CA2782639C - Therapies for preventing or suppressing clostridium difficile infection - Google Patents
Therapies for preventing or suppressing clostridium difficile infection Download PDFInfo
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- CA2782639C CA2782639C CA2782639A CA2782639A CA2782639C CA 2782639 C CA2782639 C CA 2782639C CA 2782639 A CA2782639 A CA 2782639A CA 2782639 A CA2782639 A CA 2782639A CA 2782639 C CA2782639 C CA 2782639C
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- antibody
- antibodies
- toxin
- trypsin
- difficile
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0921288.7 | 2009-12-04 | ||
| GBGB0921288.7A GB0921288D0 (en) | 2009-12-04 | 2009-12-04 | Therapies for preventing or suppressing clostridium difficile infection |
| PCT/GB2010/050288 WO2010094970A1 (en) | 2009-02-20 | 2010-02-19 | Antibodies to clostridium difficile toxins |
| GBPCT/GB2010/050288 | 2010-02-19 | ||
| PCT/GB2010/052035 WO2011067616A1 (en) | 2009-12-04 | 2010-12-06 | Therapies for preventing or suppressing clostridium difficile infection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2782639A1 CA2782639A1 (en) | 2011-06-09 |
| CA2782639C true CA2782639C (en) | 2019-02-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2782639A Active CA2782639C (en) | 2009-12-04 | 2010-12-06 | Therapies for preventing or suppressing clostridium difficile infection |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8921529B2 (OSRAM) |
| EP (1) | EP2506877B1 (OSRAM) |
| JP (1) | JP5877161B2 (OSRAM) |
| CN (1) | CN102740889A (OSRAM) |
| BR (1) | BR112012013496A2 (OSRAM) |
| CA (1) | CA2782639C (OSRAM) |
| GB (1) | GB0921288D0 (OSRAM) |
| MY (1) | MY158712A (OSRAM) |
| SG (1) | SG181127A1 (OSRAM) |
| WO (1) | WO2011067616A1 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010094970A1 (en) | 2009-02-20 | 2010-08-26 | Health Protection Agency | Antibodies to clostridium difficile toxins |
| GB0921288D0 (en) | 2009-12-04 | 2010-01-20 | Health Prot Agency | Therapies for preventing or suppressing clostridium difficile infection |
| HUE033342T2 (en) | 2010-09-03 | 2017-11-28 | Valneva Austria Gmbh | Isolated polypeptide of the toxin a and toxin b proteins of c. difficile and uses thereof |
| GB201016742D0 (en) * | 2010-10-05 | 2010-11-17 | Health Prot Agency | Clostridium difficile antigens |
| HUE047085T2 (hu) | 2011-04-22 | 2020-04-28 | Wyeth Llc | Clostridium difficile mutáns toxinjához kapcsolódó készítmények és eljárásai |
| SG11201400916XA (en) | 2011-08-22 | 2014-06-27 | Cangene Corp | Clostridium difficile antibodies |
| CA2858519A1 (en) | 2011-12-08 | 2013-06-13 | Novartis Ag | Clostridium difficile toxin-based vaccine |
| DE102011121237A1 (de) * | 2011-12-14 | 2013-06-20 | Universitätsklinikum Hamburg-Eppendorf | Einzeldomänen-Antikörper gegen Clostridium difficile Toxin CDTa |
| AR089797A1 (es) * | 2012-01-27 | 2014-09-17 | Merck Sharp & Dohme | Vacunas contra clostridum difficile que comprenden toxinas recombinantes |
| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| BR112015021501A2 (pt) | 2013-03-08 | 2017-07-18 | Cipla Ltd | composição farmacêutica, composição farmacêutica espumável, processo para fabricação de uma composição farmacêutica para administração retal, lata de aerossol para uma composição farmacêutica, uso de uma composição farmacêutica e método para tratar ou manter a remissão de infecções causadas por clostridium difficile |
| CA2907156A1 (en) * | 2013-03-15 | 2014-09-18 | Sanofi Pasteur, Inc. | Toxins, compositions and related methods |
| CN105451762A (zh) * | 2013-04-22 | 2016-03-30 | 俄克拉荷马州大学评议会 | 艰难梭菌疫苗及使用方法 |
| SG11201510166YA (en) | 2013-06-14 | 2016-01-28 | Sanofi Pasteur Inc | Compositions and methods of immunizing against c. difficile |
| EP2957570B1 (en) * | 2014-06-20 | 2019-04-17 | Immunimed Inc. | Polyclonal antibodies against clostridium difficile and uses thereof |
| US10513552B2 (en) | 2014-06-20 | 2019-12-24 | Immunimed Inc. | Use of polyclonal antibodies against clostridium difficile for treatment of inflammatory bowel disease |
| DK3174553T3 (en) * | 2014-07-25 | 2018-07-23 | Biosynth Srl | GLYCOCOONJUGATE VACCINES INCLUDING BASIC UNITS OF A MOLECULE CONSTRUCTION THAT EXPRESSES MULTIPLE INTEGRATED EPITOPES FOR THE FORMULATION OF A WIDE-SPECTED VACCINE AGAINST INFECTIONS BASED ON BACTEROGEN |
| EP3121272A1 (en) * | 2015-07-24 | 2017-01-25 | Zymetech ehf. | Novel fish trypsin isoforms and their use |
| US20190111001A1 (en) * | 2016-03-30 | 2019-04-18 | University Of Maryland, Baltimore | Microparticulate system for colonic drug delivery |
| GB201701404D0 (en) * | 2017-01-27 | 2017-03-15 | Micropharm Ltd | Therapies for treating inflammatory disorders |
| GB202019817D0 (en) * | 2020-12-15 | 2021-01-27 | Univ Oxford Innovation Ltd | Ligand-binding polypeptides and uses thereof |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS608225A (ja) | 1983-06-29 | 1985-01-17 | Kowa Co | 腸管吸収医薬組成物 |
| US5601823A (en) * | 1989-10-31 | 1997-02-11 | Ophidian Pharmaceuticals, Inc. | Avian antitoxins to clostridium difficle toxin A |
| JPH10505358A (ja) | 1994-09-06 | 1998-05-26 | ギャラゲン・インコーポレイテッド | クロストリジウム・ディフィシル関連疾患の治療処置 |
| CZ296806B6 (cs) * | 1994-10-24 | 2006-06-14 | Allergan, Inc. | Rozpustný fúzní protein a zpusob výroby rozpustného rekombinantního botulinového toxinu |
| US6096310A (en) | 1997-04-15 | 2000-08-01 | Bier; Milan | Oral immunotherapy of bacterial overgrowth |
| WO1998059053A1 (en) | 1997-06-20 | 1998-12-30 | Queen Mary & Westfield College | Immonogenic fragments of toxin a of clostridium difficile |
| US6214341B1 (en) | 1997-10-20 | 2001-04-10 | Oravax | Passive immunization against Clostridium difficile disease |
| US6969520B2 (en) | 1997-10-20 | 2005-11-29 | Acambis Inc. | Active immunization against clostridium difficile disease |
| US6074689A (en) | 1998-03-10 | 2000-06-13 | Immucell Corporation | Colonic delivery of protein or peptide compositions |
| US20020009429A1 (en) | 1999-01-29 | 2002-01-24 | Galagen, Inc. | Pharmaceutical composition comprising a selected antigen and candida species antigen and methods |
| US6673574B2 (en) * | 2000-11-30 | 2004-01-06 | Unigene Laboratories Inc. | Oral delivery of peptides using enzyme-cleavable membrane translocators |
| GB0205206D0 (en) | 2002-03-06 | 2002-04-17 | Oxoid Ltd | Synthetic peptides |
| AU2003299527A1 (en) | 2002-06-17 | 2004-06-07 | Jimmy D. Ballard | Mutant of clostridium difficile toxin b and methods of use |
| WO2004003145A2 (en) * | 2002-06-28 | 2004-01-08 | Nastech Pharmaceutical Company Inc. | Compositions and methods for modulating physiology of epithelial junctional adhesion molecules for enhanced mucosal delivery of therapeutic compounds |
| GB0309126D0 (en) | 2003-04-17 | 2003-05-28 | Neutec Pharma Plc | Clostridium difficile focussed antibodies |
| JP4588763B2 (ja) | 2004-02-06 | 2010-12-01 | ユニバーシティー オブ マサチューセッツ | クロストリジウム・ディフィシル（Ｃｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅ）毒素に対する抗体およびその使用 |
| CA2565368A1 (en) * | 2004-04-29 | 2005-11-24 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Oral formulations comprising bone morphogenetic proteins for treating metabolic bone diseases |
| AU2005321974B2 (en) | 2004-12-27 | 2011-11-17 | Progenics Pharmaceuticals (Nevada), Inc. | Orally deliverable and anti-toxin antibodies and methods for making and using them |
| US7794721B2 (en) | 2006-12-13 | 2010-09-14 | Simon Michael R | Synthesis of human secretory IgM and the treatment of clostridium difficile associated diseases herewith |
| CN101363867B (zh) | 2008-05-26 | 2012-12-19 | 北京庄笛浩禾生物医学科技有限公司 | 一种艰难梭菌a、b毒素胶体金检测试纸条及其制备方法 |
| WO2010094970A1 (en) | 2009-02-20 | 2010-08-26 | Health Protection Agency | Antibodies to clostridium difficile toxins |
| GB0921288D0 (en) | 2009-12-04 | 2010-01-20 | Health Prot Agency | Therapies for preventing or suppressing clostridium difficile infection |
-
2009
- 2009-12-04 GB GBGB0921288.7A patent/GB0921288D0/en not_active Ceased
-
2010
- 2010-12-06 CA CA2782639A patent/CA2782639C/en active Active
- 2010-12-06 SG SG2012039616A patent/SG181127A1/en unknown
- 2010-12-06 MY MYPI2012002466A patent/MY158712A/en unknown
- 2010-12-06 BR BR112012013496A patent/BR112012013496A2/pt not_active IP Right Cessation
- 2010-12-06 US US13/513,555 patent/US8921529B2/en active Active
- 2010-12-06 JP JP2012541584A patent/JP5877161B2/ja active Active
- 2010-12-06 EP EP10787170.9A patent/EP2506877B1/en active Active
- 2010-12-06 WO PCT/GB2010/052035 patent/WO2011067616A1/en not_active Ceased
- 2010-12-06 CN CN2010800537789A patent/CN102740889A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN102740889A (zh) | 2012-10-17 |
| SG181127A1 (en) | 2012-07-30 |
| JP5877161B2 (ja) | 2016-03-02 |
| WO2011067616A1 (en) | 2011-06-09 |
| US8921529B2 (en) | 2014-12-30 |
| EP2506877B1 (en) | 2021-08-04 |
| EP2506877A1 (en) | 2012-10-10 |
| BR112012013496A2 (pt) | 2016-08-16 |
| US20130004561A1 (en) | 2013-01-03 |
| AU2010325764A1 (en) | 2012-06-07 |
| CA2782639A1 (en) | 2011-06-09 |
| MY158712A (en) | 2016-11-15 |
| GB0921288D0 (en) | 2010-01-20 |
| JP2013512889A (ja) | 2013-04-18 |
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Effective date: 20151124 |