AU2008228863A1 - Inhibitors of fibroblast activation protein, and methods of use thereof - Google Patents

Inhibitors of fibroblast activation protein, and methods of use thereof Download PDF

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Publication number
AU2008228863A1
AU2008228863A1 AU2008228863A AU2008228863A AU2008228863A1 AU 2008228863 A1 AU2008228863 A1 AU 2008228863A1 AU 2008228863 A AU2008228863 A AU 2008228863A AU 2008228863 A AU2008228863 A AU 2008228863A AU 2008228863 A1 AU2008228863 A1 AU 2008228863A1
Authority
AU
Australia
Prior art keywords
compound
amino acid
carbonyl
acid residue
side chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2008228863A
Other languages
English (en)
Inventor
William W. Bachovchin
Hung-Sen Lai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tufts University
Original Assignee
Tufts University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tufts University filed Critical Tufts University
Publication of AU2008228863A1 publication Critical patent/AU2008228863A1/en
Abandoned legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2008228863A 2007-03-20 2008-03-20 Inhibitors of fibroblast activation protein, and methods of use thereof Abandoned AU2008228863A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89578707P 2007-03-20 2007-03-20
US60/895,787 2007-03-20
PCT/US2008/057636 WO2008116054A1 (en) 2007-03-20 2008-03-20 Inhibitors of fibroblast activation protein, and methods of use thereof

Publications (1)

Publication Number Publication Date
AU2008228863A1 true AU2008228863A1 (en) 2008-09-25

Family

ID=39766448

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008228863A Abandoned AU2008228863A1 (en) 2007-03-20 2008-03-20 Inhibitors of fibroblast activation protein, and methods of use thereof

Country Status (6)

Country Link
US (1) US20100105753A1 (enExample)
EP (1) EP2139337A4 (enExample)
JP (1) JP2010523477A (enExample)
AU (1) AU2008228863A1 (enExample)
CA (1) CA2681351A1 (enExample)
WO (1) WO2008116054A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120053222A1 (en) * 2009-01-23 2012-03-01 Mark Gorrell Novel Metabolic Disease Therapy
WO2012082672A2 (en) * 2010-12-14 2012-06-21 Merck Sharp & Dohme Corp. Process and intermediates for preparing macrolactams
JP6207509B2 (ja) * 2011-08-30 2017-10-04 トラスティーズ オブ タフツ カレッジ 固形腫瘍を治療するためのfap活性化プロテアソーム阻害剤
AU2012340887A1 (en) 2011-11-22 2014-07-03 Trustees Of Tufts College Small molecule enhancer for dendritic cell cancer vaccines
US20200237936A1 (en) 2016-12-14 2020-07-30 Purdue Research Foundation Fibroblast activation protein (fap)-targeted imaging and therapy
EP3763726A1 (en) 2019-07-08 2021-01-13 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
KR20220032078A (ko) 2019-07-08 2022-03-15 쓰리비 파마슈티컬스 게엠베하 섬유모세포 활성화 단백질 리간드를 포함하는 화합물 및 그의 용도
EP3997103B9 (en) 2019-07-08 2025-02-26 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
EP4147053B1 (en) 2020-05-07 2026-01-28 Institut Curie Antxr1 as a biomarker of immunosuppressive fibroblast populations and its use for predicting response to immunotherapy
EP4050018A1 (en) 2021-01-07 2022-08-31 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
JP2024503637A (ja) 2021-01-07 2024-01-26 3ベー ファーマシューティカルズ ゲーエムベーハー 線維芽細胞活性化タンパク質リガンドを含む化合物およびその使用
CN114316136B (zh) * 2022-01-13 2023-01-31 西华师范大学 一种氢键增强型水合物抑制剂及其制备方法
KR20250057810A (ko) * 2022-08-25 2025-04-29 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 섬유아세포 활성화 단백질 알파-절단가능 프로-펩티드 및 사용 방법
AU2024334645A1 (en) 2023-08-31 2026-02-26 Stichting Radboud Universitair Medisch Centrum Endometriosis tracer
US20250186630A1 (en) 2023-12-12 2025-06-12 Viewpoint Molecular Targeting, Inc. Fibroblast activation protein targeting peptides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1520582A3 (en) * 1998-02-02 2009-07-01 Trustees Of Tufts College Use of dipeptidylpetidase inhibitors to regulate glucose metabolism
US6890904B1 (en) * 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
US7041696B2 (en) * 2002-06-17 2006-05-09 The Procter & Gamble Company Interleukin-1β converting enzyme inhibitors
KR20150003157A (ko) * 2005-12-19 2015-01-08 트러스티즈 오브 터프츠 칼리지 소프트 단백질분해효소 억제자 및 이의 프로-소프트 폼

Also Published As

Publication number Publication date
EP2139337A4 (en) 2012-09-19
WO2008116054A1 (en) 2008-09-25
JP2010523477A (ja) 2010-07-15
CA2681351A1 (en) 2008-09-25
EP2139337A1 (en) 2010-01-06
US20100105753A1 (en) 2010-04-29

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Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application