ATE365026T1 - Mikroporation von gewebe zur verabreichung von bioaktiven substanzen - Google Patents

Mikroporation von gewebe zur verabreichung von bioaktiven substanzen

Info

Publication number
ATE365026T1
ATE365026T1 AT03002035T AT03002035T ATE365026T1 AT E365026 T1 ATE365026 T1 AT E365026T1 AT 03002035 T AT03002035 T AT 03002035T AT 03002035 T AT03002035 T AT 03002035T AT E365026 T1 ATE365026 T1 AT E365026T1
Authority
AT
Austria
Prior art keywords
microporation
permeant
administration
tissue
organism
Prior art date
Application number
AT03002035T
Other languages
English (en)
Inventor
Jonathan A Eppstein
Original Assignee
Altea Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1997/011670 external-priority patent/WO1998000193A1/en
Application filed by Altea Therapeutics Corp filed Critical Altea Therapeutics Corp
Application granted granted Critical
Publication of ATE365026T1 publication Critical patent/ATE365026T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00137—Details of operation mode
    • A61B2017/00154—Details of operation mode pulsed
    • A61B2017/00172—Pulse trains, bursts, intermittent continuous operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Radiation-Therapy Devices (AREA)
  • Electrotherapy Devices (AREA)
  • Laser Surgery Devices (AREA)
  • Surgical Instruments (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
AT03002035T 1996-12-31 1997-12-30 Mikroporation von gewebe zur verabreichung von bioaktiven substanzen ATE365026T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77841596A 1996-12-31 1996-12-31
PCT/US1997/011670 WO1998000193A1 (en) 1996-07-03 1997-07-03 Multiple mechanical microporation of skin or mucosa

Publications (1)

Publication Number Publication Date
ATE365026T1 true ATE365026T1 (de) 2007-07-15

Family

ID=25113276

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03002035T ATE365026T1 (de) 1996-12-31 1997-12-30 Mikroporation von gewebe zur verabreichung von bioaktiven substanzen

Country Status (9)

Country Link
EP (2) EP0952850A2 (de)
JP (5) JP2001512329A (de)
AT (1) ATE365026T1 (de)
AU (1) AU5623298A (de)
CA (2) CA2789115C (de)
DE (1) DE69737836T2 (de)
DK (1) DK1314400T3 (de)
ES (1) ES2289192T3 (de)
WO (1) WO1998029134A2 (de)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6183434B1 (en) * 1996-07-03 2001-02-06 Spectrx, Inc. Multiple mechanical microporation of skin or mucosa
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US6517532B1 (en) 1997-05-15 2003-02-11 Palomar Medical Technologies, Inc. Light energy delivery head
US6527716B1 (en) 1997-12-30 2003-03-04 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
US6173202B1 (en) * 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
AU4219399A (en) * 1998-06-08 1999-12-30 Valentis, Inc. Formulations for electroporation
AU759738B2 (en) 1998-07-14 2003-04-17 Nitto Denko Corporation Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport
AU765429B2 (en) * 1999-01-22 2003-09-18 Powderject Research Limited Method of enhancing needleless transdermal powdered drug delivery
EP2168497A3 (de) 1999-06-08 2010-12-01 Altea Therapeutics Corporation Vorrichtung zum Mikrobetrieb von biologischen Membranen mithilfe Dünnfilm-Gewebeschnittstellenvorrichtungen
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
US20030078499A1 (en) 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US7133717B2 (en) 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US7113821B1 (en) * 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
WO2001026689A1 (fr) * 1999-10-14 2001-04-19 Pola Chemical Industries Inc. Compositions d'electroporation
WO2001076553A2 (en) * 2000-04-06 2001-10-18 Sontra Medical, Inc. Method and device for enhanced transdermal drug delivery
US7404815B2 (en) 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
IL137689A0 (en) * 2000-08-03 2001-10-31 L R Res & Dev Ltd System for enhanced chemical debridement
BR0113749A (pt) * 2000-09-08 2004-06-22 Alza Corp Métodos para inibir a diminuição no fluxo de droga transdérmica por inibição do fechamento das vias
US7632522B2 (en) 2000-09-28 2009-12-15 Nanocyte Inc. Use of stinging cells/capsules for the delivery of active agents to keratinous substances
IL155097A0 (en) 2000-09-28 2003-10-31 Nanocyte Inc Methods, compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue
US6882884B1 (en) 2000-10-13 2005-04-19 Soundskin, L.L.C. Process for the stimulation of production of extracellular dermal proteins in human tissue
US6794376B2 (en) * 2000-12-06 2004-09-21 William Beaumont Hospital Methods and compositions for enhancing diffusion of therapeutic agents through tissue
JP2004529906A (ja) 2001-03-19 2004-09-30 イオマイ コーポレイシヨン 経皮的免疫賦活
AU2003219805B2 (en) * 2002-02-15 2009-06-04 Eisai Inc. Electroporation methods for introducing bioactive agents into cells
US7392080B2 (en) 2002-03-11 2008-06-24 Altea Therapeutics Corporation Transdermal drug delivery patch system, method of making same and method of using same
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
ATE394125T1 (de) 2002-03-26 2008-05-15 Nanocyte Inc Nesselzellen mit expression eines exogenen polynucleotids, das ein therapeutisches, diagnostisches oder kosmetisches mittel kodiert, und diese nesselzellen verwendende verfahren, zusammensetzungen und vorrichtungen oder daraus gewonnene kapseln zur abgabe des therapeutischen, diagnostischen oder kosmetischen mittels in ein gewebe
WO2003089043A2 (en) 2002-04-19 2003-10-30 Transpharma Medical Ltd. Handheld transdermal drug delivery and analyte extraction
WO2004000098A2 (en) 2002-06-19 2003-12-31 Palomar Medical Technologies, Inc. Method and apparatus for treatment of cutaneous and subcutaneous conditions
US8016811B2 (en) 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
WO2006111201A1 (en) 2005-04-18 2006-10-26 Pantec Biosolutions Ag Laser microporator
US8834862B2 (en) 2005-04-19 2014-09-16 Nanocyte Inc. Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of an active agent
US7856985B2 (en) 2005-04-22 2010-12-28 Cynosure, Inc. Method of treatment body tissue using a non-uniform laser beam
US20070088248A1 (en) 2005-09-02 2007-04-19 Iomai Corporation Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof
CA2622560A1 (en) 2005-09-15 2007-03-29 Palomar Medical Technologies, Inc. Skin optical characterization device
JP4921795B2 (ja) 2006-01-06 2012-04-25 株式会社東芝 超音波薬剤導入装置及び医用画像診断装置
US7586957B2 (en) 2006-08-02 2009-09-08 Cynosure, Inc Picosecond laser apparatus and methods for its operation and use
US9132031B2 (en) 2006-09-26 2015-09-15 Zeltiq Aesthetics, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
US8192474B2 (en) 2006-09-26 2012-06-05 Zeltiq Aesthetics, Inc. Tissue treatment methods
US20080077201A1 (en) 2006-09-26 2008-03-27 Juniper Medical, Inc. Cooling devices with flexible sensors
US20100004582A1 (en) * 2006-10-25 2010-01-07 Pantec Biosolutions Ag Wide-Area Parasystemic Treatment of Skin Related Conditions
EP2120825B8 (de) 2007-01-22 2017-05-24 Nitto Denko Corporation Transdermaler porator und patch-system
US20080287839A1 (en) 2007-05-18 2008-11-20 Juniper Medical, Inc. Method of enhanced removal of heat from subcutaneous lipid-rich cells and treatment apparatus having an actuator
US8523927B2 (en) 2007-07-13 2013-09-03 Zeltiq Aesthetics, Inc. System for treating lipid-rich regions
WO2009026471A1 (en) 2007-08-21 2009-02-26 Zeltiq Aesthetics, Inc. Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue
JP5466161B2 (ja) 2007-10-09 2014-04-09 トランスファーマ メディカル リミテッド 磁気的なパッチ連結物
CA2696227A1 (en) 2007-10-17 2009-04-23 Transpharma Medical Ltd. Dissolution rate verification
WO2009072108A2 (en) 2007-12-05 2009-06-11 Syneron Medical Ltd. A disposable electromagnetic energy applicator and method of using it
US8603073B2 (en) 2008-12-17 2013-12-10 Zeltiq Aesthetics, Inc. Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
EP2769703B1 (de) 2009-04-30 2022-04-06 Zeltiq Aesthetics, Inc. Vorrichtung zur Wärmeabführung aus subkutanen fettreichen Zellen
US9919168B2 (en) 2009-07-23 2018-03-20 Palomar Medical Technologies, Inc. Method for improvement of cellulite appearance
EP2459268B1 (de) * 2009-07-30 2013-05-29 Alma Lasers Ltd Sonotrode
US9014799B2 (en) * 2009-10-08 2015-04-21 Palo Alto Research Center Incorporated Transmucosal drug delivery device and method including electrically-actuated permeation enhancement
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
CA2787374A1 (en) 2010-01-25 2011-07-28 Zeltiq Aesthetics, Inc. Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associated devices, systems and methods
WO2012009443A1 (en) * 2010-07-13 2012-01-19 Scott Mcnulty System, method and apparatus for sensing biometric information
US8676338B2 (en) 2010-07-20 2014-03-18 Zeltiq Aesthetics, Inc. Combined modality treatment systems, methods and apparatus for body contouring applications
US9598472B2 (en) 2010-09-03 2017-03-21 Valneva Austria Gmbh Isolated polypeptide of the toxin A and toxin B proteins of C. difficile and uses thereof
WO2012103242A1 (en) 2011-01-25 2012-08-02 Zeltiq Aesthetics, Inc. Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells
KR102136901B1 (ko) 2012-04-18 2020-07-22 싸이노슈어, 엘엘씨 피코초 레이저 장치 및 그를 사용한 표적 조직의 치료 방법
US9944019B2 (en) * 2012-05-01 2018-04-17 University of Pittsburgh—of the Commonwealth System of Higher Education Tip-loaded microneedle arrays for transdermal insertion
US9545523B2 (en) 2013-03-14 2017-01-17 Zeltiq Aesthetics, Inc. Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue
US9844460B2 (en) 2013-03-14 2017-12-19 Zeltiq Aesthetics, Inc. Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same
WO2014145707A2 (en) 2013-03-15 2014-09-18 Cynosure, Inc. Picosecond optical radiation systems and methods of use
US10517892B2 (en) * 2013-10-22 2019-12-31 Medtronic Minimed, Inc. Methods and systems for inhibiting foreign-body responses in diabetic patients
EP3099260A2 (de) 2014-01-31 2016-12-07 Zeltiq Aesthetics, Inc. Behandlungssysteme, verfahren und vorrichtungen zur verbesserung des erscheinungsbildes der haut und zur bereitstellung anderer behandlungen
US10675176B1 (en) 2014-03-19 2020-06-09 Zeltiq Aesthetics, Inc. Treatment systems, devices, and methods for cooling targeted tissue
USD777338S1 (en) 2014-03-20 2017-01-24 Zeltiq Aesthetics, Inc. Cryotherapy applicator for cooling tissue
US10278334B2 (en) 2014-04-07 2019-05-07 Premier Citrus Apz, Llc Systems and methods for delivering nucleic acids to a plant
US9265260B1 (en) 2014-04-07 2016-02-23 Gpd Technologies Llc Systems and methods for using light energy to facilitate penetration of substances in plants
US11178823B2 (en) 2014-04-07 2021-11-23 Premier Citrus Apz, Llc Systems and methods for using light energy to facilitate penetration of substances in plants
US10952891B1 (en) 2014-05-13 2021-03-23 Zeltiq Aesthetics, Inc. Treatment systems with adjustable gap applicators and methods for cooling tissue
US10568759B2 (en) 2014-08-19 2020-02-25 Zeltiq Aesthetics, Inc. Treatment systems, small volume applicators, and methods for treating submental tissue
US10935174B2 (en) 2014-08-19 2021-03-02 Zeltiq Aesthetics, Inc. Stress relief couplings for cryotherapy apparatuses
US9459201B2 (en) 2014-09-29 2016-10-04 Zyomed Corp. Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing
US10441768B2 (en) 2015-03-18 2019-10-15 University of Pittsburgh—of the Commonwealth System of Higher Education Bioactive components conjugated to substrates of microneedle arrays
WO2017066768A1 (en) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices
EP3364900B1 (de) 2015-10-19 2021-08-18 Zeltiq Aesthetics, Inc. Gefässbehandlungsverfahren zum kühlen von gefässstrukturen
WO2017099787A1 (en) * 2015-12-10 2017-06-15 Gpd Technologies Llc Systems and methods for using light energy to facilitate penetration of substances in plants
WO2017120322A1 (en) 2016-01-05 2017-07-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
CA3009414A1 (en) 2016-01-07 2017-07-13 Zeltiq Aesthetics, Inc. Temperature-dependent adhesion between applicator and skin during cooling of tissue
US10765552B2 (en) 2016-02-18 2020-09-08 Zeltiq Aesthetics, Inc. Cooling cup applicators with contoured heads and liner assemblies
US11191278B2 (en) 2016-03-25 2021-12-07 Premier Citrus Apz, Llc Systems and methods for delivering nucleic acids to a plant
US9554738B1 (en) 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
US10682297B2 (en) 2016-05-10 2020-06-16 Zeltiq Aesthetics, Inc. Liposomes, emulsions, and methods for cryotherapy
US10555831B2 (en) 2016-05-10 2020-02-11 Zeltiq Aesthetics, Inc. Hydrogel substances and methods of cryotherapy
US11382790B2 (en) 2016-05-10 2022-07-12 Zeltiq Aesthetics, Inc. Skin freezing systems for treating acne and skin conditions
KR101929761B1 (ko) * 2017-01-03 2018-12-17 (주)엠큐어 약물주입홀이 형성된 니들모듈
KR101938187B1 (ko) * 2017-01-03 2019-01-14 (주)엠큐어 약물주입홀의 개폐가 가능한 니들모듈
CN110582245B (zh) 2017-03-27 2022-09-16 诺服塞尔有限公司 用于皮内溶液递送的系统、设备和方法
US11076879B2 (en) 2017-04-26 2021-08-03 Zeltiq Aesthetics, Inc. Shallow surface cryotherapy applicators and related technology
EP3759770A4 (de) 2018-02-26 2021-12-08 Cynosure, LLC Gütegeschalteter cavity-dump-subnanosekundenlaser
CN110604867A (zh) * 2018-06-15 2019-12-24 博健通大健康(深圳)有限公司 一种超声中频导药仪
CA3107932A1 (en) 2018-07-31 2020-02-06 Zeltiq Aesthetics, Inc. Methods, devices, and systems for improving skin characteristics
US11622943B2 (en) * 2019-05-10 2023-04-11 Chamkurkishtiah Panduranga Rao System and method for allergen-specific epicutaneous immunotherapy
CN112490602B (zh) * 2020-10-19 2021-09-24 电子科技大学 一种基于多层结构的THz导波调控装置
WO2023161966A1 (en) * 2022-02-24 2023-08-31 Teoresi S.P.A. Device for inducing cell permeability in a portion of tissue by opto-poration

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5850905Y2 (ja) * 1981-05-27 1983-11-19 桜アルミ株式会社 温熱治療器
JPS58121943A (ja) * 1982-01-16 1983-07-20 小林　敏男 高周波脱毛装置用脱毛針
JPS6268466A (ja) * 1985-09-24 1987-03-28 大盛商事株式会社 つぼ当て治療器
US4775361A (en) * 1986-04-10 1988-10-04 The General Hospital Corporation Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport
ATE131081T1 (de) * 1988-01-21 1995-12-15 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
US5749847A (en) * 1988-01-21 1998-05-12 Massachusetts Institute Of Technology Delivery of nucleotides into organisms by electroporation
US5115805A (en) * 1990-02-23 1992-05-26 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
JPH04150871A (ja) * 1990-10-12 1992-05-25 Azusa Eng:Kk 流動磁場応用健康用具
IT1244667B (it) * 1991-03-28 1994-08-08 Enea Procedimento di microperforazione laser di cellule.
CA2066963A1 (en) * 1991-05-15 1992-11-16 Norio Daikuzono Laser light irradiation apparatus
US5225282A (en) * 1991-12-13 1993-07-06 Molecular Bioquest, Inc. Biodegradable magnetic microcluster comprising non-magnetic metal or metal oxide particles coated with a functionalized polymer
JP3368603B2 (ja) * 1992-02-28 2003-01-20 オリンパス光学工業株式会社 遺伝子治療用処置具
EP0637942B1 (de) * 1992-04-24 1999-05-06 Surgical Laser Technologies, Inc. Medizinische vorrichtung
US5342355A (en) * 1992-10-19 1994-08-30 Laser Centers Of America Energy delivering cap element for end of optic fiber conveying laser energy
US5643252A (en) * 1992-10-28 1997-07-01 Venisect, Inc. Laser perforator
US5458140A (en) * 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
CA2187023A1 (en) * 1994-04-13 1995-10-26 Steven Andrew Giannos Temporally controlled drug delivery systems
EP0766579A1 (de) * 1994-06-24 1997-04-09 Cygnus, Inc. Abgabesystem von pulsierender elektrospannung benützenden biologisch aktiven substanzen zum steuern der permeabilität einer membrane
US5586981A (en) * 1994-08-25 1996-12-24 Xin-Hua Hu Treatment of cutaneous vascular and pigmented lesions
WO1996037256A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
DE69624668T2 (de) * 1995-07-25 2003-08-28 Massachusetts Inst Technology Verbesserter transdermaler transport unter verwendung von ultraschall
CA2199002C (en) * 1995-08-29 1999-02-23 Jonathan A. Eppstein Microporation of human skin for drug delivery and monitoring applications
US6183434B1 (en) * 1996-07-03 2001-02-06 Spectrx, Inc. Multiple mechanical microporation of skin or mucosa

Also Published As

Publication number Publication date
AU5623298A (en) 1998-07-31
WO1998029134A2 (en) 1998-07-09
ES2289192T3 (es) 2008-02-01
JP2001512329A (ja) 2001-08-21
WO1998029134A3 (en) 1998-10-15
EP1314400B1 (de) 2007-06-20
DK1314400T3 (da) 2007-10-15
DE69737836D1 (de) 2007-08-02
JP2013165967A (ja) 2013-08-29
CA2276312C (en) 2012-11-27
EP1314400A2 (de) 2003-05-28
JP2008307391A (ja) 2008-12-25
CA2789115A1 (en) 1998-07-09
EP1314400A3 (de) 2003-10-15
JP5657040B2 (ja) 2015-01-21
EP0952850A2 (de) 1999-11-03
CA2276312A1 (en) 1998-07-09
JP2010005425A (ja) 2010-01-14
JP2013099586A (ja) 2013-05-23
DE69737836T2 (de) 2008-03-06
CA2789115C (en) 2014-04-29
JP5680685B2 (ja) 2015-03-04

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