DE69734683D1 - Phosporeszierende dentrische makromolekül-verbindungen zur bilddarstellung des sauerstoffgehalts von gewebe - Google Patents

Phosporeszierende dentrische makromolekül-verbindungen zur bilddarstellung des sauerstoffgehalts von gewebe

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Publication number
DE69734683D1
DE69734683D1 DE69734683T DE69734683T DE69734683D1 DE 69734683 D1 DE69734683 D1 DE 69734683D1 DE 69734683 T DE69734683 T DE 69734683T DE 69734683 T DE69734683 T DE 69734683T DE 69734683 D1 DE69734683 D1 DE 69734683D1
Authority
DE
Germany
Prior art keywords
tissue
phosporescent
macromolekül
dentric
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69734683T
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English (en)
Other versions
DE69734683T2 (de
Inventor
A Vinogradov
F Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxygen Enterprises Ltd
Original Assignee
Oxygen Enterprises Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxygen Enterprises Ltd filed Critical Oxygen Enterprises Ltd
Application granted granted Critical
Publication of DE69734683D1 publication Critical patent/DE69734683D1/de
Publication of DE69734683T2 publication Critical patent/DE69734683T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14556—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6832—Means for maintaining contact with the body using adhesives
    • A61B5/6833—Adhesive patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6848—Needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G01N31/223—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating presence of specific gases or aerosols
    • G01N31/225—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating presence of specific gases or aerosols for oxygen, e.g. including dissolved oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/14—Coupling media or elements to improve sensor contact with skin or tissue
    • A61B2562/146—Coupling media or elements to improve sensor contact with skin or tissue for optical coupling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
DE69734683T 1996-12-16 1997-12-12 Phosporeszierende dentrische makromolekül-verbindungen zur bilddarstellung des sauerstoffgehalts von gewebe Expired - Lifetime DE69734683T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US767158 1996-12-16
US08/767,158 US5837865A (en) 1993-10-15 1996-12-16 Phosphorescent dendritic macromolecular compounds for imaging tissue oxygen
PCT/US1997/023599 WO1998026708A1 (en) 1996-12-16 1997-12-12 Phosphorescent dendritic macromolecular compounds for imaging tissue oxygen

Publications (2)

Publication Number Publication Date
DE69734683D1 true DE69734683D1 (de) 2005-12-22
DE69734683T2 DE69734683T2 (de) 2006-08-17

Family

ID=25078652

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69734683T Expired - Lifetime DE69734683T2 (de) 1996-12-16 1997-12-12 Phosporeszierende dentrische makromolekül-verbindungen zur bilddarstellung des sauerstoffgehalts von gewebe

Country Status (9)

Country Link
US (1) US5837865A (de)
EP (1) EP1021712B1 (de)
JP (1) JP2002501479A (de)
AT (1) ATE310243T1 (de)
AU (1) AU722502B2 (de)
CA (1) CA2275191C (de)
DE (1) DE69734683T2 (de)
DK (1) DK1021712T3 (de)
WO (1) WO1998026708A1 (de)

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US6274086B1 (en) * 1996-12-16 2001-08-14 The Trustees Of The University Of Pennsylvania Apparatus for non-invasive imaging oxygen distribution in multi-dimensions
EP1978110B1 (de) * 2000-09-06 2010-05-26 Transnetyx, Inc. Computer-basiertes Verfahren und System zum Screenen von genomischer DNS
CA2725716C (en) * 2000-11-17 2015-02-10 Biomoda, Inc. Method of making 5, 10, 15, 20-tetrakis(carboxyphenyl) porphine solutions and compositions thereof
EP1601955B1 (de) * 2003-03-07 2013-01-09 Luxcel Biosciences Limited Sauerstoffempfindliche Sonde und Verfahren zum Messen der Sauerstoffaufnahme
WO2005044723A2 (en) * 2003-10-16 2005-05-19 The University Of Akron Carbon nanotubes on carbon nanofiber substrate
WO2006026396A2 (en) * 2004-08-26 2006-03-09 Oxygen Enterprises, Ltd. Imaging of oxygen by phosphorescence quenching
CN1302049C (zh) * 2005-05-26 2007-02-28 复旦大学 一种超支化高分子电致发光材料
DE102005036410A1 (de) * 2005-07-29 2007-02-01 Biocam Gmbh Verfahren zur Ermittlung der Sauerstoffpartialdruckverteilung in zumindest einem Gewebeflächenabschnitt, insbesondere Hautgewebeflächenabschnitt
JP2007064999A (ja) * 2005-08-29 2007-03-15 Mitsubishi Electric Corp 液晶表示装置
US7575890B2 (en) * 2006-01-18 2009-08-18 Oxygen Enterprises, Ltd. Method for rapid detection and evaluation of cultured cell growth
US20080051646A1 (en) * 2006-07-24 2008-02-28 Papkovsky Dmitri B Probe for cellular oxygen
WO2009108947A2 (en) * 2008-02-28 2009-09-03 The Trustees Of The University Of Pennsylvania Imaging dendrimer nanoprobes and uses thereof
WO2010044465A1 (ja) * 2008-10-17 2010-04-22 国立大学法人 群馬大学 新規化合物およびそれを含む機能性発光プローブ
CN102265136B (zh) * 2008-11-07 2014-08-13 膜康公司 用于光学氧传感器的校准卡
US8323978B2 (en) * 2008-11-07 2012-12-04 Mocon, Inc. Calibration system and technique for photoluminescent oxygen sensors with zero point maintained with a metal-air battery
US8241911B2 (en) * 2008-11-07 2012-08-14 Mocon, Inc. Calibration card for photoluminescent oxygen sensors with zero point maintained with a metal-air battery
WO2010066273A1 (en) 2008-12-11 2010-06-17 Luxcel Biosciences Limited Optochemical sensor active element, method of its preparation and use
US8332007B2 (en) * 2009-01-12 2012-12-11 The Board Of Trustees Of The University Of Illinois Quantitative three-dimensional mapping of oxygen tension
US20110136247A1 (en) * 2009-12-07 2011-06-09 Dmitri Boris Papkovsky Photoluminescent oxygen probe with reduced cross-sensitivity to humidity
EP2630488B1 (de) 2010-10-22 2016-08-17 University College Cork, National University of Ireland, Cork Verfahren zur Bestimmung der Sauerstoffkonzentration in einer lebenden Probe von Säugetierzellen
US9274060B1 (en) 2011-01-13 2016-03-01 Mocon, Inc. Methods for transmembrane measurement of oxygen concentration and monitoring changes in oxygen concentration within a space enclosed by a membrane employing a photoluminescent transmembrane oxygen probe
US9556213B2 (en) 2012-02-27 2017-01-31 Sergei A. Vinogradov Phosphorescent meso-unsubstituted metallo-tetrabenzoporphyrin probe molecules for measuring oxygen and imaging methods
US10493168B2 (en) * 2012-02-27 2019-12-03 Oxygen Enterprises, Ltd Phosphorescent meso-unsubstituted metallo-porphyrin probe molecules for measuring oxygen and imaging methods
US9057687B2 (en) 2012-04-20 2015-06-16 Mocon, Inc. Calibration vial and technique for calibrating a fiber optic oxygen sensing needle
ES2957540T3 (es) 2012-07-10 2024-01-22 Massachusetts Gen Hospital Sistema y método para monitorizar y tratar una superficie de un sujeto
US8658429B1 (en) 2012-08-06 2014-02-25 Mocon, Inc. Photoluminescent oxygen probe tack
EP2967454B1 (de) 2013-03-14 2020-04-22 Profusa, Inc. Verfahren und vorrichtung zur korrektur von optischen signalen
EP3488871B1 (de) 2013-03-14 2020-09-02 Profusa, Inc. Sauerstoffsensoren
WO2014153428A1 (en) 2013-03-19 2014-09-25 Surgisense Corporation Apparatus, systems and methods for determining tissue oxygenation
US9789206B2 (en) 2013-07-10 2017-10-17 The General Hospital Corporation Compounds, systems, and methods for monitoring and treating a surface of a subject
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Also Published As

Publication number Publication date
CA2275191C (en) 2007-02-13
WO1998026708A1 (en) 1998-06-25
US5837865A (en) 1998-11-17
CA2275191A1 (en) 1998-06-25
JP2002501479A (ja) 2002-01-15
DE69734683T2 (de) 2006-08-17
EP1021712A1 (de) 2000-07-26
AU722502B2 (en) 2000-08-03
DK1021712T3 (da) 2006-03-27
AU5385798A (en) 1998-07-15
ATE310243T1 (de) 2005-12-15
EP1021712B1 (de) 2005-11-16
EP1021712A4 (de) 2000-07-26

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