ATE310243T1 - Phosporeszierende dentrische makromolekül- verbindungen zur bilddarstellung des sauerstoffgehalts von gewebe - Google Patents

Phosporeszierende dentrische makromolekül- verbindungen zur bilddarstellung des sauerstoffgehalts von gewebe

Info

Publication number
ATE310243T1
ATE310243T1 AT97950994T AT97950994T ATE310243T1 AT E310243 T1 ATE310243 T1 AT E310243T1 AT 97950994 T AT97950994 T AT 97950994T AT 97950994 T AT97950994 T AT 97950994T AT E310243 T1 ATE310243 T1 AT E310243T1
Authority
AT
Austria
Prior art keywords
tissue
phosporescent
dentric
imaging
oxygen content
Prior art date
Application number
AT97950994T
Other languages
English (en)
Inventor
Sergei A Vinogradov
David F Wilson
Original Assignee
Oxygen Entpr Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxygen Entpr Ltd filed Critical Oxygen Entpr Ltd
Application granted granted Critical
Publication of ATE310243T1 publication Critical patent/ATE310243T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14556—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6832—Means for maintaining contact with the body using adhesives
    • A61B5/6833—Adhesive patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6848—Needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G01N31/223—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating presence of specific gases or aerosols
    • G01N31/225—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating presence of specific gases or aerosols for oxygen, e.g. including dissolved oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/14—Coupling media or elements to improve sensor contact with skin or tissue
    • A61B2562/146—Coupling media or elements to improve sensor contact with skin or tissue for optical coupling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medical Informatics (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Luminescent Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Porous Artificial Stone Or Porous Ceramic Products (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Materials For Medical Uses (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT97950994T 1996-12-16 1997-12-12 Phosporeszierende dentrische makromolekül- verbindungen zur bilddarstellung des sauerstoffgehalts von gewebe ATE310243T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/767,158 US5837865A (en) 1993-10-15 1996-12-16 Phosphorescent dendritic macromolecular compounds for imaging tissue oxygen
PCT/US1997/023599 WO1998026708A1 (en) 1996-12-16 1997-12-12 Phosphorescent dendritic macromolecular compounds for imaging tissue oxygen

Publications (1)

Publication Number Publication Date
ATE310243T1 true ATE310243T1 (de) 2005-12-15

Family

ID=25078652

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97950994T ATE310243T1 (de) 1996-12-16 1997-12-12 Phosporeszierende dentrische makromolekül- verbindungen zur bilddarstellung des sauerstoffgehalts von gewebe

Country Status (9)

Country Link
US (1) US5837865A (de)
EP (1) EP1021712B1 (de)
JP (1) JP2002501479A (de)
AT (1) ATE310243T1 (de)
AU (1) AU722502B2 (de)
CA (1) CA2275191C (de)
DE (1) DE69734683T2 (de)
DK (1) DK1021712T3 (de)
WO (1) WO1998026708A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4118338B2 (ja) * 1996-07-22 2008-07-16 ノバルティス アクチエンゲゼルシャフト プラチナまたはパラジウムベンゾポルフィリンおよびプラチナまたはパラジウムシクロヘキセンポルフィリンの製造法、中間体およびプラチナまたはパラジウムシクロヘキセンポルフィリンを含む酸素センサー
US6274086B1 (en) * 1996-12-16 2001-08-14 The Trustees Of The University Of Pennsylvania Apparatus for non-invasive imaging oxygen distribution in multi-dimensions
EP1978110B1 (de) * 2000-09-06 2010-05-26 Transnetyx, Inc. Computer-basiertes Verfahren und System zum Screenen von genomischer DNS
JP4307070B2 (ja) * 2000-11-17 2009-08-05 バイオモーダ・インコーポレーテツド ５，１０，１５，２０−テトラキス（カルボキシフェニル）ポルフィンを使用する、細胞および組織サンプルにおける前がん症状を検出するための組成物および方法
WO2004079349A1 (en) * 2003-03-07 2004-09-16 Luxcel Biosciences Limited An oxygen sensitive probe
KR20060133974A (ko) * 2003-10-16 2006-12-27 더 유니버시티 오브 아크론 탄소 나노섬유 기판 상의 탄소 나노튜브
WO2006026396A2 (en) * 2004-08-26 2006-03-09 Oxygen Enterprises, Ltd. Imaging of oxygen by phosphorescence quenching
CN1302049C (zh) * 2005-05-26 2007-02-28 复旦大学 一种超支化高分子电致发光材料
DE102005036410A1 (de) * 2005-07-29 2007-02-01 Biocam Gmbh Verfahren zur Ermittlung der Sauerstoffpartialdruckverteilung in zumindest einem Gewebeflächenabschnitt, insbesondere Hautgewebeflächenabschnitt
JP2007064999A (ja) * 2005-08-29 2007-03-15 Mitsubishi Electric Corp 液晶表示装置
US7575890B2 (en) * 2006-01-18 2009-08-18 Oxygen Enterprises, Ltd. Method for rapid detection and evaluation of cultured cell growth
EP2043694A2 (de) * 2006-07-24 2009-04-08 University College Cork - National University of Ireland, Cork Sonde für zellulären sauerstoff
WO2009108947A2 (en) * 2008-02-28 2009-09-03 The Trustees Of The University Of Pennsylvania Imaging dendrimer nanoprobes and uses thereof
WO2010044465A1 (ja) * 2008-10-17 2010-04-22 国立大学法人 群馬大学 新規化合物およびそれを含む機能性発光プローブ
US8241911B2 (en) * 2008-11-07 2012-08-14 Mocon, Inc. Calibration card for photoluminescent oxygen sensors with zero point maintained with a metal-air battery
WO2010053888A1 (en) * 2008-11-07 2010-05-14 Mocon, Inc Calibration card for oxygen optical sensors
US8323978B2 (en) * 2008-11-07 2012-12-04 Mocon, Inc. Calibration system and technique for photoluminescent oxygen sensors with zero point maintained with a metal-air battery
WO2010066273A1 (en) 2008-12-11 2010-06-17 Luxcel Biosciences Limited Optochemical sensor active element, method of its preparation and use
US8332007B2 (en) * 2009-01-12 2012-12-11 The Board Of Trustees Of The University Of Illinois Quantitative three-dimensional mapping of oxygen tension
US20110136247A1 (en) * 2009-12-07 2011-06-09 Dmitri Boris Papkovsky Photoluminescent oxygen probe with reduced cross-sensitivity to humidity
EP2630488B1 (de) 2010-10-22 2016-08-17 University College Cork, National University of Ireland, Cork Verfahren zur Bestimmung der Sauerstoffkonzentration in einer lebenden Probe von Säugetierzellen
US9274060B1 (en) 2011-01-13 2016-03-01 Mocon, Inc. Methods for transmembrane measurement of oxygen concentration and monitoring changes in oxygen concentration within a space enclosed by a membrane employing a photoluminescent transmembrane oxygen probe
WO2013130510A1 (en) * 2012-02-27 2013-09-06 Sergei Vinogradov Improved phosphorescent molecules for measuring oxygen and imaging methods
US10493168B2 (en) * 2012-02-27 2019-12-03 Oxygen Enterprises, Ltd Phosphorescent meso-unsubstituted metallo-porphyrin probe molecules for measuring oxygen and imaging methods
US9057687B2 (en) 2012-04-20 2015-06-16 Mocon, Inc. Calibration vial and technique for calibrating a fiber optic oxygen sensing needle
EP2872877B1 (de) 2012-07-10 2023-05-24 The General Hospital Corporation System und verfahren zur überwachung und behandlung der körperfläche einer person
US8658429B1 (en) 2012-08-06 2014-02-25 Mocon, Inc. Photoluminescent oxygen probe tack
EP3488871B1 (de) 2013-03-14 2020-09-02 Profusa, Inc. Sauerstoffsensoren
AU2014241420B2 (en) 2013-03-14 2018-05-31 Profusa, Inc. Method and device for correcting optical signals
JP6554089B2 (ja) 2013-03-19 2019-07-31 サージセンス コーポレイション 組織酸素化の測定用の器具、システムおよびメソッド
US9789206B2 (en) 2013-07-10 2017-10-17 The General Hospital Corporation Compounds, systems, and methods for monitoring and treating a surface of a subject
EP3019854B1 (de) * 2013-07-10 2021-01-06 The General Hospital Corporation Verbindungen, systeme und verfahren zur überwachung und behandlung der oberfläche eines artikels
JP2017513664A (ja) 2014-04-05 2017-06-01 サージセンス コーポレイション 組織酸素化のマッピングのための装置、システム、および方法
CN115505280A (zh) 2016-12-21 2022-12-23 普罗菲尤萨股份有限公司 可聚合的近红外染料
WO2019194875A2 (en) 2017-12-28 2019-10-10 Profusa, Inc. Oxidase-based sensors and methods of using
CA3104346A1 (en) 2018-06-27 2020-01-02 Profusa, Inc. Near-ir glucose sensors
CN111117600A (zh) * 2019-12-27 2020-05-08 复旦大学 一种氧气纳米探针及其制备方法与应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289872A (en) * 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
US4507466A (en) * 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
US4631337A (en) * 1983-01-07 1986-12-23 The Dow Chemical Company Hydrolytically-stable dense star polyamine
US4568737A (en) * 1983-01-07 1986-02-04 The Dow Chemical Company Dense star polymers and dendrimers
US4558120A (en) * 1983-01-07 1985-12-10 The Dow Chemical Company Dense star polymer
US4587329A (en) * 1984-08-17 1986-05-06 The Dow Chemical Company Dense star polymers having two dimensional molecular diameter
US4947850A (en) * 1988-03-11 1990-08-14 Trustees Of The University Of Pennsylvania Method and apparatus for imaging an internal body portion of a host animal
US5041516A (en) * 1989-06-21 1991-08-20 Cornell Research Foundation, Inc. Dendritic molecules and method of production
US5098475A (en) * 1991-01-28 1992-03-24 Xerox Corporation Inks with dendrimer colorants
US6362175B1 (en) * 1991-09-20 2002-03-26 The Trustees Of The University Of Pennsylvania Porphyrin compounds for imaging tissue oxygen
SE9200564L (sv) * 1992-02-26 1993-03-15 Perstorp Ab Dendritisk makromolekyl av polyestertyp, foerfarande foer framstaellning daerav samt anvaendning daerav
US5256193A (en) * 1992-06-25 1993-10-26 Xerox Corporation Porphyrin chromophore and dendrimer ink composition
US5387617A (en) * 1993-01-22 1995-02-07 The Dow Chemical Company Small cell foams and blends and a process for their preparation

Also Published As

Publication number Publication date
CA2275191A1 (en) 1998-06-25
EP1021712B1 (de) 2005-11-16
DE69734683D1 (de) 2005-12-22
AU5385798A (en) 1998-07-15
DK1021712T3 (da) 2006-03-27
US5837865A (en) 1998-11-17
WO1998026708A1 (en) 1998-06-25
CA2275191C (en) 2007-02-13
DE69734683T2 (de) 2006-08-17
EP1021712A1 (de) 2000-07-26
JP2002501479A (ja) 2002-01-15
EP1021712A4 (de) 2000-07-26
AU722502B2 (en) 2000-08-03

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