CA2767259A1 - Engineered microorganisms with enhanced fermentation activity - Google Patents
Engineered microorganisms with enhanced fermentation activity Download PDFInfo
- Publication number
- CA2767259A1 CA2767259A1 CA2767259A CA2767259A CA2767259A1 CA 2767259 A1 CA2767259 A1 CA 2767259A1 CA 2767259 A CA2767259 A CA 2767259A CA 2767259 A CA2767259 A CA 2767259A CA 2767259 A1 CA2767259 A1 CA 2767259A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- enzyme
- microbe
- yeast
- spp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000000694 effects Effects 0.000 title claims abstract 20
- 244000005700 microbiome Species 0.000 title abstract 3
- 238000000855 fermentation Methods 0.000 title abstract 2
- 230000004151 fermentation Effects 0.000 title abstract 2
- 108091033319 polynucleotide Proteins 0.000 claims 32
- 102000040430 polynucleotide Human genes 0.000 claims 32
- 239000002157 polynucleotide Substances 0.000 claims 32
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 21
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 20
- 108010029731 6-phosphogluconolactonase Proteins 0.000 claims 14
- 102000004190 Enzymes Human genes 0.000 claims 10
- 108090000790 Enzymes Proteins 0.000 claims 10
- 108700040099 Xylose isomerases Proteins 0.000 claims 10
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 claims 9
- 102000001762 6-phosphogluconolactonase Human genes 0.000 claims 7
- 102100031126 6-phosphogluconolactonase Human genes 0.000 claims 7
- 102100028601 Transaldolase Human genes 0.000 claims 7
- 241000233866 Fungi Species 0.000 claims 6
- 108010069341 Phosphofructokinases Proteins 0.000 claims 6
- 102000001105 Phosphofructokinases Human genes 0.000 claims 6
- 108020004530 Transaldolase Proteins 0.000 claims 6
- 102000014701 Transketolase Human genes 0.000 claims 6
- 108010043652 Transketolase Proteins 0.000 claims 6
- 230000010354 integration Effects 0.000 claims 6
- 241000235379 Piromyces Species 0.000 claims 5
- 241000192031 Ruminococcus Species 0.000 claims 5
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims 4
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 claims 4
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 claims 4
- 230000006801 homologous recombination Effects 0.000 claims 4
- 238000002744 homologous recombination Methods 0.000 claims 4
- 108010022393 phosphogluconate dehydratase Proteins 0.000 claims 4
- 230000017105 transposition Effects 0.000 claims 4
- 241000193830 Bacillus <bacterium> Species 0.000 claims 3
- 108091026890 Coding region Proteins 0.000 claims 3
- 241000588722 Escherichia Species 0.000 claims 3
- 108091052347 Glucose transporter family Proteins 0.000 claims 3
- 102000042092 Glucose transporter family Human genes 0.000 claims 3
- 229910019142 PO4 Inorganic materials 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 239000010452 phosphate Substances 0.000 claims 3
- 108010020020 phosphogluconate dehydrogenase (decarboxylating) Proteins 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 241000588724 Escherichia coli Species 0.000 claims 2
- 102000002794 Glucosephosphate Dehydrogenase Human genes 0.000 claims 2
- 241001502335 Orpinomyces Species 0.000 claims 2
- 241000589516 Pseudomonas Species 0.000 claims 2
- 241000192026 Ruminococcus flavefaciens Species 0.000 claims 2
- 241000235070 Saccharomyces Species 0.000 claims 2
- 230000004075 alteration Effects 0.000 claims 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims 2
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 2
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 2
- 108010064607 phosphoglucokinase Proteins 0.000 claims 2
- 101150010194 sol gene Proteins 0.000 claims 2
- 101150078419 zwf gene Proteins 0.000 claims 2
- IRJCQQRDILUJAQ-VPENINKCSA-N (2r,4s,5r)-2,4,5-trihydroxy-6-phosphonooxyhexanoic acid Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)C[C@@H](O)C(O)=O IRJCQQRDILUJAQ-VPENINKCSA-N 0.000 claims 1
- 102100032922 ATP-dependent 6-phosphofructokinase, muscle type Human genes 0.000 claims 1
- 101001027057 Bacillus subtilis (strain 168) Flagellin Proteins 0.000 claims 1
- 241000606123 Bacteroides thetaiotaomicron Species 0.000 claims 1
- 241001112695 Clostridiales Species 0.000 claims 1
- 241000193403 Clostridium Species 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 101150053890 EDA gene Proteins 0.000 claims 1
- 101150037782 GAL2 gene Proteins 0.000 claims 1
- 102100033925 GS homeobox 1 Human genes 0.000 claims 1
- 102100021735 Galectin-2 Human genes 0.000 claims 1
- 241000193385 Geobacillus stearothermophilus Species 0.000 claims 1
- 101000730838 Homo sapiens ATP-dependent 6-phosphofructokinase, muscle type Proteins 0.000 claims 1
- 101001068303 Homo sapiens GS homeobox 1 Proteins 0.000 claims 1
- 241000933069 Lachnoclostridium phytofermentans Species 0.000 claims 1
- 101100447536 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pgi-1 gene Proteins 0.000 claims 1
- 102000002508 Peptide Elongation Factors Human genes 0.000 claims 1
- 108010068204 Peptide Elongation Factors Proteins 0.000 claims 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
- 101150032095 SOL3 gene Proteins 0.000 claims 1
- 101100099697 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) TKL2 gene Proteins 0.000 claims 1
- 101150052008 TKL-1 gene Proteins 0.000 claims 1
- 241000193447 Thermoanaerobacter thermohydrosulfuricus Species 0.000 claims 1
- 241000589596 Thermus Species 0.000 claims 1
- 241000589499 Thermus thermophilus Species 0.000 claims 1
- 101150085516 ZWF1 gene Proteins 0.000 claims 1
- 241000193453 [Clostridium] cellulolyticum Species 0.000 claims 1
- 101150090240 edd gene Proteins 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
- C12P7/08—Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate
- C12P7/10—Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate substrate containing cellulosic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
- C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22443009P | 2009-07-09 | 2009-07-09 | |
| US61/224,430 | 2009-07-09 | ||
| US31678010P | 2010-03-23 | 2010-03-23 | |
| US61/316,780 | 2010-03-23 | ||
| US33409710P | 2010-05-12 | 2010-05-12 | |
| US61/334,097 | 2010-05-12 | ||
| PCT/US2010/041618 WO2011006136A2 (en) | 2009-07-09 | 2010-07-09 | Engineered microorganisms with enhanced fermentation activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2767259A1 true CA2767259A1 (en) | 2011-01-13 |
Family
ID=43429863
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2767259A Abandoned CA2767259A1 (en) | 2009-07-09 | 2010-07-09 | Engineered microorganisms with enhanced fermentation activity |
| CA2767361A Abandoned CA2767361A1 (en) | 2009-07-09 | 2010-07-09 | Engineered microorganisms with enhanced fermentation activity |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2767361A Abandoned CA2767361A1 (en) | 2009-07-09 | 2010-07-09 | Engineered microorganisms with enhanced fermentation activity |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US20120184007A1 (enEXAMPLES) |
| EP (1) | EP2451960A2 (enEXAMPLES) |
| AP (1) | AP3766A (enEXAMPLES) |
| BR (1) | BRPI1011934A8 (enEXAMPLES) |
| CA (2) | CA2767259A1 (enEXAMPLES) |
| IN (1) | IN2012DN00568A (enEXAMPLES) |
| WO (2) | WO2011006136A2 (enEXAMPLES) |
| ZA (1) | ZA201200506B (enEXAMPLES) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8498729B2 (en) * | 2008-08-29 | 2013-07-30 | Smp Logic Systems Llc | Manufacturing execution system for use in manufacturing baby formula |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| US20120184007A1 (en) * | 2009-07-09 | 2012-07-19 | Stephen Picataggio | Engineered microorganisms with enhanced fermentation activity |
| WO2011059314A1 (en) * | 2009-11-12 | 2011-05-19 | Stichting Voor De Technische Wetenschappen | Pentose transporters and uses thereof |
| US20110294170A1 (en) | 2010-05-28 | 2011-12-01 | Codexis, Inc. | Pentose Fermentation By a Recombinant Microorganism |
| WO2012125027A1 (en) | 2011-03-14 | 2012-09-20 | Dsm Ip Assets B.V. | Yeast strains that ferment uronic acids |
| US8663962B2 (en) | 2011-03-30 | 2014-03-04 | Codexis, Inc. | Pentose fermentation by a recombinant microorganism |
| EP2532733B1 (en) | 2011-06-06 | 2015-01-14 | Commissariat à l'Énergie Atomique et aux Énergies Alternatives | A method for enhancing the fermentative poteltial and growth rate of microorganisms under anaerobiosis |
| WO2013003219A1 (en) | 2011-06-30 | 2013-01-03 | Codexis, Inc. | Pentose fermentation by a recombinant microorganism |
| EP2546336A1 (en) | 2011-07-11 | 2013-01-16 | DSM IP Assets B.V. | Yeast strains that consume uronic acids and produce fermentation products such as ethanol |
| US8609382B1 (en) * | 2011-08-03 | 2013-12-17 | The United States Of America, As Represented By The Secretary Of Agriculture | Scheffersomyces stipitis strain for increased ethanol production and uses thereof |
| SG10201602673PA (en) * | 2011-10-07 | 2016-05-30 | Lonza Ag | Regulatable promoter |
| JP5817836B2 (ja) * | 2011-10-24 | 2015-11-18 | トヨタ自動車株式会社 | 組換え酵母を用いたエタノールの製造方法 |
| US9751781B2 (en) | 2012-03-20 | 2017-09-05 | The Research Foundation For The State University Of New York | Method to separate lignin-rich solid phase from acidic biomass suspension at an acidic pH |
| BR112015001458A2 (pt) | 2012-07-23 | 2017-09-26 | Edeniq Inc | polinucleotídeo isolado, cassete de expressão, célula de levedura, método para produzir açúcar a partir de etanol, e, mistura aquosa. |
| US20150275222A1 (en) * | 2012-10-22 | 2015-10-01 | Bo Jiang | Crz1 mutant fungal cells |
| JP2016511639A (ja) | 2013-02-22 | 2016-04-21 | テフニスヘ ユニヴェルシテイト デルフト | 生産物の収量を高める方法で使用される組み換え微生物 |
| WO2014133092A1 (ja) * | 2013-02-27 | 2014-09-04 | トヨタ自動車株式会社 | 組換え酵母を用いたエタノールの製造方法 |
| US8669076B1 (en) | 2013-03-11 | 2014-03-11 | E I Du Pont De Nemours And Company | Cow rumen xylose isomerases active in yeast cells |
| US9187743B2 (en) | 2013-03-11 | 2015-11-17 | E I Du Pont De Nemours And Company | Bacterial xylose isomerases active in yeast cells |
| US9850512B2 (en) | 2013-03-15 | 2017-12-26 | The Research Foundation For The State University Of New York | Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield |
| US9951363B2 (en) | 2014-03-14 | 2018-04-24 | The Research Foundation for the State University of New York College of Environmental Science and Forestry | Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects |
| US20180030482A1 (en) | 2014-04-18 | 2018-02-01 | Moralco B.V. | Use of acetaldehyde in the fermentative production of ethanol |
| US20170130210A1 (en) * | 2014-06-09 | 2017-05-11 | Massachusetts Institute Of Technology | Dynamic knockdown of central metabolism for redirecting glucose-6-phosphate fluxes |
| WO2016012429A1 (en) | 2014-07-24 | 2016-01-28 | Dsm Ip Assets B.V. | Yeast cell with improved pentose transport |
| WO2016093294A1 (ja) * | 2014-12-11 | 2016-06-16 | 東レ株式会社 | アルコールの製造方法 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN107614516A (zh) | 2015-05-11 | 2018-01-19 | 非凡食品有限公司 | 用于基因工程改造甲基营养型酵母的表达构建体和方法 |
| US10301653B2 (en) * | 2015-07-06 | 2019-05-28 | Wisconsin Alumni Research Foundation | Microorganisms that co-consume glucose with non-glucose carbohydrates and methods of use |
| US20190112590A1 (en) | 2016-04-08 | 2019-04-18 | Ei Du Pont De Nemours And Company | Arabinose isomerases for yeast |
| WO2018106656A1 (en) | 2016-12-06 | 2018-06-14 | Danisco Us Inc | Truncated lpmo enzymes and use thereof |
| WO2018106792A1 (en) | 2016-12-06 | 2018-06-14 | Novozymes A/S | Improved processes for production of ethanol from xylose-containing cellulosic substrates using engineered yeast strains |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| EP4001416A1 (en) | 2016-12-20 | 2022-05-25 | Novozymes A/S | Recombinant yeast strains for pentose fermentation |
| US11091753B2 (en) | 2017-05-31 | 2021-08-17 | Novozymes A/S | Xylose fermenting yeast strains and processes thereof for ethanol production |
| WO2018222990A1 (en) | 2017-06-02 | 2018-12-06 | Novozymes A/S | Improved yeast for ethanol production |
| BR112019025777A2 (pt) * | 2017-06-13 | 2020-06-30 | Dsm Ip Assets B.V. | célula de levedura recombinante |
| JP6879111B2 (ja) | 2017-08-02 | 2021-06-02 | トヨタ自動車株式会社 | 組換え酵母及びこれを用いたエタノールの製造方法 |
| WO2019074828A1 (en) | 2017-10-09 | 2019-04-18 | Danisco Us Inc | CELLOBIOSE DEHYDROGENASE VARIANTS AND METHODS OF USE |
| AU2019213033A1 (en) | 2018-01-29 | 2020-09-17 | Microbiogen Pty. Ltd. | Microorganisms with improved nitrogen utilization for ethanol production |
| US12215325B2 (en) | 2018-03-27 | 2025-02-04 | Basf Se | Xylose metabolizing yeast |
| US11459574B2 (en) | 2018-05-01 | 2022-10-04 | Research Institute Of Innovative Technology For The Earth | Transformant having Entner-Doudoroff pathway and production method for organic compound using same |
| CN108753672B (zh) * | 2018-06-11 | 2020-09-18 | 浙江大学 | 一种木糖醇基因工程生产菌及其构建方法和应用 |
| AU2019309683A1 (en) | 2018-07-25 | 2021-02-11 | Novozymes A/S | Enzyme-expressing yeast for ethanol production |
| WO2020076697A1 (en) | 2018-10-08 | 2020-04-16 | Novozymes A/S | Enzyme-expressing yeast for ethanol production |
| SG11202111468SA (en) | 2019-04-17 | 2021-11-29 | Impossible Foods Inc | Materials and methods for protein production |
| EP4004029A1 (en) | 2019-07-26 | 2022-06-01 | Novozymes A/S | Microorganisms with improved nitrogen transport for ethanol production |
| US20220307036A1 (en) | 2019-08-06 | 2022-09-29 | Novozymes A/S | Fusion proteins for improved enzyme expression |
| WO2021119304A1 (en) | 2019-12-10 | 2021-06-17 | Novozymes A/S | Microorganism for improved pentose fermentation |
| CN114107357B (zh) * | 2020-08-27 | 2024-04-05 | 中国科学院天津工业生物技术研究所 | 一种磷酸果糖激酶2突变体生产乙醇的重组丝状真菌及其构建和产乙醇的应用 |
| CN117795089A (zh) | 2021-06-07 | 2024-03-29 | 诺维信公司 | 用于改善的乙醇发酵的工程化微生物 |
| CN114410672B (zh) * | 2022-01-12 | 2023-11-07 | 天津大学（青岛）海洋工程研究院有限公司 | 希瓦氏菌中木糖和葡萄糖共利用代谢的构建方法 |
| CN116286939B (zh) * | 2023-02-03 | 2023-09-01 | 齐鲁工业大学(山东省科学院) | 一种提高酿酒酵母核酸产量的方法及应用 |
| WO2024258820A2 (en) | 2023-06-13 | 2024-12-19 | Novozymes A/S | Processes for producing fermentation products using engineered yeast expressing a beta-xylosidase |
| WO2025096363A2 (en) * | 2023-10-30 | 2025-05-08 | Cargill, Incorporated | Genetically modified yeast and fermentation processes for the production of xylitol |
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2010
- 2010-07-09 US US13/382,903 patent/US20120184007A1/en not_active Abandoned
- 2010-07-09 US US13/382,902 patent/US20120184020A1/en not_active Abandoned
- 2010-07-09 CA CA2767259A patent/CA2767259A1/en not_active Abandoned
- 2010-07-09 EP EP10732608A patent/EP2451960A2/en not_active Ceased
- 2010-07-09 WO PCT/US2010/041618 patent/WO2011006136A2/en active Application Filing
- 2010-07-09 CA CA2767361A patent/CA2767361A1/en not_active Abandoned
- 2010-07-09 AP AP2012006105A patent/AP3766A/en active
- 2010-07-09 WO PCT/US2010/041607 patent/WO2011006126A2/en active Application Filing
- 2010-07-09 BR BRPI1011934A patent/BRPI1011934A8/pt not_active Application Discontinuation
- 2010-07-09 IN IN568DEN2012 patent/IN2012DN00568A/en unknown
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2011
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- 2011-03-11 US US13/045,855 patent/US8227236B2/en not_active Expired - Fee Related
- 2011-03-11 US US13/045,829 patent/US8114974B2/en not_active Expired - Fee Related
- 2011-03-11 US US13/045,841 patent/US8093037B2/en not_active Expired - Fee Related
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2012
- 2012-01-20 ZA ZA2012/00506A patent/ZA201200506B/en unknown
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| WO2011006126A3 (en) | 2011-07-21 |
| BRPI1011934A8 (pt) | 2017-10-03 |
| US20110165661A1 (en) | 2011-07-07 |
| AP3766A (en) | 2016-07-31 |
| US20120184007A1 (en) | 2012-07-19 |
| US8114974B2 (en) | 2012-02-14 |
| BRPI1011934A2 (pt) | 2016-06-21 |
| WO2011006136A3 (en) | 2011-04-28 |
| US20120184020A1 (en) | 2012-07-19 |
| US20110224416A1 (en) | 2011-09-15 |
| AP2012006105A0 (en) | 2012-02-29 |
| US20110165660A1 (en) | 2011-07-07 |
| IN2012DN00568A (enEXAMPLES) | 2015-06-12 |
| US20110229959A1 (en) | 2011-09-22 |
| WO2011006126A2 (en) | 2011-01-13 |
| ZA201200506B (en) | 2012-09-26 |
| WO2011006136A2 (en) | 2011-01-13 |
| EP2451960A2 (en) | 2012-05-16 |
| CA2767361A1 (en) | 2011-01-13 |
| US8227236B2 (en) | 2012-07-24 |
| US8093037B2 (en) | 2012-01-10 |
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