CA2774389A1 - Methods of treating aneurysmal dilatation, blood vessel wall weakness and specifically abdominal aortic and thoracic aneurysm using matrix metalloprotease-2 inhibitors - Google Patents
Methods of treating aneurysmal dilatation, blood vessel wall weakness and specifically abdominal aortic and thoracic aneurysm using matrix metalloprotease-2 inhibitors Download PDFInfo
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- CA2774389A1 CA2774389A1 CA2774389A CA2774389A CA2774389A1 CA 2774389 A1 CA2774389 A1 CA 2774389A1 CA 2774389 A CA2774389 A CA 2774389A CA 2774389 A CA2774389 A CA 2774389A CA 2774389 A1 CA2774389 A1 CA 2774389A1
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- Prior art keywords
- blood vessel
- vessel wall
- inhibitors
- treatment
- aneurysm
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24784309P | 2009-10-01 | 2009-10-01 | |
| US61/247,843 | 2009-10-01 | ||
| PCT/US2010/050907 WO2011041545A1 (en) | 2009-10-01 | 2010-09-30 | Methods of treating aneurysmal dilatation, blood vessel wall weakness and specifically abdominal aortic and thoracic aneurysm using matrix metalloprotease-2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2774389A1 true CA2774389A1 (en) | 2011-04-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2774389A Abandoned CA2774389A1 (en) | 2009-10-01 | 2010-09-30 | Methods of treating aneurysmal dilatation, blood vessel wall weakness and specifically abdominal aortic and thoracic aneurysm using matrix metalloprotease-2 inhibitors |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20110082114A1 (enExample) |
| EP (1) | EP2482817A1 (enExample) |
| JP (1) | JP2013506684A (enExample) |
| CN (1) | CN102639134A (enExample) |
| CA (1) | CA2774389A1 (enExample) |
| WO (1) | WO2011041545A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011041545A1 (en) * | 2009-10-01 | 2011-04-07 | Symphony Evolution, Inc. | Methods of treating aneurysmal dilatation, blood vessel wall weakness and specifically abdominal aortic and thoracic aneurysm using matrix metalloprotease-2 inhibitors |
| US9629891B2 (en) | 2011-10-17 | 2017-04-25 | Nationwide Children's Hospital, Inc. | Products and methods for aortic abdominal aneurysm |
| WO2014018930A1 (en) * | 2012-07-27 | 2014-01-30 | Isis Pharmaceuticals. Inc. | Modulation of renin-angiotensin system (ras) related diseases by angiotensinogen |
| WO2014028334A1 (en) * | 2012-08-11 | 2014-02-20 | Symphony Evolution, Inc. | Selective mmp inhibitors |
| WO2014069490A1 (ja) | 2012-10-30 | 2014-05-08 | 国立大学法人東北大学 | サイクロフィリンａによる心血管疾患の検査方法 |
| CA2998898A1 (en) | 2015-10-08 | 2017-04-13 | Ionis Pharmaceuticals, Inc. | Compounds and methods for modulating angiotensinogen expression |
| US11376248B2 (en) * | 2017-06-30 | 2022-07-05 | Georgia State University Research Foundation, Inc. | Treatment of aneurysms |
| CN107417629B (zh) * | 2017-08-09 | 2020-02-07 | 苏州楚凯药业有限公司 | 动脉瘤抑制剂xl784的制备方法 |
| EP3675880B1 (en) | 2017-09-01 | 2023-06-07 | The Johns Hopkins University | Targeted epigenetic therapy for inherited aortic aneurysm condition |
| CN108947850B (zh) * | 2018-07-23 | 2021-05-18 | 蚌埠中实化学技术有限公司 | 一种3,4,5-三氟苯胺的制备方法 |
| CN112569219B (zh) * | 2019-09-30 | 2023-05-02 | 中国科学院上海药物研究所 | 用于治疗动脉相关疾病的药物及其用途 |
| CN111500721B (zh) * | 2020-04-20 | 2022-11-29 | 青岛大学附属医院 | Tace在腹主动脉瘤腔内修复术后内漏诊断中的应用 |
| TW202227101A (zh) | 2020-11-18 | 2022-07-16 | 美商Ionis製藥公司 | 用於調節血管收縮素原表現之化合物及方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000517185A (ja) | 1996-08-29 | 2000-12-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 新規なメタロプロテアーゼファミリーｋｕｚ |
| US5922546A (en) | 1997-08-25 | 1999-07-13 | Smithkline Beecham Corporation | Human disintegrin metalloprotease KUZ gene |
| US6133304A (en) * | 1997-12-23 | 2000-10-17 | Warner-Lambert Company | ACE inhibitor-MMP inhibitor combinations |
| AUPP584198A0 (en) * | 1998-09-14 | 1998-10-08 | Fujisawa Pharmaceutical Co., Ltd. | New use |
| US20060135449A1 (en) * | 2002-03-29 | 2006-06-22 | Yoshiki Sawa | Decoy compositions for treating and preventing brain diseases and disorders |
| EP2428509A1 (en) | 2002-06-12 | 2012-03-14 | Symphony Evolution, Inc. | Human adam-10 inhibitors |
| US7396540B2 (en) * | 2003-04-25 | 2008-07-08 | Medtronic Vascular, Inc. | In situ blood vessel and aneurysm treatment |
| US7371228B2 (en) * | 2003-09-19 | 2008-05-13 | Medtronic Vascular, Inc. | Delivery of therapeutics to treat aneurysms |
| US20050266043A1 (en) * | 2004-05-27 | 2005-12-01 | Medtronic Vascular, Inc. | Methods and compounds for treatment of aneurysmal tissue |
| WO2007016482A2 (en) * | 2005-07-29 | 2007-02-08 | Imperial Innovations Limited | Mutant timp-3 |
| WO2007050793A2 (en) * | 2005-10-25 | 2007-05-03 | The Johns Hopkins University | Methods and compositions for the treatment of marfan syndrome and associated disorders |
| WO2011041545A1 (en) * | 2009-10-01 | 2011-04-07 | Symphony Evolution, Inc. | Methods of treating aneurysmal dilatation, blood vessel wall weakness and specifically abdominal aortic and thoracic aneurysm using matrix metalloprotease-2 inhibitors |
-
2010
- 2010-09-30 WO PCT/US2010/050907 patent/WO2011041545A1/en not_active Ceased
- 2010-09-30 US US12/895,073 patent/US20110082114A1/en not_active Abandoned
- 2010-09-30 EP EP10762834A patent/EP2482817A1/en not_active Withdrawn
- 2010-09-30 CN CN2010800545319A patent/CN102639134A/zh active Pending
- 2010-09-30 US US13/497,726 patent/US20120270884A1/en not_active Abandoned
- 2010-09-30 CA CA2774389A patent/CA2774389A1/en not_active Abandoned
- 2010-09-30 JP JP2012532316A patent/JP2013506684A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN102639134A (zh) | 2012-08-15 |
| WO2011041545A1 (en) | 2011-04-07 |
| US20110082114A1 (en) | 2011-04-07 |
| JP2013506684A (ja) | 2013-02-28 |
| EP2482817A1 (en) | 2012-08-08 |
| US20120270884A1 (en) | 2012-10-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20160930 |