CA2714251C - Therapeutic peptidomimetic macrocycles - Google Patents

Therapeutic peptidomimetic macrocycles Download PDF

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Publication number
CA2714251C
CA2714251C CA2714251A CA2714251A CA2714251C CA 2714251 C CA2714251 C CA 2714251C CA 2714251 A CA2714251 A CA 2714251A CA 2714251 A CA2714251 A CA 2714251A CA 2714251 C CA2714251 C CA 2714251C
Authority
CA
Canada
Prior art keywords
peptidomimetic
amino acid
macrocycle
independently
peptidomimetic macrocycle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2714251A
Other languages
English (en)
French (fr)
Other versions
CA2714251A1 (en
Inventor
Huw M. Nash
David Allen Annis
Rosana Kapeller-Libermann
Tomi K. Sawyer
Noriyuki Kawahata
Jiawen Han
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rein Therapeutics Inc
Original Assignee
Aileron Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aileron Therapeutics Inc filed Critical Aileron Therapeutics Inc
Publication of CA2714251A1 publication Critical patent/CA2714251A1/en
Application granted granted Critical
Publication of CA2714251C publication Critical patent/CA2714251C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1761—Apoptosis related proteins, e.g. Apoptotic protease-activating factor-1 (APAF-1), Bax, Bax-inhibitory protein(s)(BI; bax-I), Myeloid cell leukemia associated protein (MCL-1), Inhibitor of apoptosis [IAP] or Bcl-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA2714251A 2008-02-08 2009-02-09 Therapeutic peptidomimetic macrocycles Expired - Fee Related CA2714251C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2732608P 2008-02-08 2008-02-08
US61/027,326 2008-02-08
US12038008P 2008-12-05 2008-12-05
US61/120,380 2008-12-05
PCT/US2009/000837 WO2009099677A2 (en) 2008-02-08 2009-02-09 Therapeutic peptidomimetic macrocycles

Publications (2)

Publication Number Publication Date
CA2714251A1 CA2714251A1 (en) 2009-08-13
CA2714251C true CA2714251C (en) 2017-08-15

Family

ID=40952614

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2714251A Expired - Fee Related CA2714251C (en) 2008-02-08 2009-02-09 Therapeutic peptidomimetic macrocycles

Country Status (12)

Country Link
US (4) US20090275519A1 (https=)
EP (2) EP2926827A3 (https=)
JP (2) JP2011511076A (https=)
KR (1) KR20100126361A (https=)
CN (2) CN101980718A (https=)
BR (1) BRPI0907754A2 (https=)
CA (1) CA2714251C (https=)
DE (1) DE112009000300T5 (https=)
GB (1) GB2471588A (https=)
IL (2) IL207421A0 (https=)
WO (1) WO2009099677A2 (https=)
ZA (1) ZA201005741B (https=)

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Also Published As

Publication number Publication date
US20150038430A1 (en) 2015-02-05
EP2926827A2 (en) 2015-10-07
KR20100126361A (ko) 2010-12-01
CN104474529A (zh) 2015-04-01
EP2242503A4 (en) 2012-04-25
ZA201005741B (en) 2018-11-28
EP2242503A2 (en) 2010-10-27
CA2714251A1 (en) 2009-08-13
IL207421A0 (en) 2010-12-30
US20190071469A1 (en) 2019-03-07
WO2009099677A2 (en) 2009-08-13
US20090275519A1 (en) 2009-11-05
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GB2471588A (en) 2011-01-05
JP2011511076A (ja) 2011-04-07
US8808694B2 (en) 2014-08-19
CN101980718A (zh) 2011-02-23
EP2926827A3 (en) 2015-11-04
AU2009210682A1 (en) 2009-08-13
DE112009000300T5 (de) 2011-01-20
WO2009099677A3 (en) 2009-12-17
GB201014734D0 (en) 2010-10-20
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JP2015078208A (ja) 2015-04-23

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