CA2758120C - Engineered mesenchymal stem cells and method of using same to treat tumors - Google Patents

Engineered mesenchymal stem cells and method of using same to treat tumors Download PDF

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Publication number
CA2758120C
CA2758120C CA2758120A CA2758120A CA2758120C CA 2758120 C CA2758120 C CA 2758120C CA 2758120 A CA2758120 A CA 2758120A CA 2758120 A CA2758120 A CA 2758120A CA 2758120 C CA2758120 C CA 2758120C
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genetically modified
mesenchymal stem
stem cells
tumor
promoter
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Expired - Fee Related
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CA2758120A1 (en
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Peter Nelson
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Apceth GmbH and Co KG
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Apceth GmbH and Co KG
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • CCHEMISTRY; METALLURGY
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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    • C12N2510/00Genetically modified cells
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    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/15011Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/001Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2758120A 2009-04-13 2010-04-13 Engineered mesenchymal stem cells and method of using same to treat tumors Expired - Fee Related CA2758120C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16878709P 2009-04-13 2009-04-13
US61/168,787 2009-04-13
PCT/EP2010/054844 WO2010119039A1 (en) 2009-04-13 2010-04-13 Engineered mesenchymal stem cells and method of using same to treat tumors

Publications (2)

Publication Number Publication Date
CA2758120A1 CA2758120A1 (en) 2010-10-21
CA2758120C true CA2758120C (en) 2014-08-19

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CA2758120A Expired - Fee Related CA2758120C (en) 2009-04-13 2010-04-13 Engineered mesenchymal stem cells and method of using same to treat tumors

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US (2) US9434925B2 (cg-RX-API-DMAC7.html)
EP (1) EP2419113B1 (cg-RX-API-DMAC7.html)
JP (1) JP5727458B2 (cg-RX-API-DMAC7.html)
KR (1) KR20120088542A (cg-RX-API-DMAC7.html)
CN (1) CN102695517B (cg-RX-API-DMAC7.html)
AU (1) AU2010237130B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI1013771A2 (cg-RX-API-DMAC7.html)
CA (1) CA2758120C (cg-RX-API-DMAC7.html)
IL (1) IL215581A0 (cg-RX-API-DMAC7.html)
RU (1) RU2539099C2 (cg-RX-API-DMAC7.html)
SG (1) SG175127A1 (cg-RX-API-DMAC7.html)
WO (1) WO2010119039A1 (cg-RX-API-DMAC7.html)

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US12053493B2 (en) 2016-11-03 2024-08-06 Exostem Biotec Ltd. Mesenchymal stem cells populations, their products, and use thereof

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US20140065110A1 (en) 2012-08-31 2014-03-06 The Regents Of The University Of California Genetically modified msc and therapeutic methods
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US10472647B2 (en) 2012-12-21 2019-11-12 The Administrators Of The Tulane Educational Fund Primary mesenchymal stem cells as a vaccine platform
WO2015100268A1 (en) * 2013-12-23 2015-07-02 The Regents Of The University Of California Mesenchymal stem cells for targeted cancer therapy
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EP3247808B1 (en) 2015-01-21 2021-05-05 Fred Hutchinson Cancer Research Center Point-of-care and/or portable platform for gene therapy
WO2016138340A1 (en) * 2015-02-27 2016-09-01 Saint Louis University Tumor suppressor sall1 as a therapeutic agent for treating cancer
EP3262159B1 (en) * 2015-02-27 2019-07-24 Apceth GmbH & Co. KG Genetically modified mesenchymal stem cell expressing klotho
WO2016146819A1 (en) * 2015-03-18 2016-09-22 Apceth Gmbh & Co. Kg Hypoxia-induced expression of therapeutic proteins in mesenchymal stem cells
JP6890831B2 (ja) 2015-07-08 2021-06-18 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド Hiv予備免疫化および免疫療法
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WO2017036925A1 (en) * 2015-08-28 2017-03-09 Apceth Gmbh & Co. Kg Mesenchymal stem cells for the treatment of metastatic liver disease
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JP7153332B2 (ja) 2016-02-08 2022-10-14 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド Hivワクチン接種および免疫療法
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Publication number Priority date Publication date Assignee Title
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Publication number Publication date
US20120087901A1 (en) 2012-04-12
JP2012523243A (ja) 2012-10-04
EP2419113A1 (en) 2012-02-22
AU2010237130A1 (en) 2011-11-03
JP5727458B2 (ja) 2015-06-03
BRPI1013771A2 (pt) 2016-04-05
WO2010119039A1 (en) 2010-10-21
US20170015976A1 (en) 2017-01-19
EP2419113B1 (en) 2017-05-10
IL215581A0 (en) 2011-12-29
CN102695517A (zh) 2012-09-26
KR20120088542A (ko) 2012-08-08
RU2011146048A (ru) 2013-05-20
RU2539099C2 (ru) 2015-01-10
US9434925B2 (en) 2016-09-06
SG175127A1 (en) 2011-11-28
AU2010237130B2 (en) 2015-01-29
CA2758120A1 (en) 2010-10-21
CN102695517B (zh) 2015-01-28

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