CA2694284A1 - Heterocyclic compounds useful as raf kinase inhibitors - Google Patents

Heterocyclic compounds useful as raf kinase inhibitors Download PDF

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Publication number
CA2694284A1
CA2694284A1 CA2694284A CA2694284A CA2694284A1 CA 2694284 A1 CA2694284 A1 CA 2694284A1 CA 2694284 A CA2694284 A CA 2694284A CA 2694284 A CA2694284 A CA 2694284A CA 2694284 A1 CA2694284 A1 CA 2694284A1
Authority
CA
Canada
Prior art keywords
compound
optionally substituted
nitrogen
mmol
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2694284A
Other languages
English (en)
French (fr)
Inventor
Jennifer Cossrow
Bing Guan
Alexey Ishchenko
John Howard Jones
Gnanasambandam Kumaravel
Alexey Lugovskoy
Hairuo Peng
Noel Powell
Brian C. Raimundo
Hiroko Tanaka
Jeffrey Vessels
Thomas Wynn
Zhili Xin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Viracta Therapeutics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2694284A1 publication Critical patent/CA2694284A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA2694284A 2007-06-29 2008-06-30 Heterocyclic compounds useful as raf kinase inhibitors Abandoned CA2694284A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94731907P 2007-06-29 2007-06-29
US60/947,319 2007-06-29
PCT/US2008/068789 WO2009006404A2 (en) 2007-06-29 2008-06-30 Heterocyclic compounds useful as raf kinase inhibitors

Publications (1)

Publication Number Publication Date
CA2694284A1 true CA2694284A1 (en) 2009-01-08

Family

ID=40015666

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2694284A Abandoned CA2694284A1 (en) 2007-06-29 2008-06-30 Heterocyclic compounds useful as raf kinase inhibitors

Country Status (8)

Country Link
US (1) US7968536B2 (cg-RX-API-DMAC7.html)
EP (1) EP2167497A2 (cg-RX-API-DMAC7.html)
JP (1) JP2010532381A (cg-RX-API-DMAC7.html)
CN (1) CN101743242A (cg-RX-API-DMAC7.html)
AU (1) AU2008273017C1 (cg-RX-API-DMAC7.html)
CA (1) CA2694284A1 (cg-RX-API-DMAC7.html)
NZ (1) NZ582349A (cg-RX-API-DMAC7.html)
WO (1) WO2009006404A2 (cg-RX-API-DMAC7.html)

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KR102881316B1 (ko) 2019-05-13 2025-11-05 노파르티스 아게 암 치료를 위한 raf 억제제로서의 n-(3-(2-(2-하이드록시에톡시)-6-모르폴리노피리딘-4-일)-4-메틸페닐)-2 (트리플루오로메틸)이소니코틴아미드의 새로운 결정질 형태
WO2021117759A1 (ja) 2019-12-10 2021-06-17 塩野義製薬株式会社 含窒素芳香族複素環式基を有するヒストン脱アセチル化酵素阻害剤
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Also Published As

Publication number Publication date
CN101743242A (zh) 2010-06-16
WO2009006404A3 (en) 2009-07-30
WO2009006404A2 (en) 2009-01-08
EP2167497A2 (en) 2010-03-31
AU2008273017B2 (en) 2013-10-10
NZ582349A (en) 2012-06-29
AU2008273017C1 (en) 2014-02-13
JP2010532381A (ja) 2010-10-07
US7968536B2 (en) 2011-06-28
AU2008273017A1 (en) 2009-01-08
US20090005359A1 (en) 2009-01-01

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20130628

FZDE Discontinued

Effective date: 20150630