CA2715623C - 3d imaging of live cells with ultraviolet radiation - Google Patents

3d imaging of live cells with ultraviolet radiation Download PDF

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Publication number
CA2715623C
CA2715623C CA2715623A CA2715623A CA2715623C CA 2715623 C CA2715623 C CA 2715623C CA 2715623 A CA2715623 A CA 2715623A CA 2715623 A CA2715623 A CA 2715623A CA 2715623 C CA2715623 C CA 2715623C
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CA
Canada
Prior art keywords
radiation
wavelengths
light
imaging
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2715623A
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English (en)
French (fr)
Other versions
CA2715623A1 (en
Inventor
Eric J. Seibel
Alan C. Nelson
Mark E. Fauver
J. Richard Rahn
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VisionGate Inc
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VisionGate Inc
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Priority to CA2948800A priority Critical patent/CA2948800C/en
Publication of CA2715623A1 publication Critical patent/CA2715623A1/en
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Publication of CA2715623C publication Critical patent/CA2715623C/en
Expired - Fee Related legal-status Critical Current
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N15/1436—Optical arrangements the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T12/00—Tomographic reconstruction from projections
    • G06T12/20—Inverse problem, i.e. transformations from projection space into object space
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/144—Imaging characterised by its optical setup
    • G01N2015/1445—Three-dimensional imaging, imaging in different image planes, e.g. under different angles or at different depths, e.g. by a relative motion of sample and detector, for instance by tomography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N2021/178—Methods for obtaining spatial resolution of the property being measured
    • G01N2021/1785—Three dimensional
    • G01N2021/1787—Tomographic, i.e. computerised reconstruction from projective measurements

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CA2715623A 2008-02-18 2009-02-03 3d imaging of live cells with ultraviolet radiation Expired - Fee Related CA2715623C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2948800A CA2948800C (en) 2008-02-18 2009-02-03 3d imaging of live cells with ultraviolet radiation

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/032,959 US8143600B2 (en) 2008-02-18 2008-02-18 3D imaging of live cells with ultraviolet radiation
US12/032,959 2008-02-18
PCT/US2009/032969 WO2009105331A2 (en) 2008-02-18 2009-02-03 3d imaging of live cells with utraviolet radiation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2948800A Division CA2948800C (en) 2008-02-18 2009-02-03 3d imaging of live cells with ultraviolet radiation

Publications (2)

Publication Number Publication Date
CA2715623A1 CA2715623A1 (en) 2009-08-27
CA2715623C true CA2715623C (en) 2017-01-10

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CA2715623A Expired - Fee Related CA2715623C (en) 2008-02-18 2009-02-03 3d imaging of live cells with ultraviolet radiation
CA2948800A Expired - Fee Related CA2948800C (en) 2008-02-18 2009-02-03 3d imaging of live cells with ultraviolet radiation

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2948800A Expired - Fee Related CA2948800C (en) 2008-02-18 2009-02-03 3d imaging of live cells with ultraviolet radiation

Country Status (7)

Country Link
US (2) US8143600B2 (https=)
EP (1) EP2247918A4 (https=)
JP (2) JP5496115B2 (https=)
CN (1) CN102007369B (https=)
AU (1) AU2009215714B2 (https=)
CA (2) CA2715623C (https=)
WO (1) WO2009105331A2 (https=)

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