ZA9710315B - Substituted phenols and thiophenols useful as antioxidant agents. - Google Patents

Substituted phenols and thiophenols useful as antioxidant agents.

Info

Publication number
ZA9710315B
ZA9710315B ZA9710315A ZA9710315A ZA9710315B ZA 9710315 B ZA9710315 B ZA 9710315B ZA 9710315 A ZA9710315 A ZA 9710315A ZA 9710315 A ZA9710315 A ZA 9710315A ZA 9710315 B ZA9710315 B ZA 9710315B
Authority
ZA
South Africa
Prior art keywords
substituted phenols
antioxidant agents
thiophenols
useful
thiophenols useful
Prior art date
Application number
ZA9710315A
Other languages
English (en)
Inventor
Roger A Parker
Paul S Wright
Steven J Busch
Kim S Chen
Mark T Yates
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of ZA9710315B publication Critical patent/ZA9710315B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/18—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring
    • C07C39/19—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring containing carbon-to-carbon double bonds but no carbon-to-carbon triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
ZA9710315A 1996-11-20 1997-11-14 Substituted phenols and thiophenols useful as antioxidant agents. ZA9710315B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75552896A 1996-11-20 1996-11-20

Publications (1)

Publication Number Publication Date
ZA9710315B true ZA9710315B (en) 1998-05-20

Family

ID=25039544

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9710315A ZA9710315B (en) 1996-11-20 1997-11-14 Substituted phenols and thiophenols useful as antioxidant agents.

Country Status (22)

Country Link
EP (1) EP0942896B1 (xx)
JP (2) JP4267705B2 (xx)
KR (2) KR100648118B1 (xx)
CN (1) CN1168693C (xx)
AR (1) AR009429A1 (xx)
AT (1) ATE237574T1 (xx)
AU (1) AU734050B2 (xx)
BR (1) BR9713372A (xx)
CA (1) CA2271054C (xx)
DE (1) DE69721040T2 (xx)
DK (1) DK0942896T3 (xx)
ES (1) ES2191828T3 (xx)
HK (1) HK1021970A1 (xx)
HU (1) HUP9904244A3 (xx)
IL (1) IL129957A (xx)
NO (1) NO318039B1 (xx)
NZ (1) NZ335440A (xx)
PT (1) PT942896E (xx)
SI (1) SI0942896T1 (xx)
TW (1) TW508349B (xx)
WO (1) WO1998022418A1 (xx)
ZA (1) ZA9710315B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852878B2 (en) 1998-05-14 2005-02-08 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of VCAM-1
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
DK0981343T3 (da) 1997-05-14 2006-01-30 Atherogenics Inc Probucolmonoestere til behandling af kardiovaskulær og inflammatorisk sygdom
EP1695959A1 (en) * 1997-05-14 2006-08-30 Atherogenics, Inc. Compouds and methods for the inhibition of the expression of VCAM-1
US6020383A (en) * 1999-01-11 2000-02-01 Eastman Chemicals Company Method for reducing blood cholesterol and/or blood triglycerides
CN100512809C (zh) * 2001-10-25 2009-07-15 阿特罗吉尼克斯公司 化合物在制备用于慢性移植排斥的药物中的用途
WO2005102323A2 (en) 2004-04-20 2005-11-03 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
KR100725582B1 (ko) 2004-06-29 2007-06-08 주식회사 동부하이텍 식물병원균의 생장억제활성을 갖는 알킬페놀 유도체
JP5191739B2 (ja) * 2004-12-22 2013-05-08 チバ ホールディング インコーポレーテッド 抗ラジカル剤
US8252840B2 (en) 2007-03-26 2012-08-28 Salutria Pharmaceuticals Llc Methods of derivatives of probucol for the treatment of type II diabetes
KR101420083B1 (ko) * 2012-04-04 2014-07-15 이화여자대학교 산학협력단 Ｕｃｈ－ｌ１ 저해 화합물 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 ｕｃｈ－ｌ１ 관련 질환의 예방 또는 치료용 약학적 조성물
WO2014185561A1 (ko) * 2013-05-13 2014-11-20 이화여자대학교 산학협력단 신규한 화합물 또는 이의 약학적으로 허용 가능한 염 및 이를 유효성분으로 함유하는 ｕｃｈ－ｌ１ 관련 질환의 예방 또는 치료용 약학적 조성물
WO2016170704A1 (ja) * 2015-04-23 2016-10-27 株式会社日本ハイポックス 慢性呼吸器疾患治療剤及び心臓の線維化抑制組成物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57176038A (en) * 1981-04-21 1982-10-29 Fuji Photo Film Co Ltd Silver halide color photographic material
CA2050514A1 (en) * 1990-09-14 1992-03-15 Bradley C. Pearce Acyclic tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia
DE4109627A1 (de) * 1991-03-23 1992-09-24 Boehringer Mannheim Gmbh Neue phenolether, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
CA2096496A1 (en) * 1992-05-29 1993-11-30 Bradley C. Pearce Acyclic tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia
EP0589069B1 (en) * 1992-09-18 1997-01-29 Nippon Hypox Laboratories Incorporated Hydroquinone derivatives and antioxidants and tumor inhibitors containing them
JP3050733B2 (ja) * 1992-10-16 2000-06-12 中外製薬株式会社 ４−アルコキシ−２，６−ジ−ｔ−ブチルフェノール誘導体
TW393475B (en) * 1992-10-16 2000-06-11 Chugai Pharmaceutical Co Ltd 4-alkoxyl-2,6-di-t-butyl phenol derivatives

Also Published As

Publication number Publication date
SI0942896T1 (en) 2003-08-31
NO318039B1 (no) 2005-01-24
CN1168693C (zh) 2004-09-29
CA2271054C (en) 2005-12-13
EP0942896A1 (en) 1999-09-22
PT942896E (pt) 2003-07-31
JP2001504483A (ja) 2001-04-03
NO992390D0 (no) 1999-05-19
CA2271054A1 (en) 1998-05-28
AU4809897A (en) 1998-06-10
HK1021970A1 (en) 2000-07-21
EP0942896B1 (en) 2003-04-16
JP4267705B2 (ja) 2009-05-27
HUP9904244A2 (hu) 2000-09-28
KR20060016839A (ko) 2006-02-22
AR009429A1 (es) 2000-04-12
NZ335440A (en) 2001-07-27
NO992390L (no) 1999-07-16
DK0942896T3 (da) 2003-07-28
AU734050B2 (en) 2001-05-31
KR100698995B1 (ko) 2007-03-26
WO1998022418A1 (en) 1998-05-28
KR20000057135A (ko) 2000-09-15
IL129957A0 (en) 2000-02-29
DE69721040T2 (de) 2003-10-16
HUP9904244A3 (en) 2002-07-29
BR9713372A (pt) 2000-03-21
CN1237955A (zh) 1999-12-08
IL129957A (en) 2005-06-19
KR100648118B1 (ko) 2006-11-28
JP2009132710A (ja) 2009-06-18
ES2191828T3 (es) 2003-09-16
ATE237574T1 (de) 2003-05-15
DE69721040D1 (de) 2003-05-22
TW508349B (en) 2002-11-01

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