CN102265136B - 用于光学氧传感器的校准卡 - Google Patents

用于光学氧传感器的校准卡 Download PDF

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CN102265136B
CN102265136B CN200980151738.5A CN200980151738A CN102265136B CN 102265136 B CN102265136 B CN 102265136B CN 200980151738 A CN200980151738 A CN 200980151738A CN 102265136 B CN102265136 B CN 102265136B
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D·W·迈耶
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Modern Controls Inc
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Mocon Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • G01N21/278—Constitution of standards
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/100833—Simulative of a gaseous composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/207497—Molecular oxygen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25875—Gaseous sample or with change of physical state

Abstract

校准卡10和利用校准卡10校准光学传感器的方法。所述校准卡10包括：(i)第一氧敏荧光团块41，第一氧敏荧光团块41被配置和安排成将第一氧敏荧光团块41限制为暴露于接近0％的氧气，和(ii)第二氧敏荧光团块42，第二氧敏荧光团块42被配置和安排成使第二氧敏荧光团块42暴露于环境浓度的氧气。

Description

用于光学氧传感器的校准卡
本申请要求于2008年11月7日提交的美国临时申请No.61/112,434的权益。
背景技术
光学传感器是广泛采用的测量包装或容器内的被分析物的浓度(一般是氧气浓度)的方法。简单地说，通过把对被分析物敏感的荧光团放入包装或容器内，使荧光团在包装或容器内达到平衡，用辐射能激发荧光团，并测量由受激荧光团发出的发光量，能够测量包装或容器内的被分析物的浓度。这样的光学传感器可从许多供应商(包括Presens PrecisionSensing，GmbH of Regensburg，Germany)获得。
这种光学传感器一般编程有校准模式，通过使对被分析物敏感的荧光团暴露于具有已知浓度的被分析物的气体之中，并感测在这些已知浓度的被分析物条件下的发光，所述校准模式允许传感器的两点校准(即，把荧光团放入或插入已注满包含0％的被分析物的检定罐装气的容器中，并测量发光，随后把荧光团放入或插入已注满包含90％的被分析物的检定罐装气的容器中，并测量发光)。
尽管这种校准方法对精确校准光学传感器来说有效，不过这种校准方法费时并且费用高。
因而，非常需要精确并且可靠地校准光学传感器的低成本的系统和方法。
发明内容
本发明的第一方面是一种用于校准光学传感器的校准卡。所述校准卡至少包括(i)第一氧敏荧光团块，第一氧敏荧光团块与环境隔离，并与用于从第一氧敏荧光团块中清除氧气的除氧材料成流体连通，和(ii)第二氧敏荧光团块，第二氧敏荧光团块与环境成流体连通，以便使第二氧敏荧光团块暴露于环境浓度的氧气之中。
本发明的第二方面是一种校准具有校准模式的光学氧传感器的方法，包括下述步骤：(A)获得校准卡，所述校准卡至少具有(i)第一氧敏荧光团块，第一氧敏荧光团块与环境隔离，并与用于从第一氧敏荧光团块中清除氧气的除氧材料成流体连通，从而第一氧敏荧光团块所暴露于的氧浓度是已知的较低值，和(ii)第二氧敏荧光团块，第二氧敏荧光团块与环境成流体连通，以便使第二氧敏荧光团块暴露于环境浓度的氧气，从而第二氧敏荧光团块暴露于的氧浓度是已知的较高值，(B)把光学氧传感器设定成校准模式，和(C)依次从每个氧敏荧光团块获得氧浓度读数，以使得氧浓度读数与该氧敏荧光团块所暴露于的已知氧浓度相关联。
附图说明
图1是本发明的一个实施例的顶视图。
图2是在图1中描述的本发明的侧视图。
图3A是沿线3-3获得的包括0％氧区的图1和2中所示的本发明的一部分的放大侧剖视图。
图3B是沿线3-3获得的包括21％氧区的图1和2中所示的本发明的一部分的放大侧剖视图。
具体实施方式
定义
这里(包括在权利要求书中)使用的短语“阻氧层”是指不透氧气的材料层(比如金属层)，或者显著阻止氧气通过的材料层(比如塑料膜)。
这里(在包括权利要求书中)使用的术语“荧光团”是指具有能够吸收特定波长的能量，从而以不同的特定波长发出能量的官能团的分子(即，荧光分子)。
这里(包括在权利要求书中)使用的短语“氧敏荧光团”是指当暴露于氧气之中时，其荧光水平与氧气的量成比例地变化的荧光团。
术语表
10校准卡
10a校准卡的顶部
10b校准卡的底部
10r校准卡的右侧
10s校准卡的左侧
10v校准卡的上部主表面
10w校准卡的下部主表面
20支撑层
29穿过支撑层的暴露通道
30第一粘合层
40氧敏荧光团块
41第一或0％的氧敏荧光团块
42第二或21％的氧敏荧光团块
50中间层
51除氧中间层
52惰性中间层
60第二粘合层
70透明涂层或覆盖层
80标记
81指示暴露于0％的氧气之中的氧敏荧光团块的第一标记
82指示暴露于21％的氧气之中的氧敏荧光团块的第二标记
结构
参见图1和2，本发明的第一方面是一种用于校准光学氧传感器(未示出)的校准卡10。校准卡10包括第一氧敏荧光团块41，第一氧敏荧光团块41与环境隔离，并与用于从第一氧敏荧光团块41中清除氧气的除氧材料51成流体连通，和(ii)第二氧敏荧光团块42，第二氧敏荧光团块42与环境成流体连通，以便使第二氧敏荧光团块42暴露于环境浓度的氧气之中。
图3A和3B描述校准卡10的一个实施例的结构组件。如图3A和3B中所示，校准卡10包括夹在支撑层20和覆盖层70之间的，横向隔开的第一和第二氧敏荧光团块41和42(集体称为氧敏荧光团块40)。第一荧光团块41横向被中间层50的除氧部分51环绕。第二荧光团块42经由穿过支撑层20的通道29暴露于周围环境之中，并且横向被中间层50的惰性部分52环绕。粘合层30和60分别把支撑层20和覆盖层70固定到中间层50。
校准卡10具有上边缘10a、下边缘10b、右侧边缘10r、左侧边缘10s、上部主表面10v和下部主表面10w。卡10应具有约4-20厘米的长度，约4-20厘米的宽度，和小于1厘米的厚度。小于该尺寸的卡10易于丢失或者放错地方，而大于该尺寸的卡10不必要地变得笨重。卡10优选具有约6-10厘米的长度，约4-8厘米的宽度和小于3毫米的厚度，最优选的是，卡10与标准信用卡的尺寸相一致(即，约8.5厘米长、5.5厘米宽和约1毫米厚)。
卡10可以是柔性的，不过也应耐用和耐磨。
支撑层20为卡10贡献大部分的结构完整性。根据需要，支撑层20可以是透明的、半透明的或者不透明的。支撑层20还应起阻氧层的作用，以便降低氧气渗透通过卡10并与除氧中间层51接触的速率。适宜的材料具体包括(但不限于)塑料。
中间层50包括横向环绕第一荧光团块41的第一部分51、和横向环绕第二荧光团块42的第二部分52。中间层50的第一部分51包括或包含用于清除靠近第一荧光团块41渗透入卡10中的任何氧气的除氧剂(未示出)。各种各样的除氧产品(包括除氧膜)已为人们所知，并且可商业获得。可按Cryovac Freshness PlusTM OS膜的名称，从位于South Carolina，Duncan的Cryovac的Sealed Air Division获得一系列的这种除氧膜。适合于供本发明之用的两种具体的除氧膜是Cryovac的Sealed Air Division销售的OS2030和OS2O3OAF除氧膜。
校准卡10的使用期限由卡10中采用的除氧剂的有效寿命决定。为了提高卡的使用期限，通常优选的是采用能够被有选择地激活(例如，当暴露于紫外光下时)的除氧剂。Cryovac的Sealed Air Division销售的OS2030和OS2O3OAF除氧膜是两种这样的由紫外光有选择地激活的薄膜。
中间层50的第二部分52是可以从各种适宜的惰性材料(包括各种塑料)中选择的惰性材料。
在未示出的备选实施例中，荧光团块40可以被夹在两个中间层50之间，然后被层叠到支撑层20上。
粘合层30和60可以选自适合用于把塑料层层叠在一起的各种粘合剂，包括各种热熔性和压敏型粘合剂。当支撑层20、中间层50和覆盖层70能够被热焊在一起时，也可放弃使用这些粘合层。
各种对被分析物敏感的荧光团已为人们所知，可广泛从许多来源获得，包括St.Louis，Missouri的Sigma-Aldrich。例如，在WO 2007/120637中公开和说明了一系列基于钌的氧敏发光指示剂组合物。优选的荧光团是铂卟啉。采用铂卟啉而不是基于钌的化合物作为氧敏发光指示剂的好处包括：(i)对环境光不太敏感，(ii)能够在除紫外线以外的波长下激发，(iii)灵敏度提高，和(iv)衰变期更长。
覆盖层70为卡10提供额外的结构完整性，并起到荧光团块40和中间层50的保护性覆盖物的作用。覆盖层70需要至少在荧光团块40吸收和发出能量的特定波长下是透明或半透明的。覆盖层70还应起到阻氧层的作用，以便降低氧气渗透穿过卡10并与除氧中间层51接触的速率。适宜的材料具体包括(但不限于)塑料。优选的塑料是聚酯薄膜和聚对苯二甲酸乙二醇酯。
卡10的上部主表面10b压印有第一标记81和第二标记82(集体称为标记)，用于识别作为暴露于限定氧气(例如，0％、零、低的、最小的等等)之下的荧光团的第一荧光团块41，和识别作为暴露于环境浓度的氧气(例如，21％、21、高的、极大的、大气等等)之下的荧光团的第二荧光团块42。
用途
校准卡10可用于快速并且容易地校准具有校准模式的光学氧传感器(未示出)。借助校准卡10，光学氧传感器(未示出)的校准只涉及下述步骤：(1)把光学氧传感器设定成校准模式，和(2)依次从每个氧敏荧光团块41和42获得氧浓度读数，以使得氧浓度读数与氧敏荧光团块41或42所暴露于的已知氧浓度相关联。
可按照各种方式完成氧浓度读数与从其获得所述读数的氧敏荧光团41或42的关联。一种技术是按照预先输入光学氧传感器(未示出)之中的预定顺序获得氧浓度读数。第二种技术是每次获得读数时，向光学氧传感器(未示出)提供可用于指示氧敏荧光团块41和42中的哪一个被感测的附加数据。而第三种技术是每次获得读数时，向光学氧传感器(未示出)提供可用于指示在读数时被感测的氧敏荧光团块41或42所暴露于的氧浓度的附加数据。

Claims (22)

1.一种用于校准光学传感器的校准卡，所述校准卡包括(i)第一氧敏荧光团块，所述第一氧敏荧光团块被配置和安排成将第一氧敏荧光团块限制为暴露于接近0％的氧气，和(ii)第二氧敏荧光团块，所述第二氧敏荧光团块被配置和安排成使第二氧敏荧光团块暴露于环境浓度的氧气。
2.按照权利要求1所述的校准卡，其中，第一氧敏荧光团块与环境隔离，并与用于从第一氧敏荧光团块中清除氧气的除氧材料成流体连通。
3.按照权利要求1所述的校准卡，其中，所述卡具有约4-20厘米的长度，约4-20厘米的宽度，和小于1厘米的厚度。
4.按照权利要求2所述的校准卡，其中，所述卡具有约6-10厘米的长度，约4-8厘米的宽度，和小于3毫米的厚度。
5.按照权利要求1或2所述的校准卡，其中，第一和第二氧敏荧光团块中的荧光团是相同的。
6.按照权利要求1或2所述的校准卡，其中，第一和第二氧敏荧光团块被夹在阻氧支撑层和阻氧透明覆盖层之间。
7.按照权利要求6所述的校准卡，其中，透明覆盖层是聚对苯二甲酸乙二醇酯的透明层。
8.按照权利要求2所述的校准卡，其中，除氧材料通过暴露于紫外光而被激活。
9.按照权利要求8所述的校准卡，其中，除氧材料被并入到膜中。
10.按照权利要求1或2所述的校准卡，其中，所述卡包含标注作为暴露于有限氧气的荧光团的第一氧敏荧光团块的第一标记，和标注作为暴露于环境浓度的氧气的荧光团的第二氧敏荧光团块的第二标记。
11.按照权利要求10所述的校准卡，其中，第一标记至少包括0％的指示，第二标记至少包括21％的指示。
12.按照权利要求6所述的校准卡，其中，第二氧敏荧光团块通过穿过支撑层的至少一个通道，与环境成流体连通。
13.一种校准具有校准模式的光学氧传感器的方法，包括下述步骤：
(A)获得校准卡，所述校准卡至少具有(i)第一氧敏荧光团块，所述第一氧敏荧光团块被配置和安排成限制第一氧敏荧光团块对氧气的暴露，从而第一氧敏荧光团块所暴露于的氧浓度是已知的较低值，和(ii)第二氧敏荧光团块，所述第二氧敏荧光团块与环境成流体连通，以便使第二氧敏荧光团块暴露于环境浓度的氧气，从而第二氧敏荧光团块所暴露于的氧浓度是已知的较高值，
(B)把光学氧传感器设定成校准模式，和
(C)依次从每个氧敏荧光团块获得氧浓度读数，以使氧浓度读数与该氧敏荧光团块所暴露于的已知氧浓度相关联。
14.一种校准具有校准模式的光学氧传感器的方法，包括下述步骤：
(A)获得校准卡，所述校准卡至少具有(i)第一氧敏荧光团块，所述第一氧敏荧光团块与环境隔离，并与用于从第一氧敏荧光团块中清除氧气的除氧材料成流体连通，从而第一氧敏荧光团块所暴露于的氧浓度是已知的较低值，和(ii)第二氧敏荧光团块，所述第二氧敏荧光团块与环境成流体连通，以便使第二氧敏荧光团块暴露于环境浓度的氧气，从而第二氧敏荧光团块所暴露于的氧浓度是已知的较高值，
(B)把光学氧传感器设定成校准模式，和
(C)依次从每个氧敏荧光团块获得氧浓度读数，以使氧浓度读数与该氧敏荧光团块所暴露于的已知氧浓度相关联。
15.按照权利要求13或14所述的方法，其中，步骤(C)至少包括按照预定顺序从每个氧敏荧光团块获得氧浓度读数的步骤。
16.按照权利要求13或14所述的方法，其中，步骤(C)至少包括下述步骤：
(1)利用处于校准模式的光学传感器感测氧敏荧光团块之一所暴露于的氧浓度，
(2)向光学传感器提供指示校准卡上的氧敏荧光团块中的哪个氧敏荧光团块被感测的数据，和
(3)利用处于校准模式的光学传感器感测另一个氧敏荧光团块所暴露于的氧浓度。
17.按照权利要求13或14所述的方法，其中，步骤(C)至少包括下述步骤：
(1)利用处于校准模式的光学传感器感测氧敏荧光团块之一所暴露于的氧浓度，
(2)向光学传感器提供指示该氧敏荧光团块所暴露于的已知的氧浓度的数据，
(3)利用处于校准模式的光学传感器，感测另一个氧敏荧光团块所暴露于的氧浓度，和
(4)向光学传感器提供指示所述另一个氧敏荧光团块所暴露于的已知的氧浓度的数据。
18.按照权利要求13所述的方法，其中，所述卡具有约6-10厘米的长度，约4-8厘米的宽度，和小于3毫米的厚度。
19.按照权利要求13或14所述的方法，其中，第一和第二氧敏荧光团块被夹在阻氧支撑层和阻氧透明覆盖层之间。
20.按照权利要求14所述的方法，其中，在从各氧敏荧光团块获得氧浓度读数之前，除氧材料通过暴露于紫外光而被激活。
21.按照权利要求13或14所述的方法，其中，所述卡包含标注作为不暴露于氧气的氧敏荧光团块的第一氧敏荧光团块的第一标记，和标注作为暴露于环境浓度的氧气的氧敏荧光团块的第二氧敏荧光团块的第二标记。
22.按照权利要求21所述的方法，其中，第一标记至少包括数值0％，第二标记至少包括数值21％。
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Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2350614A4 (en) 2008-11-07 2017-01-11 Mocon, Inc. Calibration card for oxygen optical sensors
US8323978B2 (en) 2008-11-07 2012-12-04 Mocon, Inc. Calibration system and technique for photoluminescent oxygen sensors with zero point maintained with a metal-air battery
US8241911B2 (en) 2008-11-07 2012-08-14 Mocon, Inc. Calibration card for photoluminescent oxygen sensors with zero point maintained with a metal-air battery
US9188536B2 (en) 2010-01-27 2015-11-17 Luxcel Biosciences, Ltd Photoluminescent pressure probe
WO2011114320A1 (en) * 2010-03-16 2011-09-22 Luxcel Biosciences, Ltd. Photoluminescent analyte partial volume probe set
US9274060B1 (en) * 2011-01-13 2016-03-01 Mocon, Inc. Methods for transmembrane measurement of oxygen concentration and monitoring changes in oxygen concentration within a space enclosed by a membrane employing a photoluminescent transmembrane oxygen probe
EP2525221B1 (en) * 2011-05-20 2018-08-08 Mocon, Inc. Calibration system and technique for photoluminescent oxygen sensors with zero point maintained with a metal-air battery
US20120327214A1 (en) * 2011-06-21 2012-12-27 HNJ Solutions, Inc. System and method for image calibration
US9121827B2 (en) 2011-06-30 2015-09-01 Mocon, Inc. Method of contemporaneously monitoring changes in analyte concentration in a plurality of samples on individual schedules
EP4016051A1 (en) * 2011-08-17 2022-06-22 Agilent Technologies, Inc. Tool and method for validating operational performance of a photoluminescence based analytical instrument
US11293866B2 (en) 2012-03-22 2022-04-05 John EASTMAN Fiber optic analyte sensor
US9057687B2 (en) 2012-04-20 2015-06-16 Mocon, Inc. Calibration vial and technique for calibrating a fiber optic oxygen sensing needle
US8658429B1 (en) * 2012-08-06 2014-02-25 Mocon, Inc. Photoluminescent oxygen probe tack
US9970913B2 (en) * 2014-09-30 2018-05-15 The Boeing Company Multi-component sensing coating for pressure and temperature measurements
US9316554B1 (en) 2014-12-23 2016-04-19 Mocon, Inc. Fiber optic analyte sensor with integrated in situ total pressure correction
ES2918006T3 (es) 2016-01-20 2022-07-13 Gea Food Solutions Weert Bv Envolvedora de flujo con control de fugas de los envases resultantes y método para producir un envase
US10295514B1 (en) 2016-10-17 2019-05-21 Mocon, Inc. Instrument and method for sealed penetration of rigid packaging to measure internal oxygen concentration with an optical oxygen analyzer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1130943A (zh) * 1993-09-13 1996-09-11 光传感器股份有限公司 氧气的比率荧光测量法
US6379969B1 (en) * 2000-03-02 2002-04-30 Agilent Technologies, Inc. Optical sensor for sensing multiple analytes
US6777479B1 (en) * 1999-08-10 2004-08-17 Eastman Chemical Company Polyamide nanocomposites with oxygen scavenging capability

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3612866A (en) * 1969-07-08 1971-10-12 Brian Stevens Instrument for determining oxygen quantities by measuring oxygen quenching of fluorescent radiation
US4476870A (en) 1982-03-30 1984-10-16 The United States Of America As Represented By The Department Of Health And Human Services Fiber optic PO.sbsb.2 probe
US5030420A (en) * 1982-12-23 1991-07-09 University Of Virginia Alumni Patents Foundation Apparatus for oxygen determination
US4810655A (en) 1985-07-03 1989-03-07 Abbott Laboratories Method for measuring oxygen concentration
US5190729A (en) 1986-09-08 1993-03-02 C. R. Bard, Inc. Luminescent oxygen sensor based on a lanthanide complex
US4947850A (en) 1988-03-11 1990-08-14 Trustees Of The University Of Pennsylvania Method and apparatus for imaging an internal body portion of a host animal
GB8823986D0 (en) 1988-10-13 1988-11-23 Secr Defence Apparatus to provide oxygen-free gas
US5092467A (en) * 1989-02-27 1992-03-03 The Clorox Company Shipping and display container
US5407829A (en) 1990-03-27 1995-04-18 Avl Medical Instruments Ag Method for quality control of packaged organic substances and packaging material for use with this method
US6362175B1 (en) 1991-09-20 2002-03-26 The Trustees Of The University Of Pennsylvania Porphyrin compounds for imaging tissue oxygen
US5382163A (en) 1992-07-20 1995-01-17 Putnam; David L. Method and apparatus for detecting the presence of dental plaque or calculus
US5371016A (en) 1993-04-26 1994-12-06 Becton, Dickinson And Company Detecting biological activities in culture vials
US5837865A (en) 1993-10-15 1998-11-17 Trustees Of The University Of Pennsylvania Phosphorescent dendritic macromolecular compounds for imaging tissue oxygen
JPH07238181A (ja) 1994-01-21 1995-09-12 Minnesota Mining & Mfg Co <3M> 親水化多孔性物品
US5483819A (en) 1994-05-27 1996-01-16 W.R. Grace & Co.-Conn. Method of detecting the permeability of an object to oxygen
US6074870A (en) 1994-08-15 2000-06-13 Becton, Dickinson And Company Optical blood culture sensor
US5718842A (en) 1994-10-07 1998-02-17 Joanneum Reserach Forschungsgesellschaft Mbh Luminescent dye comprising metallocomplex of a oxoporphyrin
US6060196A (en) 1995-10-06 2000-05-09 Ceramtec, Inc. Storage-stable zinc anode based electrochemical cell
US5863460A (en) 1996-04-01 1999-01-26 Chiron Diagnostics Corporation Oxygen sensing membranes and methods of making same
US6165741A (en) 1997-05-30 2000-12-26 The Trustees Of The University Of Pennsylvania Method for rapid detection of bacterial growth in cultures
US6266211B1 (en) 1997-09-26 2001-07-24 Iomega Corporation Latent illuminance discrimination marker for data storage cartridges
AU770909B2 (en) 1998-08-26 2004-03-04 Sensors For Medicine And Science, Inc. Optical-based sensing devices
US6171368B1 (en) 1998-11-06 2001-01-09 Med-E-Cell Gas extraction from closed containers
US6153701A (en) 1998-11-20 2000-11-28 International Paper Company Wettable polypropylene composition and related method of manufacture
US6410255B1 (en) 1999-05-05 2002-06-25 Aurora Biosciences Corporation Optical probes and assays
US6395555B1 (en) 1999-10-14 2002-05-28 David F. Wilson Method and apparatus for determining the effect of a drug on cells
CN100520372C (zh) 2001-05-04 2009-07-29 医药及科学传感器公司 带有参考通道的电光传感器件
US6689438B2 (en) 2001-06-06 2004-02-10 Cryovac, Inc. Oxygen detection system for a solid article
ES2633729T3 (es) * 2001-08-22 2017-09-25 Instrumentation Laboratory Company Método para calibrar sensores electroquímicos
DE60336296D1 (de) 2002-01-17 2011-04-21 Univ College Cork Nat Univ Ie Testvorrichtung und verfahren zum chemischen oder biologischen screening
US7368153B2 (en) 2002-12-06 2008-05-06 Cryovac, Inc. Oxygen detection system for a rigid container
EP1601955B1 (en) 2003-03-07 2013-01-09 Luxcel Biosciences Limited An oxygen sensitive probe and method for measuring oxygen uptake
US7740965B2 (en) 2003-08-01 2010-06-22 The Gillette Company Battery
US7384988B2 (en) 2003-08-26 2008-06-10 Union College Method and device for fabricating aerogels and aerogel monoliths obtained thereby
JP2005195354A (ja) * 2003-12-26 2005-07-21 Toyota Motor Corp 酸素濃度測定装置および方法
US7248356B2 (en) 2004-04-06 2007-07-24 Pulsion Medical Systems Ag Calibration aid
JP2005300540A (ja) * 2004-04-06 2005-10-27 Pulsion Medical Systems Ag 較正補助手段
CN1280623C (zh) * 2004-07-16 2006-10-18 北京博奥生物芯片有限责任公司 一种用于荧光仪器校准测量的校准基片及其制备方法
US7534615B2 (en) 2004-12-03 2009-05-19 Cryovac, Inc. Process for detecting leaks in sealed packages
US20060144811A1 (en) 2005-01-05 2006-07-06 Lifetime Hoan Corporation Oxygen absorbing appliance
US8642285B2 (en) 2005-04-15 2014-02-04 Luxcel Biosciences Limited Assessment of consumption or release of a gaseous analyte from biological or chemical samples
EP1886126A4 (en) 2005-06-02 2010-07-28 Glaxo Group Ltd INDUCTIVELY FOSED REMOTE LAMBDASON
EP1742038A1 (en) 2005-07-06 2007-01-10 Academisch Medisch Centrum bij de Universiteit van Amsterdam Device and method for determining the concentration of a substance
EP1742039A1 (en) 2005-07-07 2007-01-10 F. Hoffmann-La Roche Ltd. Method for the determination of the concentration of a non-volatile analyte
US7310142B2 (en) 2005-08-22 2007-12-18 Sandia National Laboratories Fast time-correlated multi-element photon detector and method
US7569395B2 (en) 2006-03-13 2009-08-04 Cryovac, Inc. Method and apparatus for measuring oxygen concentration
US7749768B2 (en) 2006-03-13 2010-07-06 Cryovac, Inc. Non-invasive method of determining oxygen concentration in a sealed package
US20070243618A1 (en) 2006-04-11 2007-10-18 Oxysense, Inc. Device and method for non-invasive oxygen sensing of sealed packages
US20080051646A1 (en) 2006-07-24 2008-02-28 Papkovsky Dmitri B Probe for cellular oxygen
US7679745B2 (en) 2006-11-21 2010-03-16 Neptec Optical Solutions Time-resolved fluorescence spectrometer for multiple-species analysis
US8242162B2 (en) 2006-12-15 2012-08-14 Ohio Aerospace Institute Fluorescent aromatic sensors and their methods of use
US7849729B2 (en) 2006-12-22 2010-12-14 The Boeing Company Leak detection in vacuum bags
US20080199360A1 (en) 2007-02-16 2008-08-21 Ocean Optics, Inc. Method and composition for a platinum embedded sol gel optical chemical sensor with improved sensitivity and chemical stability
US7862770B2 (en) 2007-07-27 2011-01-04 Ocean Optics, Inc. Patches for non-intrusive monitoring of oxygen in packages
JP4725593B2 (ja) * 2008-03-31 2011-07-13 トヨタ自動車株式会社 試料濃度検出方法、装置およびプログラム
US8241911B2 (en) 2008-11-07 2012-08-14 Mocon, Inc. Calibration card for photoluminescent oxygen sensors with zero point maintained with a metal-air battery
EP2350614A4 (en) 2008-11-07 2017-01-11 Mocon, Inc. Calibration card for oxygen optical sensors
US8323978B2 (en) 2008-11-07 2012-12-04 Mocon, Inc. Calibration system and technique for photoluminescent oxygen sensors with zero point maintained with a metal-air battery
US20110084199A1 (en) * 2009-10-09 2011-04-14 Electronics And Telecommunications Research Institute Optical sensor using nano-spacer and detection method using the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1130943A (zh) * 1993-09-13 1996-09-11 光传感器股份有限公司 氧气的比率荧光测量法
US6777479B1 (en) * 1999-08-10 2004-08-17 Eastman Chemical Company Polyamide nanocomposites with oxygen scavenging capability
US6379969B1 (en) * 2000-03-02 2002-04-30 Agilent Technologies, Inc. Optical sensor for sensing multiple analytes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
基于荧光猝灭原理的光纤氧气传感器研究;黄俊等;《传感技术学报》;20010715(第02期);97-99 *
黄俊等.基于荧光猝灭原理的光纤氧气传感器研究.《传感技术学报》.2001,(第02期),97-99.

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