CA2686835C - Novel herbicide resistance genes - Google Patents
Novel herbicide resistance genes Download PDFInfo
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- CA2686835C CA2686835C CA2686835A CA2686835A CA2686835C CA 2686835 C CA2686835 C CA 2686835C CA 2686835 A CA2686835 A CA 2686835A CA 2686835 A CA2686835 A CA 2686835A CA 2686835 C CA2686835 C CA 2686835C
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- herbicide
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
- C12N15/8275—Glyphosate
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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| AU2006308959B2 (en) | 2005-10-28 | 2012-09-06 | Corteva Agriscience Llc | Novel herbicide resistance genes |
| CN101688219B (zh) * | 2007-05-09 | 2017-06-30 | 美国陶氏益农公司 | 新除草剂抗性基因 |
| BRPI0922641B1 (pt) | 2008-12-17 | 2021-10-26 | Dow Agrosciences Llc | Método de integração de uma ou mais sequências de ácido nucleico exógenas no genoma de uma célula vegetal |
| AU2010326672A1 (en) | 2009-07-10 | 2011-08-04 | Syngenta Participations Ag | Novel hydroxyphenylpyruvate dioxygenase polypeptides and methods of use |
| AU2010284284B2 (en) | 2009-08-19 | 2015-09-17 | Corteva Agriscience Llc | AAD-1 event DAS-40278-9, related transgenic corn lines, and event-specific identification thereof |
| US8598413B2 (en) * | 2009-08-19 | 2013-12-03 | Dow AgroSciecnes, LLC. | AAD-1 event DAS-40278-9, related transgenic corn lines, event-specific identification thereof, and methods of weed control involving AAD-1 |
| CN102686109B (zh) * | 2009-10-28 | 2015-03-25 | 陶氏益农公司 | 包含氟草烟和五氟磺草胺、氯吡嘧磺隆、甲氧咪草烟或咪唑乙烟酸的协同除草剂组合物 |
| NZ600375A (en) * | 2009-11-23 | 2014-10-31 | Bayer Cropscience Nv | Herbicide tolerant soybean plants and methods for identifying same |
| JP2013511293A (ja) | 2009-11-23 | 2013-04-04 | バイエル・クロップサイエンス・エヌ・ヴェー | 優良イベントｅｅ−ｇｍ３及び生物学的試料におけるそのようなイベントを識別するための方法及びキット |
| CN102711444B (zh) * | 2009-11-24 | 2015-08-12 | 陶氏益农公司 | Aad-12事件416、相关的转基因大豆系及其事件特异性鉴定 |
| UY33057A (es) * | 2009-11-24 | 2011-06-30 | Dow Agrosciences Llc | Control de plantas voluntarias dicotiledóneas aad en cultivos de plantas monocotiledóneas |
| NZ600733A (en) | 2010-01-22 | 2014-09-26 | Dow Agrosciences Llc | Engineered landing pads for gene targeting in plants |
| JP2011246436A (ja) | 2010-04-28 | 2011-12-08 | Sumitomo Chemical Co Ltd | 有害生物防除組成物 |
| DK2576623T3 (en) * | 2010-06-04 | 2015-03-30 | Dow Agrosciences Llc | A method for the detection of monoclonal antibodies to enzymes, which results in resistance to 2,4-dichlorophenoxyacetic acid in plants |
| AU2011268316B2 (en) * | 2010-06-17 | 2015-04-16 | Corteva Agriscience Llc | Synergistic herbicidal composition containing clopyralid and florasulam |
| JP5940538B2 (ja) * | 2010-09-15 | 2016-06-29 | ダウ アグロサイエンシィズ エルエルシー | ２，４−ジクロロフェノキシ酢酸に対する抵抗性をもたらす酵素に対するモノクローナル抗体および検出方法 |
| WO2012043372A1 (ja) | 2010-09-29 | 2012-04-05 | 東海ゴム工業株式会社 | 水系ホース用ゴム組成物およびそれを用いて得られる水系ホース |
| WO2012075429A1 (en) * | 2010-12-03 | 2012-06-07 | Dow Agrosciences Llc | Stacked herbicide tolerance event 8291.45.36.2, related transgenic soybean lines, and detection thereof |
| CA2820706C (en) * | 2010-12-03 | 2018-05-22 | Ms Technologies, Llc | Optimized expression of glyphosate resistance encoding nucleic acid molecules in plant cells |
| EP2646559A2 (en) | 2010-12-03 | 2013-10-09 | MS Technologies, LLC | Optimized expression of glyphosate resistance encoding nucleic acid molecules in plant cells |
| WO2012075426A1 (en) | 2010-12-03 | 2012-06-07 | Dow Agrosciences Llc | Stacked herbicide tolerance event 8264.44.06.1, related transgenic soybean lines, and detection thereof |
| TWI667347B (zh) | 2010-12-15 | 2019-08-01 | 瑞士商先正達合夥公司 | 大豆品種ｓｙｈｔ０ｈ２及偵測其之組合物及方法 |
| ES2903230T3 (es) | 2010-12-16 | 2022-03-31 | Basf Agro Bv | Plantas que tienen mayor tolerancia a los herbicidas |
| JP5842594B2 (ja) | 2010-12-27 | 2016-01-13 | 住友化学株式会社 | ピリダジノン化合物、それを含有する除草剤及び有害節足動物防除剤 |
| UY33860A (es) * | 2011-01-07 | 2012-08-31 | Dow Agrosciences Llc | Tolerancia aumentada de plantas habilitadas por dht a herbicidas auxínicos resultante de diferencias de porciones en estructuras moleculares del herbicida |
| MY161279A (en) | 2011-03-07 | 2017-04-14 | Sumitomo Chemical Co | Method for controlling weeds in paddy rice cultivation |
| AR087185A1 (es) | 2011-07-13 | 2014-02-26 | Dow Agrosciences Llc | Evento 8264.42.32.1 de tolerancia apilada a los herbicidas, lineas de soja transgenicas relacionadas y su deteccion |
| CN102286501B (zh) * | 2011-07-25 | 2012-12-12 | 南京农业大学 | 噻吩磺隆水解酶基因tsmE及其应用 |
| BR102012019434B1 (pt) | 2011-07-26 | 2021-11-09 | Dow Agrosciences Llc | Métodos de controle de pestes, de insetos, molécula e sequência de dna diagnóstica para o evento de soja 9582.814.19.1 |
| GB201116131D0 (en) * | 2011-09-19 | 2011-11-02 | Epistem Ltd | Probe |
| CN104427862B (zh) * | 2012-01-23 | 2019-09-24 | 陶氏益农公司 | 除草剂耐受性棉花事件pDAB4468.18.07.1 |
| CA2863405C (en) * | 2012-02-01 | 2023-09-19 | Dow Agrosciences Llc | Novel class of glyphosate resistance genes |
| US10041087B2 (en) | 2012-06-19 | 2018-08-07 | BASF Agro B.V. | Plants having increased tolerance to herbicides |
| AR091489A1 (es) | 2012-06-19 | 2015-02-11 | Basf Se | Plantas que tienen una mayor tolerancia a herbicidas inhibidores de la protoporfirinogeno oxidasa (ppo) |
| CN102766697B (zh) * | 2012-08-16 | 2013-11-06 | 江苏省农业科学院 | 一种检测甘蓝型油菜抗咪唑啉酮类除草剂基因的分子标记方法 |
| JP6371307B2 (ja) | 2012-12-20 | 2018-08-08 | ダウ アグロサイエンシィズ エルエルシー | フルロキシピルおよびフルメツラムを含む除草組成物 |
| AU2013361220A1 (en) * | 2012-12-21 | 2015-04-02 | Pioneer Hi-Bred International, Inc. | Compositions and methods for auxin-analog conjugation |
| CN103060279B (zh) * | 2012-12-25 | 2014-08-13 | 北京大北农科技集团股份有限公司 | 除草剂抗性蛋白质、其编码基因及用途 |
| CN103255154B (zh) * | 2013-05-16 | 2014-07-02 | 南京农业大学 | 一种加氧酶基因caceO及其编码的蛋白质和应用 |
| EA201690374A1 (ru) | 2013-08-12 | 2016-07-29 | Басф Агро Б.В. | Растения с повышенной устойчивостью к гербицидам |
| BR112016002835A2 (pt) | 2013-08-12 | 2017-09-19 | Basf Agro Bv | Plantas, semente, células vegetais, produtos vegetais, prole ou planta descendente derivada de uma planta, método de controle de ervas, método de produção de planta, método de produção de plantas de prole, método de produção de produtos vegetais, método de cultivo da planta, combinação útil para controle de ervas, processos de preparação da combinação útil para controle de ervas e uso da combinação |
| TW201605346A (zh) | 2013-12-10 | 2016-02-16 | 陶氏農業科學公司 | 來自２，４－ｄ－膽鹼與草銨膦之組合的協同性除草劑的雜草控制 |
| CA2932138A1 (en) | 2013-12-20 | 2015-06-25 | Dow Agrosciences Llc | Synergistic herbicidal weed control and improved crop tolerance from combinations of 2,4-d-choline, glyphosate, and glufosinate in 2,4-d-, glyphosate- and glufosinate-tolerant soybeans, corn, cotton and other crop areas |
| CN103740666B (zh) * | 2013-12-26 | 2016-05-18 | 北京大北农科技集团股份有限公司 | 除草剂抗性蛋白质、其编码基因及用途 |
| WO2015150465A2 (en) | 2014-04-03 | 2015-10-08 | Basf Se | Plants having increased tolerance to herbicides |
| AR100785A1 (es) | 2014-06-09 | 2016-11-02 | Dow Agrosciences Llc | Control herbicida de maleza a partir de combinaciones de fluroxipir e inhibidores de als |
| EP3234129B1 (en) * | 2014-12-16 | 2021-09-15 | Farmhannong Co., Ltd. | Methods for conferring or enhancing herbicide resistance on plants and/or alga with protoporphyrinogen oxidase variants |
| EP3247200B1 (en) | 2015-01-21 | 2025-10-15 | Basf Se | Plants having increased tolerance to herbicides |
| CN104611308B (zh) * | 2015-02-13 | 2019-01-11 | 北京大北农科技集团股份有限公司 | 除草剂抗性蛋白质、其编码基因及用途 |
| CA2989531A1 (en) | 2015-06-17 | 2016-12-22 | BASF Agro B.V. | Plants having increased tolerance to herbicides |
| AR106452A1 (es) | 2015-10-22 | 2018-01-17 | Basf Se | Plantas que tienen una mayor tolerancia a herbicidas |
| US20180312864A1 (en) | 2015-10-22 | 2018-11-01 | Basf Se | Plants having increased tolerance to herbicides |
| CN106689170A (zh) * | 2015-11-16 | 2017-05-24 | 江苏龙灯化学有限公司 | 一种除草组合物 |
| CN105746255B (zh) * | 2016-03-22 | 2019-01-11 | 北京大北农科技集团股份有限公司 | 除草剂耐受性蛋白质的用途 |
| CN105766992B (zh) * | 2016-03-22 | 2018-06-22 | 北京大北农科技集团股份有限公司 | 除草剂耐受性蛋白质的用途 |
| CN105802933B (zh) * | 2016-03-22 | 2020-05-05 | 北京大北农科技集团股份有限公司 | 除草剂耐受性蛋白质、其编码基因及用途 |
| EA201892517A1 (ru) | 2016-05-20 | 2019-05-31 | Басф Агро Б.В. | Двойные транзитные пептиды для нацеливания полипептидов |
| JP6875426B2 (ja) * | 2016-06-16 | 2021-05-26 | ファームハンノン・カンパニー・リミテッドＦａｒｍｈａｎｎｏｎｇ Ｃｏ．， Ｌｔｄ． | プロトポルフィリノーゲンオキシダーゼ変異体およびこれを用いる除草剤耐性付与および／または増進のための組成物および方法 |
| EP3472184A4 (en) | 2016-06-16 | 2019-11-20 | Farmhannong Co., Ltd. | METHOD AND COMPOSITIONS FOR INDUCING AND / OR IMPROVING HERBICIDE TOLERANCE WITH PROTOPORPHYRINOGENOXIDASE OR A VARIANT THEREOF |
| MX392602B (es) | 2016-07-15 | 2025-03-21 | Basf Se | Plantas que tienen una mayor tolerancia a herbicidas. |
| CN109790153A (zh) | 2016-07-27 | 2019-05-21 | 巴斯夫农业公司 | 具有增加的除草剂耐受性的植物 |
| WO2018114759A1 (en) | 2016-12-20 | 2018-06-28 | BASF Agro B.V. | Plants having increased tolerance to herbicides |
| CN107517977A (zh) * | 2017-10-13 | 2017-12-29 | 北京科发伟业农药技术中心 | 含嘧草硫醚和异噁草松的除草组合物 |
| AR114807A1 (es) | 2017-11-29 | 2020-10-21 | Basf Se | Plantas que tienen una mayor tolerancia a herbicidas |
| AU2019210093B2 (en) | 2018-01-17 | 2025-03-20 | Basf Se | Plants having increased tolerance to herbicides |
| US20220061326A1 (en) * | 2018-12-26 | 2022-03-03 | Sumitomo Chemical Company, Limited | Method for controlling weed |
| CN110054684B (zh) * | 2019-04-20 | 2021-07-20 | 中国农业科学院植物保护研究所 | 东亚飞蝗丝氨酸蛋白酶抑制剂serpin-5及其编码基因和应用 |
| US20230175004A1 (en) * | 2019-06-14 | 2023-06-08 | Farmhannong Co., Ltd. | Methods and compositions for conferring and/or enhancing herbicide tolerance using protoporphyrinogen ix oxidase of various cyanobacteria or variant thereof |
| CA3164811A1 (en) | 2019-12-19 | 2021-06-24 | Bayer Aktiengesellschaft | 1,5-diphenylpyrazolyl-3-oxyalkyl acids and 1-phenyl-5-thienylpyrazolyl-3-oxyalkyl acids and the use thereof for control of undesired plant growth |
| MX2022016346A (es) * | 2020-06-29 | 2023-01-24 | Monsanto Technology Llc | Mezclas de herbicida de auxina y l-glufosinato. |
| CN114085849B (zh) * | 2020-08-06 | 2024-03-29 | 青岛清原种子科学有限公司 | 除草剂抗性蛋白、基因和用途 |
| WO2023031161A1 (en) | 2021-09-03 | 2023-03-09 | BASF Agricultural Solutions Seed US LLC | Plants having increased tolerance to herbicides |
| CN114276954B (zh) * | 2021-12-07 | 2023-09-26 | 广西大学 | 一株发根农杆菌菌株at13及其应用 |
| WO2023222226A1 (en) | 2022-05-19 | 2023-11-23 | Evonik Operations Gmbh | Enzymatic method for producing l-glufosinate |
| WO2023222227A1 (en) | 2022-05-19 | 2023-11-23 | Evonik Operations Gmbh | Enzymatic method for producing l-glufosinate |
| CN115633684A (zh) * | 2022-10-26 | 2023-01-24 | 青岛农业大学 | 一种除草剂及2-氯-4-硝基苯酚作为除草剂活性成分的应用 |
| CN120529828A (zh) | 2022-12-12 | 2025-08-22 | 巴斯夫农业解决方案美国有限责任公司 | 对除草剂具有增加的耐受性的植物 |
| WO2024218220A1 (en) | 2023-04-19 | 2024-10-24 | Syngenta Crop Protection Ag | Herbicide resistant plants |
| WO2025038723A1 (en) | 2023-08-14 | 2025-02-20 | The Texas A&M University System | Corn endotype-derived polypeptides capable of metabolizing fumonisin |
| WO2025153595A1 (en) | 2024-01-17 | 2025-07-24 | Basf Se | Plants having increased tolerance to herbicides |
| WO2025153657A2 (en) | 2024-01-17 | 2025-07-24 | Basf Se | Plants having increased tolerance to herbicides |
| CN119799660B (zh) * | 2024-12-30 | 2025-09-23 | 东北农业大学 | 一种莠去津降解酶及其相关生物材料与应用 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4762785A (en) | 1982-08-12 | 1988-08-09 | Calgene, Inc. | Novel method and compositions for introducting alien DNA in vivo |
| EP0116718B2 (en) | 1983-01-13 | 1996-05-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Process for the introduction of expressible genes into plant cell genomes and agrobacterium strains carrying hybrid Ti plasmid vectors useful for this process |
| JPS60500438A (ja) | 1983-01-17 | 1985-04-04 | モンサント カンパニ− | 植物細胞を形質転換するためのプラスミド |
| NL8300698A (nl) | 1983-02-24 | 1984-09-17 | Univ Leiden | Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten. |
| NL8300699A (nl) | 1983-02-24 | 1984-09-17 | Univ Leiden | Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; werkwijze voor het produceren van agrobacterium tumefaciens bacterien; stabiele cointegraat plasmiden; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten. |
| US5380831A (en) | 1986-04-04 | 1995-01-10 | Mycogen Plant Science, Inc. | Synthetic insecticidal crystal protein gene |
| NL8401048A (nl) | 1984-04-03 | 1985-11-01 | Rijksuniversiteit Leiden En Pr | Werkwijze voor het inbouwen van vreemd dna in het genoom van eenzaadlobbige planten. |
| US5231019A (en) | 1984-05-11 | 1993-07-27 | Ciba-Geigy Corporation | Transformation of hereditary material of plants |
| NL8401780A (nl) | 1984-06-04 | 1986-01-02 | Rijksuniversiteit Leiden En Pr | Werkwijze voor het inbouwen van vreemd dna in het genoom van planten. |
| US5149645A (en) | 1984-06-04 | 1992-09-22 | Rijksuniversiteit Leiden | Process for introducing foreign DNA into the genome of plants |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5569597A (en) | 1985-05-13 | 1996-10-29 | Ciba Geigy Corp. | Methods of inserting viral DNA into plant material |
| WO1987006614A1 (en) | 1986-04-30 | 1987-11-05 | Boyce Thompson Institute For Plant Research, Inc. | Electric field mediated dna transformation of plant cells and organelles |
| US5188958A (en) | 1986-05-29 | 1993-02-23 | Calgene, Inc. | Transformation and foreign gene expression in brassica species |
| US5177010A (en) | 1986-06-30 | 1993-01-05 | University Of Toledo | Process for transforming corn and the products thereof |
| DE3629890A1 (de) | 1986-08-29 | 1988-03-10 | Schering Ag | Mikroorganismen und plasmide fuer die 2,4-dichlorphenoxyessigsaeure (2,4-d)-monooxigenase - bildung und verfahren zur herstellung dieser plasmide und staemme |
| EP0267159A3 (de) | 1986-11-07 | 1990-05-02 | Ciba-Geigy Ag | Verfahren zur genetischen Modifikation monokotyler Pflanzen |
| SE455438B (sv) | 1986-11-24 | 1988-07-11 | Aga Ab | Sett att senka en brennares flamtemperatur samt brennare med munstycken for oxygen resp brensle |
| US5004863B2 (en) | 1986-12-03 | 2000-10-17 | Agracetus | Genetic engineering of cotton plants and lines |
| ES2121803T3 (es) | 1987-05-20 | 1998-12-16 | Novartis Ag | Plantas de zea mays y plantas transgenicas de zea mays generadas a partir de protoplastos o celulas derivadas de protoplastos. |
| US5316931A (en) | 1988-02-26 | 1994-05-31 | Biosource Genetics Corp. | Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes |
| US5302523A (en) | 1989-06-21 | 1994-04-12 | Zeneca Limited | Transformation of plant cells |
| US5141131A (en) | 1989-06-30 | 1992-08-25 | Dowelanco | Method and apparatus for the acceleration of a propellable matter |
| DE69132124T2 (de) | 1990-11-23 | 2000-11-23 | Aventis Cropscience N.V., Gent | Verfahren zur transformation monokotyler pflanzen |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| US5731180A (en) | 1991-07-31 | 1998-03-24 | American Cyanamid Company | Imidazolinone resistant AHAS mutants |
| US5679558A (en) | 1992-04-15 | 1997-10-21 | Plant Genetic Systems, N.V. | Transformation of monocot cells |
| ATE398679T1 (de) | 1992-07-07 | 2008-07-15 | Japan Tobacco Inc | Verfahren zur transformation einer monokotyledon pflanze |
| US5469976A (en) | 1993-04-30 | 1995-11-28 | Burchell; James R. | Shelf allocation and management system |
| ES2105415T3 (es) | 1993-06-04 | 1997-10-16 | Cavis Srl | Dispositivo de inercia para interrumpir el circuito electrico de un vehiculo con un motor de combustion interna. |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US5925806A (en) * | 1995-06-06 | 1999-07-20 | Mcbride; Kevin E. | Controlled expression of transgenic constructs in plant plastids |
| BR9611000A (pt) | 1995-10-13 | 1999-12-28 | Dow Agro Sciences Llc | Seq³ência de nucleotídeos otimizada de plantas e de gene inseticida otimizada específica do milho, construção genética sintética capaz de expressão em células de plantas, planta transgênica, somente de plantas, processo de construção de uma seq³ência de gene inseticida otimizada específica de milho e promotor recombinante. |
| WO1997047771A1 (en) * | 1996-06-14 | 1997-12-18 | Rutgers, The State University Of New Jersey | Editing-based selectable plastid marker genes |
| CZ161699A3 (cs) * | 1996-11-07 | 1999-08-11 | Zeneca Limited | Polynukleotid kódující rezistenci nebo toleranci k herbicidům, rostlina obsahující tento polynukleotid a způsob selektivního hubení plevelů |
| US5792907A (en) * | 1997-01-14 | 1998-08-11 | Pioneer Hi-Bred International, Inc. | Soybean variety 9492 |
| US6376754B1 (en) * | 1997-03-07 | 2002-04-23 | Asgrow Seed Company | Plants having resistance to multiple herbicides and its use |
| US7105724B2 (en) * | 1997-04-04 | 2006-09-12 | Board Of Regents Of University Of Nebraska | Methods and materials for making and using transgenic dicamba-degrading organisms |
| EP1105510A2 (en) * | 1998-08-12 | 2001-06-13 | Maxygen, Inc. | Dna shuffling to produce herbicide selective crops |
| JP2002534129A (ja) | 1999-01-14 | 2002-10-15 | モンサント テクノロジー エルエルシー | ダイズ形質転換方法 |
| EP1108781A3 (en) | 1999-01-19 | 2001-09-12 | Maxygen, Inc. | Method for making character strings, polynucleotides and polypeptides |
| BR0016030A (pt) | 1999-11-29 | 2002-07-30 | Midwest Oilseeds Inc | Métodos e composições para a introdução de moléculas em células |
| JP2004528808A (ja) * | 2000-09-29 | 2004-09-24 | シンジェンタ リミテッド | 除草剤抵抗性植物 |
| EP1521833A2 (en) * | 2001-10-24 | 2005-04-13 | The United States of America, represented by The Secretary of Agriculture | Synthetic herbicide resistance gene |
| AR037754A1 (es) * | 2001-12-11 | 2004-12-01 | Syngenta Participations Ag | Herbicidas |
| EP2368982A3 (en) | 2002-03-21 | 2011-10-12 | Sangamo BioSciences, Inc. | Methods and compositions for using zinc finger endonucleases to enhance homologous recombination |
| CN1244536C (zh) * | 2003-05-27 | 2006-03-08 | 沈阳化工研究院 | 具有除草活性的芳氧苯氧羧酸酯类化合物 |
| MXPA06001389A (es) * | 2003-08-04 | 2006-05-15 | Dow Agrosciences Llc | Formulaciones herbicidas de glifosato de baja viscosidad, alta intensidad. |
| EP1737964A1 (en) | 2004-03-26 | 2007-01-03 | Dow AgroSciences LLC | Cry1f and cry1ac transgenic cotton lines and event-specific identification thereof |
| CN102094032B (zh) * | 2004-04-30 | 2014-02-26 | 美国陶氏益农公司 | 新除草剂抗性基因 |
| US7265266B2 (en) * | 2005-01-24 | 2007-09-04 | Arizona Board of Regents/Behalf of University of Arizona | Transgenic evaluation of activated mutant alleles of SOS2 reveals a critical requirement for its kinase activity and C-terminal regulatory domain for salt tolerance in Arabidopsis thaliana |
| AU2006308959B2 (en) * | 2005-10-28 | 2012-09-06 | Corteva Agriscience Llc | Novel herbicide resistance genes |
| CN101688219B (zh) * | 2007-05-09 | 2017-06-30 | 美国陶氏益农公司 | 新除草剂抗性基因 |
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| JP5907657B2 (ja) | 2016-04-26 |
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| CN101688219A (zh) | 2010-03-31 |
| WO2008141154A3 (en) | 2009-02-05 |
| US9624505B2 (en) | 2017-04-18 |
| CO6241168A2 (es) | 2011-01-20 |
| EP2145007A4 (en) | 2010-08-04 |
| MX2009012120A (es) | 2010-02-12 |
| ZA200907746B (en) | 2010-07-28 |
| CN107177606A (zh) | 2017-09-19 |
| NZ581361A (en) | 2012-11-30 |
| BRPI0811294A2 (pt) | 2014-10-07 |
| EP2145007A2 (en) | 2010-01-20 |
| US20130040815A1 (en) | 2013-02-14 |
| WO2008141154A2 (en) | 2008-11-20 |
| US20100251432A1 (en) | 2010-09-30 |
| US8278505B2 (en) | 2012-10-02 |
| AR066520A1 (es) | 2009-08-26 |
| BRPI0811294B1 (pt) | 2018-05-29 |
| AU2008251445A1 (en) | 2008-11-20 |
| US20160002662A1 (en) | 2016-01-07 |
| CA2686835A1 (en) | 2008-11-20 |
| US9062284B2 (en) | 2015-06-23 |
| BRPI0811294B8 (pt) | 2022-06-28 |
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