CA2727684C - Diamino-pyridine, pyrimidine, and pyridazine modulators of the histamine h4 receptor - Google Patents

Diamino-pyridine, pyrimidine, and pyridazine modulators of the histamine h4 receptor Download PDF

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Publication number
CA2727684C
CA2727684C CA2727684A CA2727684A CA2727684C CA 2727684 C CA2727684 C CA 2727684C CA 2727684 A CA2727684 A CA 2727684A CA 2727684 A CA2727684 A CA 2727684A CA 2727684 C CA2727684 C CA 2727684C
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Canada
Prior art keywords
amine
methylamino
pyrimidin
pyrrolidin
pyridin
Prior art date
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Expired - Fee Related
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CA2727684A
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English (en)
French (fr)
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CA2727684A1 (en
Inventor
Hui Cai
Frank Chavez
Paul J. Dunford
Andrew J. Greenspan
Steven P. Meduna
Jorge A. Quiroz
Brad M. Savall
Kevin L. Tays
Robin L. Thurmond
Jianmei Wei
Ronald L. Wolin
Xiaohu Zhang
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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Publication of CA2727684A1 publication Critical patent/CA2727684A1/en
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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  • Pharmacology & Pharmacy (AREA)
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  • Epidemiology (AREA)
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  • Diabetes (AREA)
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  • Hematology (AREA)
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  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
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CA2727684A 2008-06-12 2009-06-11 Diamino-pyridine, pyrimidine, and pyridazine modulators of the histamine h4 receptor Expired - Fee Related CA2727684C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US6103908P 2008-06-12 2008-06-12
US61/061,039 2008-06-12
US11441608P 2008-11-13 2008-11-13
US11442508P 2008-11-13 2008-11-13
US61/114,416 2008-11-13
US61/114,425 2008-11-13
PCT/US2009/047033 WO2009152325A1 (en) 2008-06-12 2009-06-11 Diamino-pyridine, pyrimidine, and pyridazine modulators of the histamine h4 receptor

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CA2727684A1 CA2727684A1 (en) 2009-12-17
CA2727684C true CA2727684C (en) 2017-01-31

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CA2727684A Expired - Fee Related CA2727684C (en) 2008-06-12 2009-06-11 Diamino-pyridine, pyrimidine, and pyridazine modulators of the histamine h4 receptor

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US (3) US8841287B2 (enExample)
EP (1) EP2315521B1 (enExample)
JP (1) JP5658662B2 (enExample)
KR (1) KR101600278B1 (enExample)
CN (1) CN102118969B (enExample)
AU (1) AU2009257434B2 (enExample)
BR (1) BRPI0915720A2 (enExample)
CA (1) CA2727684C (enExample)
CO (1) CO6321192A2 (enExample)
CR (1) CR20110029A (enExample)
EA (1) EA018198B1 (enExample)
EC (1) ECSP10010675A (enExample)
IL (1) IL209593A (enExample)
MX (1) MX2010013726A (enExample)
MY (1) MY158927A (enExample)
NI (1) NI201000214A (enExample)
NZ (1) NZ589532A (enExample)
PE (1) PE20110061A1 (enExample)
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ZA (1) ZA201100298B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME01143B (me) 2006-03-31 2013-03-20 Janssen Pharmaceutica Nv BENZOIMIDAZOL-2-IL PIRIMIDINI l PIRAZINI KAO MODULATORI HISTAMINSKOG H4 RECEPTORA
AU2009257434B2 (en) 2008-06-12 2014-12-11 Janssen Pharmaceutica Nv Diamino-pyridine, pyrimidine, and pyridazine modulators of the histamine H4 receptor
NZ603074A (en) * 2008-06-12 2013-08-30 Janssen Pharmaceutica Nv Use of histamine h4 antagonist for the treatment of post-operative adhesions
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