
US10501731B2 (en) 2019-12-10
US20180119126A1 (en) 2018-05-03
HK1180592A1 (zh) 2013-10-25
WO2011146704A1 (en) 2011-11-24
EP2571509A1 (de) 2013-03-27
DK3106170T3 (da) 2020-07-13
US20130288334A1 (en) 2013-10-31
MX369263B (es) 2019-11-04
JP6467000B2 (ja) 2019-02-06
JP2013529213A (ja) 2013-07-18
US9284545B2 (en) 2016-03-15
SG10201506567UA (en) 2015-10-29
IL223100A0 (en) 2013-02-03
EP3106170A1 (de) 2016-12-21
US20130330807A1 (en) 2013-12-12
EP2571509B1 (de) 2016-07-06
US20240018500A1 (en) 2024-01-18
US20200190496A1 (en) 2020-06-18
ZA201208753B (en) 2013-09-25
KR20130054967A (ko) 2013-05-27
US20140127783A1 (en) 2014-05-08
ES2600463T3 (es) 2017-02-09
RU2012154862A (ru) 2014-06-27
CA2799969A1 (en) 2011-11-24
RU2561465C2 (ru) 2015-08-27
JP6220830B2 (ja) 2017-10-25
US9279116B2 (en) 2016-03-08
JP2015193669A (ja) 2015-11-05
KR20190010720A (ko) 2019-01-30
UA108646C2 (xx) 2015-05-25
US20130273633A1 (en) 2013-10-17
US20140220627A1 (en) 2014-08-07
US20110287517A1 (en) 2011-11-24
US9297003B2 (en) 2016-03-29
TW201142026A (en) 2011-12-01
KR20200118234A (ko) 2020-10-14
US8685693B2 (en) 2014-04-01
ES2813650T3 (es) 2021-03-24
JP6644177B2 (ja) 2020-02-12
US9850476B2 (en) 2017-12-26
KR102164166B1 (ko) 2020-10-13
BR112012029666A2 (pt) 2020-10-06
SG185663A1 (en) 2012-12-28
MX2012013381A (es) 2013-02-21
EP2650003A1 (de) 2013-10-16
IL223100B (en) 2018-02-28
KR102321664B1 (ko) 2021-11-04
EP2650003B1 (de) 2016-07-27
JP6148979B2 (ja) 2017-06-14
KR20210132753A (ko) 2021-11-04
AU2011255525A1 (en) 2012-12-20
NZ703378A (en) 2016-10-28
NZ604322A (en) 2015-01-30
DK2571509T3 (en) 2016-10-24
US8697414B2 (en) 2014-04-15
TWI516594B (zh) 2016-01-11
KR101942106B1 (ko) 2019-01-25
US8685692B2 (en) 2014-04-01
CN103228286A (zh) 2013-07-31
AR081407A1 (es) 2012-08-29
US20130330806A1 (en) 2013-12-12
US8841111B2 (en) 2014-09-23
AU2011255525B2 (en) 2015-09-10
CN103228286B (zh) 2018-01-02
JP2018012696A (ja) 2018-01-25
JP2019088296A (ja) 2019-06-13
US8512992B2 (en) 2013-08-20

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