CA2692742A1 - Methods and devices for charged molecule manipulation - Google Patents
Methods and devices for charged molecule manipulation Download PDFInfo
- Publication number
- CA2692742A1 CA2692742A1 CA 2692742 CA2692742A CA2692742A1 CA 2692742 A1 CA2692742 A1 CA 2692742A1 CA 2692742 CA2692742 CA 2692742 CA 2692742 A CA2692742 A CA 2692742A CA 2692742 A1 CA2692742 A1 CA 2692742A1
- Authority
- CA
- Canada
- Prior art keywords
- needle structure
- locus
- molecular material
- needle
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000000463 material Substances 0.000 claims abstract description 115
- 238000007599 discharging Methods 0.000 claims abstract description 11
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 210000004027 cell Anatomy 0.000 claims description 49
- 210000000287 oocyte Anatomy 0.000 claims description 28
- 230000033001 locomotion Effects 0.000 claims description 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 9
- 229920000642 polymer Polymers 0.000 claims description 6
- 150000002500 ions Chemical class 0.000 claims description 5
- 210000003855 cell nucleus Anatomy 0.000 claims description 2
- 108020004414 DNA Proteins 0.000 description 65
- FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 17
- 239000000758 substrate Substances 0.000 description 10
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- 210000004940 nucleus Anatomy 0.000 description 8
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 239000012153 distilled water Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 229910021420 polycrystalline silicon Inorganic materials 0.000 description 6
- 238000012546 transfer Methods 0.000 description 6
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- 238000000520 microinjection Methods 0.000 description 5
- 229920005591 polysilicon Polymers 0.000 description 5
- 238000005868 electrolysis reaction Methods 0.000 description 4
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- 102000004169 proteins and genes Human genes 0.000 description 4
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 3
- 229910052737 gold Inorganic materials 0.000 description 3
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- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
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- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
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- 239000004065 semiconductor Substances 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- ZEMPKEQAKRGZGQ-AAKVHIHISA-N 2,3-bis[[(z)-12-hydroxyoctadec-9-enoyl]oxy]propyl (z)-12-hydroxyoctadec-9-enoate Chemical compound CCCCCCC(O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(O)CCCCCC)COC(=O)CCCCCCC\C=C/CC(O)CCCCCC ZEMPKEQAKRGZGQ-AAKVHIHISA-N 0.000 description 1
- FPNZBYLXNYPRLR-UHFFFAOYSA-N 2-(4-carbamimidoylphenyl)-1h-indole-6-carboximidamide;hydron;dichloride Chemical compound Cl.Cl.C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FPNZBYLXNYPRLR-UHFFFAOYSA-N 0.000 description 1
- JBRZTFJDHDCESZ-UHFFFAOYSA-N AsGa Chemical compound [As]#[Ga] JBRZTFJDHDCESZ-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 229910001218 Gallium arsenide Inorganic materials 0.000 description 1
- 108700011259 MicroRNAs Proteins 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 108091030071 RNAI Proteins 0.000 description 1
- 229910052581 Si3N4 Inorganic materials 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 108091027967 Small hairpin RNA Proteins 0.000 description 1
- 108020004459 Small interfering RNA Proteins 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 108020004566 Transfer RNA Proteins 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
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- 239000002299 complementary DNA Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 229920001940 conductive polymer Polymers 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 230000032798 delamination Effects 0.000 description 1
- 229940071161 dodecylbenzenesulfonate Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
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- 230000005611 electricity Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
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- 230000009368 gene silencing by RNA Effects 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 239000011796 hollow space material Substances 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 description 1
- AMGQUBHHOARCQH-UHFFFAOYSA-N indium;oxotin Chemical compound [In].[Sn]=O AMGQUBHHOARCQH-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000013101 initial test Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 229910001092 metal group alloy Inorganic materials 0.000 description 1
- 239000013528 metallic particle Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000002679 microRNA Substances 0.000 description 1
- 229910021421 monocrystalline silicon Inorganic materials 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000012811 non-conductive material Substances 0.000 description 1
- 210000000633 nuclear envelope Anatomy 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 125000005342 perphosphate group Chemical group 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920000128 polypyrrole Polymers 0.000 description 1
- 230000001846 repelling effect Effects 0.000 description 1
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000004055 small Interfering RNA Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- 238000001890 transfection Methods 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 238000001429 visible spectrum Methods 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Sustainable Development (AREA)
- Cell Biology (AREA)
- Electromagnetism (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95862407P | 2007-07-09 | 2007-07-09 | |
| US60/958,624 | 2007-07-09 | ||
| PCT/US2008/069550 WO2009009610A2 (en) | 2007-07-09 | 2008-07-09 | Methods and devices for charged molecule manipulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2692742A1 true CA2692742A1 (en) | 2009-01-15 |
Family
ID=40229464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2692742 Abandoned CA2692742A1 (en) | 2007-07-09 | 2008-07-09 | Methods and devices for charged molecule manipulation |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20100323419A1 (enExample) |
| EP (1) | EP2167632A4 (enExample) |
| JP (1) | JP2010532997A (enExample) |
| KR (1) | KR20100037615A (enExample) |
| AU (1) | AU2008275064A1 (enExample) |
| CA (1) | CA2692742A1 (enExample) |
| WO (1) | WO2009009610A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2167632A4 (en) | 2007-07-09 | 2013-12-18 | Univ Brigham Young | METHODS AND DEVICES FOR HANDLING CHARGED MOLECULES |
| US9305735B2 (en) | 2007-09-28 | 2016-04-05 | Brigham Young University | Reinforced polymer x-ray window |
| US8498381B2 (en) | 2010-10-07 | 2013-07-30 | Moxtek, Inc. | Polymer layer on X-ray window |
| US8736138B2 (en) | 2007-09-28 | 2014-05-27 | Brigham Young University | Carbon nanotube MEMS assembly |
| US8247971B1 (en) | 2009-03-19 | 2012-08-21 | Moxtek, Inc. | Resistively heated small planar filament |
| US7983394B2 (en) | 2009-12-17 | 2011-07-19 | Moxtek, Inc. | Multiple wavelength X-ray source |
| US8526574B2 (en) | 2010-09-24 | 2013-09-03 | Moxtek, Inc. | Capacitor AC power coupling across high DC voltage differential |
| US8804910B1 (en) | 2011-01-24 | 2014-08-12 | Moxtek, Inc. | Reduced power consumption X-ray source |
| US8750458B1 (en) | 2011-02-17 | 2014-06-10 | Moxtek, Inc. | Cold electron number amplifier |
| US8929515B2 (en) | 2011-02-23 | 2015-01-06 | Moxtek, Inc. | Multiple-size support for X-ray window |
| WO2012149166A1 (en) * | 2011-04-27 | 2012-11-01 | Brigham Young University | Delivery of biological materials into cellular organelles |
| US9174412B2 (en) | 2011-05-16 | 2015-11-03 | Brigham Young University | High strength carbon fiber composite wafers for microfabrication |
| US8989354B2 (en) | 2011-05-16 | 2015-03-24 | Brigham Young University | Carbon composite support structure |
| US9076628B2 (en) | 2011-05-16 | 2015-07-07 | Brigham Young University | Variable radius taper x-ray window support structure |
| WO2012159058A2 (en) * | 2011-05-18 | 2012-11-22 | Brigham Young University | Apparatuses and related methods for delivering biological material into a cell |
| WO2013003790A1 (en) * | 2011-06-29 | 2013-01-03 | Brigham Young University | Systems and devices for restraining a cell and associated methods |
| WO2013059717A1 (en) * | 2011-10-21 | 2013-04-25 | Nanoinjection Technologies, L.L.C. | Systems and devices for restraining a micro-object and associated methods |
| WO2013059818A1 (en) * | 2011-10-21 | 2013-04-25 | Nanoinjection Technologies, L.L.C. | Nanoinjection lance coupling device and associated methods |
| US20130102060A1 (en) * | 2011-10-21 | 2013-04-25 | Nanoinjection Technologies, L.L.C. | Lance device and associated methods for delivering a biological material into a biological structure |
| US20130177988A1 (en) * | 2011-11-17 | 2013-07-11 | Brigham Young University | Cytoplasm to organelle delivery system and associated methods |
| US9173623B2 (en) | 2013-04-19 | 2015-11-03 | Samuel Soonho Lee | X-ray tube and receiver inside mouth |
| KR101588962B1 (ko) | 2014-07-18 | 2016-01-28 | 인제대학교 산학협력단 | 양말 착용 보조장치 |
| US11788042B2 (en) * | 2015-07-31 | 2023-10-17 | Redwire Space Technologies, Inc. | Biomanufacturing system, method, and 3D bioprinting hardware in a reduced gravity environment |
| WO2018070447A1 (ja) * | 2016-10-13 | 2018-04-19 | 東京エレクトロン株式会社 | 培養容器連結装置、培養システムおよびニードルの洗浄方法 |
Family Cites Families (122)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US1946288A (en) * | 1929-09-19 | 1934-02-06 | Gen Electric | Electron discharge device |
| US2316214A (en) * | 1940-09-10 | 1943-04-13 | Gen Electric X Ray Corp | Control of electron flow |
| US2340363A (en) * | 1942-03-03 | 1944-02-01 | Gen Electric X Ray Corp | Control for focal spot in X-ray generators |
| US2502070A (en) * | 1949-01-19 | 1950-03-28 | Dunlee Corp | Getter for induction flashing |
| US3741797A (en) * | 1970-04-30 | 1973-06-26 | Gen Technology Corp | Low density high-strength boron on beryllium reinforcement filaments |
| US3665236A (en) * | 1970-12-09 | 1972-05-23 | Atomic Energy Commission | Electrode structure for controlling electron flow with high transmission efficiency |
| DE2154888A1 (de) * | 1971-11-04 | 1973-05-17 | Siemens Ag | Roentgenroehre |
| US3882339A (en) * | 1974-06-17 | 1975-05-06 | Gen Electric | Gridded X-ray tube gun |
| US3962583A (en) * | 1974-12-30 | 1976-06-08 | The Machlett Laboratories, Incorporated | X-ray tube focusing means |
| US4007375A (en) * | 1975-07-14 | 1977-02-08 | Albert Richard D | Multi-target X-ray source |
| FR2333344A1 (fr) * | 1975-11-28 | 1977-06-24 | Radiologie Cie Gle | Tube radiogene a cathode chaude avec anode en bout et appareil comportant un tel tube |
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-
2008
- 2008-07-09 EP EP08796124.9A patent/EP2167632A4/en not_active Withdrawn
- 2008-07-09 KR KR1020107001996A patent/KR20100037615A/ko not_active Withdrawn
- 2008-07-09 US US12/668,369 patent/US20100323419A1/en not_active Abandoned
- 2008-07-09 WO PCT/US2008/069550 patent/WO2009009610A2/en not_active Ceased
- 2008-07-09 AU AU2008275064A patent/AU2008275064A1/en not_active Abandoned
- 2008-07-09 JP JP2010516228A patent/JP2010532997A/ja active Pending
- 2008-07-09 CA CA 2692742 patent/CA2692742A1/en not_active Abandoned
-
2010
- 2010-06-15 US US12/816,183 patent/US20100248343A1/en not_active Abandoned
-
2013
- 2013-12-11 US US14/103,618 patent/US10119151B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100037615A (ko) | 2010-04-09 |
| WO2009009610A2 (en) | 2009-01-15 |
| AU2008275064A1 (en) | 2009-01-15 |
| JP2010532997A (ja) | 2010-10-21 |
| US20100323419A1 (en) | 2010-12-23 |
| US10119151B2 (en) | 2018-11-06 |
| WO2009009610A3 (en) | 2009-03-12 |
| US20100248343A1 (en) | 2010-09-30 |
| EP2167632A4 (en) | 2013-12-18 |
| EP2167632A2 (en) | 2010-03-31 |
| US20140227785A1 (en) | 2014-08-14 |
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