CA2750230C - Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran - Google Patents

Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran Download PDF

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Publication number
CA2750230C
CA2750230C CA2750230A CA2750230A CA2750230C CA 2750230 C CA2750230 C CA 2750230C CA 2750230 A CA2750230 A CA 2750230A CA 2750230 A CA2750230 A CA 2750230A CA 2750230 C CA2750230 C CA 2750230C
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composition
dextran
dtpa
concentration
sodium
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CA2750230A
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English (en)
French (fr)
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CA2750230A1 (en
Inventor
Gerald Ross Magneson
Richard Cushman Orahood
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Cardinal Health 414 LLC
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Cardinal Health 414 LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/005—Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C07B63/04—Use of additives
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CA2750230A 2009-01-30 2010-01-28 Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran Active CA2750230C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/362,778 US20100196272A1 (en) 2009-01-30 2009-01-30 Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran
US12/362,778 2009-01-30
PCT/US2010/000222 WO2010087959A1 (en) 2009-01-30 2010-01-28 Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran

Publications (2)

Publication Number Publication Date
CA2750230A1 CA2750230A1 (en) 2010-08-05
CA2750230C true CA2750230C (en) 2018-06-05

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ID=42395938

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2750230A Active CA2750230C (en) 2009-01-30 2010-01-28 Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran

Country Status (9)

Country Link
US (4) US20100196272A1 (OSRAM)
EP (2) EP2392012B1 (OSRAM)
JP (5) JP5743905B2 (OSRAM)
KR (2) KR101765717B1 (OSRAM)
CN (1) CN102301429A (OSRAM)
AU (1) AU2010208624B2 (OSRAM)
BR (1) BRPI1007487A2 (OSRAM)
CA (1) CA2750230C (OSRAM)
WO (1) WO2010087959A1 (OSRAM)

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JP6163698B2 (ja) * 2013-03-21 2017-07-19 国立大学法人 千葉大学 マクロファージマンノース受容体を認識する新規多糖金属錯体化合物、及び、その医薬組成物
EP3024493A1 (en) 2013-07-22 2016-06-01 Navidea Biopharmaceuticals, Inc. Compositions, methods and kits for diagnosing and treating cd206 expressing cell-related disorders
US10328149B2 (en) 2014-06-13 2019-06-25 Tenboron Oy Conjugates comprising an anti-EGFR1 antibody
CA2955438C (en) * 2014-07-17 2024-07-02 Ohio State Innovation Foundation DEXTRANE CONJUGATES TO TARGET MACROPHAGES AND OTHER CELLS EXPRESSING THE D-MANBOSE BINDING TYPE C LECTIN RECEPTOR
US10806803B2 (en) 2014-07-17 2020-10-20 Ohio State Innovation Foundation Compositions for targeting macrophages and other CD206 high expressing cells and methods of treating and diagnosis
CN115536714B (zh) * 2014-11-13 2026-04-24 沃特世科技公司 快速标记的n-聚糖的液相色谱校准方法
GB201504064D0 (en) 2015-03-10 2015-04-22 Accretion Biotechnology Ltd Method and kits for preparing radionuclide complexes
CN106317237B (zh) * 2015-07-03 2019-07-19 华中科技大学 一种用于spect成像的当归多糖衍生物及其合成方法
CN106188226B (zh) * 2016-07-04 2019-12-24 江苏省原子医学研究所 一种用于淋巴结检查的大分子显像剂及其制备方法
US10695450B2 (en) 2016-07-26 2020-06-30 Laboratoires Cyclopharma Synthesis of a radioactive agent composition
FR3054445B1 (fr) * 2016-07-26 2019-07-05 Laboratoires Cyclopharma Synthese d'une composition d'agent radioactif
IL265846B2 (en) 2016-10-07 2024-02-01 Navidea Biopharmaceuticals Inc Compounds and methods for diagnosis and treatment of viral infections
JP6329302B2 (ja) * 2017-05-10 2018-05-23 国立大学法人千葉大学 マクロファージマンノース受容体を認識する新規多糖金属錯体化合物、及び、その医薬組成物
US20220175973A1 (en) * 2019-03-29 2022-06-09 National Institutes for Quantum Science and Technology Method for producing radiopharmaceutical and radiopharmaceutical
CA3168879A1 (en) 2020-07-08 2022-01-13 Navidea Biopharmaceuticals, Inc. Synthesis of uniformly defined molecular weight mannosylated dextrans and derivatives thereof
WO2023225273A1 (en) 2022-05-20 2023-11-23 Navidea Biopharmaceuticals, Inc. Cd206 targeted drug delivery vehicles carrying novel bisphosphonate drug payloads via a degradable linker
JP2025535006A (ja) 2022-10-03 2025-10-22 ナビディア、バイオファーマスーティカルズ、インコーポレイテッド 炭水化物ポリマーに結合されたアミン終端リーシュへの糖部分のアミド結合

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CA2955438C (en) 2014-07-17 2024-07-02 Ohio State Innovation Foundation DEXTRANE CONJUGATES TO TARGET MACROPHAGES AND OTHER CELLS EXPRESSING THE D-MANBOSE BINDING TYPE C LECTIN RECEPTOR
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Also Published As

Publication number Publication date
US20140023586A1 (en) 2014-01-23
JP6040276B2 (ja) 2016-12-07
US20120213700A1 (en) 2012-08-23
EP2392012A4 (en) 2012-11-14
KR20170027874A (ko) 2017-03-10
US20100196272A1 (en) 2010-08-05
JP2021088566A (ja) 2021-06-10
JP2012516328A (ja) 2012-07-19
KR20110115148A (ko) 2011-10-20
AU2010208624B2 (en) 2016-02-04
CN102301429A (zh) 2011-12-28
US8545808B2 (en) 2013-10-01
EP2392012A1 (en) 2011-12-07
US9439985B2 (en) 2016-09-13
BRPI1007487A2 (pt) 2018-02-20
JP2019178133A (ja) 2019-10-17
JP6833892B2 (ja) 2021-02-24
JP2015164933A (ja) 2015-09-17
CA2750230A1 (en) 2010-08-05
JP6509796B2 (ja) 2019-05-08
KR101713559B1 (ko) 2017-03-08
JP2017066148A (ja) 2017-04-06
US20160347679A1 (en) 2016-12-01
JP5743905B2 (ja) 2015-07-01
EP3884965A1 (en) 2021-09-29
AU2010208624A1 (en) 2011-08-25
WO2010087959A1 (en) 2010-08-05
KR101765717B1 (ko) 2017-08-07
EP2392012B1 (en) 2021-01-20

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