DE69721040D1 - Als antioxydanten verwendbare substituierte phenole und thiophenole - Google Patents
Als antioxydanten verwendbare substituierte phenole und thiophenoleInfo
- Publication number
- DE69721040D1 DE69721040D1 DE69721040T DE69721040T DE69721040D1 DE 69721040 D1 DE69721040 D1 DE 69721040D1 DE 69721040 T DE69721040 T DE 69721040T DE 69721040 T DE69721040 T DE 69721040T DE 69721040 D1 DE69721040 D1 DE 69721040D1
- Authority
- DE
- Germany
- Prior art keywords
- antioxydants
- thiophenols
- substituted phenols
- phenols
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/18—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring
- C07C39/19—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring containing carbon-to-carbon double bonds but no carbon-to-carbon triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75552896A | 1996-11-20 | 1996-11-20 | |
PCT/US1997/018055 WO1998022418A1 (en) | 1996-11-20 | 1997-10-07 | Substituted phenols and thiophenols useful as antioxidant agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69721040D1 true DE69721040D1 (de) | 2003-05-22 |
DE69721040T2 DE69721040T2 (de) | 2003-10-16 |
Family
ID=25039544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69721040T Expired - Lifetime DE69721040T2 (de) | 1996-11-20 | 1997-10-07 | Als antioxydanten verwendbare substituierte phenole und thiophenole |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0942896B1 (de) |
JP (2) | JP4267705B2 (de) |
KR (2) | KR100698995B1 (de) |
CN (1) | CN1168693C (de) |
AR (1) | AR009429A1 (de) |
AT (1) | ATE237574T1 (de) |
AU (1) | AU734050B2 (de) |
BR (1) | BR9713372A (de) |
CA (1) | CA2271054C (de) |
DE (1) | DE69721040T2 (de) |
DK (1) | DK0942896T3 (de) |
ES (1) | ES2191828T3 (de) |
HK (1) | HK1021970A1 (de) |
HU (1) | HUP9904244A3 (de) |
IL (1) | IL129957A (de) |
NO (1) | NO318039B1 (de) |
NZ (1) | NZ335440A (de) |
PT (1) | PT942896E (de) |
SI (1) | SI0942896T1 (de) |
TW (1) | TW508349B (de) |
WO (1) | WO1998022418A1 (de) |
ZA (1) | ZA9710315B (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6852878B2 (en) | 1998-05-14 | 2005-02-08 | Atherogenics, Inc. | Thioketals and thioethers for inhibiting the expression of VCAM-1 |
US6670398B2 (en) | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
EP1695959A1 (de) * | 1997-05-14 | 2006-08-30 | Atherogenics, Inc. | Verbindungen und Methoden zur Hemmung der VCAM-1 Expression |
PL194329B1 (pl) * | 1997-05-14 | 2007-05-31 | Atherogenics Inc | Zastosowanie monoestru probukolu kwasu bursztynowego lub jego farmaceutycznie dopuszczalnej soli dowytwarzania leku do leczenia choroby, której mediatorem jest VCAM-1 |
US6020383A (en) * | 1999-01-11 | 2000-02-01 | Eastman Chemicals Company | Method for reducing blood cholesterol and/or blood triglycerides |
AU2002363318B2 (en) * | 2001-10-25 | 2008-09-11 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
US20070260087A1 (en) | 2004-04-20 | 2007-11-08 | Atherogenics, Inc. | Process of Preparing Esters and Ethers of Probucol and Derivatives Thereof |
KR100725582B1 (ko) | 2004-06-29 | 2007-06-08 | 주식회사 동부하이텍 | 식물병원균의 생장억제활성을 갖는 알킬페놀 유도체 |
MX2007007453A (es) * | 2004-12-22 | 2007-07-19 | Ciba Sc Holding Ag | Agentes antirradicales. |
WO2008118948A1 (en) | 2007-03-26 | 2008-10-02 | Atherogenics, Inc. | Methods and compositions of derivatives of probucol for the treatment of diabetes |
KR101420083B1 (ko) * | 2012-04-04 | 2014-07-15 | 이화여자대학교 산학협력단 | Uch-l1 저해 화합물 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 uch-l1 관련 질환의 예방 또는 치료용 약학적 조성물 |
WO2014185561A1 (ko) * | 2013-05-13 | 2014-11-20 | 이화여자대학교 산학협력단 | 신규한 화합물 또는 이의 약학적으로 허용 가능한 염 및 이를 유효성분으로 함유하는 uch-l1 관련 질환의 예방 또는 치료용 약학적 조성물 |
WO2016170704A1 (ja) * | 2015-04-23 | 2016-10-27 | 株式会社日本ハイポックス | 慢性呼吸器疾患治療剤及び心臓の線維化抑制組成物 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57176038A (en) * | 1981-04-21 | 1982-10-29 | Fuji Photo Film Co Ltd | Silver halide color photographic material |
CA2050514A1 (en) * | 1990-09-14 | 1992-03-15 | Bradley C. Pearce | Acyclic tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia |
DE4109627A1 (de) * | 1991-03-23 | 1992-09-24 | Boehringer Mannheim Gmbh | Neue phenolether, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
CA2096496A1 (en) * | 1992-05-29 | 1993-11-30 | Bradley C. Pearce | Acyclic tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia |
EP0589069B1 (de) * | 1992-09-18 | 1997-01-29 | Nippon Hypox Laboratories Incorporated | Hydrochinonderivate und diese enthaltende Antioxydantien sowie Tumorinhibitoren |
JP3050733B2 (ja) * | 1992-10-16 | 2000-06-12 | 中外製薬株式会社 | 4−アルコキシ−2,6−ジ−t−ブチルフェノール誘導体 |
TW393475B (en) * | 1992-10-16 | 2000-06-11 | Chugai Pharmaceutical Co Ltd | 4-alkoxyl-2,6-di-t-butyl phenol derivatives |
-
1997
- 1997-10-07 KR KR1019997004402A patent/KR100698995B1/ko not_active IP Right Cessation
- 1997-10-07 DK DK97910819T patent/DK0942896T3/da active
- 1997-10-07 AU AU48098/97A patent/AU734050B2/en not_active Ceased
- 1997-10-07 CN CNB971999104A patent/CN1168693C/zh not_active Expired - Fee Related
- 1997-10-07 ES ES97910819T patent/ES2191828T3/es not_active Expired - Lifetime
- 1997-10-07 DE DE69721040T patent/DE69721040T2/de not_active Expired - Lifetime
- 1997-10-07 KR KR1020067001270A patent/KR100648118B1/ko not_active IP Right Cessation
- 1997-10-07 WO PCT/US1997/018055 patent/WO1998022418A1/en not_active Application Discontinuation
- 1997-10-07 EP EP97910819A patent/EP0942896B1/de not_active Expired - Lifetime
- 1997-10-07 CA CA002271054A patent/CA2271054C/en not_active Expired - Fee Related
- 1997-10-07 NZ NZ335440A patent/NZ335440A/en unknown
- 1997-10-07 HU HU9904244A patent/HUP9904244A3/hu unknown
- 1997-10-07 IL IL12995797A patent/IL129957A/xx not_active IP Right Cessation
- 1997-10-07 AT AT97910819T patent/ATE237574T1/de not_active IP Right Cessation
- 1997-10-07 SI SI9730517T patent/SI0942896T1/xx unknown
- 1997-10-07 PT PT97910819T patent/PT942896E/pt unknown
- 1997-10-07 JP JP52363998A patent/JP4267705B2/ja not_active Expired - Fee Related
- 1997-10-07 BR BR9713372A patent/BR9713372A/pt not_active IP Right Cessation
- 1997-11-14 ZA ZA9710315A patent/ZA9710315B/xx unknown
- 1997-11-15 TW TW086117094A patent/TW508349B/zh not_active IP Right Cessation
- 1997-11-17 AR ARP970105361A patent/AR009429A1/es not_active Application Discontinuation
-
1999
- 1999-05-19 NO NO19992390A patent/NO318039B1/no not_active IP Right Cessation
-
2000
- 2000-02-14 HK HK00100872A patent/HK1021970A1/xx not_active IP Right Cessation
-
2008
- 2008-11-19 JP JP2008295012A patent/JP2009132710A/ja active Pending
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: AVENTIS HOLDINGS INC., GREENVILLE, DEL., US |