CA2731730C - Inhibiteurs de desacetylase et leurs utilisations - Google Patents

Inhibiteurs de desacetylase et leurs utilisations Download PDF

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Publication number
CA2731730C
CA2731730C CA2731730A CA2731730A CA2731730C CA 2731730 C CA2731730 C CA 2731730C CA 2731730 A CA2731730 A CA 2731730A CA 2731730 A CA2731730 A CA 2731730A CA 2731730 C CA2731730 C CA 2731730C
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CA
Canada
Prior art keywords
moiety
substituted
compound
aliphatic
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2731730A
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English (en)
Other versions
CA2731730A1 (fr
Inventor
Weiping Tang
James Elliot Bradner
Stuart L. Schreiber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard College
Dana Farber Cancer Institute Inc
Original Assignee
Harvard College
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Harvard College, Dana Farber Cancer Institute Inc filed Critical Harvard College
Publication of CA2731730A1 publication Critical patent/CA2731730A1/fr
Application granted granted Critical
Publication of CA2731730C publication Critical patent/CA2731730C/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2731730A 2008-07-23 2009-07-22 Inhibiteurs de desacetylase et leurs utilisations Expired - Fee Related CA2731730C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8289908P 2008-07-23 2008-07-23
US61/082,899 2008-07-23
PCT/US2009/004235 WO2010011296A2 (fr) 2008-07-23 2009-07-22 Inhibiteurs de désacétylase et leurs utilisations

Publications (2)

Publication Number Publication Date
CA2731730A1 CA2731730A1 (fr) 2010-01-28
CA2731730C true CA2731730C (fr) 2017-06-13

Family

ID=41570773

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2731730A Expired - Fee Related CA2731730C (fr) 2008-07-23 2009-07-22 Inhibiteurs de desacetylase et leurs utilisations

Country Status (11)

Country Link
US (2) US8440716B2 (fr)
EP (1) EP2321264B1 (fr)
JP (2) JP5665740B2 (fr)
KR (1) KR101708946B1 (fr)
CN (1) CN102164888B (fr)
AU (1) AU2009274549B2 (fr)
CA (1) CA2731730C (fr)
HK (1) HK1161583A1 (fr)
IL (1) IL210804A (fr)
RU (1) RU2515611C2 (fr)
WO (1) WO2010011296A2 (fr)

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WO2011019393A2 (fr) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Inhibiteurs de hdac classe- et isoforme-spécifiques et utilisations de ceux-ci
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EP2321264B1 (fr) 2016-05-04
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AU2009274549A1 (en) 2010-01-28
IL210804A (en) 2015-06-30
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US9434686B2 (en) 2016-09-06
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US8440716B2 (en) 2013-05-14
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CA2731730A1 (fr) 2010-01-28
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