ES2573642T3 - Anticuerpos anti-FLT3 y métodos de usar los mismos - Google Patents

Anticuerpos anti-FLT3 y métodos de usar los mismos Download PDF

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Publication number
ES2573642T3
ES2573642T3 ES10798340.5T ES10798340T ES2573642T3 ES 2573642 T3 ES2573642 T3 ES 2573642T3 ES 10798340 T ES10798340 T ES 10798340T ES 2573642 T3 ES2573642 T3 ES 2573642T3
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Prior art keywords
antibodies
antibody
amino acid
modifications
fcγr
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English (en)
Spanish (es)
Inventor
Ludger Grosse-Hovest
Hans-Jörg BÜHRING
Martin Hofmann
Steffen Aulwurm
Grundram Jung
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Synimmune GmbH
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Synimmune GmbH
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72Increased effector function due to an Fc-modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES10798340.5T 2009-12-23 2010-12-23 Anticuerpos anti-FLT3 y métodos de usar los mismos Active ES2573642T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28952909P 2009-12-23 2009-12-23
US289529P 2009-12-23
PCT/EP2010/070659 WO2011076922A1 (en) 2009-12-23 2010-12-23 Anti-flt3 antibodies and methods of using the same

Publications (1)

Publication Number Publication Date
ES2573642T3 true ES2573642T3 (es) 2016-06-09

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ES10798340.5T Active ES2573642T3 (es) 2009-12-23 2010-12-23 Anticuerpos anti-FLT3 y métodos de usar los mismos

Country Status (13)

Country Link
US (1) US9023996B2 (OSRAM)
EP (1) EP2516468B1 (OSRAM)
JP (1) JP5944831B2 (OSRAM)
CN (1) CN102770453B (OSRAM)
BR (1) BR112012015740B1 (OSRAM)
CA (1) CA2785178C (OSRAM)
DK (1) DK2516468T3 (OSRAM)
EA (1) EA027502B1 (OSRAM)
ES (1) ES2573642T3 (OSRAM)
HR (1) HRP20160422T1 (OSRAM)
HU (1) HUE028629T2 (OSRAM)
SI (1) SI2516468T1 (OSRAM)
WO (1) WO2011076922A1 (OSRAM)

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EP2516468B1 (en) 2016-03-02
US20120328612A1 (en) 2012-12-27
WO2011076922A1 (en) 2011-06-30
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DK2516468T3 (en) 2016-05-23
SI2516468T1 (sl) 2016-06-30
CA2785178A1 (en) 2011-06-30
BR112012015740A2 (pt) 2017-04-25
CA2785178C (en) 2019-09-03
EP2516468A1 (en) 2012-10-31
JP2013515472A (ja) 2013-05-09
US9023996B2 (en) 2015-05-05
CN102770453B (zh) 2014-10-08
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BR112012015740B1 (pt) 2020-09-29
EA201290370A1 (ru) 2013-04-30

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