CA2681351A1 - Inhibitors of fibroblast activation protein, and methods of use thereof - Google Patents

Inhibitors of fibroblast activation protein, and methods of use thereof Download PDF

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Publication number
CA2681351A1
CA2681351A1 CA002681351A CA2681351A CA2681351A1 CA 2681351 A1 CA2681351 A1 CA 2681351A1 CA 002681351 A CA002681351 A CA 002681351A CA 2681351 A CA2681351 A CA 2681351A CA 2681351 A1 CA2681351 A1 CA 2681351A1
Authority
CA
Canada
Prior art keywords
compound
amino acid
carbonyl
acid residue
side chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002681351A
Other languages
English (en)
French (fr)
Inventor
William W. Bachovchin
Hung-Sen Lai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tufts University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2681351A1 publication Critical patent/CA2681351A1/en
Abandoned legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002681351A 2007-03-20 2008-03-20 Inhibitors of fibroblast activation protein, and methods of use thereof Abandoned CA2681351A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89578707P 2007-03-20 2007-03-20
US60/895,787 2007-03-20
PCT/US2008/057636 WO2008116054A1 (en) 2007-03-20 2008-03-20 Inhibitors of fibroblast activation protein, and methods of use thereof

Publications (1)

Publication Number Publication Date
CA2681351A1 true CA2681351A1 (en) 2008-09-25

Family

ID=39766448

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002681351A Abandoned CA2681351A1 (en) 2007-03-20 2008-03-20 Inhibitors of fibroblast activation protein, and methods of use thereof

Country Status (6)

Country Link
US (1) US20100105753A1 (enExample)
EP (1) EP2139337A4 (enExample)
JP (1) JP2010523477A (enExample)
AU (1) AU2008228863A1 (enExample)
CA (1) CA2681351A1 (enExample)
WO (1) WO2008116054A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010083570A1 (en) * 2009-01-23 2010-07-29 The University Of Sydney Novel metabolic disease therapy
JP6034802B2 (ja) * 2010-12-14 2016-11-30 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 大環状ラクタムの調製のための方法および中間体
HUE060305T2 (hu) 2011-08-30 2023-02-28 Tufts College FAP-aktivált proteaszóma inhibitorok a szolid tumorok kezelésére
EP2782994B1 (en) 2011-11-22 2017-05-10 Trustees Of Tufts College Small molecule enhancer for dendritic cell cancer vaccines
WO2018111989A1 (en) 2016-12-14 2018-06-21 Purdue Research Foundation Fibroblast activation protein (fap)-targeted imaging and therapy
EP3763726A1 (en) 2019-07-08 2021-01-13 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
BR112022000144A2 (pt) 2019-07-08 2022-02-22 3B Pharmaceuticals Gmbh Compostos que compreendem um ligante de proteína de ativação de fibroblastos e uso dos mesmos
HUE070009T2 (hu) 2019-07-08 2025-05-28 3B Pharmaceuticals Gmbh Fibroblaszt aktiváló protein ligandumot tartalmazó vegyületek és alkalmazásuk
JP2023525082A (ja) 2020-05-07 2023-06-14 アンスティテュ・クリー 免疫抑制線維芽細胞集団のバイオマーカーとしてのantxr1及び免疫療法に対する応答を予測するためのその使用
EP4050018A1 (en) 2021-01-07 2022-08-31 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
WO2022148843A1 (en) 2021-01-07 2022-07-14 3B Pharmaceuticals Gmbh Compounds comprising a fibroblast activation protein ligand and use thereof
CN114316136B (zh) * 2022-01-13 2023-01-31 西华师范大学 一种氢键增强型水合物抑制剂及其制备方法
CA3263725A1 (en) * 2022-08-25 2024-02-29 Univ California PRO-PEPTIDES CLIVABLE BY ALPHA FIBROBLAST ACTIVATING PROTEIN AND METHODS OF USE
WO2025046043A1 (en) 2023-08-31 2025-03-06 Stichting Radboud Universitair Medisch Centrum Endometriosis tracer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6803357B1 (en) * 1998-02-02 2004-10-12 New England Medical Center Hospitals, Inc. Method of regulating glucose metabolism, and reagents related thereto
US6890904B1 (en) * 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
US7041696B2 (en) * 2002-06-17 2006-05-09 The Procter & Gamble Company Interleukin-1β converting enzyme inhibitors
CA2633803A1 (en) * 2005-12-19 2007-09-07 Trustees Of Tufts College Soft protease inhibitors and pro-soft forms thereof

Also Published As

Publication number Publication date
JP2010523477A (ja) 2010-07-15
AU2008228863A1 (en) 2008-09-25
WO2008116054A1 (en) 2008-09-25
EP2139337A4 (en) 2012-09-19
EP2139337A1 (en) 2010-01-06
US20100105753A1 (en) 2010-04-29

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20140320