BRPI1007487A2 - composição para radiomarcar ácido dietilenotriaminopentacético (dtpa)-dextrano - Google Patents
composição para radiomarcar ácido dietilenotriaminopentacético (dtpa)-dextranoInfo
- Publication number
- BRPI1007487A2 BRPI1007487A2 BRPI1007487A BRPI1007487A BRPI1007487A2 BR PI1007487 A2 BRPI1007487 A2 BR PI1007487A2 BR PI1007487 A BRPI1007487 A BR PI1007487A BR PI1007487 A BRPI1007487 A BR PI1007487A BR PI1007487 A2 BRPI1007487 A2 BR PI1007487A2
- Authority
- BR
- Brazil
- Prior art keywords
- radiolabelling
- dtpa
- dextran
- composition
- diethylenetriaminopentacetic acid
- Prior art date
Links
- 229920002307 Dextran Polymers 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 238000000163 radioactive labelling Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/005—Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
- A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B63/00—Purification; Separation; Stabilisation; Use of additives
- C07B63/04—Use of additives
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/362,778 US20100196272A1 (en) | 2009-01-30 | 2009-01-30 | Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran |
| PCT/US2010/000222 WO2010087959A1 (en) | 2009-01-30 | 2010-01-28 | Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1007487A2 true BRPI1007487A2 (pt) | 2018-02-20 |
Family
ID=42395938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1007487A BRPI1007487A2 (pt) | 2009-01-30 | 2010-01-28 | composição para radiomarcar ácido dietilenotriaminopentacético (dtpa)-dextrano |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US20100196272A1 (pt) |
| EP (2) | EP3884965A1 (pt) |
| JP (5) | JP5743905B2 (pt) |
| KR (2) | KR101765717B1 (pt) |
| CN (1) | CN102301429A (pt) |
| AU (1) | AU2010208624B2 (pt) |
| BR (1) | BRPI1007487A2 (pt) |
| CA (1) | CA2750230C (pt) |
| WO (1) | WO2010087959A1 (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100196272A1 (en) * | 2009-01-30 | 2010-08-05 | Neoprobe Corporation | Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran |
| JP6163698B2 (ja) * | 2013-03-21 | 2017-07-19 | 国立大学法人 千葉大学 | マクロファージマンノース受容体を認識する新規多糖金属錯体化合物、及び、その医薬組成物 |
| US20150023876A1 (en) | 2013-07-22 | 2015-01-22 | Navidea Biopharmaceuticals, Inc. | Compositions, methods and kits for diagnosing and treating cd206 expressing cell-related disorders |
| JP5924795B2 (ja) | 2014-06-13 | 2016-05-25 | テンボロン オイ | 複合体 |
| US10806803B2 (en) | 2014-07-17 | 2020-10-20 | Ohio State Innovation Foundation | Compositions for targeting macrophages and other CD206 high expressing cells and methods of treating and diagnosis |
| EP3169792A4 (en) * | 2014-07-17 | 2018-04-11 | The Ohio State Innovation Foundation | Compounds and compositions for targeting macrophages and other mannose-binding c-type lectin receptor high expressing cells and methods of treating and diagnosis using same |
| CN111796039B (zh) * | 2014-11-13 | 2023-03-17 | 沃特世科技公司 | 快速标记的n-聚糖的液相色谱校准方法 |
| GB201504064D0 (en) | 2015-03-10 | 2015-04-22 | Accretion Biotechnology Ltd | Method and kits for preparing radionuclide complexes |
| CN106317237B (zh) * | 2015-07-03 | 2019-07-19 | 华中科技大学 | 一种用于spect成像的当归多糖衍生物及其合成方法 |
| CN106188226B (zh) * | 2016-07-04 | 2019-12-24 | 江苏省原子医学研究所 | 一种用于淋巴结检查的大分子显像剂及其制备方法 |
| US10695450B2 (en) | 2016-07-26 | 2020-06-30 | Laboratoires Cyclopharma | Synthesis of a radioactive agent composition |
| FR3054445B1 (fr) * | 2016-07-26 | 2019-07-05 | Laboratoires Cyclopharma | Synthese d'une composition d'agent radioactif |
| US11007272B1 (en) | 2016-10-07 | 2021-05-18 | Navidea Biopharmaceuticals, Inc. | Compounds and methods for diagnosis and treatment of viral infections |
| JP6329302B2 (ja) * | 2017-05-10 | 2018-05-23 | 国立大学法人千葉大学 | マクロファージマンノース受容体を認識する新規多糖金属錯体化合物、及び、その医薬組成物 |
| US20220175973A1 (en) * | 2019-03-29 | 2022-06-09 | National Institutes for Quantum Science and Technology | Method for producing radiopharmaceutical and radiopharmaceutical |
| WO2022011184A1 (en) | 2020-07-08 | 2022-01-13 | Navidea Biopharmaceuticals, Inc. | Synthesis of uniformly defined molecular weight mannosylated dextrans and derivatives thereof |
| WO2023225273A1 (en) | 2022-05-20 | 2023-11-23 | Navidea Biopharmaceuticals, Inc. | Cd206 targeted drug delivery vehicles carrying novel bisphosphonate drug payloads via a degradable linker |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1053508B (it) * | 1970-07-06 | 1981-10-10 | Searle & Co | Procedimento per prepare composizioni marcate adatte a mettere in evidenza alterazioni della mucosa gastrointestinale prodotto ottenuto e relativo metodo di impiego |
| US4364920A (en) * | 1975-04-30 | 1982-12-21 | Medi-Physics, Inc. | Stable diagnostic reagents |
| US4048296A (en) * | 1975-05-27 | 1977-09-13 | Mallinckrodt, Inc. | Radiopharmaceutical scanning agents |
| JPS5569517A (en) * | 1978-11-20 | 1980-05-26 | Nippon Mejifuijitsukusu Kk | Labelling preparation for labelling of erythrocytes with radio-active technetium |
| SE465907B (sv) | 1984-11-01 | 1991-11-18 | Nyegaard & Co As | Diagnosticeringsmedel innehaallande en paramagnetisk metall |
| US5336762A (en) | 1985-11-18 | 1994-08-09 | Access Pharmaceuticals, Inc. | Polychelating agents for image and spectral enhancement (and spectral shift) |
| US4822594A (en) | 1987-01-27 | 1989-04-18 | Gibby Wendell A | Contrast enhancing agents for magnetic resonance images |
| CS263561B1 (en) | 1987-09-18 | 1989-04-14 | Kery Vladimir | Process for preparing water soluble allylderivatives of oligo and polysaccharides |
| GB8801646D0 (en) * | 1988-01-26 | 1988-02-24 | Nycomed As | Chemical compounds |
| US5328679A (en) * | 1988-04-01 | 1994-07-12 | Immunomedics, Inc. | Methods for technetium/rhenium labeling of proteins |
| DD286598A5 (de) | 1989-06-29 | 1991-01-31 | Adw Der Ddr,Zi F. Mulekularbiologie,De | Verfahren zur einfuehrung von primaeren aminogruppen in wasserloesliche polymere |
| EP0516873A1 (en) * | 1991-06-06 | 1992-12-09 | THE STATE of ISRAEL Atomic Energy Commission Soreq Nuclear Research Center | A method and kit for protein labelling with 99 mTC |
| US5789578A (en) | 1996-01-11 | 1998-08-04 | Massey University | Methods for the preparation of resins with ligands attached thereto through a linking group comprising sulfide, sulfoxide or sulfone functionality |
| US20010055563A1 (en) * | 1999-09-09 | 2001-12-27 | Rhomed Incorporated | Post-labeling stabilization of radiolabeled proteins and peptides |
| US6066309A (en) * | 1996-02-02 | 2000-05-23 | Rhomed Incorporated | Post-labeling stabilization of radiolabeled proteins and peptides |
| CA2279349C (en) * | 1996-02-02 | 2007-09-25 | Rhomed Incorporated | Ascorbate-stabilized radiopharmaceutical method and composition |
| AU5135698A (en) | 1996-11-28 | 1998-06-22 | Nihon Schering K.K. | Contrast compound, contrast medium for mri, and method for mri |
| ES2228536T3 (es) | 1999-05-14 | 2005-04-16 | The Regents Of The University Of California | Soporte macromolecular a base de dextrano para un farmaco y suministro de un agente de diagnosotico. |
| US6887462B2 (en) * | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
| US7666979B2 (en) | 2002-03-01 | 2010-02-23 | Bracco International B.V. | Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same |
| EP2316922B1 (en) * | 2002-05-24 | 2013-05-22 | Merck Sharp & Dohme Corp. | Neutralizing human anti-IGFR antibody |
| DK2949658T3 (en) | 2003-03-03 | 2018-10-01 | Dyax Corp | Peptides that specifically bind HGF receptor (cMet) and uses thereof |
| RS50510B (sr) * | 2004-10-29 | 2010-03-02 | Pharma Mar S.A., Sociedad Unipersonal | Formulacije koje sadrže ekteinascidin i disaharid |
| TWI398272B (zh) * | 2005-03-08 | 2013-06-11 | Intervet Int Bv | 化學定義的安定劑 |
| JP2009510136A (ja) * | 2005-10-04 | 2009-03-12 | アルク−アベッロ エイ／エス | 固体ワクチン製剤 |
| AU2007234612B2 (en) * | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
| JP5179521B2 (ja) * | 2007-03-05 | 2013-04-10 | カディラ・ヘルスケア・リミテッド | ペグ‐インターフェロンアルファ接合体および凍結保護剤としてラフィノースを含む組成物 |
| US20100196272A1 (en) | 2009-01-30 | 2010-08-05 | Neoprobe Corporation | Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran |
| US20150023876A1 (en) | 2013-07-22 | 2015-01-22 | Navidea Biopharmaceuticals, Inc. | Compositions, methods and kits for diagnosing and treating cd206 expressing cell-related disorders |
| WO2016011419A1 (en) | 2014-07-17 | 2016-01-21 | Ohio State Innovation Foundation | Compositions for targeting macrophages and other cd206 high expressing cells and methods of treating and diagnosis |
| EP3169792A4 (en) | 2014-07-17 | 2018-04-11 | The Ohio State Innovation Foundation | Compounds and compositions for targeting macrophages and other mannose-binding c-type lectin receptor high expressing cells and methods of treating and diagnosis using same |
-
2009
- 2009-01-30 US US12/362,778 patent/US20100196272A1/en not_active Abandoned
-
2010
- 2010-01-28 WO PCT/US2010/000222 patent/WO2010087959A1/en active Application Filing
- 2010-01-28 KR KR1020177005797A patent/KR101765717B1/ko active IP Right Grant
- 2010-01-28 KR KR1020117020202A patent/KR101713559B1/ko active IP Right Grant
- 2010-01-28 BR BRPI1007487A patent/BRPI1007487A2/pt not_active IP Right Cessation
- 2010-01-28 CA CA2750230A patent/CA2750230C/en active Active
- 2010-01-28 EP EP21152405.3A patent/EP3884965A1/en not_active Withdrawn
- 2010-01-28 CN CN2010800062510A patent/CN102301429A/zh active Pending
- 2010-01-28 JP JP2011547973A patent/JP5743905B2/ja active Active
- 2010-01-28 EP EP10736135.4A patent/EP2392012B1/en active Active
- 2010-01-28 AU AU2010208624A patent/AU2010208624B2/en active Active
-
2012
- 2012-05-01 US US13/461,306 patent/US8545808B2/en active Active
-
2013
- 2013-09-27 US US14/039,648 patent/US9439985B2/en active Active
-
2015
- 2015-04-27 JP JP2015090380A patent/JP6040276B2/ja active Active
-
2016
- 2016-08-10 US US15/233,144 patent/US20160347679A1/en not_active Abandoned
- 2016-11-07 JP JP2016217326A patent/JP6509796B2/ja active Active
-
2019
- 2019-04-03 JP JP2019071387A patent/JP6833892B2/ja active Active
-
2021
- 2021-02-03 JP JP2021015866A patent/JP2021088566A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015164933A (ja) | 2015-09-17 |
| US8545808B2 (en) | 2013-10-01 |
| JP6509796B2 (ja) | 2019-05-08 |
| EP2392012A1 (en) | 2011-12-07 |
| WO2010087959A1 (en) | 2010-08-05 |
| CA2750230C (en) | 2018-06-05 |
| US20160347679A1 (en) | 2016-12-01 |
| AU2010208624B2 (en) | 2016-02-04 |
| JP6833892B2 (ja) | 2021-02-24 |
| JP2017066148A (ja) | 2017-04-06 |
| US20140023586A1 (en) | 2014-01-23 |
| CA2750230A1 (en) | 2010-08-05 |
| EP2392012B1 (en) | 2021-01-20 |
| JP2012516328A (ja) | 2012-07-19 |
| JP2021088566A (ja) | 2021-06-10 |
| KR20170027874A (ko) | 2017-03-10 |
| CN102301429A (zh) | 2011-12-28 |
| KR20110115148A (ko) | 2011-10-20 |
| AU2010208624A1 (en) | 2011-08-25 |
| US20100196272A1 (en) | 2010-08-05 |
| US20120213700A1 (en) | 2012-08-23 |
| KR101713559B1 (ko) | 2017-03-08 |
| JP6040276B2 (ja) | 2016-12-07 |
| EP3884965A1 (en) | 2021-09-29 |
| JP5743905B2 (ja) | 2015-07-01 |
| US9439985B2 (en) | 2016-09-13 |
| EP2392012A4 (en) | 2012-11-14 |
| KR101765717B1 (ko) | 2017-08-07 |
| JP2019178133A (ja) | 2019-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |