CA2681351A1 - Inhibitors of fibroblast activation protein, and methods of use thereof - Google Patents

Inhibitors of fibroblast activation protein, and methods of use thereof Download PDF

Info

Publication number
CA2681351A1
CA2681351A1 CA002681351A CA2681351A CA2681351A1 CA 2681351 A1 CA2681351 A1 CA 2681351A1 CA 002681351 A CA002681351 A CA 002681351A CA 2681351 A CA2681351 A CA 2681351A CA 2681351 A1 CA2681351 A1 CA 2681351A1
Authority
CA
Canada
Prior art keywords
compound
amino acid
carbonyl
acid residue
side chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002681351A
Other languages
English (en)
French (fr)
Inventor
William W. Bachovchin
Hung-Sen Lai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tufts University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2681351A1 publication Critical patent/CA2681351A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002681351A 2007-03-20 2008-03-20 Inhibitors of fibroblast activation protein, and methods of use thereof Abandoned CA2681351A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89578707P 2007-03-20 2007-03-20
US60/895,787 2007-03-20
PCT/US2008/057636 WO2008116054A1 (en) 2007-03-20 2008-03-20 Inhibitors of fibroblast activation protein, and methods of use thereof

Publications (1)

Publication Number Publication Date
CA2681351A1 true CA2681351A1 (en) 2008-09-25

Family

ID=39766448

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002681351A Abandoned CA2681351A1 (en) 2007-03-20 2008-03-20 Inhibitors of fibroblast activation protein, and methods of use thereof

Country Status (6)

Country Link
US (1) US20100105753A1 (enExample)
EP (1) EP2139337A4 (enExample)
JP (1) JP2010523477A (enExample)
AU (1) AU2008228863A1 (enExample)
CA (1) CA2681351A1 (enExample)
WO (1) WO2008116054A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010083570A1 (en) * 2009-01-23 2010-07-29 The University Of Sydney Novel metabolic disease therapy
KR20130143084A (ko) * 2010-12-14 2013-12-30 머크 샤프 앤드 돔 코포레이션 마크로락탐의 제조 방법 및 중간체
WO2013033396A2 (en) * 2011-08-30 2013-03-07 Trustees Of Tufts College Fap-activated proteasome inhibitors for treating solid tumors
HK1201871A1 (en) 2011-11-22 2015-09-11 Trustees Of Tufts College Small molecule enhancer for dendritic cell cancer vaccines
CN116474108A (zh) 2016-12-14 2023-07-25 普渡研究基金会 成纤维细胞活化蛋白(fap)-靶向成像和治疗
CN114341159B (zh) 2019-07-08 2024-04-26 3B制药有限公司 包含成纤维细胞活化蛋白配体的化合物及其用途
EP3763726A1 (en) 2019-07-08 2021-01-13 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
BR112022000144A2 (pt) 2019-07-08 2022-02-22 3B Pharmaceuticals Gmbh Compostos que compreendem um ligante de proteína de ativação de fibroblastos e uso dos mesmos
EP4147053A1 (en) 2020-05-07 2023-03-15 Institut Curie Antxr1 as a biomarker of immunosuppressive fibroblast populations and its use for predicting response to immunotherapy
EP4050018A1 (en) 2021-01-07 2022-08-31 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
CA3206863A1 (en) 2021-01-07 2022-07-14 3B Pharmaceuticals Gmbh Compounds comprising a fibroblast activation protein ligand and use thereof
CN114316136B (zh) * 2022-01-13 2023-01-31 西华师范大学 一种氢键增强型水合物抑制剂及其制备方法
CA3263725A1 (en) * 2022-08-25 2024-02-29 The Regents Of The University Of California PRO-PEPTIDES CLIVABLE BY ALPHA FIBROBLAST ACTIVATING PROTEIN AND METHODS OF USE
WO2025046043A1 (en) 2023-08-31 2025-03-06 Stichting Radboud Universitair Medisch Centrum Endometriosis tracer
US20250186630A1 (en) 2023-12-12 2025-06-12 Viewpoint Molecular Targeting, Inc. Fibroblast activation protein targeting peptides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2433623A1 (en) * 1998-02-02 2012-03-28 Trustees Of Tufts College Use of dipeptidylpeptidase inhibitors to regulate glucose metabolism
US6890904B1 (en) * 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
US7041696B2 (en) * 2002-06-17 2006-05-09 The Procter & Gamble Company Interleukin-1β converting enzyme inhibitors
KR20150003157A (ko) * 2005-12-19 2015-01-08 트러스티즈 오브 터프츠 칼리지 소프트 단백질분해효소 억제자 및 이의 프로-소프트 폼

Also Published As

Publication number Publication date
AU2008228863A1 (en) 2008-09-25
JP2010523477A (ja) 2010-07-15
EP2139337A4 (en) 2012-09-19
EP2139337A1 (en) 2010-01-06
US20100105753A1 (en) 2010-04-29
WO2008116054A1 (en) 2008-09-25

Similar Documents

Publication Publication Date Title
CA2681351A1 (en) Inhibitors of fibroblast activation protein, and methods of use thereof
US20100184706A1 (en) Fap-activated chemotherapeutic compounds, and methods of use thereof
WO2009006473A2 (en) Pro-soft polypeptide proteasome inhibitors, and methods of use thereof
JP4778519B2 (ja) インクレチンホルモン活性を持つペプチドの経上皮送達
WO2008022015A2 (en) Retro-inverso incretin analogues, and methods of use thereof
ES2282130T3 (es) Nuevos efectores de la dipeptidil peptidasa iv para la aplicacion topica.
JP5908000B2 (ja) 長期間作用性ペプチド類似体のための組成物
FI72732B (fi) Foerfarande foer framstaellning av nya, i 8-staellning aminosyraestergrupp innehaollande, angiotensin-ii-antagoniserande oktapeptidestrar.
EP2692730B1 (en) Site-directed mono-substituted pegylated exendin analog and preparation method therefor
RU2360922C2 (ru) Агонисты рецептора (vpac2) гипофизарного пептида, активирующего аденилатциклазу (расар), и фармакологические способы их применения
CN102124023A (zh) 用于疾病治疗的肽Des-[ASP1]-[ALA1],血管紧张素-(1-7)激动剂和药物组合物
WO2009149148A2 (en) Long-acting glp-1 derivatives, and methods of treating cardiac dysfunction
JP5360738B2 (ja) 細胞増殖促進活性を有するペプチド
Albertshofer et al. Structure− activity relationship study on a simple cationic peptide motif for cellular delivery of antisense peptide nucleic acid
JP4933708B2 (ja) 骨形成作用を有する新規なペプチドおよびこれを固定化してなる骨形成促進剤
JP3786533B2 (ja) ペプチド及び骨形成促進剤
CN111494642B (zh) 一种原位构筑人造细胞外基质的自组装材料及其制备方法和应用
CN102746380B (zh) 血管生成抑制剂多肽在制备治疗肿瘤及类风湿性关节炎药物中的应用
JPH03261800A (ja) ペプチド類
EP2846819A1 (en) Variants of tace pro-domain as tnf-a inhibitor and their medical use
CA3132808C (en) NEW PEPTIDE AND ITS USE
WO2008128064A2 (en) Truncated analogs of peptide and polypeptide therapeutics
MXPA04007170A (es) Peptidos sinteticos y usos de los mismos para la prevencion y la terapia de metastasis e invasion de cancer.
JP5395915B2 (ja) 骨形成作用を有する新規なペプチドおよびこれを固定化してなる骨形成促進剤
KR101178497B1 (ko) 노나펩타이드 유도체를 함유하는 화장료 조성물

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20140320