CA2761018A1 - Composes aromatiques substitues et utilisations pharmaceutiques de ceux-ci - Google Patents

Composes aromatiques substitues et utilisations pharmaceutiques de ceux-ci Download PDF

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Publication number
CA2761018A1
CA2761018A1 CA2761018A CA2761018A CA2761018A1 CA 2761018 A1 CA2761018 A1 CA 2761018A1 CA 2761018 A CA2761018 A CA 2761018A CA 2761018 A CA2761018 A CA 2761018A CA 2761018 A1 CA2761018 A1 CA 2761018A1
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alkyl
halogen
haloalkyl
alkenyl
compound
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CA2761018A
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CA2761018C (fr
Inventor
Boulos Zacharie
Christopher Penney
Lyne Gagnon
Jean-Francois Bienvenu
Valerie Perron
Brigitte Grouix
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Liminal R&D Biosciences Inc
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Prometic Biosciences Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/39—Unsaturated compounds containing six-membered aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
CA2761018A 2009-05-04 2010-05-03 Composes aromatiques substitues et utilisations pharmaceutiques de ceux-ci Active CA2761018C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17523509P 2009-05-04 2009-05-04
US61/175,235 2009-05-04
PCT/CA2010/000677 WO2010127440A1 (fr) 2009-05-04 2010-05-03 Composés aromatiques substitués et utilisations pharmaceutiques de ceux-ci

Publications (2)

Publication Number Publication Date
CA2761018A1 true CA2761018A1 (fr) 2010-11-11
CA2761018C CA2761018C (fr) 2018-03-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2761018A Active CA2761018C (fr) 2009-05-04 2010-05-03 Composes aromatiques substitues et utilisations pharmaceutiques de ceux-ci

Country Status (22)

Country Link
US (4) US8927765B2 (fr)
EP (1) EP2427416B1 (fr)
JP (2) JP2012526052A (fr)
KR (2) KR20120024696A (fr)
CN (1) CN102438975B (fr)
AU (1) AU2010244930B2 (fr)
BR (1) BRPI1015124B8 (fr)
CA (1) CA2761018C (fr)
DK (1) DK2427416T3 (fr)
EA (1) EA022445B1 (fr)
ES (1) ES2575100T3 (fr)
HK (1) HK1169645A1 (fr)
HU (1) HUE029126T2 (fr)
IL (1) IL216006A (fr)
MX (1) MX2011011757A (fr)
MY (1) MY156780A (fr)
NZ (1) NZ595978A (fr)
PL (1) PL2427416T3 (fr)
PT (1) PT2427416E (fr)
SG (1) SG175855A1 (fr)
TW (1) TWI485134B (fr)
WO (1) WO2010127440A1 (fr)

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PL2427417T3 (pl) * 2009-05-04 2014-03-31 Prometic Pharma Smt Ltd Sole kwasu 3-pentylofenylooctowego i ich farmaceutyczne zastosowania
MY156780A (en) 2009-05-04 2016-03-31 Prometic Biosciences Inc Substituted aromatic compounds and pharmaceutical uses thereof
AT509045B1 (de) * 2010-01-29 2011-06-15 Planta Naturstoffe Vertriebsges M B H Verbindungen zur behandlung von asthma bronchiale
WO2012097428A1 (fr) * 2010-10-27 2012-07-26 Prometic Biosciences Inc. Composés et compositions pharmaceutiques pour utilisation dans le diabète
EP2632452B1 (fr) 2010-10-27 2018-09-26 Prometic Pharma Smt Limited Composés et compositions pour le traitement du cancer
TWI689489B (zh) * 2013-03-15 2020-04-01 英商邊緣生物科技有限公司 用於治療肺纖維化、肝纖維化、皮膚纖維化及心臟纖維化之經取代之芳族化合物
TWI689490B (zh) 2013-03-15 2020-04-01 英商邊緣生物科技有限公司 用於治療纖維化之經取代之芳族化合物及相關方法
US9856214B2 (en) * 2013-11-15 2018-01-02 The Wistar Institute Of Anatomy And Biology EBNA1 inhibitors and their method of use
GB201416017D0 (en) * 2014-09-10 2014-10-22 New Royal Holloway & Bedford An Anticonvulsant Compound
MX2017004733A (es) * 2014-10-10 2017-07-17 Prometic Pharma Smt Ltd Compuestos aromaticos sustituidos y composiciones farmaceuticas para la prevencion y tratamiento de osteoporosis.
CA2967499C (fr) 2014-11-12 2023-01-17 Prometic Biosciences Inc. Composes aromatiques substitues et compositions pharmaceutiques pour auto-reparation et regeneration de tissu
JP6771491B2 (ja) 2015-05-14 2020-10-21 ザ ウィスター インスティテュート オブ アナトミー アンド バイオロジー Ｅｂｎａ１阻害剤およびその使用方法
EP3793546A4 (fr) 2018-05-17 2021-12-08 The Wistar Institute Formes cristallines d'inhibiteur d'ebna1 et procédés de préparation et méthodes d'utilisation de celles-ci
CN108997202A (zh) * 2018-07-10 2018-12-14 湖南华腾制药有限公司 一种（5-三氟甲基-吡啶-2-基）-乙酸盐的制备方法
CA3121830A1 (fr) * 2018-12-05 2020-06-11 Liminal R&D Biosciences Inc. Utilisation de 2-(3-pentylphenyl)acetate de sodium dans le traitement du syndrome d'alstrom
US20220380288A1 (en) * 2019-10-31 2022-12-01 Teva Pharmaceuticals International Gmbh Solid state forms of fezagepras and process for preparation thereof

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KR101923354B1 (ko) 2018-11-28
MY156780A (en) 2016-03-31
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JP2012526052A (ja) 2012-10-25
EP2427416A4 (fr) 2012-10-03
US20120088784A1 (en) 2012-04-12
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CN102438975A (zh) 2012-05-02
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US8927765B2 (en) 2015-01-06
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BRPI1015124B1 (pt) 2021-02-23
KR20120024696A (ko) 2012-03-14
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US20150094372A1 (en) 2015-04-02
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US20210002202A1 (en) 2021-01-07
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IL216006A (en) 2015-03-31
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