CA2789115C - Microporation of tissue for delivery of bioactive agents - Google Patents
Microporation of tissue for delivery of bioactive agents Download PDFInfo
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- CA2789115C CA2789115C CA2789115A CA2789115A CA2789115C CA 2789115 C CA2789115 C CA 2789115C CA 2789115 A CA2789115 A CA 2789115A CA 2789115 A CA2789115 A CA 2789115A CA 2789115 C CA2789115 C CA 2789115C
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- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00137—Details of operation mode
- A61B2017/00154—Details of operation mode pulsed
- A61B2017/00172—Pulse trains, bursts, intermittent continuous operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Optics & Photonics (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Medicinal Preparation (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Electrotherapy Devices (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Laser Surgery Devices (AREA)
- Surgical Instruments (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77841596A | 1996-12-31 | 1996-12-31 | |
| US08/778,415 | 1996-12-31 | ||
| PCT/US1997/011670 WO1998000193A1 (en) | 1996-07-03 | 1997-07-03 | Multiple mechanical microporation of skin or mucosa |
| WOPCT/US97/11670 | 1997-07-03 | ||
| CA2276312A CA2276312C (en) | 1996-12-31 | 1997-12-30 | Microporation of tissue for delivery of bioactive agents |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2276312A Division CA2276312C (en) | 1996-12-31 | 1997-12-30 | Microporation of tissue for delivery of bioactive agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2789115A1 CA2789115A1 (en) | 1998-07-09 |
| CA2789115C true CA2789115C (en) | 2014-04-29 |
Family
ID=25113276
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2789115A Expired - Lifetime CA2789115C (en) | 1996-12-31 | 1997-12-30 | Microporation of tissue for delivery of bioactive agents |
| CA2276312A Expired - Lifetime CA2276312C (en) | 1996-12-31 | 1997-12-30 | Microporation of tissue for delivery of bioactive agents |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2276312A Expired - Lifetime CA2276312C (en) | 1996-12-31 | 1997-12-30 | Microporation of tissue for delivery of bioactive agents |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP0952850A2 (enExample) |
| JP (5) | JP2001512329A (enExample) |
| AT (1) | ATE365026T1 (enExample) |
| AU (1) | AU5623298A (enExample) |
| CA (2) | CA2789115C (enExample) |
| DE (1) | DE69737836T2 (enExample) |
| DK (1) | DK1314400T3 (enExample) |
| ES (1) | ES2289192T3 (enExample) |
| WO (1) | WO1998029134A2 (enExample) |
Families Citing this family (106)
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| US20060002949A1 (en) | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
| US6797276B1 (en) | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
| US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
| US6517532B1 (en) | 1997-05-15 | 2003-02-11 | Palomar Medical Technologies, Inc. | Light energy delivery head |
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| US6173202B1 (en) | 1998-03-06 | 2001-01-09 | Spectrx, Inc. | Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue |
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| JP2005504002A (ja) | 2001-02-13 | 2005-02-10 | ガバメント オブ ザ ユナイテッド ステイツ、 アズ リプリゼンティッド バイ ザ セクレタリィ オブ ジ アーミイ | 経皮免疫感作のためのワクチン |
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-
1997
- 1997-12-30 AT AT03002035T patent/ATE365026T1/de active
- 1997-12-30 CA CA2789115A patent/CA2789115C/en not_active Expired - Lifetime
- 1997-12-30 DK DK03002035T patent/DK1314400T3/da active
- 1997-12-30 ES ES03002035T patent/ES2289192T3/es not_active Expired - Lifetime
- 1997-12-30 EP EP97952676A patent/EP0952850A2/en not_active Ceased
- 1997-12-30 DE DE69737836T patent/DE69737836T2/de not_active Expired - Lifetime
- 1997-12-30 AU AU56232/98A patent/AU5623298A/en not_active Abandoned
- 1997-12-30 EP EP03002035A patent/EP1314400B1/en not_active Expired - Lifetime
- 1997-12-30 WO PCT/US1997/024127 patent/WO1998029134A2/en not_active Ceased
- 1997-12-30 JP JP53029898A patent/JP2001512329A/ja not_active Withdrawn
- 1997-12-30 CA CA2276312A patent/CA2276312C/en not_active Expired - Lifetime
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2008
- 2008-06-16 JP JP2008157298A patent/JP2008307391A/ja not_active Withdrawn
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2009
- 2009-09-02 JP JP2009203124A patent/JP2010005425A/ja not_active Withdrawn
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2013
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- 2013-03-08 JP JP2013046499A patent/JP5680685B2/ja not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| EP1314400B1 (en) | 2007-06-20 |
| DE69737836T2 (de) | 2008-03-06 |
| EP1314400A3 (en) | 2003-10-15 |
| JP5657040B2 (ja) | 2015-01-21 |
| JP2008307391A (ja) | 2008-12-25 |
| CA2789115A1 (en) | 1998-07-09 |
| JP2013099586A (ja) | 2013-05-23 |
| CA2276312A1 (en) | 1998-07-09 |
| EP1314400A2 (en) | 2003-05-28 |
| JP2001512329A (ja) | 2001-08-21 |
| CA2276312C (en) | 2012-11-27 |
| EP0952850A2 (en) | 1999-11-03 |
| ES2289192T3 (es) | 2008-02-01 |
| JP2010005425A (ja) | 2010-01-14 |
| DK1314400T3 (da) | 2007-10-15 |
| JP2013165967A (ja) | 2013-08-29 |
| ATE365026T1 (de) | 2007-07-15 |
| WO1998029134A3 (en) | 1998-10-15 |
| WO1998029134A2 (en) | 1998-07-09 |
| JP5680685B2 (ja) | 2015-03-04 |
| DE69737836D1 (de) | 2007-08-02 |
| AU5623298A (en) | 1998-07-31 |
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