CA2785178C - Anti-flt3 antibodies and methods of using the same - Google Patents

Anti-flt3 antibodies and methods of using the same Download PDF

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Publication number
CA2785178C
CA2785178C CA2785178A CA2785178A CA2785178C CA 2785178 C CA2785178 C CA 2785178C CA 2785178 A CA2785178 A CA 2785178A CA 2785178 A CA2785178 A CA 2785178A CA 2785178 C CA2785178 C CA 2785178C
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antibody
antibodies
amino acid
seq
set forth
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French (fr)
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CA2785178A1 (en
Inventor
Ludger Grosse-Hovest
Hans-Joerg Buehring
Martin Hofmann
Steffen Aulwurm
Grundram Jung
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Synimmune GmbH
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Synimmune GmbH
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72Increased effector function due to an Fc-modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2785178A 2009-12-23 2010-12-23 Anti-flt3 antibodies and methods of using the same Active CA2785178C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28952909P 2009-12-23 2009-12-23
US61/289,529 2009-12-23
PCT/EP2010/070659 WO2011076922A1 (en) 2009-12-23 2010-12-23 Anti-flt3 antibodies and methods of using the same

Publications (2)

Publication Number Publication Date
CA2785178A1 CA2785178A1 (en) 2011-06-30
CA2785178C true CA2785178C (en) 2019-09-03

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CA2785178A Active CA2785178C (en) 2009-12-23 2010-12-23 Anti-flt3 antibodies and methods of using the same

Country Status (13)

Country Link
US (1) US9023996B2 (OSRAM)
EP (1) EP2516468B1 (OSRAM)
JP (1) JP5944831B2 (OSRAM)
CN (1) CN102770453B (OSRAM)
BR (1) BR112012015740B1 (OSRAM)
CA (1) CA2785178C (OSRAM)
DK (1) DK2516468T3 (OSRAM)
EA (1) EA027502B1 (OSRAM)
ES (1) ES2573642T3 (OSRAM)
HR (1) HRP20160422T1 (OSRAM)
HU (1) HUE028629T2 (OSRAM)
SI (1) SI2516468T1 (OSRAM)
WO (1) WO2011076922A1 (OSRAM)

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EA027502B1 (ru) 2017-08-31
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EP2516468B1 (en) 2016-03-02
HK1172910A1 (zh) 2013-05-03
HUE028629T2 (en) 2016-12-28
EP2516468A1 (en) 2012-10-31
US9023996B2 (en) 2015-05-05
CA2785178A1 (en) 2011-06-30
US20120328612A1 (en) 2012-12-27
WO2011076922A1 (en) 2011-06-30
CN102770453B (zh) 2014-10-08
ES2573642T3 (es) 2016-06-09
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HRP20160422T1 (hr) 2016-05-20
SI2516468T1 (sl) 2016-06-30

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