CA2786692A1 - Biomarkers of immunomodulatory effects in humans treated with anti-cd200 antibodies - Google Patents
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- CA2786692A1 CA2786692A1 CA2786692A CA2786692A CA2786692A1 CA 2786692 A1 CA2786692 A1 CA 2786692A1 CA 2786692 A CA2786692 A CA 2786692A CA 2786692 A CA2786692 A CA 2786692A CA 2786692 A1 CA2786692 A1 CA 2786692A1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70517—CD8
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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| US61/401,442 | 2010-08-12 | ||
| US41697410P | 2010-11-24 | 2010-11-24 | |
| US61/416,974 | 2010-11-24 | ||
| PCT/US2011/020750 WO2011085343A1 (en) | 2010-01-11 | 2011-01-11 | Biomarkers of immunomodulatory effects in humans treated with anti-cd200 antibodies |
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| US8846098B2 (en) | 2009-07-10 | 2014-09-30 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Artificial cell constructs for cellular manipulation |
| US11090363B2 (en) | 2009-07-10 | 2021-08-17 | University of Pittsburgh—of the Commonwealth System of Higher Education | Vasoactive intestinal peptide release from microparticles |
| JP2013519682A (ja) | 2010-02-11 | 2013-05-30 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 抗ｃｄ２００抗体を使用する治療方法 |
| WO2012106634A1 (en) | 2011-02-03 | 2012-08-09 | Alexion Pharmaceuticals, Inc. | Use of an anti-cd200 antibody for prolonging the survival of allografts |
| CN102698266A (zh) * | 2012-05-15 | 2012-10-03 | 中国医学科学院北京协和医院 | Cd200在制备系统性红斑狼疮治疗药物中的应用 |
| AU2013285355A1 (en) | 2012-07-06 | 2015-01-29 | Genmab B.V. | Dimeric protein with triple mutations |
| CN105164535B (zh) * | 2013-02-14 | 2018-04-10 | 法龙药品公司 | 测定急性呼吸窘迫综合征(ards)相关生物标志物的方法、监测患者的ards的发展和治疗的方法 |
| JP7022067B2 (ja) * | 2016-01-14 | 2022-02-17 | メモリアル スローン ケタリング キャンサー センター | Ｆｏｘｐ３由来のペプチドに特異的なｔ細胞受容体様抗体 |
| GB201608197D0 (en) * | 2016-05-10 | 2016-06-22 | Ducentis Biotherapeutics Ltd | Novel proteins |
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| WO2018102594A1 (en) * | 2016-12-01 | 2018-06-07 | Alexion Pharmaceuticals, Inc. | Methods of treating solid tumors with anti-cd200 antibodies |
| IL270366B1 (en) * | 2017-05-08 | 2025-09-01 | Adimab Llc | Anti-cd3-binding domains and antibodies comprising them, and methods for their generation and use |
| WO2019067499A1 (en) | 2017-09-27 | 2019-04-04 | Alexion Pharmaceuticals, Inc. | BIOMARKER SIGNATURE FOR PREDICTING A TUMOR RESPONSE TO ANTI-CD200 THERAPY |
| WO2019126133A1 (en) | 2017-12-20 | 2019-06-27 | Alexion Pharmaceuticals, Inc. | Liquid formulations of anti-cd200 antibodies |
| WO2019126536A1 (en) | 2017-12-20 | 2019-06-27 | Alexion Pharmaceuticals Inc. | Humanized anti-cd200 antibodies and uses thereof |
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Also Published As
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| EP2523976B1 (en) | 2018-04-25 |
| JP2015155465A (ja) | 2015-08-27 |
| SG182408A1 (en) | 2012-08-30 |
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| EP2523976A1 (en) | 2012-11-21 |
| EP2523976A4 (en) | 2013-10-30 |
| JP2013516494A (ja) | 2013-05-13 |
| KR20130005264A (ko) | 2013-01-15 |
| US9180186B2 (en) | 2015-11-10 |
| RU2012134369A (ru) | 2014-02-20 |
| WO2011085343A1 (en) | 2011-07-14 |
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| MX2012008108A (es) | 2012-10-03 |
| CN102906115A (zh) | 2013-01-30 |
| US20130202602A1 (en) | 2013-08-08 |
| JP6012473B2 (ja) | 2016-10-25 |
| US20160033514A1 (en) | 2016-02-04 |
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